Clinical trials: Blastocyst
Fertility, Implantation, Embryo
Cycle-to-cycle Variability of Progesterone in the Endometrium in Patients Undergoing an Euploid Blastocyst Transfer in a Hormone Replacement Therapy (HRT) Cycle (PROMICOFET)
This study looks at progesterone, a hormone that prepares the womb lining (endometrium) for pregnancy, in women having a frozen embryo transfer after IVF.
- Trial name
- PROMICOFET (NCT07818278)
- Testing
- Oestrogel® 0.75 mg (estradiol transdermal gel), Progesterone 200 mg vaginal capsules, Endometrial biopsy
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Infertility
Natural Cycle Versus Endometrial Preparation for Healthy Blastocyst Transfer
This study evaluates the difference in pregnancy rate transferring a healthy blastocyst in natural or artificial cycle.
- Trial name
- NCT02378584
- Testing
- embryo transfer
- Where
- 2 sites in Italy
- Volunteers
- 236 people
- Sponsor
- European Hospital
Aneuploidy, Chromosome Abnormality
Clinical Value of Mosaicism Diagnosis on the Trophectoderm Biopsies
Mosaicism within an embryo is defined as the presence of two or more cell populations with different genotypes. Blastocysts classified as mosaic by Preimplamtation Genetic Testing for Aneuploidy (PGT-A) have been reported to…
- Trial name
- NS-MOSAICISM (NCT03673592)
- Testing
- PGT-A
- Where
- 3 sites in Italy
- Volunteers
- 783 people
- Sponsor
- Igenomix
Other Complications Associated With Artificial Fertilization
Comparison of Individual Culture and Group Culture of Preimplantation Embryos in Human IVF Treatments
Prospective randomized comparison of two widely used in vitro culture system in human IVF treatments. In vitro fertilized oocytes and embryos are cultured in individual culture media droplets using conventional petridish or in…
- Trial name
- GroupCulture (NCT01774006)
- Testing
- individual embryo culture or group culture
- Where
- Hungary
- Volunteers
- 532 people
- Sponsor
- Semmelweis University
Pregnancy, Spontaneous Abortions
Study of the Best Blastocyst Post Transfer by aCGH
An Observational, blind and prospective study of Preimplantational Aneuploidy Screening by aCGH in Trophectoderm Biopsy
- Conditions
- Pregnancy, Spontaneous Abortions, Stillbirth
- Trial name
- NCT01664546
- Testing
- Trophectoderm biopsy
- Where
- Argentina
- Volunteers
- 150 people
- Sponsor
- University of Buenos Aires
The Focus is to Validate the Accuracy of a Non-invasive Artificial Intelligence Model for the Prediction of the Human Blastocyst Ploidy, Preimplantation Genetic Testing (PGT)
Evaluation of an Artificial Intelligence Model for the Prediction of Human Blastocyst Ploidy Without Invasive Procedures
The goal of this clinical trial is to evaluate an artificial intelligence model for the prediction of human blastocyst ploidy without invasive procedures in couples that receive preimplantation genetic testing.
- Trial name
- NCT06762704
- Testing
- Video recording
- Where
- 5 sites in China
- Volunteers
- 1,408 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Infertility
Mitochondrial Activity of Cumulus Cells From the Cumulus-oocyte Complex and Oocyte Competence
The need for non-invasive biomarkers of oocyte competency has become urgent as women increasingly delay attempts at childbearing.
- Trial name
- NCT02793752
- Testing
- Age
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Main Line Fertility Center
Primary Infertility, Secondary Infertility
LANDA Embryo Freezing Technique.
The aim of this study is to track the outcome from the patients who had embryo cryopreservation as part of their Advanced Reproductive Technology (ART) treatment at West Coast Fertility Centers.
- Conditions
- Primary Infertility, Secondary Infertility, Genital Diseases, Male, Genital Diseases, Female
- Trial name
- Freezing (NCT01271400)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- West Coast Fertility Centers
Infertility, Female, Infertility
Phase II Clinical Trial to Evaluate the Ongoing Pregnancy Rate With OXO-001 in IVF/ICSI With Donor Oocytes.
The main objective of this clinical research trial is to test the efficacy of OXO-001 in a daily oral administration increasing the pregnancy rate in IVF/ICSI by preparing the uterus to receive the embryo.
- Trial name
- OXOART2 (NCT05076032)
- Testing
- OXO-001
- Where
- 28 sites in Czechia, Poland and 1 more
- Volunteers
- 408 people
- Sponsor
- OXOLIFE
Infertility (IVF Patients)
Cleavage-stage Versus Blastocyst-stage Embryo Transfer in IVF Patients With Few Embryos
Infertility affects more than 6 million women the United States and is a major life event that results in a wide range of socio-cultural, emotional, physical and financial problems.
- Trial name
- PRECiSE (NCT06746129)
- Testing
- embryo transfer
- Where
- United States
- Volunteers
- 1,126 people
- Sponsor
- Beth Israel Deaconess Medical Center
Sub-optimal Culture Conditions
Blastocyst Culture in a Time-lapse Incubator
Culture media used to support development of zygotes to the blastocyst stage is based on two basic philosophies: a single step medium "let-the-embryo-choose" or a sequential medium "back-to-nature".
- Trial name
- NCT02778217
- Testing
- Culture media renwal
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Dar AlMaraa Center
Infertility
Clinical Outcomes of Slow Developing Blastocysts
This study evaluates which transfer strategy will result in a higher probability of pregnancy in patients whose single best day 5 embryo resulting from an IVF cycle is classified as expansion grade <4 by Gardner and Schoolcraft…
- Trial name
- LATEBLOOM (NCT03360097)
- Testing
- Frozen Embryo Transfer
- Where
- Spain
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Fundacion Dexeus
Severe Oligoasthenoteratozoospermia, Sperm Quality
PRP Improves Blastocyst Formation in ICSI Cycles
The goal of this clinical trial is to learn if platelet rich plasma (PRP) works to improve embryo development rates and embryo quality in IVF cycles, involving male adult patients with severe sperm disorders.
- Conditions
- Severe Oligoasthenoteratozoospermia, Sperm Quality, Spermatazoa Disorders, Sperm Parameters in Fertile and Infertile Men
- Trial name
- PRP ICSI SOAT (NCT07579858)
- Testing
- Platelet Rich Plasma
- Where
- Indonesia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Stella Maris Women and Children Hospital
IVF, Infertility
eValuating iDA Selection Ability. The VISA Study.
A non-inferiority, prospective parallel group, multi-center, randomized controlled trial to investigate whether selection of a single blastocyst for transfer using the deep learning tool, iDA, results in non-inferior clinical…
- Trial name
- NCT04969822
- Testing
- iDAScore®
- Where
- 14 sites in Australia, Denmark and 2 more
- Volunteers
- 1,066 people
- Sponsor
- Vitrolife
Infertility, Fertility Issues
Optimal Timing of Euploid Day 6 Blastocyst Transfer in Frozen HRT Cycles, Day 6 or Day 7 of Progesterone Administration.
The goal of this study is to compare the difference in clinical pregnancy, miscarriage and livebirth rate between day 6 euploid blastocyst transfer on the 6th and the 7th day of progesterone exposure in Hormonal Replacement…
- Conditions
- Infertility, Fertility Issues, Infertility, Female
- Trial name
- NCT05980091
- Testing
- Transvaginal ultrasound, Serum LH, E2, P4, Estradiol Valerate 2 MG
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility
Ultrasound Study by Texturization as a Predictor of Pregnancy in Oocyte Donation Programs
This study is focused on analysing the application of ultrasound scanning techniques as new biomarkers in reproductive medicine.
- Trial name
- TEXTUGEST (NCT03507322)
- Testing
- Ultrasound texturization
- Where
- Spain
- Sponsor
- Vida Recoletas Sevilla
Infertility, Female, Infertility, Male
Effects of Antioxidant Supplementation of Culture Media on IVF Embryos
The goal of this clinical trial is to investigate the impact of repeated antioxidant supplementation on blastocyst utilization and expansion rates in embryos under different oxygen concentrations.
- Trial name
- NCT05919186
- Testing
- EmbryORP®, O2 tension 20%, O2 tension 5%
- Where
- Mexico
- Volunteers
- 293 people
- Sponsor
- Liliana Berenice Ramírez Domínguez
Luteal Phase Progesterone Levels
The Effect of Luteal Blood Progesterone Levels on Ongoing Pregnancy Rates
Progesterone (P4) is essential for the secretory development of endometrium and the maintenance of early pregnancy. In the luteal phase following controlled ovarian stimulation in in vitro fertilization (IVF) treatment, P4…
- Trial name
- NCT04128436
- Testing
- Taking blood samples for analyzing progesterone levels
- Where
- 3 sites in Brazil, Denmark and 1 more
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation
Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Women With PCOS Undergoing PGT-A
This randomized trial aims to compare the euploid rate of blastocysts between PPOS (progestin-primed ovarian stimulation) and GnRH (gonadotrophin releasing hormone) antagonist protocols in patients with PCOS (polycystic ovary…
- Conditions
- Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation, Polycystic Ovarian Syndrome, GnRH Antagonist
- Trial name
- NCT05326087
- Testing
- GnRH antagonist, MPA
- Volunteers
- 204 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Infertility
Embryo DNA Repair Capacity Project
The mail aim of the present study is to use molecular methods to analyze the ability of human preimplantation embryos to repair their DNA
- Trial name
- NCT03953859
- Testing
- double strand break
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Reproductive Medicine Associates of New Jersey