Clinical trials: Bleeding Cardiac Surgery Patients
Acute Coronary Syndrome, Coronary Stent Occlusion
Perioperative Management of Patients With Coronary Stents Undergoing Noncardiac Surgery
The purpose of this study is to evaluate and monitor perioperative management of patients with coronary stents undergoing noncardiac surgery.
- Conditions
- Acute Coronary Syndrome, Coronary Stent Occlusion, Surgery
- Trial name
- RegistStents (NCT01171612)
- Where
- 13 sites in Spain
- Volunteers
- 483 people
- Sponsor
- Corporacion Parc Tauli
Blood Loss, Surgical
Haemate HS in Patients With Severe Bleeding Undergoing Valve Replacement Due to Aortic Stenosis
Evaluation of efficacy by determination of transfusion requirements and safety by determination of adverse events in administration of Von Willebrand factor concentrate F VIII (Haemate).
- Trial name
- HAVAS (NCT00618293)
- Testing
- Haemate HS, NaCl-solution
- Where
- Germany
- Sponsor
- Heinrich-Heine University, Duesseldorf
Anemia, Blood Loss Anemia
Patient Blood Management In CARdiac sUrgical patientS
Nowadays up to 40% of patients undergoing cardiac surgery receives at least 1 unit of red blood cell transfusion during surgery or during the first week after surgery.
- Conditions
- Anemia, Blood Loss Anemia, Iron-deficiency, Iron Deficiency Anemia
- Trial name
- ICARUS (NCT04744181)
- Testing
- Ferric carboxymaltose, B vitamin, Folic acid
- Where
- Italy
- Volunteers
- 479 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Postoperative Hemorrhage, Postoperative Anemia
Autologous Whole Blood Management for Transfusion Reduction in Adult Cardiac Surgery Patients
The goal of this pilot trial is to test a protocol for a planned Canada-wide clinical trial looking at whether or not the use of a patients own blood works as good as the current standard of care using donated blood products to…
- Conditions
- Postoperative Hemorrhage, Postoperative Anemia, Postoperative Blood Loss
- Trial name
- NCT05889494
- Testing
- Autologous Whole Blood Management, Standard Care involving allogenic and/or derivative transfusion.
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Heart Failure, Ventricular Dysfunction
The Use of CoSeal (Sealant Agent) in Patients During Left Ventricular Assist Device Surgery
The purpose of this study is to evaluate the use of a device called CoSeal™. CoSeal™ is an FDA approved synthetic (man-made) surgical sealant which is currently used to help stop leaks in blood vessels during surgery.
- Trial name
- NCT01605019
- Testing
- CoSeal, BioGlue® Surgical Adhesive
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- The Methodist Hospital Research Institute
Anticoagulation Treatment Overdose, Heart Valve Diseases
A Trial of Genotype-based Warfarin Initiation in Patients With Mechanical Prosthetic Heart Valve
Until very recently, warfarin is still the best drug of choice for long-term anticoagulation for patients with mechanical prosthetic heart valve.
- Trial name
- SYSU-WARFA (NCT01633957)
- Testing
- Genotype-based Warfarin Initiation model, clinical factor-based warfarin initiation model
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xi Zhang
C.Surgical Procedure; Cardiac
Acute Normovolemic Hemodilution in High Risk Cardiac Surgery Patients.
Transfusions are one of the most overused treatments in modern medicine, and saving blood is one important issue all around the world.
- Trial name
- ANH (NCT03913481)
- Testing
- Acute normovolemic hemodilution, Standard care
- Where
- 32 sites in United States, Bahrain and 9 more
- Volunteers
- 2,000 people
- Sponsor
- Università Vita-Salute San Raffaele
Bleeding
Platelet Inhibition and Bleeding in Patients Undergoing Emergent Cardiac Surgery
The aim of the study is to evaluate if there is an association between platelet inhibition and surgery-related bleeding in patients undergoing emergent cardiac surgery during dual antiplatelet therapy.
- Trial name
- NCT01468597
- Where
- Austria
- Volunteers
- 167 people
- Sponsor
- Medical University of Graz
Atrial Fibrillation, Anticoagulant-induced Bleeding
Perioperative Management of Factor Xa Inhibitors
This study aims to analyze the safety and effectiveness of the discontinuation/resumption protocol of factor Xa inhibitors before and after invasive procedures/surgeries in non-valvular atrial fibrillation patients who are at…
- Trial name
- PERIXa (NCT05801068)
- Testing
- Factor Xa Inhibitor
- Where
- South Korea
- Volunteers
- 2,500 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Bypass Graft Triple Vessel, Blood Coagulation Disorders
Goal-orientated Therapy of Perioperative Disturbance in Hemostasis in Cardiac Surgery
Aim of this study is to investigate whether patients preoperatively treated with acetylsalicylic acid and/or clopidogrel have fewer perioperative bleeding and lower amounts of blood substitution when managed by ROTEM (whole blood…
- Trial name
- NCT00516126
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Thrombosis, Cancer
Safety of Perioperative Anticoagulation Management in People With Active Cancer Undergoing Cancer-Related Surgery or Procedures (ACE-HIGH Study)
The purpose of this study is to help find how safe current practices are when managing blood thinners in people with cancer who are having surgery or medical procedures.
- Conditions
- Thrombosis, Cancer, Thrombosis, Deep Vein, Atrial Fibrillation (AF)
- Trial name
- ACE-HIGH (NCT07372716)
- Testing
- standardized perioperative anticoagulation management Guideline
- Where
- Canada
- Volunteers
- 700 people
- Sponsor
- Ottawa Hospital Research Institute
Bleeding and Cardiac Surgery, Allogeneic Blood Transfusion
Comparison of Aprotinin and Tranexamic Acid in Routine Cardiac Surgery
The hypothesis of this study is that the antifibrinolytic drugs aprotinin and tranexamic acid equally influence bleeding tendency and transfusion requirement in patients undergoing first time cardiac procedures with a low risk of…
- Conditions
- Bleeding and Cardiac Surgery, Allogeneic Blood Transfusion, Aortic Valve Replacement, Coronary Artery Bypass Graft Surgery
- Trial name
- NCT00396760
- Testing
- aprotinin or tranexamic acid
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- German Heart Center
Coronary Artery Disease, Anemia
Clinical and Chemical Outcomes Following Cardiac Surgery: The Post-Operative Effects of MUF
It is hypothesized that on-line modified ultrafiltration (MUFF) post-cardiopulmonary bypass will result in improved patient outcomes over the 12-hour post-operative period as compared to control and off-line MUFF.
- Trial name
- MUF (NCT01864395)
- Testing
- Centrifugation Method, Online MUF, Offline MUF
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Saskatchewan
Atrial Fibrillation New Onset, Hemorrhage
Randomized Double Blind Control Trial on Effects of Ranolazine on New Onset Atrial Fibrillation
The aim of this study is to evaluate the prophylactic effects of Ranolazine on new onset atrial fibrillation in post-operative coronary artery bypass graft and valve surgery patient population at Staten Island University hospital.
- Conditions
- Atrial Fibrillation New Onset, Hemorrhage, Prolonged QTc Interval, Ventricular Tachycardia
- Trial name
- NCT01590979
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northwell Health
Postoperative Bleeding
Platelet Inhibition and Bleeding in Patients Undergoing Non-Cardiac Surgery
The aim of the study is to evaluate if there is an association between platelet inhibition and surgery-related bleeding in patients undergoing non-cardiac surgery during dual antiplatelet therapy.
- Trial name
- BIANCA (NCT01606865)
- Where
- Austria
- Volunteers
- 207 people
- Sponsor
- Medical University of Graz
Fibrinogen Deficiency in Complex Cardiac Surgery
Haemocomplettan® P During Elective Complex Cardiac Surgery
Fibrinogen concentrate is increasingly used in cardiac surgery to reverse coagulopathy. Whether its use reduces blood loss, transfusion and occurrence of clinical adverse events remains unknown.
- Trial name
- NCT01124981
- Testing
- Haemocomplettan® P
- Where
- 2 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- Isala