Clinical trials: Bleed Intracranial
Acute Subdural Hematoma, Acquired Brain Injury
A Comparative Analysis of Prognostic Factors for Functional Outcomes in Patients With Acute Subdural Hematoma
Acute subdural hematoma (ASDH) is the most common intracranial traumatic lesion that requires surgical intervention. Although there is extensive published research on acute subdural, there remains uncertainty regarding mortality…
- Trial name
- NCT06364059
- Testing
- Decompressive craniectomy with evacuation of subdural hematoma
- Where
- Czechia
- Volunteers
- 175 people
- Sponsor
- Charles University, Czech Republic
Traumatic Brain Injury (TBI), Subarachnoid Hemorrhage (SAH)
Non-invasive Brain Pressure Monitoring After Trauma or Hemorrhage
Introduction: Increased intracranial pressure (ICP) is considered to be the most important intracranial mechanism causing secondary injury in patients admitted after acute traumatic brain injury (TBI) and intracranial haemorrhage…
- Trial name
- NCT02172703
- Testing
- Non-invasive ICP measurement device
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- Javier Fandino, MD
Intracranial Hemorrhages, Atrial Fibrillation (AF)
Comparison of LAA-Closure vs Oral Anticoagulation in Patients With NVAF and Status Post Intracranial Bleeding.
Atrial fibrillation is the most common cardiac arrhythmia. In atrial fibrillation, there is a risk that clots can form in the heart, especially in the left atrium. If these clots come loose, there is a risk of stroke.
- Conditions
- Intracranial Hemorrhages, Atrial Fibrillation (AF), Atrial Flutter
- Trial name
- CLEARANCE (NCT04298723)
- Testing
- Percutaneous closure of the LAA (Watchman / Watchman FLX)
- Where
- 39 sites in Germany, Poland
- Volunteers
- 530 people
- Sponsor
- Jena University Hospital
Intracerebral Hemorrhage
Efficacy and Safety Study: Repetitive Transcranial Magnetic Stimulation (rTMS) for Treating Movement Disorders in Patients With Intracranial Hemorrhage (ICH).
This pilot study aims to assess the effectiveness and safety of rTMS in the treatment of movement disorders in patients with ICH.
- Trial name
- NCT05920473
- Testing
- rTMS with Magstim Rapid 2 magnetic stimulation device
- Where
- 3 sites in China
- Volunteers
- 130 people
- Sponsor
- Beijing Tiantan Hospital
Head Injury, Intracerebral Hemorrhage
The Prediction of Intracranial Pressure and Clinical Outcome by Transcranial Doppler in Neurocritical Patients
The purpose of this study is to use transcranial Doppler (TCD) to predict intracranial pressure (ICP) and clinical outcome of neurocritical patients.
- Conditions
- Head Injury, Intracerebral Hemorrhage, Ischemic Stroke, Subarachnoid Hemorrhage
- Trial name
- NCT00886054
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Stroke, Neurologic Diseases, General
Cerebril™ in Patients With Lobar Hemorrhage Related to Cerebral Amyloid Angiopathy
The main objective of this study is to evaluate the safety, tolerability and pharmacokinetics of Cerebril™ in Cerebral Amyloid Angiopathy (CAA) patients who have had lobar cerebral hemorrhage.
- Trial name
- NCT00056238
- Testing
- NC-758 (Anti amyloidotic [Aß] agent)
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Bellus Health Inc. - a GSK company
Aneurysmal Subarachnoid Hemorrhage
FLudrocortisone Administration in Aneurysmal Subarachnoid Haemorrhage
A multi-centre, prospective, blinded, randomised clinical trial of fludrocortisone compared with placebo in patients presenting with aneurysmal subarachnoid haemorrhage.
- Trial name
- FLASH (NCT06409364)
- Testing
- Fludrocortisone
- Where
- 16 sites in Australia, New Zealand
- Volunteers
- 524 people
- Sponsor
- The George Institute
Delayed Cerebral Ischemia After Subarachnoid Hemorrhage, Ischemic Stroke of Large or Medium Vessels
Thrombo-inflammation in Acute Neurovascular Diseases: Definition of New Therapeutic Targets (TARGETS)
The objective of this observational study is to compare the relative concentrations of various thrombo-inflammatory markers at different follow-up time points in: patients with or without delayed cerebral ischemia after…
- Trial name
- NCT07354321
- Volunteers
- 499 people, healthy volunteers welcome
- Sponsor
- François Delvoye
Anticoagulation Associated (VKA & NOAC) Intracerebral Hemorrhage
Multicenter Analysis of Oral Anticoagulant-associated ICH - Part Two
Intracerebral hemorrhage [ICH] is the most feared complication of oral anticoagulation [OAC], yet therapeutic strategies are limited reflected by overall weak guideline recommendations.
- Trial name
- RETRACE-II (NCT03093233)
- Testing
- no intervention
- Volunteers
- 1,369 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Cerebral (CVAs), Ischemic Cerebrovascular Accident
Population-based Brest Stroke Registry
The registry is the main objective exhaustive list of cases validated stroke brain on a geographical area defined to calculate an incidence.
- Conditions
- Cerebral (CVAs), Ischemic Cerebrovascular Accident, Stroke, Brain Ischemia
- Trial name
- BREST (NCT02900521)
- Where
- France
- Volunteers
- 15,000 people
- Sponsor
- University Hospital, Brest
Intracerebral Hemorrhage
The REgistry Study on Multimodality trEAtment foR Cerebral Hemorrhage
The REgistry Study on multimodality trEAtment foR Cerebral Hemorrhage (RESEARCH) aims to address these challenges by establishing a comprehensive national registry.
- Trial name
- RESEARCH (NCT06629532)
- Testing
- medical management, surgical interventions, and rehabilitative strategies
- Volunteers
- 100,000 people
- Sponsor
- Tao Liu
Stroke, Acute Ischemic Stroke
Trial of pRehospital Intervention With trAditional Chinese Medicine for Acute strokE
The main purpose of this trial is to observe whether Xingnaojing, intravenously administered within 24 hours of symptom onset on pre-hospital emergency ambulance, improves the Early neurological deterioration of acute stroke at 3…
- Conditions
- Stroke, Acute Ischemic Stroke, Acute Intracranial Hemorrhage
- Trial name
- TRACE (NCT04275349)
- Testing
- Xingnaojing injection within 24 hours of symptom onset
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Dongzhimen Hospital, Beijing
Craniocerebral Injuries, Head Injuries
Defining the Operating Characteristics of NIRS in the Diagnosis of Pediatric Traumatic Intracranial Hemorrhage
In this study, investigators look at a different type of technology that might help to avoid having to perform CT scans in certain patients suspected of having a head injury.
- Conditions
- Craniocerebral Injuries, Head Injuries, Head Injury, Minor, Head Trauma
- Trial name
- NCT03905031
- Testing
- InfraScanner 2000
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Dayton Children's Hospital
Cerebral Small Vessel Diseases, Cadasil
Taiwan Associated Genetic and Nongenetic Small Vessel Disease
The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD…
- Conditions
- Cerebral Small Vessel Diseases, Cadasil, HTRA1-Related Autosomal Dominant Cerebral Angiopathy, COL4A1-Related Brain Small Vessel Disease With Haemorrhage
- Trial name
- TAG-SVD (NCT05473637)
- Testing
- MRI
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Trauma, Craniocerebral Trauma
Early Versus Late Intubation Trial in Physician Manned Emergency Medical Services
This study looks at advanced airway management in critically ill or injured patients treated by physician manned emergency medical services, comparing early (on-scene) intubation to late (emergency department) intubation.
- Conditions
- Trauma, Craniocerebral Trauma, Intracerebral Hemorrhage, Seizures
- Trial name
- ELITE (NCT01730001)
- Testing
- Early Intubation, Late intubation
- Where
- 2 sites in Norway
- Sponsor
- Norwegian Air Ambulance Foundation
Intracerebral Hemorrhage
Minimally Invasive Soft Channel Brain Haemorrhage Evacuation for Acute Basal Ganglia Haemorrhage-- Large Hemorrhage Evacuation (MIRACLE-L)
To determine if minimally invasive soft channel brain hemorrhage evacuation (scMIS), compared with any other neurosurgical technique that includes open craniotomy, small skull window microsurgery , and endoscopic surgery, is at…
- Trial name
- MIRACLE-L (NCT06688201)
- Testing
- Other neurosurgical techniques, Minimally Invasive Soft Channel Brain Haemorrhage Evacuation
- Where
- China
- Volunteers
- 550 people
- Sponsor
- Capital Medical University
Chronic Subdural Hematoma
Outcome of Chronic Subdural Hematoma Management With Double Burr Hole Craniotomy Versus Single Burr Hole Craniotomy and Subdural Drain Evacuation
The goal of this clinical trial is to compare the outcome of double burr hole versus single burr hole in patients of chronic subdural hematoma undergoing subdural drain evacuation. The main questions it aims to answers are 1.
- Trial name
- NCT07368101
- Testing
- Single Burr hole Craniotomy, Double Burr hole Craniotomy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Chronic Subdural Hematomas
Embolization of Middle Meningeal Artery in Chronic Subdural Hematoma
Chronic subdural hematoma (cSDH) is a common neurological affliction which affects mostly frail and elderly patients. Surgical evacuation by using burr hole craniostomy (BHC) is the most frequently used treatment but carries a…
- Trial name
- ELIMINATE (NCT04511572)
- Testing
- embolization of the middle meningeal artery
- Where
- Netherlands
- Volunteers
- 170 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage
The Anaesthetic Ketamine as Treatment for Patients With Severe Acute Brain Injury
Cortical spreading depolarisations are pathological depolarisation waves that occur frequently after severe acute brain injury and has been associated with poor outcome.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage, Traumatic Brain Injury
- Trial name
- KETA-BID (NCT05095857)
- Testing
- S-ketamine
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Aneurysmal Subarachnoid Hemorrhage, Neurobehavioral Manifestations
Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin
A Blind-adjudication Multi-center Phase II Randomized Clinical Trial of Continuous Low-dose Intravenous Heparin Therapy in Coiled Low-grade Aneurysmal Subarachnoid Hemorrhage Patients with Significant Hemorrhage Burden.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Neurobehavioral Manifestations, Vasospasm, Intracranial, Intracranial Aneurysm
- Trial name
- ASTROH (NCT02501434)
- Testing
- Continuous Low-Dose IV Unfractionated Heparin Infusion
- Where
- 9 sites in United States
- Volunteers
- 88 people
- Sponsor
- Robert F. James
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