Clinical trials: Bleed Intracranial
Subarachnoid Hemorrhage
Intravenous Magnesium Sulfate in Aneurysmal Subarachnoid Haemorrhage (IMASH)
The IMASH trial is a simple, randomized, double-blinded, placebo-controlled, multi-center trial to answer the question: "Does intravenous magnesium sulfate improve clinical outcome after aneurysmal subarachnoid hemorrhage?"
- Trial name
- NCT00124150
- Testing
- Intravenous magnesium sulfate infusion
- Where
- China
- Volunteers
- 327 people
- Sponsor
- Chinese University of Hong Kong
Intracerebral Hemorrhage
A Cohort Study of Patients With Intracranial Hemorrhage
As one of the most serious forms of acute stroke, the early mortality rate of intracerebral hemorrhage(ICH) can be as high as 30-40%. The incidence of intracerebral hemorrhage increases with the increase of age.
- Trial name
- NCT05760950
- Testing
- Routine clinical treatment
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Intra-Arterial Tenecteplase Following Endovascular Thrombectomy for Large Vessel Occlusion Stroke
The purpose of this study is to determine the safety and feasibility of using intra-arterial Tenecteplase in patients undergoing blood clot extraction for treatment of acute ischemic (non-bleeding) stroke.
- Trial name
- TNK-FLOW (NCT06781385)
- Testing
- Intra-arterial Tenecteplase, Intra-arterial Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Intracranial Hemorrhage
Factor VII, Prothrombin Complex Concentrate, and Fresh Frozen Plasma in Warfarin-Related Intracranial Hemorrhage
The purpose of this dose-ranging pilot study is to compare Recombinant Activated Factor VII, Prothrombin Complex Concentrate and Fresh Frozen Plasma (each starting at low doses with escalation if necessary) for the reversal of…
- Trial name
- NCT00770718
- Testing
- Recombinant Activated Factor VII (rFVIIa), Prothrombin Complex Concentrate, Fresh Frozen Plasma
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Utah
Subarachnoid Hemorrhage
Deferoxamine to Prevent Delayed Cerebral Ischemia After Subarachnoid Hemorrhage
The investigators will test the central hypothesis that DFO treatment after SAH may improve cerebrovascular regulation, mitigate ischemic neural injury, and serve as an effective neuroprotectant against delayed ischemic injury…
- Trial name
- NCT02216513
- Testing
- desferrioxamine (DFO)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brigham and Women's Hospital
Intracranial Pressure, Intracranial Pressure Changes
CoMind Early Feasibility Study
The purpose of this research, which has been determined as non-significant risk by the central IRB overseeing the study, is to obtain information to help further develop a machine (a medical device) to measure the pressure around…
- Conditions
- Intracranial Pressure, Intracranial Pressure Changes, Traumatic Brain Injury, Intracerebral Hemorrhage
- Trial name
- CoMind EFS (NCT06368648)
- Where
- 17 sites in United States
- Volunteers
- 581 people
- Sponsor
- CoMind Technologies Limited
Stroke, Acute Stroke
Stroke and Cerebrovascular Diseases Registry
This is a single institutional registry database for the patients with stroke and cerebrovascular diseases. Stroke is the fifth leading cause of death in the United States.
- Conditions
- Stroke, Acute Stroke, Acute Brain Injury, Ischemic Stroke
- Trial name
- NCT03281590
- Where
- United States
- Volunteers
- 4,594 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Ischemic Stroke
Safety and Efficacy of Two Doses of SP-8203 in Patients With Ischemic Stroke Requiring rtPA
The current study aims to evaluate the safety of SP-8203, designing in two stages (stage-1, stage-2) to evaluate the safety and efficacy of the combination therapy of SP-8203 and rtPA for the occurrence of cerebral hemorrhage in…
- Trial name
- SP-8203-2001 (NCT02787278)
- Testing
- SP-8203 High dose, SP-8203 Low dose
- Where
- 8 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Perinatal Brain Injury
Neuro-MoD: Neuroplasticity With Motor Development
This study is for infants and toddlers between 8 and 24 months old who use one arm and/or hand differently following a perinatal brain injury.
- Trial name
- NCT07738432
- Testing
- Constraint-Induced Movement Therapy (CIMT), Transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Wisconsin, Madison
Intracerebral Hemorrhage
A PILOT TRIAL of a DISPOSABLE INTRACEREBRAL ASPIRATION ENDOSCOPE for the TREATMENT of INTRACEREBRAL HEMATOMA（FAST-HET）
This clinical trial is a prospective, open-label, single-arm clinical trial. According to the inclusion and exclusion criteria specified in the trial protocol, no fewer than 16 subjects with cerebral hemorrhage will be enrolled…
- Trial name
- NCT06843616
- Testing
- Endoscopic surgery
- Where
- China
- Volunteers
- 16 people
- Sponsor
- MicroPort NeuroTech Co., Ltd.
Stroke
Long Term Outcome After Hemorrhagic Stroke Surgery
The investigators retrospectively reviewed all patients with neurosurgical operations for hemorrhagic stroke (intracerebral hemorrhage) between 1999 and 2008.
- Trial name
- NCT01409252
- Where
- China
- Volunteers
- 191 people
- Sponsor
- Chinese University of Hong Kong
Intracerebral Hemorrhage, Hemorrhagic Stroke, Intracerebral
Safety and Feasibility of Using Cerebrolysin in the Treatment of Primary Intracerebral Hemorrhage - a Prospective Randomized Open Blinded End-point Trial
This study is designed to determine the safety and feasibility of using Cerebrolysin in treating primary intracerebral hemorrhage (ICH).
- Conditions
- Intracerebral Hemorrhage, Hemorrhagic Stroke, Intracerebral, Hemorrhagic Stroke, Stroke
- Trial name
- CLINCH (NCT06899464)
- Testing
- 14-day Cerebrolysin treatment, Standard of Care (SOC)
- Volunteers
- 30 people
- Sponsor
- Cardinal Stefan Wyszynski University
Ischemic Stroke, Subarachnoid Hemorrhage, Aneurysmal
Effect of Targeted Temperature Management on Cerebral Autoregulation in Patients With Neurocritical Diseases
Change and effect of cerebral autoregulation during targeted temperature management in neurocritical patients
- Conditions
- Ischemic Stroke, Subarachnoid Hemorrhage, Aneurysmal, Sepsis, TBI (Traumatic Brain Injury)
- Trial name
- NCT04728438
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xiangya Hospital of Central South University
Basal Ganglia Hemorrhage, Intraventricular Hemorrhage
RAINBOW-ICH Trial of AI Guided Minimally Invasive Neurosurgery for ICH
Intracerebral hemorrhage (ICH) is one of the most devastating forms of stroke, with high rates of death and disability worldwide. Despite advances in medical and surgical care, effective therapeutic options remain limited.
- Conditions
- Basal Ganglia Hemorrhage, Intraventricular Hemorrhage, Brainstem Stroke, Intracranial Hemorrhage, Spontaneous
- Trial name
- RAINBOW-ICH (NCT07205263)
- Testing
- AI-assisted robotic-guided endoscopic hematoma evacuation, Conventional craniotomy, AI-assisted robotic-guided puncture and hematoma evacuation
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Aneurysm, Hypothermia
Hypothermia During Intracranial Aneurysm Surgery Trial
This is a large multi-center, prospective, randomized trial designed to determine whether mild intraoperative hypothermia results in improved neurological outcome in patients with an acute subarachnoid hemorrhage (SAH) who are…
- Conditions
- Aneurysm, Hypothermia, Subarachnoid Hemorrhage
- Trial name
- NCT00029133
- Testing
- mild intraoperative hypothermia (33 degrees Celsius)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Subarachnoid Hemorrhage, Intracerebral Hemorrhage
Safety and Efficacy of Nicardipine for the Control of Blood Pressure After SAH
The purpose of this research is to explore ways to improve and simplify control of blood pressure in patients with SAH or ICH. This research will be done by comparing tow different medications that are routinely used to help…
- Trial name
- NCT00490464
- Testing
- Nicardipine and Nipride
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- University of Illinois Chicago
Cerebral Hemorrhage, Intracranial Hemorrhages
Study of Antithrombotic Treatment After IntraCerebral Haemorrhage
The study evaluates the effects of antithrombotic drugs (anticoagulant drugs or antiplatelet drugs) for prevention of ischaemic events in patients With recent intracerebral haemorrhage.
- Conditions
- Cerebral Hemorrhage, Intracranial Hemorrhages, Atrial Fibrillation, Anticoagulant-Induced Bleeding
- Trial name
- STATICH (NCT03186729)
- Testing
- Antithrombotic Agent
- Where
- 3 sites in Denmark, Norway and 1 more
- Volunteers
- 134 people
- Sponsor
- Oslo University Hospital
Subarachnoid Hemorrhage, Aneurysmal
Trial of Prophylactic Decompressive Craniectomy for Poor-grade Aneurysmal Subarachnoid Hemorrhage
Decompressive craniectomy has been reported for the treatment of patients with aneurysmal subarachnoid hemorrhage (aSAH). But no prospective randomised controlled trials have yet been undertaken to confirm its effect.The purpose…
- Trial name
- NCT02995928
- Testing
- Decompressive craniectomy, Best medical treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tang-Du Hospital
Traumatic Intracranial Hemorrhage
Platelet Transfusion and Repeat TEG-PM in Patients With Severe TBI on Antiplatelet Therapy (Repeat TEG-PM)
The aim of this study is to see if administering platelets (cells in our blood that stop or prevent bleeding) results in improved platelet function and slows/stops the progression of a head bleed for patients who have a traumatic…
- Trial name
- NCT06433622
- Testing
- Repeat Thromboelastography with Platelet Mapping
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Lancaster General Hospital
Subarachnoid Hemorrhage, Cerebral Vasospasm
Safety Study of Dantrolene in Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a devastating acute brain injury due to bleeding onto the brain surface from a ruptured aneurysm.
- Trial name
- NCT01024972
- Testing
- Dantrolene
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Massachusetts, Worcester
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