Clinical trials: Bleeding Disorder, open to volunteers
Myeloproliferative Neoplasm, Polycythemia Vera
Functional and Phenotypic Characterization of Monocytes in Myeloproliferative Syndromes
Prospective study for functional and phenotypic characterization of monocytes in philadelphia-negative myeloproliferative neoplasms
- Conditions
- Myeloproliferative Neoplasm, Polycythemia Vera, Essential Thrombocythemia, Primary Myelofibrosis
- Trial name
- PHEMOP (NCT06361641)
- Testing
- Monocytes signatures in myeloproliferative neoplasms at diagnosis
- Where
- 3 sites in France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Angers
Internal Hemorrhoid
Outcomes and Quality of Life Following Rectal Artery Embolization for Bleeding Internal Hemorrhoids
This study will assess how effective and safe rectal artery embolization works to treat symptomatic bleeding predominant internal hemorrhoids.
- Trial name
- HEMBO-1 (NCT06106269)
- Testing
- Rectal Artery Embolization
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Thrombotic Thrombocytopenic Purpura (TTP), Immune Thrombotic Thrombocytopenic Purpura
Retrospective Epidemiological Study of Patients in the National Cohort of the French TMA Center
Immune thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening disorder characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic organ damage due to microvascular thrombosis.
- Conditions
- Thrombotic Thrombocytopenic Purpura (TTP), Immune Thrombotic Thrombocytopenic Purpura, Thrombotic Microangiopathies, Microangiopathy, Thromboic
- Trial name
- TWILIGHT (NCT07205861)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Premature Infants, Bronchopulmonary Dysplasia
Optimization of Saturation Targets And Resuscitation Trial (OptiSTART)
This study is designed to answer one of the fundamental gaps in knowledge in the resuscitation of preterm infants at birth: What is the optimal target oxygen saturation (SpO2) range that increases survival without long-term…
- Conditions
- Premature Infants, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage, Neurodevelopmental Outcomes
- Trial name
- OptiSTART (NCT05849077)
- Testing
- Sat75, Sat50
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- University of Texas Southwestern Medical Center
Haemophilia, Hemophilia A
Synovial Proliferation on Routine Ultrasound: Active or Inactive?
There is cumulating evidence for the presence of non-observed or subclinical joint bleeding in patients with haemophilia. Early detection of active subclinical synovial proliferation would allow early intervention in order to…
- Conditions
- Haemophilia, Hemophilia A, Hemophilia B
- Trial name
- 2BEGIN (NCT06809972)
- Testing
- Ultrasound imaging
- Where
- Netherlands
- Volunteers
- 46 people
- Sponsor
- Van Creveldkliniek
Immune Thrombocytopenia
Cognitive Dysfunction in Chronic and Persistent Immune Thrombocytopenia
Individuals with immune thrombocytopenia (ITP) frequently report difficulties with attention and memory. The main question this study seeks to answer is: Do patients with ITP have evidence of cognitive impairment as detected by a…
- Trial name
- COGFIT (NCT06817395)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Lumbar Spinal Stenosis, Lumbar Degenerative Disease
Effect of Obesity Phenotype on Intraabdominal Pressure and Bleeding in Major Lumbar Spinal Surgery
Obesity is prevalent among patients with lumbar degenerative disease and is a known risk factor for perioperative complications in spinal surgery.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Degenerative Disease, Obesity, Intraabdominal Hypertension
- Trial name
- OBESPINE (NCT07688265)
- Testing
- Intraabdominal Pressure Measurement via Urinary Bladder Catheter, Total Intravenous Anesthesia (TIVA)
- Volunteers
- 90 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Immune Thrombocytopenia, Autoimmune Hemolytic Anemia
OBS'CEREVANCE: French Cohort of Pediatric Autoimmune Cytopenia
From 2004, OBS'CEREVANCE is a national real-world prospective clinical cohort of patients with auto-immune cytopenia of pediatric-onset : Immune thrombocytopenia (ITP), Autoimmune Hemolytic anemia (AIHA), or Evans syndrome (all…
- Conditions
- Immune Thrombocytopenia, Autoimmune Hemolytic Anemia, Evans Syndrome
- Trial name
- OBS'CEREVANCE (NCT05937828)
- Testing
- data collection
- Where
- 9 sites in France
- Volunteers
- 3,500 people
- Sponsor
- University Hospital, Bordeaux
Immune (Idiopathic) Thrombocytopenic Purpura (ITP)
Romiplostim for Oral TPO-RA Resistant ITP
This study is a prospective, multicenter, open-label, single-arm cohort study to evaluate the effectiveness and safety of romiplostim in patients with immune thrombocytopenia (ITP) who have not responded to oral thrombopoietin…
- Trial name
- NCT07612319
- Testing
- Romiplostim
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Atrial Fibrillation, Stroke Prevention in Patients With Atrial Fibrillation
CLOT-LESS - CLOsure Tailored: LEss Antithrombotic Strategy After LAAC for Stroke Prevention
This is a prospective, non-randomized, observational cohort study conducted at the FSBI "NMRC TPM" of the Ministry of Healthcare of the Russian Federation.
- Conditions
- Atrial Fibrillation, Stroke Prevention in Patients With Atrial Fibrillation, Left Atrial Appendage Closure, Hemorrhage
- Trial name
- CLOT-LESS (NCT07575867)
- Testing
- Left Atrial Appendage Closure, Apixaban 2.5 mg BID, Standard-dose DOAC
- Where
- Russia
- Volunteers
- 464 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
Drug Coated Balloon vs. Drug-eluting Stent in Patients With Coronary Artery Disease
Studies exploring the feasibility of drug-eluting balloon (DCB) in de-novo coronary lesions are limited. There are scarce data comparing DCB with drug-eluting stent (DES) in patients with high bleeding risk (HBR), a situation in…
- Trial name
- DCB_DES (NCT07442500)
- Testing
- Drug coated balloon, Drug-eluting stent
- Where
- South Korea
- Volunteers
- 470,000 people
- Sponsor
- Samsung Medical Center
Immune Thrombocytopenia, Treatment
Anti-CD38 Antibody Treating Pediatric Primary Immune Thrombocytopenia (ITP)
To evaluate the safety and efficacy of Anti-CD38 Antibody in the treatment of pediatric primary immune thrombocytopenia in patients who have not responded adequately or relapsed after first-line treatment and at least one…
- Trial name
- NCT06168851
- Testing
- Anti-CD38 antibody Injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
STEMI (ST Elevation MI), STEMI - ST Elevation Myocardial Infarction
Effect of Guanxinning Tablet on Coronary Microcirculation After Primary Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction
①Research objective: In a small sample population, through the pre - experimental method, explore and evaluate the effect of Guanxinning tablets on the coronary microcirculation after primary percutaneous coronary intervention…
- Conditions
- STEMI (ST Elevation MI), STEMI - ST Elevation Myocardial Infarction, STEMI, CMD
- Trial name
- NCT07621107
- Testing
- Guanxinning Tablet(GXNT)
- Volunteers
- 70 people
- Sponsor
- Beijing Anzhen Hospital
Severe Hemophilia A, Severe Hemophilia A With Inhibitor
Dynamics of the Anti-factor VIII Antibody Signature During Treatment With Emicizumab
The goal of this observational study is to learn about the changes of antibodies and inhibitors against the coagulation factor VIII in patients with severe hemophilia A receiving emicizumab therapy.
- Conditions
- Severe Hemophilia A, Severe Hemophilia A With Inhibitor, Severe Hemophilia A Without Inhibitor
- Trial name
- NAVIGATE (NCT05802836)
- Testing
- no interventions
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Christoph Königs
Surgery, Liver Metastases
Improved Recovery by Iron Following Surgery With Blood Loss, the IRIS-trial
The aim of the study is to investigate if iv iron formulation improve recovery after surgery with blood loss. Post-operative anaemia is a common debilitating condition after major surgery due to a combination of preoperative iron…
- Conditions
- Surgery, Liver Metastases, Liver Cancer, Pancreas Cancer
- Trial name
- IRIS (NCT05744219)
- Testing
- Ferric carboxymaltose
- Where
- Sweden
- Volunteers
- 338 people
- Sponsor
- Jon Unosson
Abnormal Uterine Bleeding
Evaluation of Safety, Efficacy, and Pharmacokinetics of BT-114143 Injection in Patients With Abnormal Uterine Bleeding
This is a randomized, double-blind, placebo-controlled, multiple-dose escalation, Phase Ib clinical study conducted in patients with abnormal uterine bleeding (e.g., AUB).
- Trial name
- NCT07169214
- Testing
- BT-114143 Injection at low dose, BT-114143 Injection at Medium-dose, BT-114143 Injection at High-dose
- Where
- China
- Volunteers
- 39 people
- Sponsor
- ScinnoHub Pharmaceutical Co., Ltd.
Blood Platelet Disorders, Cardiac Surgery
Observational Study of Platelet Dysfunction Assessed by Thromboelastography in Cardiovascular Surgery (DISPLATEG)
Perioperative bleeding requiring blood transfusion is common during cardiovascular surgery, especially in procedures requiring cardiopulmonary bypass. Adenosine diphosphate (ADP) plays a fundamental role in platelet function.
- Conditions
- Blood Platelet Disorders, Cardiac Surgery, Postoperative Bleeding
- Trial name
- DISPLATEG (NCT06961175)
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Atrial Fibrillation, Stroke
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
The primary objective of this study is to evaluate the effectiveness (prevention of thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to background antiplatelet therapy in patients who…
- Conditions
- Atrial Fibrillation, Stroke, Bleeding
- Trial name
- PACES (NCT04045665)
- Testing
- Antiplatelet-only strategy, Oral Anticoagulant plus background antiplatelet therapy
- Where
- 106 sites in United States, Brazil and 3 more
- Volunteers
- 3,200 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Intracerebral Hemorrhage (ICH)
Research on the Clinical Value of Cranial CT and CTA for Cerebral Hemorrhage Patients
The objective of this observational study is to investigate the predictive value of various imaging signs in patients with intracerebral hemorrhage, thereby providing a reference for clinical diagnosis and treatment.
- Trial name
- NCT07100132
- Volunteers
- 300 people
- Sponsor
- The Affiliated Hospital Of Guizhou Medical University
Advanced Heart Failure, Left Ventricular Assist Devices
Trial of Low-intensity Anticoagulation to Reduce GI or Other Bleeding Complications With Equivalent Therapeutic Efficacy in HeartMate 3 LVAD Patients
The TARGET trial is a prospective, single-center, randomized, open-label, active-controlled inequality clinical trial designed to evaluate the safety and efficacy of low-intensity anticoagulation therapy (target INR 1.5-2.0)…
- Conditions
- Advanced Heart Failure, Left Ventricular Assist Devices, Anticoagulation Treatment, Bleeding Complications
- Trial name
- TARGET (NCT07081035)
- Testing
- Warfarin (low-intensity anticoagulation), Warfarin (standard anticoagulation)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Asan Medical Center
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