Clinical trials: Blastocyst
Culture Media, Blastocyst
Comparisons of Human Embryonic Development Using Single Medium With and Without the Addition of Antioxidants
Aim: To investigate the impact of antioxidants (acetyl-L-carnitine, N-acetyl-L-cysteine and a-lipoic acid) on embryo development and subsequently the clinical outcome.
- Conditions
- Culture Media, Blastocyst, Antioxidants, Embryo
- Trial name
- NCT02971878
- Testing
- Acetyl-L-carnitine (ALC), N-acetyl-L-cysteine (NAC) and α-lipoic acid (ALA)
- Where
- Sweden
- Volunteers
- 128 people
- Sponsor
- Fertilitetscentrum AB
Pregnancy
PGT-A Versus Blastocyst Morphology Selection
Introduction Embryo aneuploidy is likely the leading cause of implantation failure in IVF cycles. Since the inception of IVF, non-invasive morphology based scoring has been the most widely used embryo selection method, resulting…
- Trial name
- NCT03095053
- Testing
- comprehensive chromosome screening
- Where
- Turkey (Türkiye)
- Volunteers
- 302 people
- Sponsor
- Antalya IVF
Infertility, OHSS
Implantation Enhancement by Elective Cryopreservation of All Viable Embryos
A randomised controlled open-label clinical trial to compare the clinical pregnancy rates between fresh embryo transfer and elective all-embryo vitrification with thawing and transfer in a subsequent cycle in high-responders
- Trial name
- ICE (NCT02148393)
- Testing
- Vitrification with subsequent-cycle embryo thawing/transfer, Intensified luteal phase support for fresh embryo transfer, Pregnyl®
- Where
- Belgium
- Volunteers
- 212 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility
The Importance of Blastocyst Diamater and Its Correlation to Reproductive Outcomes in PGT-A Cases
Morphometric measurement of blastocyst diameter was taken on the day of trophoectoderm biopsy. PGT-A was done using NGS platform, followed by thawing and transfer of euploid blastocyts.
- Trial name
- NCT05499988
- Where
- Egypt
- Volunteers
- 1,000 people
- Sponsor
- Ganin Fertility Center
ART
Assisted Hatching in Frozen Blastocysts
The current study aims to assess the effect of assisted hatching on the implantation rate of frozen blastocytes.
- Trial name
- NCT03833869
- Testing
- Assisted hatching
- Where
- Israel
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Infertility
International Pilot Study for Dual Non-invasive Assesment of Embryo Development
Choosing the best embryo is one of the major challenges for achieving success in in vitro fertilization (IVF). Traditionally, embryo evaluation has been based on morphological quality (how the embryo looks like) and chromosomal…
- Trial name
- PANDORA (NCT06524648)
- Testing
- niPGT-A
- Where
- 8 sites in Austria, Spain and 1 more
- Volunteers
- 200 people
- Sponsor
- Igenomix
IVF, Frozen Embryo Transfer (FET)
Single Step Protocol and Multi-step Warming Protocol for Blastocyst FET
The multi-step thawing protocol with a reduction of non-permeable cryoprotectant concentrations to reduce osmotic shock caused by the rapid influx of water.
- Conditions
- IVF, Frozen Embryo Transfer (FET), Embryo Thawing Protocol
- Trial name
- ONESTEP (NCT07088640)
- Testing
- Single-step warming protocol by thawing solution only, Standard warming protocol
- Where
- Vietnam
- Volunteers
- 816 people
- Sponsor
- Mỹ Đức Hospital
Infertility
MENOPUR® in a Gonadotropin-Releasing Hormone (GnRH) Antagonist Cycle With Single-Blastocyst Transfer in a High Responder Subject Population
The purpose of this trial is to demonstrate non-inferiority of MENOPUR® versus recombinant Follicle Stimulating Hormone (rFSH) (Gonal-f®) with respect to ongoing pregnancy rate in women undergoing controlled ovarian stimulation…
- Trial name
- MEGASET HR (NCT02554279)
- Testing
- menotropin, recombinant FSH
- Where
- 35 sites in United States
- Volunteers
- 620 people
- Sponsor
- Ferring Pharmaceuticals
Fertility
Evaluation of Group Culture in WOW Dishes of Human Embryos in Order to Optimize the Single Embryo Transfer (SET) Strategy.
In cattle less than 10% of the embryos develop to the blastocyst stage when embryos are cultured individually, however when bovine embryos are cultured in groups a typical 25-35% of blastocysts can be observed.
- Trial name
- WOW (NCT02010424)
- Testing
- control group, Primo Vision embryo culture dish (CE labeled, Vitrolife)
- Where
- 2 sites in Belgium
- Volunteers
- 158 people
- Sponsor
- University Hospital, Ghent
Infertility
Comparing the Ongoing Pregnancy Rate for Vitrification of Day-4 Morula With Day-5 Blast
Comparing the vitrification at Day-4 (morula stage) with the blastocyst stage vitrification outcomes with the transfer of all day 5 after warming seems need evaluation.
- Trial name
- NCT03787901
- Testing
- Morula Vitrification
- Where
- 4 sites in Egypt
- Volunteers
- 53 people
- Sponsor
- Egyptian Foundation of Reproductive Endocrinology
Infertility
Atosiban in Women With Previous Implantation Failure and Abnormal Uterine Contractions
This study aims to evaluate the efficacy of atosiban in patients with previous pregnancy failure and abnormal uterine contractions during the peri-embryo transfer period in assisted reproductive technology.
- Trial name
- NCT07185230
- Testing
- Atosiban
- Where
- China
- Volunteers
- 792 people
- Sponsor
- Northwest Women's and Children's Hospital, Xi'an, Shaanxi
Infertility Assisted Reproductive Technology, Infertility (IVF Patients)
Blastocyst AI Assisted Morphokinetics in ART
The goal of this observational study is to learn if embryo characteristics obtained via the recording of real-time embryo activity via 30-seconds video capture (e.g.: Embryo Morphokinetics) can correlate with known embryo outcome…
- Trial name
- AIM (NCT07611448)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Viable Biosciences
Male Infertility
Correlating In Vitro Fertilization Outcomes After Euploid Blastocyst Transfer With Sperm DNA Fragmentation
The purpose of this study is to determine if sperm DNA fragmentation is associated with in vitro fertilization (IVF) outcomes when euploid embryos are transferred.
- Trial name
- NCT02268123
- Where
- 2 sites in United States
- Volunteers
- 323 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Blastocoele Fluid
Identification and Standardization of a Method That Would Allow the Study of the Metabolic Profile of Blastocoele Lays the Foundation to Assess Blastocyst Metabolomic Profile and Its Relation With Embryo Morphology and Embryo Implantation
While the number of assisted reproduction cycles increases worldwide, the introduction of actual technological improvements in the ability to quickly and non-invasively identify the best embryos for transfer still represents a…
- Trial name
- NCT01427413
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Cervesi Hospital, Cattolica, Italy
Infertility
Frozen Blastocyst Transfer in Natural Cycle
The rational of the study is to assess the pregnancy rate after the transfer of frozen blastocyst in natural cycle controlled by external administration of hCG.
- Trial name
- NCT01892826
- Testing
- hCG
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility, Success Rate of Assisted Reproductive Therapy
Impact of Uterine Immune Profiling and Personalized Treatments in Patients Receiving a Single Blastocyst: a Matched Controlled Study
A recent randomised controlled trial and previous large cohort studies have shown that the uterine immune environment is a crucial element in improving the performance of Assisted Reproductive therapy (ART).
- Conditions
- Infertility, Success Rate of Assisted Reproductive Therapy, Single Embryo Transfer, Pregnancy Outcomes
- Trial name
- UTIMPROSET (NCT06503952)
- Where
- 2 sites in France
- Volunteers
- 340 people
- Sponsor
- Matricelab Innove
Blastocyst Time, Pronuclear Appearance
Does DNA Sperm Fragmentation Affects Embryo Morphokinetic?
The embryokinetics may be a new prognostic factor for choosing the human embryos with the highest implantation potential. In order to identify the factors that may affect the rate of embryo cleavage, there are many studies about…
- Conditions
- Blastocyst Time, Pronuclear Appearance, Pronuclear Fading, Embryo Compaction
- Trial name
- MACs-ESD (NCT02214537)
- Testing
- MACS
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- IVI Madrid
Infertility, In Vitro Fertilization
Effect of Antioxydant-enriched Media on Blastocyst Euploidy Rates.
One of the most sensible factors in IVF culture conditions is the susceptibility of gametes and embryos to an induced increase in reactive oxidative species (ROS) caused by the artificial environment.
- Trial name
- GX (NCT06261671)
- Testing
- antioxidants-enriched culture medium (Gx)
- Where
- United Arab Emirates
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Cryopreservation, Blastocyst
Cryosurvival of Embryos From Dysmorphic Oocytes
Various morphological abnormalities of human oocytes were reported to detrimentally affect embryo development. We observed development of frozen thawed embryos derived from oocytes with normal or abnormal morphological features…
- Trial name
- NCT00521443
- Testing
- Cryopreservation, thawing and blastocyst culture
- Where
- Turkey (Türkiye)
- Sponsor
- V.K.V. American Hospital, Istanbul
Aneuploidy, Chromosome Abnormality
Multi-center Study to Validate niPGT-A
Abnormal chromosome number, or aneuploidy, is common in human embryos. It is responsible for more than half of all miscarriages, and it is the leading cause of congenital birth defects.
- Conditions
- Aneuploidy, Chromosome Abnormality, Infertility
- Trial name
- niPGT-A (NCT03520933)
- Testing
- PGT-A, niPGT-A
- Where
- 10 sites in United States, Argentina and 6 more
- Volunteers
- 2,586 people
- Sponsor
- Igenomix