Clinical trials: Block
Progress Free Survival (PFS) and Overall Survival (OS)
Combination of PD-1 and VEGFR-2 Blockade for Advanced Hepatocellular Carcinoma
The aie of this clinical study is the safety and efficacy of combination therapy for HCC patients.
- Trial name
- NCT04393220
- Testing
- Bevacizumab Injection, Nivolumab
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Surgery, Postoperative Pain
Effect of NMBA on Surgical Conditions in THR
During Total hip replacement arthroplasty (THA), the hip joint first must be luxated in order to have access to the joints. A lot of force and torque must be carried out on the joint to perform this manipulation.
- Trial name
- NCT03369782
- Testing
- Rocuronium, Sugammadex
- Where
- Belgium
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Typical Facial Pain, Atypical Facial Pain
Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain
Trigeminal neuralgia is a craniofacial pain syndrome that is typically characterized by unilateral severe, recurrent, electrical pain in one or more distributions of the trigeminal nerve.
- Trial name
- NCT02024724
- Testing
- Bupivacaine, Triamcinolone, Dexamethasone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwestern University
Asthma
Phase 2a, AMP Challenge, Dose Escalation Study to Assess the Dose Response for Topical Efficacy and Systemic Activity in Asthmatic Subjects
This is a randomized, placebo-controlled, 2-period crossover, escalating repeat dose study, aiming to investigate whether higher potency of different inhaled corticosteroid confers an improvement in the topical efficacy to…
- Trial name
- NCT02991859
- Testing
- Fluticasone furoate (FF) Dry Powder Inhaler, Fluticasone propionate (FP) Dry Powder Inhaler, Budesonide (BUD) Turbuhaler
- Where
- 3 sites in Germany, United Kingdom
- Volunteers
- 56 people
- Sponsor
- GlaxoSmithKline
Ophthalmic Surgery, Parabulbar Block
Anaesthesia for Ophthalmic Surgery: How "Retro" is the Peribulbar Block?
Ophthalmic surgery on the posterior section of the eye can either be performed under general anaesthesia or under local aneasthesia. The local anaesthesia is performed by injecting local anaesthetics behind the eye.
- Trial name
- NCT01258959
- Testing
- Ultrasound detection of local anesthetics spread
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Sunnybrook Health Sciences Centre
Arthropathy of Knee, Early Ambulation
Peripheral Nerve Blocks and Postoperative Pain and Mobilization After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is frequently associated with significant postoperative pain, which may delay early mobilization and negatively affect functional recovery.
- Conditions
- Arthropathy of Knee, Early Ambulation, Pain, Postoperative, Pain Management
- Trial name
- NCT07442123
- Testing
- Fascia Iliaca Plane Block, Adductor Canal Block + IPACK Block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Ilioinguinal Nerve Block, Local Anesthesia
Comparing Ilioinguinal Single-shot and Three-layer Blocks
Ilio-inguinal nerve blocks have a long history of efficacy in treatment of post-operative pain following inguinal surgery. Several anatomic studies have shown that the nerves supplying the inguinal area have a certain degree of…
- Conditions
- Ilioinguinal Nerve Block, Local Anesthesia, Post-operative Analgesia
- Trial name
- NCT01625780
- Testing
- 3-layer block, Single-shot block
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Alberta
Acute Ischemic Stroke, Basilar Artery Occlusion
Selective Intra-Arterial Hypothermia After Endovascular Treatment for Acute Basilar Artery Occlusion
This study will examine whether cooling part of the brain through a catheter after endovascular treatment improves recovery in adults with acute basilar artery occlusion, a type of severe stroke.
- Trial name
- NCT07896655
- Testing
- Mechanical thrombectomy, Normothermic saline infusion, 4°C saline infusion
- Where
- 2 sites in China
- Volunteers
- 818 people
- Sponsor
- Guangdong Second Provincial General Hospital
Erector Spinae Plane Block, Children
Erector Spinae Plane Block for Children Undergoing Thoracoscopic Sympathectomy
This study aims to evaluate the influence of ultrasound-guided erector spinae plane block on postoperative pain and diaphragmatic dysfunction in pediatric patients undergoing thoracoscopic sympathectomy.
- Conditions
- Erector Spinae Plane Block, Children, Thoracoscopic Sympathectomy
- Trial name
- NCT06984874
- Testing
- Erector spinae plane block, General anesthesia
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Masticatory Performance
Masticatory Performance in Bilateral Balanced Occlusion and Lingualized Occlusion in Complete Denture
This is a randomized control trial to compare masticatory performance in complete dentures with bilateral balanced occlusion or lingualized occlusion.
- Trial name
- NCT06811818
- Testing
- complete denture with bilateral balanced occlusion, complete denture with lingualized occlusion
- Where
- Pakistan
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Heart Transplantation
Comparison of Coronary CT With IVUS in Heart Transplant Population
To compare results of Intravascular Ultrasound (which occurs during cardiac catheterization) with Computed Tomography (CT) scan to detect blockages or narrowing of the arteries that feed the heart.
- Trial name
- NCT00589524
- Testing
- Computed tomography (CT)
- Sponsor
- Mayo Clinic
Stroke, Acute
Prehospital Prediction of Large Anterior Vessel Occlusion
For the clinical benefit of intravenous thrombolysis "IVT" or intra-arterial thrombectomy "IAT" time is the most crucial factor. Reducing the time between stroke onset en treatment is therefore a major goal.
- Trial name
- PHPLAVO (NCT04442659)
- Testing
- pre hospital triage tool
- Where
- Netherlands
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Post Surgical Pain
Dose Escalation of Dexamethasone to Increase Duration of Transversus Abdominal Plane Block Following Cesarean Section
The study aims to improve the care of the obstetric population after cesarean section and improve total patient satisfaction by improving post-surgical pain control with the use of dexamethasone in combination with bilateral TAP…
- Trial name
- NCT03098420
- Testing
- 2mg Dexamethasone, 4mg Dexamethasone, Ropivacaine (TAP blocks)
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Gynecologic Cancer, Post-operative Pain
Transversus Abdominis Plane Blocks for Patients Undergoing Robotic Gynecologic Oncology Surgery
This study is a single-center, randomized, placebo-controlled, double-blind clinical trial. The purpose of this study is to evaluate the impact of pre-operative transverses abdominis plane (TAP) blocks on post-operative analgesia…
- Trial name
- NCT01444924
- Testing
- Bupivicaine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Wisconsin, Madison
Heart Block, Aortic Stenosis
Glucocorticoid Treatment in Transaortic Valve Replacement to Reduce the Incidence of Conduction Disturbances (GLUCO-TAVR).
The goal of this phase IV, randomized, controlled and open-label study is to assess the efficacy of peri-procedure glucocorticoid treatment in the prevention of conduction abnormalities and the need for pacemaker implantation in…
- Conditions
- Heart Block, Aortic Stenosis, Bundle-Branch Block
- Trial name
- GLUCO-TAVR (NCT06076824)
- Testing
- Methylprednisolone
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital General Universitario de Alicante
Aortic Stenosis Symptomatic, Aortic Valve Stenosis
Romanian National Registry of Outcomes After Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis - RO-TAVI
RO-TAVI is a national prospective, observational, multi-center registry registry of patients with aortic valve stenosis undergoing transcatheter aortic valve implantation (TAVI) to assess patient care and outcomes.
- Trial name
- RO-TAVI (NCT04694859)
- Testing
- Transcatheter Aortic Valve Implantation
- Where
- Romania
- Volunteers
- 500 people
- Sponsor
- Romanian Society of Cardiology
Pain
Fentanyl as an Adjuvant to Peribulbar Block in Buckle or Squint Surgeries
The use of fentanyl as an adjuvant to local anesthetic mixture in many regional blocks. It was effective when used in peribulbar block in cataract and vitreoretinal surgeries.
- Trial name
- NCT05539911
- Testing
- Fentanyl
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Research Institute of Ophthalmology, Egypt
Covid19
Patterns of Arrhythmias and Conduction Block in COVID-19 Patients and Its Relation to Myocardial Injury Detected by Cardiac Magnetic Resonance
Detection of the incidence and types of arrhythmia and conduction block in COVID - 19 patients Detection and description of CMR patterns of myocardial injury in COVID-19 patients with arrhythmias.
- Trial name
- NCT04584411
- Testing
- Cardiac Magnetic resonance imaging
- Volunteers
- 50 people
- Sponsor
- Assiut University
STEMI - ST Elevation Myocardial Infarction, Anterior Wall Myocardial Infarction
A Study to Evaluate the Safety and Efficacy of PiCSO in Anterior STEMI Patients
The objective of this study is to assess the safety and efficacy of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) as adjunct to percutaneous coronary intervention (PCI) compared to PCI in the setting of acute…
- Trial name
- PiCSO-AMI-II (NCT05497011)
- Testing
- PiCSO Impulse System
- Sponsor
- Miracor Medical SA
Colorectal Cancer, Constipation, Impaction, and Bowel Obstruction
Endoscopic Placement of Metal Stent in Patients With Cancer-Related Bowel Obstruction
RATIONALE: The use of endoscopy to place a metal stent in the large intestine is less invasive than surgery for treating cancer-related bowel obstruction and may have fewer side effects and improve recovery.
- Conditions
- Colorectal Cancer, Constipation, Impaction, and Bowel Obstruction, Gastric Cancer, Gastrointestinal Carcinoid Tumor
- Trial name
- NCT00004911
- Testing
- bowel obstruction management, quality-of-life assessment
- Where
- United States
- Sponsor
- Northwestern University