Clinical trials: Bleed Intracranial
Fallers Aged 60 Years and Older, Biomarkers / Blood
Contribution of GFAP and UCH-L1 Assays in Whole Blood to Optimizing Personalized Care for "Repeated Fallers" Hospitalized in Geriatric Wards
The BACHUS study focuses on a population of patients aged 75 years and older who are hospitalized after recurrent falls. The objective is to evaluate the performance of an innovative, personalized biological screening strategy to…
- Conditions
- Fallers Aged 60 Years and Older, Biomarkers / Blood, Intracranial Bleeding
- Trial name
- BACHUS (NCT07342023)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 770 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hematoma Absorption and Neurological Function Recovery
Clinical Study on the Treatment of Hypertensive Intracerebral Hemorrhage With Panax Notoginseng Saponin
The purpose of this study is to determine whether panax notoginseng saponins are effective in the treatment of Hypertensive Intracerebral Hemorrhage Patients.
- Trial name
- CSTHIHPNS (NCT02999048)
- Testing
- Panax Notoginseng Saponins
- Volunteers
- 90 people
- Sponsor
- The First People's Hospital of Jingzhou
Intracerebral Hemorrhage
Precision Use of TXA in Intracerebral Hemorrhage
Primary Intracerebral hemorrhage (ICH) is a severe and disabling disease. The hematoma will expand within the first few hours, which contributes to increasing brain injury and worsening neurological prognosis.
- Trial name
- NCT07365150
- Testing
- Tranexamic Acid (IV)
- Where
- 3 sites in Hong Kong
- Volunteers
- 70 people
- Sponsor
- The University of Hong Kong
Subarachnoid Hemorrhage
Short Duration Levetiracetam to Extended Course for Seizure Prophylaxis After aSAH
Our primary objective is to compare two treatment options for prevention of seizures following a subarachnoid hemorrhage and determine if a short-course regimen of levetiracetam is as efficacious in the prevention of in-hospital…
- Trial name
- DOPAST (NCT01137110)
- Testing
- Brief LEV, Extended LEV
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Washington University School of Medicine
Electrolyte Disturbances, Subarachnoid Hemorrhage
Electrolyte and Fluid Disturbances in Subarachnoid Hemorrhage and Traumatic Brain Injury
During the course of their acute illness patients with subarachnoid hemorrhage and severe traumatic brain injury often develop disturbances in their fluid balance and electrolyte homeostasis.
- Conditions
- Electrolyte Disturbances, Subarachnoid Hemorrhage, Traumatic Brain Injury, Natriuretic Peptides
- Trial name
- NCT01313975
- Where
- Switzerland
- Volunteers
- 85 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Subarachnoid Hemorrhage, Delayed Cerebral Ischemia
MicroRNA Diagnostics in Subarachnoid Hemorrhage 2
The purpose of this study is to validate results from a related trial (NCT01791257) and to compare the profile of microRNA in blood from patients suffering subarachnoid hemorrhage with and without systemic complications.
- Conditions
- Subarachnoid Hemorrhage, Delayed Cerebral Ischemia, Acute Lung Injury, Cardiac Dysfunction
- Trial name
- NCT02320539
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Trauma, Craniocerebral Trauma
Early Versus Late Intubation Trial in Physician Manned Emergency Medical Services
This study looks at advanced airway management in critically ill or injured patients treated by physician manned emergency medical services, comparing early (on-scene) intubation to late (emergency department) intubation.
- Conditions
- Trauma, Craniocerebral Trauma, Intracerebral Hemorrhage, Seizures
- Trial name
- ELITE (NCT01730001)
- Testing
- Early Intubation, Late intubation
- Where
- 2 sites in Norway
- Sponsor
- Norwegian Air Ambulance Foundation
Myocardial Depression, Takotsubo Syndrome
Predicting the Development of Myocardial Depression in Acute Neurological Patients
The purpose of this study is to assess the levels of serum catecholamines associated with myocardial depression (MD) in patients with acute neurological injury.
- Conditions
- Myocardial Depression, Takotsubo Syndrome, Subarachnoid Hemorrhage, Acute Ischemic Stroke
- Trial name
- NCT03801694
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Ohio State University
Intracerebral Hemorrhage, Hypertension
Huayu Jiedu Formula (FTFY-919) Granules Versus Traditional Decoction for Acute Hypertensive Intracerebral Hemorrhage
This is a multicenter, randomized, double-blind, controlled, non-inferiority clinical trial to evaluate the efficacy and safety of Huayu Jiedu Formula (FTFY-919) Chinese medicine formula granules compared with traditional…
- Trial name
- CHAIN3 (NCT07801599)
- Testing
- Huayu Jiedu Formula (FTFY-919) Granules, Huayu Jiedu Formula (FTFY-919) Traditional Decoction
- Volunteers
- 300 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Brain Injuries, Intracranial Aneurysm
Hypopituitarism Following Traumatic Brain Injury or Spontaneous Subarachnoidal Haemorrhages
The purpose of this study is to assess the prevalence and predictors of pituitary dysfunction, as well as secondary out-come in patients with traumatic brain injury or spontaneous subarachnoidal haemorrhages.
- Trial name
- NCT00435006
- Where
- Denmark
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Traumatic Brain Injury, Intracranial Hemorrhages
Improving Diagnosis and Prediction of Outcome in Patients With Severe Disorders of Consciousness
Patients with acute severe brain injury are usually admitted to the Intensive Care Unit. A substantial proportion of these patients will have disorders of consciousness (DOC) after interruption of sedation.
- Conditions
- Traumatic Brain Injury, Intracranial Hemorrhages, Subarachnoid Hemorrhage, Meningitis
- Trial name
- IMPROVE-DOC (NCT06283901)
- Where
- 5 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Subarachnoid Hemorrhage
Ultra-early Tranexamic Acid After Subarachnoid Hemorrhage.
This is a multicenter, prospective, randomized, open-label trial with blinded endpoint (PROBE) assessment. Adult patients with the diagnosis of non-traumatic SAH, as proven by computed tomography (CT) within 24 hours after the…
- Trial name
- ULTRA (NCT02684812)
- Testing
- Tranexamic Acid
- Where
- Netherlands
- Volunteers
- 955 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Ischemic Stroke
Reperfusion Injury After Endovascular Stroke Treatment
Endovascular stroke treatment with mechanical thrombectomy (MT) has become the standard therapy for intracranial large vessel occlusion (LVO).
- Trial name
- DYNASTROKE (NCT05273216)
- Testing
- Transcranial Duplex Sonography, Brain MRI, Blood biomarkers
- Where
- 3 sites in Austria
- Volunteers
- 600 people
- Sponsor
- Medical University of Graz
Chronic Subdural Hematoma
Endovascular Embolization of Chronic Subdural Hematomas After Surgery
Chronic subdural hematomas (CSH) are one of the most frequent pathologies in emergency neurosurgical practice. Standard therapy for symptomatic CSH is surgical drainage.
- Trial name
- ENCLOSURE (NCT05220826)
- Testing
- Post surgical embolization of middle meningeal artery with liquid embolic agents (ethylene vinyl alcohol copolymers as Onix, Squid, Phil or Libro)
- Where
- Spain
- Volunteers
- 280 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Subarachnoid Hemorrhage, Aneurysmal
New Therapeutic System of Ruptured Intracranial Aneurysms Based on Big Data From Chinese Population
This study aims at clarifying the current situation of Emergency treatment of aneurysmal subarachnoid hemorrhage (SAH) in China, and analyzing the safety and efficacy of the treatment strategy between interventional treatment and…
- Trial name
- NATIONAL-2 (NCT03153748)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Changhai Hospital
Hematoma, Subdural, Chronic
The Role of Meningeal Lymphatic Vessels in the Absorption of Chronic Subdural Hematoma and Its Injury Mechanism
Chronic subdural hematoma (CSDH) is a very common hemorrhagic disease of the nervous system, accounting for about 10% of hemorrhagic strokes.
- Trial name
- NCT05426889
- Testing
- subdural hematoma burr hole drainage, drug conservative treatment
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Anticoagulant-induced Bleeding, Intracranial Hemorrhages
Anticoagulant-associated Intracranial Hemorrhage
Oral anticoagulant therapy, including factors Xa and 2a inhibitors has become more popular in recent years due to its efficacy and convenience in preventing thrombotic events and reducing the risk for stroke in patients with rosk…
- Trial name
- AAIHINNN (NCT06168838)
- Testing
- Anticoagulant
- Where
- Mexico
- Volunteers
- 1,200 people
- Sponsor
- El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Basal Ganglia Hemorrhage
Minimally Invasive Treatment of Hypertensive Basal Ganglia Hemorrhage by Transfrontal Keyhole Neuroendoscopy
To compare the prognosis of patients with hypertensive intracerebral hemorrhage treated by two different surgical methods, and to clarify the therapeutic effect of minimally invasive surgery, so as to find a better surgical…
- Trial name
- NCT04958525
- Testing
- Keyhole neuroendoscopic transfrontal ultrasound-guided hematoma removal, Small bone window craniotomy for hematoma removal under microscope
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Peking University Third Hospital
Intracerebral Hemorrhage
Role of Neuroinflammation and Blood-Brain Barrier Breakdown in Intracerebral Hemorrhage.
In this prospective, multicenter study of patients with acute spontaneous supratentorial Intracerebral Hemorrhage (ICH), each participant will have a standardized multimodal evaluation of neuroinflammation at 10 (±2) days after…
- Trial name
- INFINITE (NCT07583147)
- Testing
- TEP with 18F-DPA-714 injection
- Where
- 3 sites in France
- Volunteers
- 117 people
- Sponsor
- University Hospital, Toulouse
Cerebral Hemorrhage, Cerebral Ischemia
Study on Data Acquisition and Image Characteristics of Brain Multifrequency EIT in Healthy People and Patients With Brain Diseases
The goal of this observational study is to compare the differences in the features of cerebral multifrequency EIT(cMFEIT) images between healthy subjects and patients with brain diseases and to explore the possibility of applying…
- Conditions
- Cerebral Hemorrhage, Cerebral Ischemia, Cerebral Edema, Healthy
- Trial name
- NCT05796349
- Testing
- multifrequency EIT-based for detecting intracranial abnormalities
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jieshi Ma
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