Clinical trials: Bladder, Neurogenic
Neurogenic Bladder Disorder
Predictive Urodynamic Parameters for The Treatment Efficacy of Onabotulinum A Toxin in Neurogenic Lower Urinary Tract Dysfunction
Purpose: To evaluate urodynamic parameters predicting the treatment efficacy of onabotulinumtoxin A (onaBoNT-A) in patients with neurogenic lower urinary tract dysfunction (NLUTD).
- Trial name
- NCT06485453
- Testing
- Botox 200 UNT Injection
- Volunteers
- 74 people
- Sponsor
- University of Gaziantep
Incontinence, Urinary and Urinary Bladder, Overactive, Overactive Bladder
Effects Of GW679769 On Bladder Nerve Function And Symptoms Of Overactive Bladder In Spinal Cord Injury Patients
This is a two-part study in which Part A will assess the effects of GW679769 after 1 dose on the function of the nerves that supply the bladder. The technique for measuring the nerves function is called Neurometry.
- Trial name
- NCT00332319
- Testing
- GW679769
- Where
- 3 sites in United States
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Neurogenic Bladder, Spina Bifida
Comparing Urinary Tract Infections in Children With Spina Bifida Using Two Types of Catheters for Catheterization
The primary aim of this study was to determine if using the SpeediCath hydrophilic catheter would reduce the incidence of symptomatic urinary tract infections (UTI)in children with spina bifida who perform clean intermittent…
- Trial name
- NCT01263392
- Testing
- Intermittent catheterization
- Where
- 4 sites in Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Alberta
UTI, Neurogenic Bladder
Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods)
Due to the damage caused to the spinal cord, patients with spinal cord injury, cauda equina syndrome, multiple sclerosis and transverse myelitis may encounter loss of bladder function, which in turn can lead to a debilitating and…
- Conditions
- UTI, Neurogenic Bladder, Antibiotic Resistance
- Trial name
- PReSuTINeB (NCT02591901)
- Testing
- Uro vaxom
- Where
- 2 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- Buckinghamshire Healthcare NHS Trust
Multiple Sclerosis, Neurogenic Bladder
Vaginal Estriol in Multiple Sclerosis
Study to evaluate the efficiency of vaginal estriol, as a treatment for urogenital symptoms in female patients with RRMS. The secondary objective is to evaluate the potential role of vaginal estriol in re-myelination in RRMS…
- Trial name
- NCT03774407
- Testing
- vaginal estriol
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Texas Tech University Health Sciences Center
Spinal Cord Injuries
Transcutaneous Tibial Nerve Stimulation for Spinal Cord Injury Neurogenic Bladder
The purpose of this study is to determine if electric stimulation to the leg, called transcutaneous tibial nerve stimulation (TTNS), can improve bladder outcomes in acute spinal cord injury.
- Trial name
- TTNS1yr (NCT04350359)
- Testing
- Variable-dose TTNS Protocol 5 x week, Fixed-dose TTNS Protocol, Variable-dose TTNS Protocol 2 x week
- Where
- 2 sites in United States
- Volunteers
- 111 people
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Injury, Neurogenic Lower Urinary Tract Dysfunction
Representation of the Bladder Innervation Using Diffusion Tensor Imaging Fiber Tracking With MRI - a Pilot Study
The exact innervation of the bladder and the changes after a spinal cord injury have been not yet been illustrated. Diffusion tensor imaging with magnetic resonance imaging is a new technique which can be used to visualize single…
- Trial name
- NCT02138201
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Neurogenic Bladder, Overactive Detrusor
Efficacy of Two Onabotulinum Toxin Doses
The changes in bladder function after the injection of Onabotulinum toxin into the detrusor in individuals with neurogenic bladder overactivity will be investigated retrospectively.
- Trial name
- NCT03388086
- Testing
- Injection of Onabotulinum toxin
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Neurogenic Bladder, Voiding Dysfunction
Efficacy and Safety of Silodosin on Voiding Dysfunction Associated With Neurogenic Bladder
Because the bladder neck and proximal urethra contain abundant α1-adrenergic receptors, α-blockers or α1-blockers are well-known to reduce bladder neck obstruction in patients with or without neurogenic bladder.
- Trial name
- NCT01228370
- Testing
- silodosin
- Where
- 6 sites in South Korea
- Volunteers
- 95 people
- Sponsor
- JW Pharmaceutical
Spina Bifida
Efficacy of Intravesical Oxybutynin in Children With Neurogenic Bladder Dysfunction
Malformation of the lumbosacral region (spina bifida) affects the innervation of the bladder in children. The usual evolution leads to a neurological bladder with small capacity, poor compliancy and overactivity, exposing to…
- Trial name
- POXIPEN (NCT07027020)
- Testing
- Oxybutynin Hydrochloride
- Where
- 19 sites in France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Incontinence, Bladder Dysfunction
Bladder Neck Surgery in Children with Neurogenic Bladder
Surgical outcomes of bladder neck surgery in children with neurogenic bladder. Consequences on bladder voiding.
- Conditions
- Incontinence, Bladder Dysfunction, Spina Bifida, Neurogenic Bladder Disorder
- Trial name
- CERPED (NCT06734390)
- Testing
- Bladder Neck Surgery
- Where
- France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Clermont-Ferrand
Bladder Dysfunction, Bowel Dysfunction
Comparison of Transcutaneous Electrical Nerve Stimulation and Manual Therapy in Children With Cerebral Palsy
There are many studies in the literature on healthy children with lower urinary tract dysfunction (LUTD), but there are limited number of studies in children with cerebral palsy (CP) with LUTD.
- Conditions
- Bladder Dysfunction, Bowel Dysfunction, Cerebral Palsy, Neurogenic Bladder
- Trial name
- NCT05351138
- Testing
- TENS, Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Bahçeşehir University
Neurogenic Bladder
Effect of Botulinum Toxin A on Neurogenic Detrusor Overactivity in Chronic Spinal Cord Injured Patients
This study investigated the changes in urothelial dysfunction and sensory protein expression in the bladder urothelium with time after onabotulinumtoxin injection in spinal cord injured (SCI) patients.
- Trial name
- NCT03063827
- Testing
- OnabotulinumtoxinA 200 UNT, Urothelial sensory protein levels
- Volunteers
- 36 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Myelopathy, Neurogenic Bladder
Urinary and Sexual Function Before and After Surgical Decompression of Cervical Myelopathy
Hypotheses: Decompressive surgery of cervical myelopathy will improve bladder function. Decompressive surgery of cervical myelopathy will improve sexual function.
- Conditions
- Myelopathy, Neurogenic Bladder, Erectile Dysfunction, Psychosexual Dysfunctions
- Trial name
- NCT02059798
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- The Catholic University of Korea
Spina Bifida
Transcutaneous Tibial Nerve Stimulation (TTNS) Treatment in Spina Bifida Pediatric Patients With Neurogenic Bladder
The purpose of this research study is to determine the effectiveness of a treatment called "transcutaneous tibial nerve stimulation" or "TTNS" in the treatment of urinary leakage for patients with spina bifida.
- Trial name
- NCT06025734
- Testing
- Transcutaneous Tibial Nerve Stimulation (TTNS) treatment
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Texas Southwestern Medical Center
Detrusor Function, Overactive
Extended-Release Oxybutynin for the Treatment of Neurogenic Detrusor Overactivity
The purpose of this study is to evaluate the effects and tolerability (how well a participant can stand a particular medicine or treatment) of flexible dose Oxybutynin Extended-Release (OXY-ER, Lyrinel) including safety and…
- Trial name
- RONDO (NCT01796548)
- Testing
- Oxybutinin Extended-Release
- Where
- 3 sites in Thailand
- Volunteers
- 17 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Spina Bifida
Nerve Rerouting Treatment for Neurogenic Bladder in Spina Bifida
The goal of this study is to evaluate a surgical procedure (operation) that reroutes lumbar to sacral nerves in the spinal column to improve the bladder's ability to empty properly in patients born with Spina Bifida.
- Trial name
- NCT01096459
- Testing
- Nerve Rerouting
- Sponsor
- Kenneth Peters, MD
Spinal Cord Injuries (SCI), Neurogenic Bladder
Intravesical Lactobacillus Crispatus: Clinical Safety and Microbiome Evaluation
The goal of this clinical trial is to determine whether Lactobacillus crispatus strains isolated from the lower urinary tracts of adult women can be used as an antibiotic-sparing treatment for urinary symptoms and urinary tract…
- Conditions
- Spinal Cord Injuries (SCI), Neurogenic Bladder, Urinary Tract Infection (Diagnosis)
- Trial name
- NCT07308808
- Testing
- Lactobacillus Crispatus, Saline bladder wash
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medstar Health Research Institute
Incontinence, Urge, Stroke
Evaluation of the Efficacy of Transcutaneous Tibial Nerve Stimulation on Post-Stroke Overactive Bladder
The goal of this clinical trial is to comparing the efficacies of different managements in patients with overactive bladder symptoms with stroke The main question it aims to answer are: Are pelvic floor training exercises and…
- Conditions
- Incontinence, Urge, Stroke, Neurogenic Bladder
- Trial name
- NCT06247033
- Testing
- Tibial Nerve Stimulation with TENS device, Pelvic muscle training exercise with bladder training
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Urinary Incontinence, Overactive Bladder
Dysport® Treatment of Urinary Incontinence in Adults Subjects With Neurogenic Detrusor Overactivity (NDO) Due to Spinal Cord Injury or Multiple Sclerosis - Study 1
The purpose of this study is to provide confirmatory evidence of the safety and efficacy of two Dysport® (AbobotulinumtoxinA) doses (600 units [U] and 800 U), compared to placebo in reducing urinary incontinence (UI) in adult…
- Trial name
- CONTENT1 (NCT02660138)
- Testing
- Botulinum toxin type A
- Where
- 81 sites in United States, Canada and 8 more
- Volunteers
- 227 people
- Sponsor
- Ipsen