Clinical trials: Bleed Intracranial
Intracerebral Hemorrhage
Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial - Part 2
The objective of the rFVIIa for Acute Hemorrhagic Stroke Administered at Earliest Time (FASTEST) Trial is to establish the first treatment for acute spontaneous intracerebral hemorrhage (ICH) within a time window and subgroup of…
- Trial name
- FASTEST Part 2 (NCT07227246)
- Testing
- Recombinant Factor VIIa
- Where
- 89 sites in United States, Canada and 4 more
- Volunteers
- 350 people
- Sponsor
- Joseph Broderick, MD
Headaches Associated With Subarachnoid Hemorrhage (SAH)
MMA Infusion of Lidocaine for Treatment of Headache in Patients With Aneurysmal SAH
The purpose of the MIL-SAH trial is to evaluate the efficacy and safety of middle meningeal artery (MMA) lidocaine infusion for the treatment of headache in patients with aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- MIL-SAH (NCT07816159)
- Testing
- Lidocaine hydrochloride, Isotonic saline
- Volunteers
- 90 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Intracerebral Hemorrhage (ICH), Hemorrhagic Stroke, Intracerebral
Spleen Volume Change Predicts 45-Day Mortality in Neurocritical Care: A Prospective Cohort Study
This study investigates whether changes in spleen size over 72 hours can help predict the risk of death within 45 days in patients who were admitted to the emergency department with a type of bleeding in the brain called…
- Conditions
- Intracerebral Hemorrhage (ICH), Hemorrhagic Stroke, Intracerebral, Neurocritical Care, Acute Brain Injury
- Trial name
- SCOPE (NCT07132996)
- Testing
- POCUS-based Splenic Volume Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ankara City Hospital Bilkent
Intracerebral Hemorrhage, Hemiplegia
Feasibility Study of Transcranial Ultrasound Stimulation (TUS) on Stroke Patients
Currently, the main treatment method for Intracerebral Hemorrhage (ICH) is medication or surgery. However, the effectiveness of medicines is moderate and there are several side effects.
- Trial name
- NCT04877184
- Testing
- Transcranial ultrasound stimulation and rehabilitation, Rehabilitation
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Cheng-Hsin General Hospital
Stroke, Subarachnoid Hemorrhage
Inhalatorial Sedation in Patient With Subarachnoid Hemorrhage (SAH) Versus Conventional Intravenous Sedation
Recent study has shown that inhalatory sedation is a practicable, effective and not risky method in Intensive Care Unit. Sevoflurane effect on cerebral system have been described in previous studies: it causes an increasing of…
- Trial name
- GAS-SAH (NCT00830843)
- Testing
- Propofol, Isoflurane
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Traumatic Brain Injury, Subarachnoid Hemorrhage
Pituitary Functions After Traumatic Brain Injury (TBI) and/or Subarachnoid Hemorrhage (SAH)
This study performs assessments of pituitary functions by basal hormone levels in the acute phase after TBI and/or SAH followed by detailed endocrine tests (insulin-induced hypoglycemia or growth hormone releasing…
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Hypopituitarism
- Trial name
- NCT00507104
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Brain Neoplasms, Meningioma
Preoperative Embolization for Highly Vascular Brain Tumors
Highly vascular brain tumors, including meningiomas, hemangioblastomas, and certain metastases, have a rich blood supply that can lead to substantial blood loss and technical difficulties during surgical removal.
- Conditions
- Brain Neoplasms, Meningioma, Hemangioblastoma, Brain Metastases
- Trial name
- NCT07823985
- Testing
- Preoperative Endovascular Embolization
- Volunteers
- 55 people
- Sponsor
- Assiut University
Stroke
Guideline-recommended Basic Parameter Adherence in Neurocritical Care Patients
The aim of the planned study project is to assess the current situation regarding the treatment of patients with severe stroke at the neuro-critical care unit.
- Trial name
- NORMONICU (NCT06367543)
- Testing
- Time in therapeutic range of vital parameters
- Where
- Germany
- Volunteers
- 474 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Intracerebral Hemorrhage
The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial II
The vast majority of intracerebral hemorrhage (ICH) patients present with elevated blood pressure(BP). Management of BP is controversial with two competing rationales.
- Trial name
- ICH-ADAPT II (NCT02281838)
- Testing
- labetalol/hydralazine/enalapril
- Where
- 2 sites in Canada
- Volunteers
- 142 people
- Sponsor
- University of Alberta
Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Intrasaccular neCk Occlusion deVice Treatment of Intracranial Aneurysm in Acute Subarachnoid hemorRhAGE
Rationale: Intrasaccular neck occlusion devices have been used for unruptured aneurysm without safety concerns and good occlusion rates.
- Trial name
- COVERAGE (NCT05171465)
- Testing
- Neqstent or Contour
- Volunteers
- 120 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Intracranial Hemorrhage
Evaluation of 4-Factor PCC in DOAC-associated Intracranial Hemorrhage
Intracranial hemorrhage (ICH) can occur due to traumatic and spontaneous events.1 The incidence of non-traumatic, spontaneous ICH is approximately 40,000 to 67,000 cases per year while the incidence of traumatic brain injury…
- Trial name
- NCT06096051
- Testing
- Use of fixed-dosed 4F-PCC
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Methodist Health System
Chronic Subdural Hematoma
Efficacy of a Minimally Invasive Therapy Adjuvant to the Standards of Care by Cyanoacrylate Embolization
Chronic subdural hematomas (CSH) are collections of blood in the subdural space. CSH are becoming the most common cranial neurosurgical condition among adults, and a significant public health problem, due to an increasing use of…
- Trial name
- LEADH (NCT05374681)
- Testing
- Medical treatment, Surgical treatment, embolization of the MMA
- Where
- 11 sites in France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Brest
Traumatic Brain Injury, Subarachnoid Hemorrhage
Optimal Brain Oxygenation in Neurologic Intensive Care Unit : The NeurO2 Study
The NeurO2 study is a multicenter observational study looking at NIRS monitoring in neurocrocritically ill patients during the acute phase of care following an acute brain injury.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Brain Injuries, Near-Infrared Spectroscopy
- Trial name
- NeurO2 (NCT04935866)
- Testing
- Near-infrared spectroscopy (NIRS)
- Where
- 2 sites in Canada
- Volunteers
- 286 people
- Sponsor
- CHU de Quebec-Universite Laval
Traumatic Brain Injury, Aneurysmal Subarachnoid Hemorrhage
Dysregulated CNS Inflammation After Acute Brain Injury
By doing this study, the investigator hopes to learn how the levels of important proteins involved in inflammation change over time in patients with acute brain injury.
- Trial name
- NCT03287557
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Kentucky
Subarachnoid Hemorrhage
Impact of Ultra-Early Intracranial Aneurysm Treatment in SAH
This is the first prospective study in Hong Kong that recruit patients with poor neurological status after intracranial aneurysm rupture in all seven public neurosurgical services in Hong Kong.
- Trial name
- UEAT (NCT03894202)
- Where
- China
- Volunteers
- 293 people
- Sponsor
- Chinese University of Hong Kong
Subarachnoid Hemorrhage, Intracranial Hemorrhages
Time Frequency Analysis of Electrocardiogram and Blood Pressure in Intracranial Hemorrhage Patients
Dysregulation of autonomic nervous system is evident in patients with spontaneous intracranial hemorrhage. In this study, we utilize a non-invasive method (heart rate and blood pressure variability analysis to analyze the…
- Conditions
- Subarachnoid Hemorrhage, Intracranial Hemorrhages, Cerebral Hemorrhage
- Trial name
- NCT00713375
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Intracerebral Hemorrhage
Use of Minocycline in Intracerebral Hemorrhage
To date, no neuroprotective drugs have demonstrated clinical efficacy in intracerebral hemorrhage (ICH). This study will use intravenous (IV) minocycline in ICH to evaluate for (1) safety/ tolerability and (2) evaluate for…
- Trial name
- NCT03040128
- Testing
- Minocycline, normal saline infusion
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Subarachnoid Hemorrhage, Aneurysmal, Time Delay
A Multicenter Registry Study of Aneurysmal SAH
Firstly, this study aims at clarifying the current situation of Emergency treatment of aneurysmal subarachnoid hemorrhage (SAH) in China, and analyzing the influencing factors contributing to transport delay, so as to improve the…
- Trial name
- NCT03094975
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Jian-min Liu
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial
Soluble epoxide hydrolase (sEH) is the metabolizing enzyme of epoxyeicosatrienoic acids (EETs), which may play a role in reducing neuroinflammation and regulating cerebral blood flow after subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Vasospasm, Cerebral, Endothelial Dysfunction
- Trial name
- SUSHI (NCT03318783)
- Testing
- GSK2256294
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Subarachnoid Hemorrhage, Aneurysmal
Shuxuening Injection for the Prevention of CVS in Patients With aSAH(SXN-CVS)
Aneurysmal subarachnoid hemorrhage (SAH) is a frequent worldwide cause for stroke with a mortality of around 30%. Worldwide, almost 500 000 patients have aneurysmal SAH annually.An incidence of 2-16 cases of spontaneous SAH per…
- Trial name
- SXN-CVS (NCT06138353)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xiaolin Chen, MD
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