Clinical trials: Bleeding Gastric Varices, open to volunteers
Portal Hypertension, Gastroesophageal Varices Hemorrhage
Optimizing Endoscopic and Interventional Treatment for Portal Hypertensive Bleeding
This study aims to evaluate the impact of high-risk factors-such as elevated portal venous pressure, concurrent large extra-luminal vessels, portal vein thrombosis, and prominent portosystemic shunts-on the efficacy of endoscopic…
- Conditions
- Portal Hypertension, Gastroesophageal Varices Hemorrhage, Gastric Varices, Esophageal Varices
- Trial name
- NCT07502729
- Volunteers
- 1,066 people
- Sponsor
- Shanghai Zhongshan Hospital
Liver Cirrhosis, Gastroesophageal Varices Bleeding
Comparison of Underdilated Versus Standard TIPS in Preventing Variceal Rebleeding in Patients With Cirrhosis
Transjugular intrahepatic portosystemic shunt (TIPS) is a key therapeutic intervention for complications of portal hypertension.
- Trial name
- UVR-TIPS (NCT07253389)
- Testing
- Underdilated TIPS, Standard TIPS
- Where
- China
- Volunteers
- 648 people
- Sponsor
- Air Force Military Medical University, China
Portal Hypertension, Gastric Varices Bleeding
Preemptive TIPS for Gastric Variceal Bleeding in Patients With Cirrhosis
The prevalence of gastric varices is approximately 20%. It is important to note that gastric varices tend to bleed more severely, have a higher morbidity and mortality rate, and have a 35% to 90% risk of rebleeding after the…
- Conditions
- Portal Hypertension, Gastric Varices Bleeding, Portosystemic Shunt
- Trial name
- NCT06122792
- Testing
- preemptive TIPS, standard second prophylaxis
- Volunteers
- 144 people
- Sponsor
- West China Hospital
Hepatocellular Carcinoma (HCC), Esophageal Varices
Endoscopic Variceal Ligation vs Carvedilol for the Prevention of First Esophageal Variceal Bleeding in Patients With HCC
The goal of this clinical trial is to evaluate whether endoscopic variceal ligation (EVL) or carvedilol is more effective at preventing the first esophageal variceal bleeding (EVB) in patients with hepatocellular carcinoma (HCC).
- Trial name
- P-HCC-CVL (NCT06594744)
- Testing
- Endoscopic variceal ligation, Carvedilol
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Arteriovenous Malformation, Gastrointestinal Bleed
Case-Specific Health Care Professional Clinical Survey for Concerto Versa™ Detachable Coils
The purpose of the Case-Specific Health Care Professional (HCP) Clinical Survey for Concerto Versa™ Detachable Coils, also known as the Concerto Versa HCP Clinical Assessment, is to collect early clinical data from HCPs to assess…
- Conditions
- Arteriovenous Malformation, Gastrointestinal Bleed, Gastric Varices, Hemorrhoid
- Trial name
- NCT07639853
- Testing
- Concerto Versa™ Detachable Coils
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Medtronic Endovascular
TIPS, Portal Hypertension
TIPS for Complicated Portal Hypertension Related to Porto-Sinusoidal Vascular Disease
Porto-sinusoidal Vascular Disease (PSVD) is characterized by a portal hypertension (PH) without cirrhosis. This can induce PH complications, like digestive hemorrhage from esophageal or gastric varices, ascites, or even portal…
- Conditions
- TIPS, Portal Hypertension, Porto-Sinusoidal Vascular Disease, Refractory Ascite
- Trial name
- TIPS-PSVD (NCT07163689)
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Gastric Varix, Sepsis
Antibiotic Prophylaxis in Patients Undergoing GVO
We design a randomized trial to clarify the necessity of antibiotic prophylaxis for the patients chronic liver disease with gastric varices treated by elective GVO.
- Conditions
- Gastric Varix, Sepsis, Liver Cirrhoses, Fever
- Trial name
- ABX-GV (NCT04140578)
- Testing
- Ertapenem
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Esophageal Varices, Portal Hypertension
Improve the Strategies of Endoscopic and Interventional Treatment of Gastroesophageal Hemorrhage in Portal Hypertension
Endoscopic esophageal variceal ligation combined with gastric variceal embolization using tissue glue is currently the first-choice method for preventing rebleeding in patients with cirrhosis and portal hypertension.
- Trial name
- NCT06970509
- Where
- 10 sites in China
- Volunteers
- 1,450 people
- Sponsor
- Shanghai Zhongshan Hospital
Gastric Varices Bleeding
Efficacy and Safety of Contrast EUS-Guided Tissue Glue/Coil Devascularization vs. BRTO for Preventing Recurrent Gastric Variceal Bleeding
The goal of this clinical trial is to compare the effectiveness of EUS-guided tissue glue/coil injection and BRTO in preventing rebleeding of gastric varices (GVs) in patients with portal hypertension and GVs (including those…
- Trial name
- NCT07049146
- Testing
- EUS-guided tissue glue/coil injection, BRTO
- Where
- China
- Volunteers
- 242 people
- Sponsor
- West China Hospital
Occlusive Portal Vein Thrombosis (OPVT), Cavernous Transformation of Portal Vein
Mesenteric Vein Access for OPVT-Related Recurrent Variceal Bleeding: An Ambispective Cohort
Occlusive portal vein thrombosis (OPVT) is defined as complete thrombosis of the main portal vein trunk, resulting in total interruption of portal venous inflow and representing the most severe form of portal vein thrombosis.
- Conditions
- Occlusive Portal Vein Thrombosis (OPVT), Cavernous Transformation of Portal Vein, Gastroesophageal Varices Bleeding
- Trial name
- NCT07666256
- Testing
- Percutaneous mesenteric vein-assisted interventional treatment
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Air Force Military Medical University, China
Gastric Varices Bleeding, Gastric Varices
Cyanoacrylate Glue Versus Absorbable Gelatin Sponge for Gastric Varices
This study compares two endoscopic ultrasound-guided treatments for gastric varices, which are enlarged veins in the stomach that can bleed. Both treatments use small coils placed into the varix.
- Conditions
- Gastric Varices Bleeding, Gastric Varices, Portal Hypertension
- Trial name
- CoAGS-GV (NCT07699354)
- Testing
- EUS-Guided Coil Embolization With Cyanoacrylate Glue and Lipiodol, EUS-Guided Coil Embolization With Absorbable Gelatin Sponge
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Unity Health Toronto
Liver Cirrhosis, Portal Hypertension
Underdilated VCX-TIPS Versus EVL Plus NSBB for Secondary Prophylaxis of Variceal Bleeding in Cirrhosis
Variceal bleeding is a major complication of portal hypertension in patients with cirrhosis and is associated with substantial risks of rebleeding and death.
- Conditions
- Liver Cirrhosis, Portal Hypertension, Gastroesophageal Varices Bleeding, Esophageal Varices
- Trial name
- U-TIPS (NCT07587671)
- Testing
- Underdilated VCX-TIPS, Endoscopic Variceal Ligation, Nonselective Beta-Blockers
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- West China Hospital
Cavernous Transformation of Portal Vein, Gastroesophageal Varices Bleeding
Efficacy and Safety of Variceal Embolization Combined With Partial Splenic Artery Embolization for Variceal Bleeding in Cavernous Transformation of Portal Vein.
The management of variceal bleeding in patients with cavernous transformation of portal vein (CTPV) generally adheres to the principles applied to cirrhotic portal hypertension, including pharmacological therapy, endoscopic…
- Trial name
- NCT07310316
- Testing
- Variceal Embolization Combined With Partial Splenic Artery Embolization
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Air Force Military Medical University, China
Variceal Bleeding, Ultrasonography
Ultrasound Prediction of Esophageal Variceal Bleeding Risk
This prospective observational study aims to evaluate the accuracy of using routine abdominal ultrasound to predict the risk of esophageal variceal bleeding in adult patients with liver cirrhosis.
- Conditions
- Variceal Bleeding, Ultrasonography, Esophageal Bleeding, Esophageal Varices
- Trial name
- NCT07571876
- Volunteers
- 165 people
- Sponsor
- Assiut University
Gastric Varices Bleeding, Cirrhosis
EUS-Guided Coil and Glue vs Glue Injection for Bleeding Gastric Varices in Cirrhosis
Gastric variceal bleeding is a life-threatening complication of portal hypertension in patients with cirrhosis and is associated with significant morbidity and mortality.
- Trial name
- NCT07855913
- Testing
- EUS-guided Coil and Cyanoacrylate Glue Injection, Endoscopic Cyanoacrylate Glue Injection
- Where
- 2 sites in United States, India
- Volunteers
- 110 people
- Sponsor
- Medanta, The Medicity, India
Hepatocellular Carcinoma, Esophageal Varix
Prophylactic Endoscopic Variceal Ligation in Patients With High-risk Esophageal Varices Receiving Atezo/Bev for HCC
The goal of this study is to evaluate whether prophylactic endoscopic variceal ligation (EVL) can prevent esophageal variceal bleeding in patients with hepatocellular carcinoma (HCC) receiving atezolizumab and bevacizumab…
- Conditions
- Hepatocellular Carcinoma, Esophageal Varix, Bleeding Esophageal Varices
- Trial name
- ESCOAT (NCT06819566)
- Testing
- Endoscopic variceal ligation (EVL)
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Asan Medical Center
Gastric Varices
Pre-emptive RTO for An Early Detected Gastric Varices in CT/MR Angiogram Trial
A number of treatment modalities are currently in use for gastric variceal bleeding (GVB). Balloon-occluded, plug-assisted, and coil-assisted retrograde transvenous obliteration (RTO) procedures are described in the literature as…
- Trial name
- PRADA (NCT07168395)
- Testing
- Non-selective beta blockers, Retrograde transvenous obliteration
- Volunteers
- 68 people
- Sponsor
- University of California, Los Angeles
Cirrhosis, Esophageal Varices
Carvedilol Plus EVL or Not for the Primary Prevention of Esophageal Variceal Bleeding in Carvedilol Non-responders
The goal of this clinical trial is to evaluate whether carvedilol plus endoscopic variceal ligation (EVL) is more effective for the primary prevention of esophageal variceal bleeding than carvedilol alone in carvedilol…
- Trial name
- CVL-NR (NCT06594783)
- Testing
- Carvedilol plus endoscopic variceal ligation, Carvedilol alone
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cirrhosis, Esophageal and Gastric Varices
Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis
The APIXABAN-PK trial is a prospective, randomized, single-blind, placebo-controlled study designed to evaluate the efficacy and safety of apixaban in combination with carvedilol versus placebo with carvedilol in preventing…
- Conditions
- Cirrhosis, Esophageal and Gastric Varices, Ascites, Hepatic Encephalopathy
- Trial name
- APIXABAN-PK (NCT07521332)
- Testing
- Apixaban, Carvedilol
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- Asian Institute Of Medical Sciences
Esophageal Varices
Carvedilol Versus Endoscopic Band Ligation for Primary Prophylaxis of Oesophageal Variceal Bleeding
Carvedilol versus endoscopic band ligation for primary prophylaxis of oesophageal variceal bleeding in cirrhotic patients with arterial hypertension
- Trial name
- NCT04499898
- Testing
- Carvedilol, Endoscopic band ligation
- Where
- Egypt
- Volunteers
- 306 people
- Sponsor
- Sherief Abd-Elsalam