Clinical trials: Blastocysts
Infertility (IVF Patients)
Correlation of the Genetic Constitution of the Spent Blastocyst Media
The main objective of this study is to improve niPGT-A (non-invasive Preimplantation Genetic Testing for Aneuploidies) to avoid the need of a biopsy to perform the genetic analysis of the embryo and to help in understanding the…
- Trial name
- CONNECTED (NCT06780605)
- Testing
- niPGT-A, Multifocal TE biopsies and ICM biopsy
- Where
- 2 sites in Cyprus
- Volunteers
- 230 people
- Sponsor
- Igenomix
Infertility, Male Infertility
To Investigate if the Harvester® Improves Sperm Motility and Blastocyst Utilization (the Percent of Fertilized Eggs That Develop to the Point That They Are Able to be Transferred) in IVF Cycles.
The goal of this prospective, multicenter randomized controlled clinical trial is to evaluate whether the SwimCount Harvester microfluidic sperm preparation device can achieve equivalent or superior clinical outcomes compared to…
- Conditions
- Infertility, Male Infertility, InVitro Fertilization, Aneuploidy Rate
- Trial name
- NCT07369362
- Testing
- microfludics semen processing device
- Where
- United States
- Volunteers
- 1,600 people
- Sponsor
- MotilityCount aps
Infertility
Correlating Time-Lapse Parameters Detected by the Eeva™ System With Comprehensive Chromosome Screening Results
The purpose of this research study protocol is to collect imaging data on embryos followed to blastocyst stage (Day 5-6) and correlate Eeva System parameters with comprehensive chromosome screening (CCS) results, implantation and…
- Trial name
- CCS (NCT01635049)
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Progyny, Inc.
Infertility, Aneuploidy
Single Embryo TrAnsfeR of Euploid Embryo
The purpose of the current study is to evaluate the effect of preimplantation genetic screening (PGS) by next generation sequencing (NGS) compared to standard morphological assessment of embryos on pregnancy rates through a…
- Trial name
- STAR (NCT02268786)
- Testing
- Preimplantation Genetic Screening by NGS
- Where
- 38 sites in United States, Australia and 2 more
- Volunteers
- 661 people
- Sponsor
- Illumina, Inc.
IVF, Infertility
Comparing KIDScore™ D5 and iDAScore®. The KiDA Study
A pilot study to gather information on clinical pregnancy rates for preparation of the planning of a larger randomized controlled trial comparing two decision support tools: the deep learning tool iDAScore® and the current…
- Trial name
- NCT04956848
- Testing
- iDAScore®
- Where
- 2 sites in Sweden
- Volunteers
- 165 people
- Sponsor
- Vitrolife
Culture Media, Blastocyst
Adding Antioxidants Into Human Sequential Culture Media System
Upon collection, human oocytes are fertilized and culture up to the blastocyst stage, followed by transfer and / or cryopreservation. Culture media systems have been developed that support each step of this process.
- Conditions
- Culture Media, Blastocyst, Antioxidants, Embryo
- Trial name
- Antioxidants (NCT02999958)
- Testing
- Antioxidants
- Where
- 2 sites in Japan
- Volunteers
- 128 people
- Sponsor
- Vitrolife
Oocyte, Zona Pellucida
To Investigate the Relationship Between the Viscoelastic Properties of the Zona Pellucida of Human Oocyte and the Blastocyst Utilization Rate
In in vitro fertilization (IVF) treatment, oocyte quality is one of the key factors influencing the success rate of fertilization.
- Conditions
- Oocyte, Zona Pellucida, Viscoelastic Property
- Trial name
- NCT06839495
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Inti Labs
IVF, Infertility
Evaluating Piezo-ICSI. - The EPI Study.
Intracytoplasmic sperm injection (ICSI) has successfully been used to treat both severe male infertility and fertilization failure since its introduction in the early 1990´s.
- Trial name
- NCT04669652
- Testing
- Piezo-ICSI
- Where
- 2 sites in United Kingdom
- Volunteers
- 265 people
- Sponsor
- Vitrolife
Infertility, Female
Controlled Ovarian Stimulation and Human Uterine Lavage
This is a feasibility study intended to demonstrate the Previvo Uterine Lavage System's ability to recover embryos from the uterus following either natural cycle (NC)/intrauterine insemination (IUI), or controlled ovarian…
- Trial name
- NCT03426007
- Testing
- Uterine lavage
- Where
- Mexico
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Previvo Genetics
Infertility, Female
Lovenox With Aspirin in Thawed Blastocyst Transfer
This prospective randomized trial will compare outcomes in patients receiving aspirin in combination with a low-molecular weight heparin and those under this center's standard protocol receiving neither medication, in order to…
- Trial name
- NCT06133803
- Testing
- Lovenox, Aspirin, Embryo transfer
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas
Infertility Assisted Reproductive Technology, Infertility (IVF Patients)
Blastocyst AI Assisted Morphokinetics in ART
The goal of this observational study is to learn if embryo characteristics obtained via the recording of real-time embryo activity via 30-seconds video capture (e.g.: Embryo Morphokinetics) can correlate with known embryo outcome…
- Trial name
- AIM (NCT07611448)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Viable Biosciences
Infertility
Eeva 12-well Dish Study
The purpose of this study is to demonstrate that the Eeva™ System is compatible with the Eeva 12-well Dish.
- Trial name
- NDS (NCT01635036)
- Testing
- In-vitro fertilization using Eeva
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Progyny, Inc.
Infertility
Eeva™ Continued Access Study: Assessing the Usability of Eeva in a Clinical Setting
User questionnaire of Eeva System usability and reports of device malfunctions.
- Trial name
- CAS (NCT01617993)
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- Progyny, Inc.
Infertility, Subfertility
Comparison of Transfers of Fresh and Thawed Embryos in Patients With Prior Failed Embryo Transfer Cycles
This study seeks to determine if patients with a history of failed fresh embryo transfer(s) will have increased success rates with embryo cryopreservation and subsequent thawed embryo transfer when compared to fresh embryo…
- Trial name
- NCT00736177
- Testing
- Embryo cryopreservation, Fresh embryo transfer
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas
Infertility, Ovarian Insufficiency
Artificial Oocyte Activation
Studies reported that calcium signal deficiency or insufficiency during oocyte activation are related with embryo arrest and blastocyst quality.
- Trial name
- NCT06290895
- Testing
- women having had a second IVF cycle with AOA
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- Clinique Ovo
IVF, Infertility
eValuating iDA Selection Ability. The VISA Study.
A non-inferiority, prospective parallel group, multi-center, randomized controlled trial to investigate whether selection of a single blastocyst for transfer using the deep learning tool, iDA, results in non-inferior clinical…
- Trial name
- NCT04969822
- Testing
- iDAScore®
- Where
- 14 sites in Australia, Denmark and 2 more
- Volunteers
- 1,066 people
- Sponsor
- Vitrolife
IVF
Pivotal Observational CHLOE Study
This pivotal study is an observational, prospective assessment, multi-center, databank based, clinical study aimed to evaluate the performance of CHLOE™ algorithm in prediction of blastocyst formation.
- Trial name
- NCT06111365
- Testing
- CHLOE
- Where
- 3 sites in United States
- Volunteers
- 59 people
- Sponsor
- Fairtility
Fetal Origin of Adult Diseases
Maternal Transcriptomic Regulation of the Preimplantation Embryo
The aim of this study is to understand the epigenetic and transcriptomic mechanisms that regulate the fetal origin of adult diseases (FOAD), either for the presence of metabolic disorders in the future mothers, such as obesity or…
- Trial name
- NCT02813746
- Testing
- Fitness program, Stop smoking, Endometrial fluid collection
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Igenomix
Aneuploidy, Chromosome Abnormality
Clinical Value of Mosaicism Diagnosis on the Trophectoderm Biopsies
Mosaicism within an embryo is defined as the presence of two or more cell populations with different genotypes. Blastocysts classified as mosaic by Preimplamtation Genetic Testing for Aneuploidy (PGT-A) have been reported to…
- Trial name
- NS-MOSAICISM (NCT03673592)
- Testing
- PGT-A
- Where
- 3 sites in Italy
- Volunteers
- 783 people
- Sponsor
- Igenomix
Infertility
International Pilot Study for Dual Non-invasive Assesment of Embryo Development
Choosing the best embryo is one of the major challenges for achieving success in in vitro fertilization (IVF). Traditionally, embryo evaluation has been based on morphological quality (how the embryo looks like) and chromosomal…
- Trial name
- PANDORA (NCT06524648)
- Testing
- niPGT-A
- Where
- 8 sites in Austria, Spain and 1 more
- Volunteers
- 200 people
- Sponsor
- Igenomix