Clinical trials: Blastocysts
Infertility
Comparison of Transfers of Thawed Blastocysts Versus Blastocysts Derived From Thawed Bipronuclear Oocytes
The purpose of this study is to determine if cryopreservation at the blastocyst stage followed by embryo thaw and transfer is as effective as cryopreservation of bipronuclear oocytes followed by post-thaw extended culture (PTEC)…
- Trial name
- NCT01247987
- Testing
- Blastocyst cryopreservation, Bipronuclear oocyte cryopreservation
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Bruce Shapiro M.D.
Aneuploidy, Chromosome Abnormality
Multi-center Study to Validate niPGT-A
Abnormal chromosome number, or aneuploidy, is common in human embryos. It is responsible for more than half of all miscarriages, and it is the leading cause of congenital birth defects.
- Conditions
- Aneuploidy, Chromosome Abnormality, Infertility
- Trial name
- niPGT-A (NCT03520933)
- Testing
- PGT-A, niPGT-A
- Where
- 10 sites in United States, Argentina and 6 more
- Volunteers
- 2,586 people
- Sponsor
- Igenomix
Infertility
Comparison of Alternative Embryo Culture Systems
This study will compare two alternative embryo culture systems. Embryos from each patient will be randomly assigned to one of two systems. One group will be cultured conventionally in oil-covered droplets in dishes.
- Trial name
- NCT02028897
- Testing
- Conventional embryo culture, Enclosed embryo culture
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bruce Shapiro M.D.
Endometriosis
Anti-TNFα Therapy for Improving Pregnancy Rates in Endometriosis Patients With Failed ICSI
This prospective study targets infertile women with endometriosis (EM) who have experienced a previously failed Intracytoplasmic Sperm Injection (ICSI) trial.
- Trial name
- NCT07509411
- Testing
- TNF-α Inhibitor, Frozen Blastocyst Transfer (FBT)
- Where
- Egypt
- Volunteers
- 145 people
- Sponsor
- Benha University
Infertility
A Randomized Controlled Study of Prolonging the Time of Progesterone Supplementation to Improve the Pregnancy Outcome of Single Day 6 Blastocyst Transfer of Freeze-thaw Cycle
This is a single-center, prospective, randomized controlled study. Patients with single blastocyst transfer in the freeze-thaw cycle, aged from 20 to 38 years, with less than three transfers, and with HRT-cycle single D6…
- Trial name
- NCT04938011
- Testing
- progesterone
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Nanjing University
Luteal Phase Progesterone Levels
The Effect of Luteal Blood Progesterone Levels on Ongoing Pregnancy Rates
Progesterone (P4) is essential for the secretory development of endometrium and the maintenance of early pregnancy. In the luteal phase following controlled ovarian stimulation in in vitro fertilization (IVF) treatment, P4…
- Trial name
- NCT04128436
- Testing
- Taking blood samples for analyzing progesterone levels
- Where
- 3 sites in Brazil, Denmark and 1 more
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
IVF, Infertility
The Rate of Embryo Euploidy in Progestin-primed Ovarian Stimulation Cycles
The main objective of this non-inferiority randomized controlled trial is to assess the rate of blastocyst euploidy and the number of euploid blastocysts in women undergoing IVF/ICSI and treated with PPOS versus conventional…
- Trial name
- PPOS (NCT04654741)
- Testing
- Medroxyprogesterone Acetate, Ganirelix Acetate
- Where
- Italy
- Volunteers
- 396 people
- Sponsor
- Casa di Cura Privata Villa Mafalda
Severe Oligoasthenoteratozoospermia, Sperm Quality
PRP Improves Blastocyst Formation in ICSI Cycles
The goal of this clinical trial is to learn if platelet rich plasma (PRP) works to improve embryo development rates and embryo quality in IVF cycles, involving male adult patients with severe sperm disorders.
- Conditions
- Severe Oligoasthenoteratozoospermia, Sperm Quality, Spermatazoa Disorders, Sperm Parameters in Fertile and Infertile Men
- Trial name
- PRP ICSI SOAT (NCT07579858)
- Testing
- Platelet Rich Plasma
- Where
- Indonesia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Stella Maris Women and Children Hospital
Reproductive Medicine
Application of Deep Learning to Jointly Assess Embryo Development to Improve Pregnancy Outcome of Embryo Transfer
Aim of this research is to apply the deep learning automation based on Time-lapse imaging to jointly assess embryo development，so that it can ensure the consistency of embryo evaluation and improve the accuracy of evaluation.
- Trial name
- NCT05671601
- Testing
- Automatic picture recognition, Manual Assessment Group
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Infertility
SprmPik AI Sperm Selection Study SiD, an Assistant for Sperm Selection During Intracytoplasmic Sperm Injection in Medically Assisted Reproduction: Effect on Fertilization, Blastocyst Formation, Early Pregnancy Loss, and Consistent Practice. A Prospective Pilot Study.
SprmPik AI Assisted Sperm Selection Study SiD, an assistant for sperm selection during intracytoplasmic sperm injection in medically assisted reproduction: effect on fertilization, blastocyst formation, early pregnancy loss, and…
- Trial name
- SprmPik (NCT06518928)
- Testing
- Artificial Intelligence assisted sperm selection
- Where
- 2 sites in United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Ovation Fertility
Infertility
Mitochondrial Activity of Cumulus Cells From the Cumulus-oocyte Complex and Oocyte Competence
The need for non-invasive biomarkers of oocyte competency has become urgent as women increasingly delay attempts at childbearing.
- Trial name
- NCT02793752
- Testing
- Age
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Main Line Fertility Center
Infertility, Infertility, Male
Laser-Assisted Versus Conventional Intracytoplasmic Sperm Injection
Laser-assisted intracytoplasmic sperm injection (ICSI) has been suggested as a more effective alterative to conventional ICSI when this method of insemination is indicated for patients undergoing in vitro fertilization (IVF).
- Trial name
- NCT00114725
- Testing
- Laser-assisted intracytoplasmic sperm injection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
OVARIAN STIMULATION, Telomere Length
Does Recombinant FSH (rFSH, i.g. Gonal F®) as Compared to Human Menopausal Gonadotrophin (hMG) Affect Telomere Length of Cumulus Cells During Antral Follicle Growth and Impact Blastocyst Status?
Gonal-F® (follitropin alfa) is a recombinant FSH without LH activity, while Menopur® contains both LH and hCG. The MEGASET trial compared Menopur® and Gonal-F® in GnRH antagonist cycles with SET, showing similar efficacy.
- Conditions
- OVARIAN STIMULATION, Telomere Length, Telomere Length, Mean Leukocyte
- Trial name
- rFSH and hMG (NCT06732843)
- Where
- United Arab Emirates
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility
Comparison of Transfers of Fresh and Thawed Embryos in High Responder Patients
This study tests the hypothesis that controlled ovarian stimulation impairs endometrial receptivity in high responders.
- Trial name
- NCT00963079
- Testing
- Embryo cryopreservation, Fresh blastocyst transfer
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas
Reproductive Techniques, Assisted, Artificial Intelligence
Retrospective Evaluation Blastocyst Development by Artificial Intelligency
In assisted reproductive technology (ART), selecting the most viable embryos from a large number of fertilized eggs is crucial. While techniques like morphological assessment, time-lapse monitoring systems, and pre-implantation…
- Conditions
- Reproductive Techniques, Assisted, Artificial Intelligence, Embryo Transfer
- Trial name
- EBAI (NCT07383480)
- Where
- France
- Volunteers
- 333 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infertility
Eeva™ System Study: Noninvasive Recording and Visualization of Individual Embryos Cultured to Blastocyst Stage
The purpose of this study is to demonstrate that the Eeva System may be used to identify embryos on Day 2 that are most likely to form blastocysts.
- Trial name
- Eeva (NCT01369446)
- Testing
- Eeva System Study
- Where
- 5 sites in United States
- Volunteers
- 160 people
- Sponsor
- Progyny, Inc.
Incubator Stay, Total Blastulation
Impact of Dry vs Humidified Culture Conditions on Blastocyst Development and Aneuploidy: A Time-lapse Sibling Oocyte Study
IVF incubators are essential for maintaining the micro-environment required for embryo development. Incubator technology has progressed from early humidified box systems to benchtop and now time-lapse platforms, driving the…
- Conditions
- Incubator Stay, Total Blastulation, Blastocyst Quality, Biopsy Rate
- Trial name
- NCT07270250
- Testing
- K- system incubator
- Where
- United Arab Emirates
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Male Infertility, Epigenetic Disorder
Human Sperm Epigenetics in Embryonic Development.
A total of 60 men (40 with a history of infertility and treatment with assisted reproduction and 20 infertile controls achieving conception naturally) will be asked to provide at least one semen sample each for conventional semen…
- Trial name
- EPI (NCT04256668)
- Testing
- Obtaining one or semen samples
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
Infertility, Female, Infertility
Is the AMH Intrafollicular Level a Predictor of the Ploidy Status of the Blastocyst?
To investigate, whether on the day of egg retrieval, after ovarian stimulation for ICSI (intracytoplasmic sperm injection), there is a correlation between the intrafollicular AMH (Anti-Müllerian hormone) levels and the ploidy…
- Trial name
- NCT05837325
- Testing
- Oocyte Pick Up - Out of Study, Denudation - Out of Study, ICSI
- Where
- United Arab Emirates
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
The Focus is to Validate the Accuracy of a Non-invasive Artificial Intelligence Model for the Prediction of the Human Blastocyst Ploidy, Preimplantation Genetic Testing (PGT)
Evaluation of an Artificial Intelligence Model for the Prediction of Human Blastocyst Ploidy Without Invasive Procedures
The goal of this clinical trial is to evaluate an artificial intelligence model for the prediction of human blastocyst ploidy without invasive procedures in couples that receive preimplantation genetic testing.
- Trial name
- NCT06762704
- Testing
- Video recording
- Where
- 5 sites in China
- Volunteers
- 1,408 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School