Clinical trials: Blast Injury
Mild Traumatic Brain Injury
Imaging [18F]PI-2620 and [18F]Florbetaben in Military Service Members With Blast Related Mild Traumatic Brain Injury
The main objective of this interdisciplinary study is to develop an understanding of the molecular imaging features of blast-related mild traumatic brain injury (mTBI) in military personnel, while helping to establish assessment…
- Trial name
- NCT05337774
- Testing
- [18F]PI-2620
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Life Molecular Imaging SA.
Burn Scar Pain, Neuropathic Pain
Ultrasound Predictors of Persistent Burn Scar Pain After Blast and Drone-Related Injuries: A Prospective Cohort Study
Persistent burn scar pain is common after blast and drone-related injuries and may be driven by scar fibrosis, vascular activity, and peripheral nerve involvement within scar tissue.
- Conditions
- Burn Scar Pain, Neuropathic Pain, Combat-Related Burn Injury, Scar-Related Pain
- Trial name
- US-SCAR-PAIN (NCT07438769)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Residual Limb Pain, Stump Pain
Post-Amputation Stump Infection as a Predictor of Persistent Residual Limb Pain: A Prospective Cohort Study
Persistent residual limb pain is common after traumatic amputation and significantly impairs rehabilitation and prosthetic use. Postoperative stump infection may contribute to peripheral nerve sensitization, scar fibrosis, and…
- Conditions
- Residual Limb Pain, Stump Pain, Post-Amputation Pain, Surgical Site Infection
- Trial name
- INF-STUMP-PAIN (NCT07438795)
- Volunteers
- 150 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Brain Concussion, Blast Injuries
Metacognitive Training to Enhance Strategy Use in Blast-Related TBI
Enhanced Goal Management Training (GMT) is a 10-week group or individual therapy that teaches strategies to improve an individual's ability to complete everyday tasks.
- Trial name
- NCT00857207
- Testing
- Goal Management Training
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- VA Office of Research and Development
Low-level Blast Exposure
Blast Overpressure Longitudinal Study
The goal of this observational study is to learn about the impact of low-level blast exposure in U.S. Special Operations Forces personnel.
- Trial name
- BLES (NCT07606651)
- Where
- 3 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Concussion, Mild
Novel Protection Against Potential Brain, Hearing and Vision Injury During Blast Wave Exposure
The purpose of the study is to monitor changes in brain structure and function between the pre-training and post-training, in a population of tactical team members wearing the Device and compared to a similar population not…
- Trial name
- BLAST (NCT03017924)
- Testing
- Q collar
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Tinnitus
Caroverin and Inner Ear Diseases
This trial is a randomized, double blind, placebo controlled study on patients suffering from inner ear diseases with tinnitus as a principal symptom.
- Trial name
- NCT01174979
- Testing
- Caroverin
- Where
- Austria
- Volunteers
- 170 people
- Sponsor
- Phafag AG
Wounds and Injuries, War-Related Injuries
Retrospective Morbidity and Mortality Study of Conflict-Related Injuries: Erbil, Iraq
A retrospective morbidity and mortality study, using routinely collected data, investigating the epidemiology of patients with conflict-related injuries presenting to a dedicated trauma hospital in Erbil, Iraq, during the…
- Conditions
- Wounds and Injuries, War-Related Injuries, Gunshot Wound, Blast Injuries
- Trial name
- NCT03358758
- Where
- Sweden
- Volunteers
- 1,832 people
- Sponsor
- Karolinska Institutet
Traumatic Brain Injury, Cognitive Dysfunction
Combined Transcranial Magnetic Stimulation and Cognitive Treatment in Blast Traumatic Brain Injury
This study investigates the efficacy of a novel neurorehabilitation program combining noninvasive brain stimulation (transcranial magnetic stimulation or TMS) and cognitive therapy, on cognitive function and quality of life in…
- Conditions
- Traumatic Brain Injury, Cognitive Dysfunction, Blast Injury
- Trial name
- COST-TBI (NCT01596569)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Cognitive Intervention
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Boston Medical Center
Traumatic Brain Injury, Blast Injuries
Long-Term Effects of Repetitive, Low-Level Blast Exposure on Special Operations Forces Service Members
This is a pilot study to identify biomarkers that individually, and in combination, demonstrate the greatest sensitivity to repetitive, low-level blast exposure (RLLBE) neurotrauma in Special Operations Forces (SOF) personnel.
- Trial name
- ReBlast (NCT05183087)
- Testing
- 3T Connectome MRI, 7 Tesla MRI, TSPO PET
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Post-Traumatic Stress Disorder, Blast Injury
Virtual Reality Therapy and Imaging in Combat Veterans With Blast Injury and Posttraumatic Stress Disorder
The main purpose of this study is to determine whether functional magnetic resonance imaging (fMRI), can distinguish between service members with and without traumatic brain injury (TBI), as well as those with posttraumatic…
- Trial name
- ViRTICo-BP (NCT01990547)
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Traumatic Brain Injury, Post-Concussion Syndrome
"Interactive Metronome Technology for Blast-Related Traumatic Brain Injury"
The purpose of this research is to see whether adding a new therapy helps people with brain injury focus better and think more clearly.
- Trial name
- NCT01248390
- Testing
- Interactive metronome
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Defense and Veterans Brain Injury Center
Mild Traumatic Brain Injury, Post-Concussive Syndrome
Hyperbaric Oxygen Therapy (HBO2T) for Post-Concussive Symptoms (PSC) After Mild Traumatic Brain Injury (mTBI)
The goal of this research is to serve as a demonstration project to determine the tolerability of individuals with persistent post-concussive symptoms from combat-related mild TBI (traumatic brain injury), identify dose-finding…
- Trial name
- HBOT (NCT01220713)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Virginia Commonwealth University
Polytrauma, Blast Injuries
Peer Visitation for OEF/OIF Veterans
The goal of this study was to train OIF/OIF Veterans with multiple injuries to be Peer Visitors, i.e., Volunteers who visit more recently OIF/OEF Veterans and provide support.
- Trial name
- NCT01193686
- Testing
- Peer Visitation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- US Department of Veterans Affairs
Traumatic Brain Injury, Cognitive Symptoms
Cognitive Rehabilitation of Blast Traumatic Brain Injury (TBI)
The purpose of this study is to investigate the efficacy of a structured rehabilitation program on cognitive function and quality of life in individuals with blast-induced traumatic brain injury (bTBI).
- Trial name
- CRbTBI (NCT01138020)
- Testing
- Cognitive Intervention, Educational intervention
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- VA Office of Research and Development
Cerebral Palsy, Developmental Coordination Disorder
Bootle Blast: Understanding the Family Experience
One in 60 children have a physical disability that can impact activities and participation. Occupational and physical therapies can be of great benefit, but are costly and difficult to access.
- Conditions
- Cerebral Palsy, Developmental Coordination Disorder, Developmental Disability, Autism Spectrum Disorder
- Trial name
- NCT06161168
- Testing
- Bootle Blast Play Phase (B)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Blast Injury
Precision Biomarkers to Detect Brain Injury in Active-Duty United States Special Operations Forces With Repeated Blast Exposure
This is a 4-year, longitudinal study of 100 active-duty Navy SEALs. The goal of the study is to determine whether repeated blast exposure affects SEAL brain health and to develop an initial diagnostic testing protocol that…
- Trial name
- NCT07131475
- Testing
- PBR28 TSPO PET
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Mild Traumatic Brain Injury
The Use of Anti-oxidants to Reduce Sequela of Mild Traumatic Brain Injury (mTBI) After Blast Exposure
The administration of N-acetyl-cysteine (an anti-oxidant) for seven days along with observation will result in improved hearing and balance function in individuals who demonstrate these disorders after blast exposure when…
- Trial name
- NCT00822263
- Testing
- N-acetyl-cysteine (NAC)
- Where
- Iraq
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Traumatic Brain Injury, Posttraumatic Stress Disorder
LED Treatment to Improve Cognition and Promote Recovery in TBI
This study investigates the efficacy of a novel neuromodulation treatment, light emitting diodes (LED), on cognition, neuropsychiatric status and quality of life in individuals with traumatic brain injury (TBI).
- Trial name
- LED-TBI (NCT02404402)
- Testing
- LED
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- VA Office of Research and Development
mTBI
Detection and Amelioration of Gamma Oscillation Abnormalities in Blast-Related Brain Injury
Combat Veterans of post-9/11 conflicts have experienced serious cognitive and emotional problems resulting from exposure to blasts.
- Trial name
- DAGABBI (NCT03836976)
- Testing
- Auditory gamma sensory stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- VA Office of Research and Development