Clinical trials: Bleed Intracranial
Aneurysmal Subarachnoid Hemorrhage
Efficacy and Safety Study of a Low-carbohydrate Tube Feed in Critically Ill Patients Under Insulin Therapy
The purpose of this study is to determine the efficacy and safety of a diabetes-specific tube feed in comparison to an isocaloric, isonitrogenous standard enteral formula in critically ill patients receiving insulin treatment for…
- Trial name
- NCT02503527
- Testing
- Diben 1.5 kcal HP, Fresubin HP Energy Fibre (1.5 kcal)
- Where
- Austria
- Volunteers
- 28 people
- Sponsor
- Fresenius Kabi
Intracranial Hemorrhage
Evaluation of 4-Factor PCC in DOAC-associated Intracranial Hemorrhage
Intracranial hemorrhage (ICH) can occur due to traumatic and spontaneous events.1 The incidence of non-traumatic, spontaneous ICH is approximately 40,000 to 67,000 cases per year while the incidence of traumatic brain injury…
- Trial name
- NCT06096051
- Testing
- Use of fixed-dosed 4F-PCC
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Methodist Health System
Arteriovenous Malformation of Central Nervous System, Aneurysm, Ruptured
The Risk Factors Related to Rupture Flow-related Aneurysms in Posterior AVM
AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in…
- Conditions
- Arteriovenous Malformation of Central Nervous System, Aneurysm, Ruptured, Aneurysmatic Subarachnoid Haemorrhage, Aneurysm Cerebral
- Trial name
- pAVM-rFA (NCT07050381)
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Hemorrhagic Stroke, Intracerebral Hemorrhage (ICH)
Efficacy, Safety and Tolerability of BAF312 Compared to Placebo in Patients With Intracerebral Hemorrhage (ICH).
This is a randomized, placebo-controlled, subject and investigator-blinded study to evaluate efficacy, safety and tolerability of BAF312 in participants with intracerebral hemorrhage (ICH)
- Trial name
- NCT03338998
- Testing
- BAF312 solution, BAF312 tablet
- Where
- 11 sites in United States
- Volunteers
- 32 people
- Sponsor
- Novartis Pharmaceuticals
Subarachnoid Hemorrhage
Ventriculostomy in Subarachnoid Hemorrhage (SAH): Intracranial Pressure (ICP) Open or Not?
The purpose of this study is to explore two currently accepted methods of intracranial pressure (ICP) management through cerebral spinal fluid (CRF) drainage for patients diagnosed with subarachnoid hemorrhage (SAH).
- Trial name
- VISION 2 (NCT01169454)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Intracerebral Hemorrhage
A Study to Evaluate the Safety, Tolerability and the Effects of Ixodes Ricinus-Contact Phase Inhibitor (Ir-CPI) in Adult Patients With Spontaneous Intracerebral Haemorrhage
The purpose of the study is to provide a first assessment of safety, tolerability and efficacy of Ir-CPI, administered on top of standard-of-care, on secondary brain injury in patients with spontaneous intracerebral haemorrhage.
- Trial name
- BIRCH (NCT05970224)
- Testing
- Ir-CPI
- Where
- 8 sites in Belgium
- Volunteers
- 23 people
- Sponsor
- Bioxodes S.A.
Aneurysmal Subarachnoid Hemorrhage
The Role of Biomarker in Serum, Cerebrospinal Fluid and Parenchyma in the Context of Aneurysmal Subarachnoid Hemorrhage.
The aim of this study is to improve the usability of biomarkers for the timely prediction of new complications following a cerebral hemorrhage, especially in combination with invasive, functional and local measurements for…
- Trial name
- bioSAB (NCT02142166)
- Testing
- Biomarker in serum, liquor, micro-dialysate, Biomarker in serum and in liquor
- Where
- Germany
- Volunteers
- 310 people
- Sponsor
- RWTH Aachen University
Abdominal Aortic Aneurysm, Coronary Heart Disease NOS
Heart Rate and Initial Presentation of Cardiovascular Diseases (Caliber)
Study of heterogeneity in associations between heart rate and the initial presentation of 12 cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease NOS, Unheralded Coronary Death, Intracerebral Haemorrhage
- Trial name
- NCT01947361
- Where
- United Kingdom
- Volunteers
- 1,961,286 people, healthy volunteers welcome
- Sponsor
- University College, London
Stenosis, Bleed Intracranial
Beacon Tip Sizing Catheter and Slip-Cath Beacon Tip Catheter Study
This prospective observational post-market clinical study will collect data in the United States to primarily support the re-launch of the re-designed Beacon Tip Sizing Catheter and Slip-Catheter Beacon Tip Catheter \& Shuttle…
- Conditions
- Stenosis, Bleed Intracranial, Stroke, TIA
- Trial name
- NCT06986954
- Testing
- Beacon Tip Catheters
- Where
- United States
- Volunteers
- 816 people
- Sponsor
- Cook Research Incorporated
Subdural Hematoma
Augmented Reality for Subdural Drain Placement
This study involves using a augmented reality (AR) system to assist in the placement of a subdural evacuating portal system (SEPS).
- Trial name
- NCT06052124
- Testing
- Augmented Reality Device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Intracerebral Hemorrhage
Statins In Intracerbral Hemorrhage
The SATURN trial aims to determine whether continuation vs. discontinuation of statin drugs after spontaneous lobar intracerebral hemorrhage (ICH) is the best strategy; and whether the decision to continue/discontinue statins…
- Trial name
- SATURN (NCT03936361)
- Testing
- Statins
- Where
- United States
- Volunteers
- 1,456 people
- Sponsor
- Beth Israel Deaconess Medical Center
Traumatic Brain Injury, Aneurysmal Subarachnoid Hemorrhage
Monitoring Brain Activity in Human Brain Injury
The outcome of brain injury (physical or stroke) may be related to a brain electrical phenomenon known as Cortical Spreading Depression (CSD). This is a brief cessation of function in a local region of brain tissue.
- Conditions
- Traumatic Brain Injury, Aneurysmal Subarachnoid Hemorrhage, Cerebral Infarction, Cerebral Hemorrhage
- Trial name
- NCT00258505
- Testing
- Procedure: intracranial monitoring up to 9 days after injury
- Where
- 2 sites in Germany, Israel
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Unruptured Cerebral Aneurysm, Artificial Intelligence (AI)
AI Models for Cerebral Aneurysms Segmentation, Detection and Stability Prediction
Aneurysmal subarachnoid hemorrhage (SAH) is one of the critical diseases that severely threaten human health, with a clinical mortality rate reaching as high as 30%.
- Conditions
- Unruptured Cerebral Aneurysm, Artificial Intelligence (AI), Subarachnoid Hemorrhage, Aneurysmal, Magnetic Resonance Angiography
- Trial name
- AI-CARE (NCT06766422)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Subarachnoid Hemorrhage, Critical Illness
Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage
Patients with subarachnoid hemorrhage are prone to suffer from dysnatriemia. Evidence shows that hyponatriemia is associated with increased incidence of vasospasm, brain swelling and mortality in these patients.
- Conditions
- Subarachnoid Hemorrhage, Critical Illness, Infusion Fluid, Sodium Disorder
- Trial name
- CRYSTALLBrain (NCT04043598)
- Testing
- 0.9% Sodium-chloride, Ringer's Lactate
- Where
- 3 sites in Switzerland
- Volunteers
- 320 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Subarachnoid Hemorrhage
Efficacy and Safety Assessment for a New UV-protected Pump Infusion Line in Intravenous Infusion Therapy
To verify the efficacy and safety of Original Perfusor Line (Art.No.8723017) in infusion therapy in Patients with light sensitive drug infusion.
- Trial name
- NCT04309708
- Testing
- Nimodipine pump infusion
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- B. Braun Medical International Trading Company Ltd.
Neurosurgery, Intracranial Hemorrhages
Arterial Pressure and Surgical Hemostasis in Elective Neurosurgery.
The objective of this observational study is to examine the impact of augmented arterial pressure during the hemostatic phase of elective supratentorial neurosurgery. The primary inquiries it seeks to address are as follows: 1.
- Conditions
- Neurosurgery, Intracranial Hemorrhages, Supratentorial Brain Tumor, Blood Pressure
- Trial name
- HemoStopArt (NCT05874050)
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Subarachnoid Hemorrhage
Quantification of Cerebral Blood Flow by Arterial Spin Labeling in Vasospasm in Subarachnoid Haemorrhage
A technique of MRI infusion -l'Arterial Spin Labeling-, non-invasive and non-irradiating, repeatable over time, appears promising in the field.
- Trial name
- ASL-HSA (NCT02557607)
- Testing
- MRI
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers
Chronic Subdural Hematoma, Trendelenburg
Effect of the Postoperative Trendelenburg Position on Chronic Subdural Hematoma Recurrence
Objective: Determine the effect of the postoperative trendelenburg position on the recurrence of chronic subdural hematoma (CSH) in patients undergoing surgery.
- Conditions
- Chronic Subdural Hematoma, Trendelenburg, Recurrence, Mortality
- Trial name
- POTHeR (NCT06911736)
- Testing
- Trendelenburg position
- Where
- 3 sites in Colombia
- Volunteers
- 254 people
- Sponsor
- Universidad de Antioquia
Ischemic Stroke, Intracerebral Hemorrhage
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke.
- Conditions
- Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular
- Trial name
- DISCOVERY (NCT04916210)
- Where
- 31 sites in United States
- Volunteers
- 8,000 people
- Sponsor
- Massachusetts General Hospital
Aneurysmal Subarachnoid Hemorrhage
Early Lumbar Drainage Plus Intrathecal Urokinase in Severe Aneurysmal Subarachnoid Hemorrhage (LD-ITUK)
The LD-ITUK is a multicenter, prospective, randomized, double-blind, blind endpoint, placebo-control design trial. All eligible patients with the diagnosis of severe aSAH will be randomly assigned to the treatment group or the…
- Trial name
- NCT06284642
- Testing
- Urokinase
- Where
- 25 sites in China
- Volunteers
- 424 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
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