Clinical trials: Bleed Intracranial
Intracerebral Hemorrhage
ROSE-Longitudinal Assessment With Neuroimaging
The investigators will perform follow-up on 250 of 500 cases recruited into the ROSE study of cases with deep and lobar intracerebral hemorrhage to perform advanced neuroimaging at 12-24 months post stroke, and evaluations of…
- Trial name
- ROSE-LAWN (NCT05089331)
- Where
- 7 sites in United States
- Volunteers
- 250 people
- Sponsor
- State University of New York at Buffalo
Subarachnoid Hemorrhage, Intracerebral Hemorrhage
Multimodal Neuromonitoring
Theoretical Framework \& Background Cortical spreading depressions (CSD) and seizures, are crucial in the development of delayed cerebral ischemia and poor functional outcome in patients suffering from acute brain injuries such…
- Conditions
- Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Traumatic Brain Injury, Cortical Spreading Depolarization and Depression
- Trial name
- MMNM (NCT04737369)
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Intracerebral Hemorrhage
Baricitinib for Patients With Intracerebral Hemorrhage
This study is an investigator-initiated, prospective, randomized, open-label, blind end-point (PROBE) phase-2 clinical trial, to preliminarily evaluate the efficacy and safety of baritinib for the treatment of acute spontaneous…
- Trial name
- BRIGHT (NCT06737705)
- Testing
- Baritinib
- Where
- 6 sites in China
- Volunteers
- 110 people
- Sponsor
- De-zhi Kang
Subarachnoid Hemorrhage, Aneurysmal, Poor Grade Subarachnoid Hemorrhage
Poor Grade Aneurysmal Subarachnoid Hemorrhage Study Group
Multicentric registry study in order to define outcome, predictors, treatment effects and their modifiers in poor grade aneurysmal subarachnoid haemorrhage patients.
- Trial name
- POGASH (NCT04945603)
- Testing
- Standard management according to international/national guidelines
- Where
- 10 sites in Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS San Raffaele
Ischemic Stroke
Dual Thrombolytic Therapy With Mutant Pro-urokinase and Low Dose Alteplase for Ischemic Stroke
Randomized controlled phase II trial to test the safety and preliminary efficacy of a dual thrombolytic treatment consisting of a small intravenous (IV) bolus of alteplase followed by IV infusion of mutant pro-urokinase against…
- Trial name
- DUMAS (NCT04256473)
- Testing
- mutant pro-urokinase, Alteplase
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Erasmus Medical Center
Subarachnoid Hemorrhage, Vasospasm
Effect of Red Blood Cell Transfusion on Brain Metabolism in Patients With Subarachnoid Hemorrhage
The purpose of this study is to determine if giving blood transfusions to anemic patients with subarachnoid hemorrhage will reduce their chances of having a stroke from vasospasm.
- Trial name
- NCT00968227
- Testing
- Red blood cell transfusion
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Washington University School of Medicine
Subarachnoid Hemorrhage
Aneurysmal Subarachnoid Hemorrhage: Red Blood Cell Transfusion and Outcome
The purpose of this study is to determine the feasibility of conducting a large trial examining the effect on clinical outcome of a liberal red blood cell (RBC) transfusion strategy compared to a restrictive strategy (usual care)…
- Trial name
- SAHaRA Pilot (NCT02483351)
- Testing
- Liberal Red Blood Cell Transfusion Strategy, Restrictive Red Blood Cell Transfusion Strategy
- Where
- 3 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Cerebral Ischemia, Subarachnoid Hemorrhage
Induced Hypertension for Treatment of Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage
The objective of this multi-centre, randomized controlled trial is to investigate the outcome after induced hypertension versus no induced hypertension in patients with delayed cerebral ischemia (DCI) after aneurysmal…
- Trial name
- HIMALAIA (NCT01613235)
- Testing
- Induced hypertension
- Where
- 2 sites in Netherlands
- Volunteers
- 26 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Subdural Hematoma
Burr Hole Ultrasound Study
Chronic subdural hematoma (CSDH) is commonly managed through burr hole evacuation. This study evaluates the feasibility of trans burr hole sonography as an alternative postoperative imaging modality.
- Trial name
- NCT06134206
- Testing
- Trans-burr hole ultrasound
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Kepler University Hospital
Spontaneous Subarachnoid Hemorrhage
Nursing Risk Management in Emergency SAH Surgery Using Healthcare Failure Mode and Effect Analysis(HFMEA)
The investigators are testing whether a new nurse-led safety program (HFMEA) lowers problems during emergency brain-aneurysm surgery better than usual care.
- Trial name
- NCT07315048
- Testing
- HFMEA-based nursing-risk programme
- Where
- China
- Volunteers
- 156 people
- Sponsor
- West China Hospital
Cerebral Amyloid Angiopathy, Subarachnoid Hemorrhage
Detailed Clinical and MRI Characteristics in Primary Non-traumatic Convexity Subarachnoid Haemorrhage Elderly Patients.
Transient focal neurological episode (TFNE) is the most frequent presenting symptom of convexity subarachnoid haemorrhage (cSAH) in elderly patients with non-traumatic cSAH with suspected, possible or probable cerebral amyloid…
- Trial name
- cSAH (NCT04825808)
- Testing
- usual care
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Intracerebral Hemorrhage
Insights From the Retina on Cerebral Microvascular Dysfunction in Haemorrhagic Stroke
Fundoscopy, optical coherence tomography (OCT) and OCT-angiography (OCTA) are established examinations and bear minimal risks. The recognition of retinal microvascular signs will enhance the pathophysiological understanding of…
- Trial name
- RETINA-ICH (NCT04363619)
- Testing
- OCT and OCTA
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- University of Zurich
Balanced Anesthesia, Intracerebral Hemorrhage
Hemodynamics and Vital Organ Function in Intracerebral Hemorrhage
Spontaneous non-traumatic intracerebral hemorrhage (ICH) is a common symptom in clinical practice and is the most serious among all types of stroke.Recently, as a relatively mainstream and recognized INTERACT2 (five well-known…
- Conditions
- Balanced Anesthesia, Intracerebral Hemorrhage, Total Intravenous Anesthesia
- Trial name
- NCT03129009
- Testing
- Total intravenous anesthesia group, Balanced anesthesia group
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xuzhou Medical University
Chronic Subdural Hematoma
General Anesthesia Versus Locoregional Anesthesia for Evacuation of Chronic Subdural Hematoma
This study compare general anesthesia versus locoregional anesthesia for evacuation of chronic subdural hematoma. Half of participant will be operated under general anesthesia, while the other half will be operated under…
- Trial name
- NCT03666949
- Testing
- All General anesthesia, All Locoregional anesthesia
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Caen
Acquired Bleeding Disorder, Intracerebral Haemorrhage
Factor VIIa in Acute Intracerebral Haemorrhage
This trial is conducted in Japan. The purpose of this trial is to evaluate the safety and preliminary efficacy of Activated Recombinant Factor VII (NN-007) in patients with acute intracerebral haemorrhage.
- Trial name
- NCT00266006
- Testing
- eptacog alfa (activated)
- Where
- Japan
- Volunteers
- 90 people
- Sponsor
- Novo Nordisk A/S
Subarachnoid Hemorrhage
Efficacy and Safety Assessment for a New UV-protected Pump Infusion Line in Intravenous Infusion Therapy
To verify the efficacy and safety of Original Perfusor Line (Art.No.8723017) in infusion therapy in Patients with light sensitive drug infusion.
- Trial name
- NCT04309708
- Testing
- Nimodipine pump infusion
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- B. Braun Medical International Trading Company Ltd.
Aneurysmal Subarachnoid Hemorrhage
Cerebrospinal Fluid (CSF) Drainage Study
When patients suffer a subarachnoid hemorrhage (bleeding around the brain), they often develop hydrocephalus. This is an enlargement of the fluid-filled spaces (ventricles) in the brain.
- Trial name
- NCT01420978
- Testing
- CSF Diversion
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Endovascular Treatment, Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for Patients With Chronic Subdural Hematoma
COMPLEMENT study (ChrOnic subdural hematoMa Patients suppLemented with Embolization of Middle mENingeal artery Trial) is a prospective, open label, blinded endpoint (PROBE), Japanese, two-arm, randomized, controlled, post-market…
- Trial name
- NCT06772740
- Testing
- Middle meningeal artery embolization
- Where
- Japan
- Volunteers
- 600 people
- Sponsor
- Kazutaka Uchida
Spontaneous Subarachnoid Hemorrhage
Factors Influencing the Mortality of Patients With Subarachnoid Haemorrhage
Spontaneous subarachnoid haemorrhage (SAH) is a serious cerebrovascular disease with high morbidity and mortality.Determining the factors associated with mortality in the ICU follow-up and treatment of patients with spontaneous…
- Trial name
- NCT06490640
- Testing
- Spontaneous subarachnoid haemorrhage survival cohort, Spontaneous subarachnoid haemorrhage mortality cohort
- Where
- Turkey (Türkiye)
- Volunteers
- 117 people
- Sponsor
- Melike Cengiz
Chronic Subdural Hematoma
Mgt of Chronic Subdural Hematoma Using Dexamethasone
Chronic subdural hematoma (cSDH) is a collection of blood and its breakdown products in the subdural compartment. It is a condition frequently seen in any neurosurgical practice.
- Trial name
- NCT02938468
- Testing
- Dexamethasone, Any surgical intervention aim at treating chronic subdural hematoma
- Where
- Canada
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Calgary
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