Clinical trials: Bleeding Hemorrhage
Hemorrhage
Retention of Tourniquet Application Skills Following Participation in a Bleeding Control Course
Prospective, observational study of students 6 months after completing a Stop the Bleed course to determine overall ability to effectively use a tourniquet to stop external extremity hemorrhage.
- Trial name
- NCT03762863
- Testing
- Tourniquet application skill retention
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Somerville Office of Emergency Management
Wound; Rupture, Surgery, Cesarean Section, Postpartum Hemorrhage
HEMOLEVEN® Expanded Access Program Prevention of Surgical/Postpartum Hemorrhage Severe Inherited Factor XI Deficiency
The objective of the Expanded Access Program is to provide HEMOLEVEN, a replacement coagulation factor XI, to patients with severe inherited factor XI deficiency where, in the opinion of the treating physician, the benefits of…
- Conditions
- Wound; Rupture, Surgery, Cesarean Section, Postpartum Hemorrhage, Surgery
- Trial name
- EAP (NCT01701947)
- Testing
- Hemoleven
- Where
- United States
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Grade II Internal Hemorrhoids With Bleeding
A Phase III Clinical Trial Evaluating the Efficacy and Safety of TriThien Duoc Capsules in Grade II Internal Haemorrhoids Patients With Bleeding Compared to Diosmin.
A Phase III, randomized, double-blind, placebo-controlled clinical trial has been conducted to evaluate the efficacy and safety of Trĩ Thiên Dược capsules in people with grade II internal hemorrhoids with bleeding.
- Trial name
- NCT07369635
- Testing
- Intervention Group: Tri Thien Duoc Capsules, Control group (diosmin)
- Where
- Vietnam
- Volunteers
- 172 people
- Sponsor
- Hanoi Medical University
Portal Hypertension, Bleeding Gastric Varices
TIPS in Fundal Variceal Bleeding (the TFB Study)
In the last years, important advances have been done in the treatment and prevention of fundal variceal bleeding in patients with cirrhosis.
- Trial name
- TFB (NCT02364297)
- Testing
- Early TIPS
- Where
- 5 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Institut d'Investigacions Biomèdiques August Pi i Sunyer
Contraception, Bleeding
Intervention to End Recurrent Unscheduled Bleeding Trial
The subdermal etonogestrel (ENG) implant, a long-acting reversible contraceptive (LARC) method, is among the most effective forms of reversible contraception and thus, an important tool in the quest to reduce unintended…
- Trial name
- INTERRUPT (NCT03118297)
- Testing
- Ulipristal Acetate
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Washington University School of Medicine
Occult Bleeding, Hemorrhage
A 48 Subject Study Using Non-invasive Multi-Technology Measurements for Early Detection of Ongoing Hemorrhage
Early detection of ongoing hemorrhage (OH) before onset of hemorrhagic shock is a universally acknowledged great unmet need, and particularly important after traumatic injury.
- Conditions
- Occult Bleeding, Hemorrhage, Hemorrhagic Shock
- Trial name
- NCT04814810
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Hemorrhage, Hemodynamic Instability
Consortium for Optimized Integration of Bio-Artificial Blood Components for Adaptive Resuscitation Therapy
There is need for a whole blood analog for use when banked blood is unavailable or undesirable. In civilian trauma, hemorrhage accounts for ~ 35% of pre-hospital deaths; moreover, ~ 20% of military casualties are in hemorrhagic…
- Trial name
- CONCERT (NCT05756426)
- Testing
- Prospective
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Systemic Lupus Erythematosus, Inflammatory Myopathy
BCMA-CD19 CAR-T Therapy for Refractory Autoimmune Diseases
The objective of this study is to evaluate the efficacy and safety of BCMA/CD19 chimeric antigen receptor (CAR)-modified T cells in the treatment of autoimmune diseases.
- Conditions
- Systemic Lupus Erythematosus, Inflammatory Myopathy, Systemic Sclerosis (SSc), ANCA-associated Vasculitis
- Trial name
- NCT06794008
- Testing
- BCMA-CD19 CAR-T therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital
Bleeding
TXA in the EMS on the Helicopter and the Ambulance
Coagulopathy in trauma increases mortality and morbidity. Early administration of tranexamic acid (TXA) seems to improve survival and outcome.
- Trial name
- TXASRZREGA (NCT02354885)
- Testing
- Tranexamic Acid
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Bleeding Esophageal Varices, Hepatocellular Carcinoma
Primary Prevention of Patients With Hepatocellular Carcinoma and Concomitant Esophageal Varices
Randomized comparison within the endoscopic esophageal varices ligation versus non-selective beta-blocker in the primary prevention of esophageal variceal bleeding in patients with HCC.
- Trial name
- P-HCC (NCT01970748)
- Testing
- Propranolol, Esophageal variceal ligation
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Surgery, Cardiac, Tranxemic Acid
The Effect of ACT and Tranexamic Acid on Bleeding in Cardiac Surgery
The goal of this clinical trial is to the dose effect of tranexamic acid and the level of ACT on bleeding in adult cardiac surgery. The main questions it aims to answer are: 1.
- Conditions
- Surgery, Cardiac, Tranxemic Acid, Activated Clotting Time, Heparin
- Trial name
- NCT06109155
- Testing
- Tranexamic acid
- Where
- 2 sites in Taiwan
- Volunteers
- 150 people
- Sponsor
- Taichung Veterans General Hospital
Aortic Dissection, Aortic Diseases
Antibiotic Prophylaxis for TEVAR
The infection rate of thoracic endovascular aortic repair (TEVAR) is unknown due to a lack of epidemiological data. The rate currently available comes from researches conducted decades ago, when open surgery was the standard of…
- Conditions
- Aortic Dissection, Aortic Diseases, Aortic Aneurysm, Thoracic, Coarctation of Aorta
- Trial name
- NCT05405790
- Testing
- thoracic endovascular aortic repair
- Where
- China
- Volunteers
- 457 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Bleeding Gastric Varices, Cirrhosis
"Early TIPS" Versus Glue Obliteration to Prevent Rebleeding From Gastric Varices
The primary objective of the study is to demonstrate the superiority of an "early tips" strategy over standard treatment by glue obliteration (G0) in preventing bleeding recurrence or death at one year after a non GOV1 gastric…
- Trial name
- GAVAPROSEC (NCT03705078)
- Testing
- Transjugular Portosytemic Shunt (TIPS), glue obliteration
- Where
- 20 sites in France
- Volunteers
- 104 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Congenital Fibrinogen Deficiency
An Observational Cohort Study of the Safety and Efficacy of Fibrinogen Concentrate, Human (FCH) in Subjects With Congenital Fibrinogen Deficiency
This is a multicenter, non interventional, retrospective cohort study with a prospective, observational follow-up component to investigate the safety and efficacy of FCH use in subjects with congenital fibrinogen deficiency.
- Trial name
- NCT02427217
- Testing
- FCH
- Where
- 11 sites in United States, Canada
- Volunteers
- 22 people
- Sponsor
- CSL Behring
Thrombotic and Bleeding Events
On-X Aortic Prosthetic Heart Valve Low Dose Warfarin Post Approval Clinical Registry Study
The purpose of the proposed study is to assess the occurrence of bleeding, valve-related thromboembolism and valve thrombosis with the On-X Aortic Prosthetic Heart Valve when targeted at an International Normalized Ratio (INR)…
- Trial name
- NCT02677974
- Testing
- On-X Aortic Heart Valve replacement
- Where
- 23 sites in United States, Canada and 1 more
- Volunteers
- 510 people
- Sponsor
- On-X Life Technologies, Inc.
Immune Thrombocytopenia Purpura
Immune Thrombocytopenia Management in Adults
Immune thrombocytopenia treatment has evolved recently. However, none of treatments have only benefits without drawbacks. This study compares the clinical outcomes and adverse drug patterns of different treatment options.
- Trial name
- NCT05861297
- Testing
- Dexamethasone, Prednisolone and Azathioprine, Rituximab
- Where
- Egypt
- Volunteers
- 467 people
- Sponsor
- Nahda University
Bone Loss
Maxillary Vascular Canal Thickness and Sinus Augmentation Bleeding
This study aims to evaluate the relationship between the maxillary intra-osseous vascular canal thickness as measured by volumetric tomography and the amount of intra-operative bleeding during open sinus floor augmentation.
- Trial name
- NCT05710497
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Marmara University
Gastrointestinal Hemorrhage, Vascular Malformation
Efficacy Study of Thalidomide in Gastrointestinal Vascular Malformation Related Bleeding
Background: Repeated bleeding from gastrointestinal vascular malformations remains to be a major therapeutic challenge. Methods: The investigators performed a randomised, double-blind, placebo-controlled, single centre study to…
- Trial name
- NCT02754960
- Testing
- Thalidomide
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Hematuria, Urothelial Carcinoma
Urine DNA Methylation Detection for Hematuria Evaluation
Background: Hematuria, a common symptom of urinary system diseases, can result from various causes including infection, stones, trauma, and tumors.
- Conditions
- Hematuria, Urothelial Carcinoma, Bladder Cancer, Ureter Cancer
- Trial name
- NCT06427993
- Where
- China
- Volunteers
- 71 people
- Sponsor
- Changhai Hospital
Post Vitrectomy State, Recurrent Diabetic Vitreous Hemorrhage
Efficacy and Safety of Intravitreal Triamcinolone Acetonide in Eyes With Post Vitrectomy Diabetic Vitreous Hemorrhage
The Purpose of this study is compare the efficacy of intravitreal triamcinolone in clearing recurrent post-vitrectomy diabetic hemorrhage with conventional treatment, air-fluid exchange.
- Trial name
- NCT00300014
- Testing
- Intravitreal triamcinolone injection, Air-fluid exchange
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Asan Medical Center