Clinical trials: Block
Postoperative Pain, Laparoscopic Hysterectomy
Impact of Preoperative Quadratus Lumborum Block on Postoperative Opioid Consumption After Laparoscopic Hysterectomy
The goal of this clinical trial is to learn if preoperative nerve block (quadratus lumborum [QL] block) works to improve pain control during and after laparoscopic hysterectomy.
- Conditions
- Postoperative Pain, Laparoscopic Hysterectomy, Nerve Block, Quadratus Lumborum Block
- Trial name
- NCT06709716
- Testing
- Quadratus Lumborum Block (QLB), Quadratus lumborum block, Local Anesthetic Solution
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Walter Reed National Military Medical Center
Thoracic Injuries, Rib Fractures
Serratus Plane Block With Parenteral Opioid Analgesia Versus Patient Controlled Analgesia in Rib Fractures
In this multicentre randomised controlled trial, adult patients with isolated chest trauma and two or more unilateral rib fractures will be randomised to either serratus plane block and patient controlled analgesia or patient…
- Conditions
- Thoracic Injuries, Rib Fractures, Anaesthesia, Local, Levobupivacaine
- Trial name
- COPE (NCT03919916)
- Testing
- Serratus plane block, Patient controlled analgesia
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Caesarian Section, Postoperative Pain
Ketamine Versus Neostigmine in Ultrasound-Guided Transversus Abdominis Plane Block in Caesarean Section
The current study investigates the efficacy and safety of ketamine and neostigmine as adjuvants in transversus abdominis plane blocks for Cesarean sections.
- Trial name
- NCT06871033
- Testing
- TAP block with neostigmine, TAP block with Ketamine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Tympanomastoid Surgery, Cochlear Implant
Great Auricular Nerve Block for Children Undergoing Tympanomastoid Surgery
The investigators goal is to determine the efficacy and duration of analgesia with the addition of Clonidine, an alpha-2 agonist, to local anesthetic blockade using bupivacaine, of the great auricular nerve in children undergoing…
- Conditions
- Tympanomastoid Surgery, Cochlear Implant, Mastoidectomy, Cholesteatoma
- Trial name
- NCT01638052
- Testing
- 0.25% Bupivacaine + Clonidine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Gastric Outlet Obstruction
Gastric Outlet Obstructions Tailored Covered Stents for GOO
gastric outlet obstruction tailored versus standard stents for malignant gastric outlet obstruction treatments
- Trial name
- NCT02299258
- Testing
- Standard stents MTN-CG-s-20/100, Tailored stents MTN-WE-20/100-A
- Where
- China
- Volunteers
- 63 people
- Sponsor
- The First People's Hospital of Yuhang District
Aortic Valve Stenosis
Transfemoral Implant of Inovare® Transcatheter Valve
Clinical trial to evaluate the early safety and efficacy of the transfemoral implant of Inovare® Transcatheter Valve for the treatment of patients with severe degenerative aortic stenosis and high surgical risk.
- Trial name
- NCT05531578
- Testing
- INOVARE® Transcatheter Valve, NexusCath Delivery System, Aureus Expandable Introducer, Balloon Catheter for Pre-Dilation and Compression Device (Crimper)
- Where
- 4 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- Braile Biomedica Ind. Com. e Repr. Ltda.
Chronic Total Occlusions
Collagenase Total Occlusion-1 Trial
A prospective, three-center, phase I safety and tolerability dose escalation study, evaluating 28 subjects in 4 discrete dose cohorts of acute intracoronary injected collagenase ranging from 300 - 1200 µg prior to routine…
- Trial name
- NCT01271335
- Testing
- collagenase
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Sunnybrook Health Sciences Centre
Bradycardia, Brady-tachy Syndrome
ALPs Single ChambEr New Device
Prospective, non-randomized, multi-center, international study designed to evaluate the initial safety and performance of the ALPS leadless pacemaker when used in patients with bradycardia.
- Conditions
- Bradycardia, Brady-tachy Syndrome, AV Block, Atrial Fibrillation (AF)
- Trial name
- ASCEND (NCT07461935)
- Testing
- Leadless ventricular pacemaker implantation
- Volunteers
- 10 people
- Sponsor
- Cairdac SA
Perioperative Inflammatory Response, Postoperative Pain
Suprazygomatic Maxillary Nerve Block Effect on Systemic Inflammatory Response in Cleft Palate Surgeries
the aim is to determine the value of adding bilateral supra zygomatic maxillary nerve block to general anesthesia in attenuating the systemic inflammatory response in paediatrics.
- Trial name
- NCT05495750
- Testing
- Bupivacaine 0.25% Injectable Solution
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Alaa Mohamed Abdel Salam Ibrahim Soliman
Occlusion of the Femoral-popliteal Segment, Femoral Access
Choosing an Access for Endovascular Treatment of Femoral-popliteal Segment Occlusions
The aim of this study is to compare the shoulder and femoral approaches used in the endovascular treatment of occlusive lesions of the femoral-popliteal segment of the lower extremity arteries in terms of the frequency of…
- Conditions
- Occlusion of the Femoral-popliteal Segment, Femoral Access, Brachial Access
- Trial name
- ATFA (NCT07694050)
- Testing
- Brachial artery catheterization, Femoral artery catheterization
- Where
- Russia
- Volunteers
- 304 people
- Sponsor
- Pirogov Russian National Research Medical University
Thoracoscopic Lobectomy
Phase Ⅱ Study of Intercostal Nerve Block With HR18034 for Postsurgical Pain Management
Phase Ⅱ, randomized, double-blind, comparator-controlled study to evaluate the efficacy, safety and pharmacokinetics of single injection intercostal nerve block with HR18034 for postoperative pain management compared with…
- Trial name
- NCT05744674
- Testing
- HR18034, Ropivacaine Hydrochloride Injection
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shanghai Hengrui Pharmaceutical Co., Ltd.
Post-operative Pain
Effectiveness of Continuous Femoral Nerve Block Versus Single Shot Femoral Nerve Block for Pain Control
Both single shot femoral nerve block and continuous femoral nerve block with catheter have been shown to be effective for pain control after anterior cruciate ligament reconstruction (ACLR).
- Trial name
- NCT01916590
- Testing
- Bupivicaine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Colorado, Denver
Aortic Valve Stenosis
Impact of Postdilatation With the InterValve V8 Aortic Valvuloplasty Balloon Following TAVI Procedure
This study is designed to monitor the safety and performance of the V8 balloon when used as a postdilatation balloon in self-expanding Transcatheter Aortic Valve Implantation (TAVI) device procedures.
- Trial name
- PostCorE (NCT02472106)
- Testing
- Post-dilatation
- Volunteers
- 9 people
- Sponsor
- InterValve, Inc.
Bowel Obstruction, Artificial Intelligence
Deep Learning-based Artificial Intelligence for the Diagnosis of Small Bowel Obstruction
The study will compare the diagnostic accuracy and time to diagnosis of computed tomography images of patients with suspected intestinal obstruction seen in the emergency room by residents and surgeons, with and without…
- Trial name
- NCT06481358
- Testing
- Artificial intelligence
- Where
- Japan
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nagoya University
Pain, Postoperative, Pain, Chest
Ideal Initial Bolus and Infusion Rate for Erector Spinae Plane Block Catheters
This study would like to identify the best starting dose and infusion rate for nerve blocks and nerve catheters related to the erector spinae plane block that can improve functional status and pain control on cardiac surgery…
- Trial name
- NCT03961048
- Testing
- Ropivacaine 0.2%-Sodium Chloride 0.9% Injectable Solution bilaterally, Ropivacaine 0.2%-Sodium Chloride 0.9% Injectable Solution unilaterally
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Chronic Total Occlusion of Coronary Artery, Diabetes Mellitus, Type 2
COronary CoLLateralization in Type 2 diabEtic Patients With Chronic Total Occlusion
A severe coronary artery obstruction is a prerequisite for spontaneous collateral recruitment. The formation of coronary collateral circulation(CCC) is significantly impaired in type 2 diabetic patients with chronic total…
- Trial name
- COLLECT (NCT06054126)
- Testing
- Echocardiography
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Ruijin Hospital
Rib Fractures
INTERCOSTAL NERVE BLOCK: Efficacy of CINB for Patients With Multiple Rib Fractures
This is a prospective, randomized, non-blinded study comparing CINB plus medical therapy versus standard medical care (non-steroidals and opioids intravenous/oral inpatient and oral outpatient) alone for patients with multiple…
- Trial name
- NCT05642026
- Testing
- Ropivacaine, Non steroidal anti-inflammatory drug and opioids
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Zachary Warriner
Atrioventricular Block, Second and Third Degree, Heart Failure
Safety and Effectiveness of Left Bundle Branch Pacing in Patients With Cardiac Dysfunction and AV Block
This study is a multicenter, prospective, randomized study to assess if cardiac dysfunction patients with LVEF <50% and the estimated ventricular pacing percentage >40% with LBBP have the non-inferior safety and efficacy than CRT…
- Conditions
- Atrioventricular Block, Second and Third Degree, Heart Failure, Left Bundle Branch Pacing
- Trial name
- NCT05553626
- Testing
- Left bundle branch pacing, Bi-ventricular pacing
- Where
- China
- Volunteers
- 160 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Open Mitral Cardiac Surgery
Role of Left Stellate Ganglion Block in Offering Myocardial Protection in On-pump Mitral Valve Replacement? A Histopathological and Clinical Assessment
Can pre-operative left stellate ganglion block offer myocardial protection in on-pump mitral valve replacement? A histopathological and clinical assessment.
- Trial name
- NCT06476925
- Testing
- sonar guided stellate ganglion injection, sonar guided stellate ganglion block
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Minia University
Chronic Migraine, Headache, Episodic Migraine
Occipital Blocks for Acute Migraine
Migraine affects 10-28% of children and adolescents and yet 20-30% of patients are ineffectively treated with current oral and nasal options.
- Trial name
- NCT03526874
- Testing
- Lidocaine 4% Topical Application Cream [LMX 4], Lidocaine Hydrochloride 2 mg/mL Injectable Solution, Normal Saline
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Children's Hospital of Philadelphia