Clinical trials: Bleeding Diathesis
Haemophilia
Validation of Questionnaires HAL and HEP
Spanish Validation of HAL and HEP questionnaire by double translation (English-Spanish-English), with a pilotage pediatric patients with hemophilia and adults and parents of children with hemophilia.
- Trial name
- VALIDATION (NCT02512211)
- Where
- 2 sites in Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Burn, Coagulation, Blood
Thromboelastography to Study Burn Coagulopathy
This pilot study examines the use of thromboelastography (TEG), a specialized blood test, to evaluate clotting abnormalities in burn patients.
- Trial name
- NCT06879509
- Testing
- Thromboelastography
- Where
- United States
- Sponsor
- Francesco Egro
DIC Syndrome
Thromboelastometry Guided DIC Prevention After Cesarean Section in Pregnant Women With Placenta Previa
Evaluation of the use of thromboelastometry for early identification of the underlying coagulopathy and to guide individualized transfusion therapy to prevent DIC development during ICU stay after cesarean section in women with…
- Trial name
- DIC (NCT03266432)
- Testing
- blood samples
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Venous Thrombosis, Venous Insufficiency
Evaluating the Relationship Between Blood Clotting Disorders, Inflammation, and Obesity in Individuals With Venous Disorders and Post-Thrombotic Syndrome
Venous thrombosis is the development of a blood clot in a vein. Post-thrombotic syndrome (PTS) is a painful condition that can develop following a venous thrombosis in one of the deep veins of the leg.
- Trial name
- NCT00395265
- Where
- United States
- Volunteers
- 2,211 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Immune Thrombocytopenia
An Investigation of rhTPO With Different Frequencies in the Management of ITP
The project was undertaking by Qilu Hospital of Shandong University and other well-known hospitals in China. In order to study the efficacy and safety of different dose and frequency Recombinant Human thrombopoietin in treating…
- Trial name
- NCT02139501
- Testing
- Recombinant Human Thrombopoietin (rhTPO)
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Shandong University
Gingival Bleeding, Von Willebrand Diseases
Gingival Bleeding and Von Willebrand Disease Typ 2 and 3
Von Willebrand disease (VWD) is the most common inherent bleeding disorder resulting in prolonged bleeding time. Gingival bleeding is a frequently reported symptom of VWD.
- Trial name
- NCT03078595
- Where
- 2 sites in Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Goethe University
Acquired Immunodeficiency Syndrome, HIV Infections
Prospective Study of HIV Infection in Hemophiliacs
To examine mechanisms of individual differences in the progression of HIV infection in hemophiliacs.
- Conditions
- Acquired Immunodeficiency Syndrome, HIV Infections, Blood Disease, Hemophilia A
- Trial name
- NCT00005309
- Sponsor
- Bloodworks
Blood Coagulation Disorders, C.Surgical Procedure; Cardiac
Blood Cell Adhesion to Arterial Filters During Cardiac Surgery
Cardiopulmonary bypass (CPB) is a unique clinical scenario that results in widespread activation of the hemostatic system. Conventional CPB interferes with normal hemostasis by diluting hemostatic cells and proteins, through…
- Trial name
- NCT03882593
- Testing
- Analysis of arterial filters after CPB
- Where
- Brazil
- Volunteers
- 28 people
- Sponsor
- Instituto do Coracao
Purpura Fulminans
Outcomes of Purpura FULminans in Adults - The hOPeFUL Study
Purpura fulminans (PF) is a rare life-threatening infectious disease characterized by the association of a sudden and extensive purpura together with acute circulatory failure.
- Trial name
- hOPeFUL (NCT03216577)
- Testing
- Phone interview measuring health-related quality of life variables
- Where
- 26 sites in France
- Volunteers
- 74 people
- Sponsor
- Henri Mondor University Hospital
Hemophilia A
Pharmacokinetic Comparison of Efanesoctocog Alfa vs Other EHL-rFVIII Products in Participants With Severe Haemophilia A
Sobi.BIVV001-003 is an open-label, 2-period, fixed sequence study for intra-participant comparison of the PK profiles of efanesoctocog alfa and the extended half-life rFVIII products damactocog alfa pegol or turoctocog alfa pegol…
- Trial name
- NCT06579144
- Testing
- Efanesoctocog alfa
- Where
- 7 sites in Bulgaria, Germany and 2 more
- Volunteers
- 24 people
- Sponsor
- Swedish Orphan Biovitrum
Haemophilia
Exercise Program to Improve Balance in Hemophilic Patients
This study evaluates the effectiveness of a program of physiotherapy exercises to train the balance and dual task in adults patients with hemophilia
- Trial name
- NCT04122014
- Testing
- Progressive balance training, Normal daily activities
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- University of Valencia
Thrombin, Hemostatic Disorder
Thrombin in Cardiac Surgery
Coagulopathy, bleeding, and transfusion are common in cardiac surgical patients. Our collaborator has developed a novel point of care device that can be used to assess thrombin generation in real-time in cardiac surgical…
- Conditions
- Thrombin, Hemostatic Disorder, Surgical Blood Loss, Coagulation Disorder
- Trial name
- NCT04762576
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Hemophilia B
An International Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia B
Alprolix (rFIXFc) is a recombinant extended half-life coagulation factor product. The purpose of this non-interventional study is to describe the real-world usage and effectiveness of Alprolix in the on-demand and prophylactic…
- Trial name
- B-MORE (NCT03901755)
- Testing
- Alprolix
- Where
- 29 sites in Czechia, Greece and 7 more
- Volunteers
- 151 people
- Sponsor
- Swedish Orphan Biovitrum
Von Willebrand Disease, Type 3
An Observational Study of Participants With Type 3 Von Willebrand Disease on Prophylactic Standard-of-Care Treatment
This non-interventional study (NIS) is designed to collect information on the effectiveness and safety of treatment received in routine clinical care, as well as measure the health-related quality of life (HRQoL) of participants…
- Trial name
- WILL-EMI NIS (NCT06883240)
- Testing
- Von Willebrand Factor Concentrates, Von Willebrand Factor Concentrates and Factor VIII Concentrates, Factor VIII Concentrates
- Where
- 26 sites in United States, Belgium and 12 more
- Volunteers
- 44 people
- Sponsor
- Hoffmann-La Roche
Congenital Bleeding Disorder, Haemophilia A With Inhibitors
Trial of NovoSeven® in Haemophilia - Joint Bleeds
This trial is conducted in the United States of America (USA). This study compares the effectiveness and safety of NovoSeven® to FEIBA (FEIBA VH) in haemophilia patients with inhibitors being treated for joint bleeds.
- Conditions
- Congenital Bleeding Disorder, Haemophilia A With Inhibitors, Haemophilia B With Inhibitors
- Trial name
- NCT00108797
- Testing
- eptacog alfa (activated), Feiba VH
- Where
- 20 sites in United States
- Volunteers
- 42 people
- Sponsor
- Novo Nordisk A/S
Hemophilia A
PK Driven Prophylaxis for Hemophilia A
The purpose of this study is to evaluate the implementation of pharmacokinetic (PK) driven prophylaxis in current clinical practice
- Trial name
- OBTC (NCT02634424)
- Testing
- MyPKFiT
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ecchymosis
Effects of Topical Vitamin K, Vitamin K and Retinol, and Arnica on Post-Laser Bruising
The objective of this study is to assess the comparative utility of topical formulations in hastening the resolution of skin bruising.
- Trial name
- NCT00363038
- Testing
- Petrolatum United States Pharmacopeia (USP), Vitamin K and retinol ointment, Arnica ointment
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Myeloproliferative Disorder, Essential Thrombocythemia
Pilot Study for the Development of a Diagnostic Score to Differentiate Myeloproliferative Neoplasms.
Prospective study for the development of a non-invasive score for differentiating prefibrotic myelofibrosis from essential thrombocytosis and overt myelofibrosis.
- Conditions
- Myeloproliferative Disorder, Essential Thrombocythemia, Primary Myelofibrosis, Prefibrotic Stage, Primary Myelofibrosis, Fibrotic Stage
- Trial name
- BioScoreSMP (NCT03869476)
- Testing
- Non-invasive diagnosis score
- Where
- 2 sites in France
- Volunteers
- 133 people
- Sponsor
- University Hospital, Angers
Hemophilia A, Hemophilia B
Gaining Insight Into the Complexity of Pain in Patients With Haemophilia
Joint pain has been reported as a major problem in people with haemophilia (PwH). Therefore, haemophilia in adults seems clinically more related to a musculoskeletal disorder than a bleeding disorder, with many patients reporting…
- Trial name
- NCT05606640
- Testing
- Biopsychological pain assessment
- Where
- 2 sites in Belgium
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Hermansky Pudlak Syndrome
A Longitudinal Study of Hermansky-Pudlak Syndrome Pulmonary Fibrosis
Hermansky-Pudlak Syndrome (HPS) is a rare genetic disease that is associated with oculocutaneous albinism, bleeding, granulomatous colitis, and pulmonary fibrosis in some subtypes, including HPS-1, HPS-2, and HPS-4.
- Trial name
- NCT02368340
- Testing
- Pulmonary function test, Chest CT, Sample collection
- Where
- 5 sites in United States
- Volunteers
- 55 people
- Sponsor
- Vanderbilt University
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