Clinical trials: Bloating
Microbiota
Effects of Resistant Potato Starch on the Gut Microbiota
This was a randomized, double-blind, three-arm, parallel group clinical trial, which assessed the shifts that occur in microbial populations after four weeks of supplementation with resistant potato starch (SolnulTM) at two…
- Trial name
- NCT05242913
- Testing
- Resistant Potato Starch
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- MSP Starch Products Inc.
Irritable Bowel Syndrome, Irritable Bowel Syndrome With Diarrhea
Probiotics as Adjuvant Therapy in the Management of Irritable Bowel Syndrome
Studying the effects of adding probiotics to the drug regimen of patients with diarrhea predominant IBS
- Trial name
- NCT05523427
- Testing
- Two probiotic strains (L. plantarum and L. acidophilus)
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- University of Mosul
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD)
Indiana University Gastrointestinal Motility Diagnosis Registry
Develop a registry (list of patients) with accurate clinical motility diagnosis. This registry will help the doctors to identify the patients with specific disease conditions.
- Conditions
- Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD), Gastroparesis, Functional Vomiting
- Trial name
- NCT04506593
- Testing
- no intervention
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Indiana University
Chronic Constipation, Constipation
Safety and Efficacy of Linaclotide in Patients With Chronic Constipation and Prominent Abdominal Bloating
The purpose of this study is to evaluate the efficacy and safety of linaclotide compared with placebo in patients with chronic constipation (CC) and prominent abdominal bloating.
- Trial name
- NCT01642914
- Testing
- Linaclotide 290 micrograms, Linaclotide 145 micrograms
- Where
- 151 sites in United States, Canada
- Volunteers
- 487 people, healthy volunteers welcome
- Sponsor
- Forest Laboratories
Irritable Bowel Syndrome, Abdominal Bloating
Galactol® Enzyme Supplement for Post-Prandial Abdominal Bloating in Irritable Bowel Syndrome
This multicenter, randomized, controlled clinical trial aims to evaluate the efficacy and safety of a dietary supplement containing a combination of digestive enzymes (alpha-galactosidase, beta-galactosidase, and…
- Trial name
- NCT07465562
- Testing
- Galactol®, High-FODMAP Exclusion Diet
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Bloating
A Study to Evaluate OPTI-BIOME™ Bacillus Subtilis MB40 on Abdominal Discomfort, Gas and Bloating in a Healthy Population
The purpose of this study is to investigate the effects of OPTI-BIOME™ (Bacillus subtilis MB40), a probiotic supplement, on bloating, gas and abdominal discomfort symptoms in otherwise healthy adults.
- Trial name
- NCT02950012
- Testing
- OPTI-BIOME™ Bacillus subtilis MB40
- Where
- 3 sites in United States, Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- BIO-CAT Microbials, LLC
Cystic Fibrosis, Gastrointestinal Dysfunction
Understanding Gut Symptoms in People With Cystic Fibrosis
Although chest infections affect wellbeing and survival in cystic fibrosis (CF), most people with CF also have difficulty digesting food and must take medication for this.
- Trial name
- GRAMPUS-CF SRC (NCT05934656)
- Testing
- Latent class analysis
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Nottingham
Gastrointestinal Dysfunction
An Efficacy Trial in the Research Area of Gastrointestinal Health & Bloating
A randomized, double-blinded, placebo-controlled, parallel study, to evaluate the effect of 8-week supplementation of a traditionally fermented organic coconut milk kefir compared to placebo on gastrointestinal symptoms in…
- Trial name
- NCT05418127
- Testing
- Active
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Coconut Goodness Food Products Inc.
IBS - Irritable Bowel Syndrome
Study to Evaluate the Efficacy of Poppi Apple Cider Vinegar Prebiotic Soda to Improve Gut Health In Participants
This exploratory observational trial provides the opportunity to gather information on the effect of daily consumption of Poppi Apple Cider Vinegar Prebiotic Soda on gut health and digestion.
- Trial name
- NCT05418439
- Testing
- Drink Poppi Soda
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Drink Poppi
Gastrointestinal Discomfort, Bloating
Multi-strain Probiotic Supplement for Digestive Comfort and Well-being in Healthy Women
This study looks at whether a daily probiotic supplement can help improve mild-to-moderate stomach and digestive symptoms, such as gas and bloating, in women who also experience symptoms commonly associated with hormonal…
- Trial name
- NCT07831317
- Testing
- Active: Multi-strain probiotic dietary supplement
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Daily Nouri
Nutritional Insufficiency
Food Energy Density in Eating Disorders
Nutritional insufficiency is defined as an inadequate amount of nutrition due to decreased food/caloric intake, often due to an eating disorder, such as anorexia nervosa or bulimia.
- Trial name
- NCT01095107
- Testing
- Low fat intake, Increased fat intake
- Sponsor
- The Cleveland Clinic
Irritable Bowel Syndrome
Fecal Microbiota Transplantation in Irritable Bowel Syndrome With Bloating
Intestinal microbiota dysbiosis is thought to play an important role in the complex pathophysiology of irritable bowel syndrome (IBS), especially in diarrhoea-predominant IBS and possibly in IBS with severe bloating.
- Trial name
- NCT02299973
- Testing
- FMT with donor stool, FMT with own stool
- Where
- Belgium
- Volunteers
- 64 people
- Sponsor
- University Hospital, Ghent
Irritable Bowel Syndrome
A Four Arm Study to Evaluate the Safety and Efficacy of 3 Different Doses of RVX-100 Versus Placebo in Subjects With Irritable Bowel Syndrome Accompanied by Diarrhea (IBS-D)
The purpose of this study is to determine if RVX-100 is safe and effective in treating acute abdominal pain in patients with irritable bowel syndrome accompanied by diarrhea.
- Trial name
- NCT01076699
- Testing
- 0.075 mg RVX-100, 0.125 mg RVX-100, 0.250 mg RVX-100
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Revogenex, Inc.
Healthy
Effect of Abdominal Wall Activity on the Responses to Meal Ingestion
Meal ingestion induces sensations that are influenced by a series of conditioning factors. Aim: to determine the effect of abdominal wall activity on the responses to a standard probe meal.
- Trial name
- NCT04691882
- Testing
- Diaphragmatic contraction, Diaphagmatic relaxation
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Liver Health, Digestive Health
A Clinical Trial to Evaluate the Effects of a Supplement on Symptoms Associated With Liver and Digestive Health
This study will evaluate the effects of Edenboost Alpha Cleanse, a dietary supplement, on symptoms associated with liver and digestive health.
- Conditions
- Liver Health, Digestive Health, Fatigue, Abdominal Bloating
- Trial name
- NCT07738744
- Testing
- Edenboost Alpha Cleanse
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Edenboost
Heartburn
Esomeprazole And Symptomatic Response In Patients With Or Without An Elevated Risk For Non-Steroidal Anti-Inflammatory Drug (NSAID)-Associated GI Damage
The purpose of this study is to compare the treatment effect in patients with upper gastro-intestinal complaints with an elevated risk for NSAID-associated GI-damage to those without an elevated risk for NSAID-associated damage…
- Trial name
- Synchronise (NCT00524329)
- Volunteers
- 1,220 people
- Sponsor
- AstraZeneca
Irritable Bowel Syndrome
A Study of Chios Mastic Water in Irritable Bowel Syndrome
Chios mastic is a natural product with strong antimicrobial, anti-inflammatory and antioxidant properties, and well-established benefits for dyspeptic disorders.
- Trial name
- MASTIQUA (NCT04893499)
- Testing
- Chios mastic water, Chios mastic fruit juice
- Where
- Greece
- Volunteers
- 55 people
- Sponsor
- Rutgers, The State University of New Jersey
Premenstrual Dysphoric Disorder
Intranasal PH80 Spray for Acute Management of the Symptoms of Premenstrual Dysphoric Disorder
The objective of this study is to evaluate the effectiveness and safety in double-blind, randomized, placebo-controlled clinical trials of self administered PH80 intranasal spray for the acute management of cycle related symptoms…
- Trial name
- PH80-PMD (NCT01217775)
- Testing
- PH80
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- Pherin Pharmaceuticals, Inc.
Idiopathic Gastroparesis
A Study to Evaluate the Efficacy and Safety of CIN-102 (Deudomperidone) in Adult Subjects With Idiopathic Gastroparesis.
The goal of this clinical trial is to evaluate if the study drug CIN-102 (deudomperidone) can help to decrease nausea severity associated with idiopathic gastroparesis severity in adult subjects.
- Trial name
- NCT06899217
- Testing
- CIN-102 Dose 15mg, CIN-102 Dose 10mg
- Where
- 85 sites in United States
- Volunteers
- 416 people
- Sponsor
- CinDome Pharma, Inc.
Small Intestine Bacterial Overgrowth
Study of Clinical Features and Efficacy of Small Intestinal Bacterial Overgrowth in Patients With Abdominal Distension
Most studies of bloating have focused on functional factors, while data on organic abdominal distention are rare, and studies that combine small intestine bacterial overgrowth and/or oral cecum transit time abnormalities are more…
- Trial name
- NCT06518850
- Testing
- Rifaximin
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital