Clinical trials: Biting, open to volunteers
Repetitive Compulsive Behavior
tDCS and Urge in BFRBs
The goal of this study is to find out if brain stimulation can help people stop skin-picking or nail-biting. The study wants to answer two main questions: 1.
- Trial name
- NCT07019571
- Testing
- Wireless Multichannel Transcranial Current Stimulator (tDCS), Cue exposure, Boredom induction
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Gopalkumar Rakesh
Tick Bites
The Tick App: Changing Behaviors With Educational Messaging
The goal of this work is to evaluate the use of ecological momentary assessments as a tool to assess risk and risk factors for tick encounters and tick-borne diseases.
- Trial name
- NCT06880692
- Testing
- Educational Materials delivered via the Tick App
- Where
- 4 sites in United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Tick Bites
Evaluating the Impacts of Informal Tick and Tickborne Disease Educational Tools on Children
The purpose of this study is to evaluate the impacts of informal educational tools used by the Midwest Center of Excellence for Vector-Borne Disease in collaboration with the Wisconsin Department of Health Services.
- Trial name
- NCT07756606
- Testing
- Tick check mannequin, Ticks on bagel, LEGO Build-a-Tick
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Incisional Hernia After Midline Laparotomy, Quality of Life (QOL)
NoPro - Norwegian Hernia Prophylaxis Study
A multicenter randomized controlled trial comparing midline laparotomy closures using the small-bite suture technique alone to those using the small-bite suture technique with an additional onlay prophylactic polypropylene mesh.
- Conditions
- Incisional Hernia After Midline Laparotomy, Quality of Life (QOL), Burst Abdomen, Surgical Site Infections
- Trial name
- NoPro (NCT06858020)
- Testing
- Prophylactic polypropylene onlay mesh
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Sykehuset Innlandet HF
Antibody Mediated Rejection After Kidney Transplantation
Safety and Efficacy of the Bispecific T-Cell Engager (BiTE) in Kidney Transplant Recipients With Chronic Active Antibody-Mediated Rejection
This clinical trial aims to determine whether a bispecific T-cell engager (BiTE) targeting BCMA×CD3 effectively treats chronic active antibody-mediated rejection (cAMR) in kidney transplant recipients.
- Trial name
- NCT07689578
- Testing
- BiTE (BCMA x CD3 Bispecific Antibody)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Turun Song
Obstructive Sleep Apnea Syndrome
Predictive Factors for Occlusal Changes in Obstructive Sleep Apnea Treatment With Mandibular Advancement Appliance
This research addresses obstructive sleep apnea syndrome (OSAS), affecting 6-12% of French adults, often treated with mandibular advancement devices (MADs).
- Trial name
- APNEAMOUVE (NCT06576310)
- Testing
- Mandibular Advancement Device
- Where
- France
- Volunteers
- 118 people
- Sponsor
- University Hospital, Toulouse
Snakebite, Snake Envenomation
Mapping Snakebite Risk in Ghana and Rwanda
Snakebite causes approximately 138,000 deaths each year and non-fatal bites lead to considerable health burden, particularly in low-income tropical countries. Data on snakebite burden are lacking.
- Trial name
- NCT06808789
- Where
- Ghana
- Volunteers
- 32,000 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Bruxism
Botulinum Toxin-A for Bruxism Using Digital Occlusal Analysis
Bruxism is a repetitive jaw-muscle activity that may lead to tooth wear, muscle pain, headaches, and functional limitations. Current diagnostic approaches mainly rely on self-reported symptoms and clinical examination findings…
- Trial name
- NCT07640035
- Testing
- Botulinum Toxin-A injection
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Bilecik Seyh Edebali Universitesi
HIV
Spironolactone and XPB-1 Integrity in the TFIIH Complex
This is a prospective, interventional, exploratory clinical study designed to evaluate the pharmacokinetics, safety, and biological effects of spironolactone on the degradation of the XPB (ERCC3) protein and its potential impact…
- Trial name
- SPIRIT-XPB (NCT07415811)
- Testing
- Spironolactone (drug)
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Colorectal Cancer, Incisional Hernia
Comparing Polypropylene Mesh and "Small Bites" Technique in Emergency Colorectal Surgery's Midline Laparotomy Closure. Study for Incisional Hernia Prevention.
The 2023 World Journal of Emergency Surgery guidelines couldn't provide a recommendation for emergency abdominal wall closure due to insufficient consensus (>80% required).
- Conditions
- Colorectal Cancer, Incisional Hernia, Wound Infection
- Trial name
- BITEME (NCT06220058)
- Testing
- Closure of the midline laparotomy using the "small bites" technique, Closure of the midline laparotomy using the "small bites" technique with an absorbable PP mesh
- Where
- Spain
- Volunteers
- 148 people
- Sponsor
- Fernandez Zamora
Pain, Postoperative
Pain Management Study
This study aims to better understand the role that narcotic vs. non-narcotic multimodal pain management play in patients' pain following bariatric surgery (Laproscopic Surgery and Robotic Assisted Surgery).
- Trial name
- NCT05231460
- Testing
- Active Comparator: narcotic regimen with TAP block, Active Comparator: narcotic regimen with no TAP block, non-narcotic regimen with TAP block
- Where
- United States
- Volunteers
- 244 people
- Sponsor
- University of Arizona
Exercise Induced Laryngeal Obstruction (EILO)
HelpILO - RCT on EILO Treatment
Exercise induced laryngeal obstruction (EILO) is a common cause of exertional breathing problems in young individuals, caused by paradoxical inspiratory adduction of laryngeal structures, and diagnosed by continuous visualization…
- Trial name
- NCT04620343
- Testing
- A: Breathing advice with bio-feedback, B: Breathing advice with bio-feedback, Inspiratory muscle training (IMT), C: Breathing advice with bio-feedback, Speech Therapy
- Where
- Norway
- Volunteers
- 350 people
- Sponsor
- Haukeland University Hospital
Adhesive Small Bowel Obstruction, Postoperative Abdominal Adhesions
Adhesion Prevention in ASBO Surgery Using 4DryField® PH
Post-surgical adhesions occur in up to 90% of abdominal surgeries, often leading to complications like adhesive small bowel obstruction (ASBO) and chronic pain.
- Conditions
- Adhesive Small Bowel Obstruction, Postoperative Abdominal Adhesions, Bowel Obstruction, Abdominal Surgery Complications
- Trial name
- ADHERE (NCT07078981)
- Volunteers
- 189 people
- Sponsor
- Alessio Giordano
Multiple Myeloma, Newly Diagnosed
MRD-Adaptive Guided Immunotherapy With CAR-T for Transplant-Ineligible Patients With Multiple Myeloma
This is a prospective, single-center, clinical study to evaluate the efficacy and safety of a fully immunotherapy-based strategy guided by MRD-driven dynamic risk stratification in transplant-ineligible patients with newly…
- Trial name
- CAREMM-008 (NCT07106736)
- Testing
- BCMA CAR-T, GPRC5D/CD3 BiTEs
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Esophageal Atresia With Tracheo-esophageal Fistula, Esophageal Atresia
Balloon Inflation Time for Esophageal Strictures (BITES): A Randomized Multi-Center Study
Esophageal atresia (EA) is one of the most common gastrointestinal congenital anomalies that affects 1 in 2500 to 1 in 4000 live births.
- Conditions
- Esophageal Atresia With Tracheo-esophageal Fistula, Esophageal Atresia, Esophageal Strictures
- Trial name
- BITES (NCT07100379)
- Testing
- Endoscopic Balloon Dilation
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- Boston Children's Hospital
Kidney Transplantation Recipients, HLA Sensitization
Safety and Efficacy of BiTE in Desensitization Therapy for Highly Sensitized Kidney Transplant Candidates With cPRA ≥ 90%
This study is a prospective, open-label, two-arm exploratory clinical trial aimed at evaluating the safety and efficacy of Bispecific T-cell Engager (BiTE) therapies in refractory, highly sensitized kidney transplant candidates.
- Trial name
- NCT07689149
- Testing
- BiTE (CD19 x CD3 Bispecific Antibody), BiTE (BCMA x CD3 Bispecific Antibody)
- Volunteers
- 20 people
- Sponsor
- West China Hospital
Post-tick Bite Illness, Mast Cell Stabilizer
Mast Cell Treatment in Post-tick Bite Illness (PTBI)
This is a Phase II double-blinded study to assess the safety, tolerability, and feasibility of the mast cell stabilizing medications ketotifen and cromolyn compared to participants receiving standard of care treatment with…
- Trial name
- NCT07526558
- Testing
- Ketotifen, fexofenadine, Cromolyn Sodium
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Dental Occlusion
Patient Perception and Oral Function of Implant Restorations
The overall aim is to evaluate the patient-reported outcome and efficiency of replacing posterior teeth with implant-supported crowns compared to RDPs and no treatment.
- Trial name
- REPLACE (NCT06463405)
- Testing
- Splinted
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Intensive Care Unit, Intraventricular Hemorrhage
Prediction of Undesired Obstruction in External Ventricular Drains.
Acute obstructive hydrocephalus often complicates intraventricular hemorrhage (IVH). The insertion of an external ventricular drain (EVD) is typically necessary in order to alleviate intracranial pressure by draining excess…
- Conditions
- Intensive Care Unit, Intraventricular Hemorrhage, External Ventricular Drain
- Trial name
- EVD-OBS (NCT06466811)
- Testing
- Patients of intensive care unit, Patients of surgical intensive care unit
- Where
- France
- Volunteers
- 640 people
- Sponsor
- Nantes University Hospital
Snake Bites, Snakebite
Analysis of the Efficacy of Pressure Pad vs Pressure Bandage Immobilisation for Snake Bite First Aid in Healthy Volunteers.
Snake bite affects thousands of Australians every year, but few die as a result due to high quality first aid and timely medical care.
- Conditions
- Snake Bites, Snakebite, Snake Envenomation, Snake Bite
- Trial name
- NCT07261982
- Testing
- Pressure bandage immobilisation first aid, Pressure pad first aid, Control - no first aid
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Townsville University Hospital