Clinical trials: Bleeding Nose, active
Postoperative Bleeding, Skin Cancer Face
Tranexamic Acid in Nasal Mohs Reconstruction
This study will be a prospective randomized control trial to evaluate the effects of subcutaneously administered TXA among patients undergoing nasal Mohs reconstruction with local flaps at VUMC.
- Trial name
- NCT06057675
- Testing
- Treatment (tranexamic acid and 1% lidocaine with 1:100,000 epinephrine), Control (1% lidocaine with 1:100,000 epinephrine)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Epistaxis Nosebleed, Greater Palatine Foramen
Management of Epistaxis Comparing Nasal Packing Versus Greater Palatine Foramen Block
The goal of this pilot randomized controlled trial is to compare pain relief efficacy while using nasal packing versus greater palatine foramen block (GPFB) in the management of acute episodes of epistaxis.
- Trial name
- ANPvsGPF block (NCT07421622)
- Testing
- Greater Palatine Foramen Block with 2% xylocaine with adrenaline, Anterior Nasal Packing
- Volunteers
- 40 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Hereditary Hemorrhagic Telangiectasia, Rendu Osler Disease
Prospective Study of Antiplatelet and Anticoagulation Therapy in Hereditary Haemorrhagic Telangiectasia
The goal of this clinical trial is to evaluate in real life, in patients with Hereditary Hemorrhagic Telangiectasia (HHT), the tolerance of the strategy of use of anticoagulant and/or antiplatelet, by comparing a new exposure…
- Trial name
- PROPLACO-Tel (NCT05641142)
- Testing
- monitoring the use of anticoagulant and/or antiplatelet therapy in patients with osler rendering disease
- Where
- 18 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Epistaxis Nosebleed
Treatment of Nosebleeds in the Emergency Department With Powder Tranexamic Acid
Nosebleeds are very common, occurring in 60% of the population; in some patients, nosebleeds are a life-threatening emergency. To stop a nosebleed in the emergency department, doctors usually have to burn the nose (called…
- Trial name
- Bloody SIMPLE (NCT06997796)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Dr. Anne Conlin
Nasal Bleeding, Nasotracheal Intubation
Adrenaline Nasal Pack vs Xylometazoline Nasal Drops During Nasotracheal Intubation
The goal of this trial is to compare efficacy of xylometazoline nasal drops and adrenaline nasal pack in participants undergoing elective oromaxillofacial surgeries.
- Trial name
- NCT06801522
- Testing
- 0.1% xylometazoline nasal drops, Adrenaline nasal pack
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Shaheed Mohtarma Benazir Bhutto Institue of Trauma
Epistaxis
The Efficacy of Local Application of B-sitosterol Versus Vasline in Cases of Idiopathic Epistaxis
Epistaxis, commonly known as nosebleed, is a frequent otorhinolaryngological complaint, affecting a large proportion of the population.
- Trial name
- NCT07511192
- Testing
- vasline, B-sitosterol
- Volunteers
- 162 people
- Sponsor
- Assiut University
Von Willebrand Disease (VWD), Inherited Bleeding Disorders in Children
Clinical Spectrum and Management of Von Willebrand Disease Among Children in Assiut Governorate
Von Willebrand disease (VWD) is the most common inherited bleeding disorder in children. It occurs due to a deficiency or dysfunction of von Willebrand factor, a protein that plays an essential role in blood clotting.
- Conditions
- Von Willebrand Disease (VWD), Inherited Bleeding Disorders in Children, Pediatric Hemostatic Disorders
- Trial name
- VWD-ASSIUT (NCT07410130)
- Testing
- Tranexamic Acid, Von Willebrand Factor-Containing Concentrates
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Assiut University
Hereditary Hemorrhagic Telangiectasia (HHT), Epistaxis
Topical TOR-582 Treatment of Epistaxis in HHT
People with hereditary hemorrhagic telangiectasia (HHT) often experience frequent and severe nosebleeds that can disrupt daily life and lead to anemia, medical procedures, and reduced quality of life.
- Trial name
- NCT07667413
- Testing
- Topical sirolimus ointment
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Columbia University
Chronic Rhinosinusitis, Intraoperative Bleeding
Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing Sinusoscopy
Functional endoscopic sinus surgery (FESS), or sinusoscopy, is a standard surgical procedure used to treat chronic rhinosinusitis and other conditions of the nasal sinuses.
- Conditions
- Chronic Rhinosinusitis, Intraoperative Bleeding, Blood Loss, Surgical
- Trial name
- NCT07866274
- Testing
- Ascorbic acid
- Volunteers
- 78 people
- Sponsor
- Assiut University
Epistaxis Nosebleed
Coblation Versus Bipolar Diathermy in Management of Refractory Idiopathic Recurrent Anterior Epistaxis in Children.
The aim of this study is to compare the outcomes of coblation technique versus bipolar technique in management of RAE in children regarding the following: 1. Efficacy of each method to stop bleeding. 2. Technical feasibility. 3.
- Trial name
- NCT06651840
- Testing
- bipolar diathermy "Standard technique"., coblation technique.
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hereditary Hemorrhagic Telangiectasia
A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT)
The purpose of this study is to: evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single ascending doses of ALN-6400 in healthy volunteers evaluate the efficacy, safety, tolerability and PD of…
- Trial name
- InsigHHT (NCT06659640)
- Testing
- ALN-6400
- Where
- 16 sites in United States, Australia and 4 more
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Alnylam Pharmaceuticals
Epistaxis
Outcome of Hyaluronic Acid Gel Versus Petroleum Jelly in Treatment of Epistaxis
The aim of this study is to compare the efficacy of Hyaluronic Acid Gel with Petroleum Jelly in treatment of epistaxis.
- Trial name
- NCT07531472
- Testing
- Hyaluronic Acid Gel, Petroleum jelly
- Volunteers
- 50 people
- Sponsor
- Assiut University
Epistaxis
Usage of Orange Peel Extract in Management of Epistaxis
Efficacy of orange peel extract in treatment of epistaxis in children
- Trial name
- NCT06836102
- Testing
- Orange
- Volunteers
- 60 people
- Sponsor
- Minia University
Postoperative Pain
RADA16 for Adult Tonsillectomy
The purpose of the research is to determine if RADA16 (also known as PuraStat®, PuraGel®, or PuraSinus®) improves patient outcomes following tonsillectomy procedures.
- Trial name
- NCT07060495
- Testing
- RADA16 hydrogel
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- Rutgers, The State University of New Jersey
Epistaxis
Medico-economic Evaluation of Management Strategies for Severe Epistaxis
Current recommendations consider surgical ligation and supra-selective embolization as equivalent in terms of efficacy and there is no clear consensus to choose between one and the other technique.
- Trial name
- EPICOST (NCT05281952)
- Testing
- endoscopic ligation, Supra-selective embolization
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Toulouse
Nasal Surgery, Anesthesia
Remifentanil vs. Nicardipine for Controlled Hypotension in Elective Nasal Surgery
This study compares remifentanil infusion versus nicardipine infusion for controlled hypotension during elective nasal surgery. Both agents are standard clinical methods.
- Conditions
- Nasal Surgery, Anesthesia, Controlled Hypotension for Nasal Surgeries
- Trial name
- NCT07660562
- Testing
- Nicardipine, Remifentanil
- Volunteers
- 44 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Nasotracheal Intubation
Nostril Side on Epistaxis
The purpose of the study is to investigate the effect of the nostril side on epistaxis during nasotracheal intubation.
- Trial name
- NCT06605989
- Testing
- Nasotracheal intubation
- Where
- 2 sites in South Korea
- Volunteers
- 208 people
- Sponsor
- Seoul National University Hospital
Telangiectasia, Hereditary Hemorrhagic
Efficacy of Nintedanib for Treatment of Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) Patients
Patients affected by hereditary hemorrhagic telangiectasia (HHT) very often suffer from recurrent nosebleeds called epistaxis. There is no treatment currently available to reduce the frequency or severity of epistaxis.
- Trial name
- EPISTOP (NCT04976036)
- Testing
- Nintedanib
- Where
- 3 sites in France, Switzerland
- Volunteers
- 48 people
- Sponsor
- Dr. Romain Lazor
Von Willebrand Disease (VWD)
Algorithm-based Management to Reduce the Recurrence of GI Bleeding and Severe Epistaxis in Von Willebrand Disease
WILL MANAGE is a prospective multicenter controlled open label randomized trial comparing an algorithm-based multidisciplinary management to a standard of care to reduce the incidence of bleeding (GI bleeding or severe epistaxis)…
- Trial name
- WILL MANAGE (NCT06651255)
- Testing
- Optimized management, Standard of care management
- Where
- 17 sites in France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Lille
Sinus Disease, Anesthesia
Bupivacaine and Epinephrine Injection Study
Endoscopic sinus surgery (ESS) is a common otolaryngologic procedure that aims to remove the partitions that separate the sinus cavities, remove inflamed tissue, and optimize the sinuses for topical medication use.
- Conditions
- Sinus Disease, Anesthesia, Bleeding
- Trial name
- NCT06456255
- Testing
- Sensorcaine with Epinephrine
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Amin Javer