Clinical trials: Biting, open to volunteers
Kidney Transplantation Recipients, HLA Sensitization
Safety and Efficacy of BiTE in Desensitization Therapy for Highly Sensitized Kidney Transplant Candidates With cPRA ≥ 90%
This study is a prospective, open-label, two-arm exploratory clinical trial aimed at evaluating the safety and efficacy of Bispecific T-cell Engager (BiTE) therapies in refractory, highly sensitized kidney transplant candidates.
- Trial name
- NCT07689149
- Testing
- BiTE (CD19 x CD3 Bispecific Antibody), BiTE (BCMA x CD3 Bispecific Antibody)
- Volunteers
- 20 people
- Sponsor
- West China Hospital
Erector Spinae Plane Block
Continuous ESP Block in Patients Undergoing CABG Surgery.
This study addresses articles and studies related to the erector spinae plane (ESP) block and its technique, advantages and disadvantages, applicability, among others.
- Trial name
- NCT07666178
- Testing
- Ropivacaine, Standard Postoperative Analgesics
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Instituto do Coracao
Bite Force, Masseter Muscle
Postoperative Bite Force After Bioflx and Zirconia Crowns in Children
This randomized clinical trial aims to compare postoperative bite force following full-crown restoration with preformed Bioflx and zirconia crowns in children undergoing comprehensive dental treatment under general anesthesia.
- Conditions
- Bite Force, Masseter Muscle, Zirconia Crowns, Primary Molars
- Trial name
- NCT07825103
- Testing
- Preformed Bioflx Crown, Preformed Zirconia Crown
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Dental Occlusion, Primary Teeth
Digital Occlusal Analysis and Bite Force Evaluation of Primary Molars Restored With Zirconia Crowns Using T-Scan
The goal of this observational study is to evaluate the adaptation of occlusion and bite force after zirconia crown restoration in children with pulp-treated primary molars.
- Conditions
- Dental Occlusion, Primary Teeth, Pulp-treated Primary Molars, Zirconia Crowns
- Trial name
- NCT07276841
- Testing
- Pulp Therapy and Zirconia Crown Restoration of Primary Molars with T-Scan Occlusal Analysis
- Where
- Egypt
- Volunteers
- 11 people
- Sponsor
- Cairo University
Dental Occlusion
Patient Perception and Oral Function of Implant Restorations
The overall aim is to evaluate the patient-reported outcome and efficiency of replacing posterior teeth with implant-supported crowns compared to RDPs and no treatment.
- Trial name
- REPLACE (NCT06463405)
- Testing
- Splinted
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Occlusion
Characterization of the Temporo-masseteric Nerve Block (TMNB) in Healthy Subjects
The proposed pilot study is aimed at preliminary characterization of the TMNB injection in 20 healthy volunteers. Assessment of bite-force distribution and surface electromyographic activity of the temporalis and the masseter…
- Trial name
- NCT05507164
- Testing
- Temporomasseteric Nerve Block
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Airway Assessment
Combined Ultrasound and Upper Lip Bite Test Assessment of Difficult Laryngoscopy in Obese Patients
The aim of this observational study is to evaluate the accuracy of the HMDR combined with the ULBT as a predictor of difficult laryngoscopy in obese patients undergoing elective surgery under general anesthesia, regarding…
- Trial name
- NCT07642206
- Testing
- Hyomental distance measured using ultrasound in neutral head position, maximum head extension and during upper lip bite test
- Where
- Egypt
- Volunteers
- 134 people
- Sponsor
- Cairo University
Snake Envenomation
Polyvalent Antivenom (Premium-PANAF) for Snakebite Envenoming in Ethiopia
Snakebite Envenomation is recognised as a Neglected Tropical Diseases with high lethality in Sub-Saharan Africa. The current syndromic treatment approach is also fraught by supply pipeline constraints and need for cold-chain…
- Trial name
- NCT07659002
- Where
- Ethiopia
- Volunteers
- 600 people
- Sponsor
- Medecins Sans Frontieres, Netherlands
Dental Occlusion, Occlusal Wear of Teeth
Evaluation of Occlusal Adjustment Material Removal on Monolithic Zirconia Blocks: An In Vitro Study
This study aims to improve understanding of the amount of tooth-replacement material removed during a single grinding "stroke" performed in the adjustment of a zirconia crown.
- Conditions
- Dental Occlusion, Occlusal Wear of Teeth, Fixed Dental Prosthesis
- Trial name
- NCT07280130
- Testing
- perform material removal on monolithic zirconia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Snake Bite
Predictive Accuracy of the Snakebite Severity Score (SSS) in Identifying Syndrome-Specific Core Outcome Parameters Among Envenomated Patients Presenting to the Emergency Department
India reports ~58,000 snakebite deaths/year, over 50% of global mortality. Clinical outcomes of antivenom may vary due to regional venom differences, delayed access to care, ineffective use of existing polyvalent antivenom.
- Trial name
- SCOPE-Snake (NCT07079137)
- Testing
- History, examination, bite documentation, SSS scoring,Baseline labs as per institutional protocol
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Endodontically Treated Teeth
Bite Force and Occlusal Force Distribution Following Root Canal Treatment.
Understanding the changes in bite force and occlusal force distribution in ETT is clinically important, as it can directly influence tooth prognosis, guide restorative treatment planning, and impact the long-term survival of the…
- Trial name
- B-FORCE RCT (NCT07626372)
- Where
- Thailand
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Abdominal Surgery Patients, Transversus Abdominis Plane (TAP) Block
Plasma Kinetics of Levobupivacaine After Transversus Abdominis Plane (TAP) Block in Abdominal Surgery
This prospective single-center observational pharmacokinetic study will evaluate plasma levobupivacaine concentrations after ultrasound-guided transversus abdominis plane (TAP) block in adult patients undergoing elective…
- Conditions
- Abdominal Surgery Patients, Transversus Abdominis Plane (TAP) Block, Pharmacokinetic Analysis, Levobupivacaine
- Trial name
- LEVO-TAP-PK (NCT07581275)
- Testing
- Ultrasound-Guided Transversus Abdominis Plane Block with Levobupivacaine
- Volunteers
- 26 people
- Sponsor
- University of Liege
Alpha-Gal Syndrome
The α-gal Syndrome - Investigating Immune Reactions to Tick Bites
Tick bites can transmit pathogens, but they can also induce a food allergy to mammalian meat. The goal of this clinical trial is to follow immune response and antibody build-up in individuals bitten by a tick.
- Trial name
- ImmunoGal (NCT07177729)
- Where
- 2 sites in Luxembourg
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health
Root Canal Treatment, Obturation Quality
Diagnostic Accuracy of a Deep Learning Framework for Automated Evaluation of Root Canal Obturation Quality From Periapical Radiographs
This study aims to develop and evaluate an artificial intelligence (AI)-based system that can automatically assess the quality of root canal fillings using dental X-ray images.
- Trial name
- NCT07684482
- Testing
- Deep learning model
- Volunteers
- 490 people
- Sponsor
- Cairo University
Stroke, Ischemic, Cerebrovascular; Disorder, Occlusive
Rescue Endovascular Therapy for Progressive Acute Mild Ischemic Stroke With Large Vascular Occlusion
Endovascular therapy (EVT) added on best medical management is currently recommended in acute large vascular occlusion (LVO) stroke patients with National Institutes of Health Stroke Scale (NIHSS) score >5.
- Trial name
- NCT06155032
- Testing
- Endovascular therapy, Best medical management
- Where
- 7 sites in China
- Volunteers
- 272 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Onychophagia
Effect of Nail Biting Habit on Mandibular Bone Structure: A Retrospective Radiological Study
Nail biting (onychophagia) is a common parafunctional habit characterized by repetitive and non-functional biting behavior. Although the effects of nail biting on dental structures and occlusion have been reported, its potential…
- Trial name
- NCT07740889
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Arrhythmias, Cardiac, Atrioventricular Block
ConTempoRary Cardiac Stimulation in Clinical practicE: lEft, BivEntriculAr, Right, and conDuction System Pacing
The goal of this observational study is to evaluate the clinical characteristics of patients undergoing permanent cardiac pacing and to compare procedural efficacy and safety of different implantation approaches in the clinical…
- Conditions
- Arrhythmias, Cardiac, Atrioventricular Block, Reduced Systolic Function, Atrial Fibrillation
- Trial name
- TREEBEARD (NCT06324682)
- Testing
- Cardiac pacing - Conventional RV pacing, Cardiac pacing - Conduction System Pacing, Cardiac pacing - Cardiac resynchronization therapy (pacing - CRTP - or defibrillation - CRTD)
- Where
- 31 sites in Italy
- Volunteers
- 8,400 people
- Sponsor
- University Hospital of Ferrara
Esophageal Atresia With Tracheo-esophageal Fistula, Esophageal Atresia
Balloon Inflation Time for Esophageal Strictures (BITES): A Randomized Multi-Center Study
Esophageal atresia (EA) is one of the most common gastrointestinal congenital anomalies that affects 1 in 2500 to 1 in 4000 live births.
- Conditions
- Esophageal Atresia With Tracheo-esophageal Fistula, Esophageal Atresia, Esophageal Strictures
- Trial name
- BITES (NCT07100379)
- Testing
- Endoscopic Balloon Dilation
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- Boston Children's Hospital
Childhood-onset Systemic Lupus Erythematosus
Immune Profiling of Refractory cSLE Exposed to CD3×CD19 BiTE
This prospective observational study aims to characterize the peripheral immune landscape of pediatric patients with childhood-onset systemic lupus erythematosus ( cSLE) who are receiving CD3×CD19 bispecific T-cell engager (BiTE)…
- Trial name
- BiTE-cSLE-IP (NCT07352332)
- Where
- China
- Volunteers
- 6 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Multiple Myeloma, Newly Diagnosed
MRD-Adaptive Guided Immunotherapy With CAR-T for Transplant-Ineligible Patients With Multiple Myeloma
This is a prospective, single-center, clinical study to evaluate the efficacy and safety of a fully immunotherapy-based strategy guided by MRD-driven dynamic risk stratification in transplant-ineligible patients with newly…
- Trial name
- CAREMM-008 (NCT07106736)
- Testing
- BCMA CAR-T, GPRC5D/CD3 BiTEs
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China