Clinical trials: Blepharitis
Meibomian Gland Dysfunction, Blepharitis
Pilot Study Comparing the Safety and Efficacy of Two Dosing Regimens of TP-03 for the Treatment of MGD
The purpose of this study is to compare the safety and efficacy of TP-03, 0.25%, an eyedrop, BID vs TID dosing regimens for the treatment of meibomian gland dysfunction in patients with Demodex lid infestation.
- Conditions
- Meibomian Gland Dysfunction, Blepharitis, Demodex Infestation
- Trial name
- Ersa (NCT05454956)
- Testing
- TP-03, TP-03 Vehicle
- Where
- 5 sites in United States
- Volunteers
- 39 people
- Sponsor
- Tarsus Pharmaceuticals, Inc.
Blepharitis
Safety and Efficacy of TP-03 for the Treatment of Demodex Blepharitis
The purpose of this study is to compare the safety and efficacy of TP-03, 0.25%, an eyedrop, to its vehicle control for the treatment of blepharitis due to Demodex, a microscopic mite frequently found in human hair follicles.
- Trial name
- Saturn-1 (NCT04475432)
- Testing
- TP-03, 0.25%, TP-03 Vehicle
- Where
- 15 sites in United States
- Volunteers
- 421 people
- Sponsor
- Tarsus Pharmaceuticals, Inc.
Blepharitis
Trial to Evaluate the Safety and Efficacy of TP-03 for the Treatment of Demodex Blepharitis
The purpose of this study is to compare the safety and efficacy of TP-03, an eyedrop, to its vehicle control for the treatment of blepharitis due to Demodex, a microscopic mite frequently found in human hair follicles.
- Trial name
- Saturn-2 (NCT04784091)
- Testing
- TP-03, TP-03 Vehicle
- Where
- 21 sites in United States
- Volunteers
- 412 people
- Sponsor
- Tarsus Pharmaceuticals, Inc.
Posterior Blepharitis, Meibomian Gland Dysfunction
Evaluation of AXR-270 for the Treatment of Posterior Blepharitis Associated With Meibomian Gland Dysfunction
This study will evaluate the safety, tolerability and efficacy of AXR-270 Cream in treating posterior blepharitis associated with Meibomian Gland Disease (MGD)
- Trial name
- NCT04469998
- Testing
- AXR-270 Low Dose, AXR-270 High Dose, AXR-270 Vehicle
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- AxeroVision, Inc.
Blepharitis
Study Evaluating the Safety and Tolerability of NCX 4251 for the Treatment of Acute Exacerbations of Blepharitis
This is a multi-center, randomized, double-masked, placebo-controlled, Phase 2 study evaluating the safety and tolerability of NCX 4251 (fluticasone propionate nanocrystal) Ophthalmic Suspension 0.1% QD and BID for the treatment…
- Trial name
- NCT03926026
- Testing
- Fluticasone Propionate
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Nicox Ophthalmics, Inc.
Blepharitis
Study Evaluating the Safety and Efficacy of NCX 4251 Ophthalmic Suspension for the Treatment of Blepharitis
This is a multi-center, randomized, double-masked, placebo-controlled, Phase 2b trial evaluating the safety and efficacy of NCX 4251 (fluticasone propionate nanocrystal) Ophthalmic Suspension 0.1% QD for the treatment of acute…
- Trial name
- Mississippi (NCT04675242)
- Testing
- NCX 4251
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Nicox Ophthalmics, Inc.
Active, Symptomatic Blepharitis
Comparative Study to Evaluate ISV-305 Compared to Vehicle in Blepharitis Subjects
The purpose of this study is to evaluate the clinical efficacy and safety of ISV-305 (Dexamethasone in DuraSite® 2) compared to Vehicle in the treatment of subjects with active, symptomatic Blepharitis.
- Trial name
- ISV-305 (NCT01543490)
- Testing
- ISV-305, Vehicle
- Where
- United States
- Volunteers
- 558 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Blepharitis, Meibomianitis
Treatment of Patients With Blepharitis and Facial Rosacea
To determine the safety and efficacy of sub-antimicrobial dose COL-101 in the treatment of patients who have both blepharitis and facial rosacea
- Conditions
- Blepharitis, Meibomianitis, Dry Eye
- Trial name
- NCT00560703
- Testing
- COL-101 (doxycycline, USP) capsules
- Where
- 8 sites in United States
- Volunteers
- 70 people
- Sponsor
- Galderma R&D
Blepharitis
Safety and Efficacy of KPI-121 in Subjects With Inflammatory Meibomian Gland Disease
The primary purpose of this study is to determine the efficacy and safety of KPI-121 ophthalmic suspension compared to vehicle (placebo) in subjects with signs and symptoms of inflammatory meibomian gland disease.
- Trial name
- Maui (NCT02218489)
- Testing
- KPI-121, Vehicle
- Where
- 8 sites in United States
- Volunteers
- 206 people
- Sponsor
- Kala Pharmaceuticals, Inc.
Bilateral Blepharitis (Disorder)
To Compare Blephapad Combo vs Standard Treatment for Eyelid Cleansing in Bilateral Posterior Blepharitis
The purpose of this study is to evaluate the efficacy of, and patient satisfaction with Blephapad Combo in the treatment of posterior blepharitis.
- Trial name
- NCT03301844
- Testing
- Blephapad Combo, Standard treatment
- Where
- Italy
- Volunteers
- 19 people
- Sponsor
- NTC srl
Blepharitis, Dry Eye Syndrome
Treatment of Meibomian Gland Dysfunction Prior to Cataract Surgery
The purpose of this pilot feasibility study is to assess whether treating meibomian gland dysfunction (MGD) prior to cataract surgery helps promote meibomian gland function, visual quality and ocular comfort after cataract…
- Trial name
- NCT01808560
- Testing
- LipiFlow Pre-Treatment, LipiFlow Post-treatment
- Where
- 7 sites in United States
- Volunteers
- 34 people
- Sponsor
- TearScience, Inc.
Chronic Blepharitis
Demodex Blepharitis Treatment Study
This is a randomized clinical trial to determine the safety and efficacy of terpinen-4-ol (T4O), the most active ingredient of tea tree oil (TTO), in eradicating ocular demodicosis (reducing ocular demodex counts and achieving…
- Trial name
- DBTS (NCT01647217)
- Testing
- Terpinen-4-ol
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- BioTissue Holdings, Inc
Blepharitis
Efficacy and Safety Assessment of Azyter® Eye Drops (T1225) in Patients With Blepharitis
The primary objective of this study is to demonstrate the efficacy of T1225 eye drops versus placebo eye drops on the global ocular discomfort (VAS).
- Trial name
- NCT01089608
- Testing
- Azithromycin, Povidone
- Where
- France
- Volunteers
- 93 people
- Sponsor
- Laboratoires Thea
Blepharitis
Comparative Study in the Efficacy of Topical Besifloxocin With Erythromycin for the Management of Acute Blepharitis
This study looks at the improvements in signs and symptoms in patients with inflammation of the lids, blepharitis, using two different FDA approved topical antibiotic agents, Besifloxocin and Erythromycin.
- Trial name
- NCT01478256
- Testing
- Erythromycin, Besifloxocin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- John, George, M.D.
Conjunctivitis, Keratitis
Loteprednol and Tobramycin Versus Tobramycin and Dexamethasone, in the Treatment of Blepharokeratoconjunctivitis
This study is to evaluate the safety and efficacy of loteprednol etabonate [LE] and tobramycin ophthalmic suspension versus tobramycin and dexamethasone ophthalmic suspension in the treatment of ocular inflammation associated…
- Conditions
- Conjunctivitis, Keratitis, Blepharitis
- Trial name
- NCT01028027
- Testing
- Loteprednol and tobramycin, Tobramycin and dexamethasone
- Where
- Singapore
- Volunteers
- 357 people
- Sponsor
- Bausch & Lomb Incorporated