Clinical trials: Block, open to volunteers
Contraception, Pain, Acute
Empathy Through Pain Control: Lidocaine Gel vs. Placebo Prior to IUD Placement
The goal of this research study is to learn more about how different uses of a numbing medication might affect pain levels while getting an IUD placed.
- Conditions
- Contraception, Pain, Acute, Anesthesia, Local
- Trial name
- EPIC3 (NCT06974032)
- Testing
- Xylocaine jelly 2%, Surgilube
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Limb Pain, Phantom
A Study of Contralateral Limb Block
This research is being done to determine if an anesthetic like Lidocaine, may be effective when injected around the sciatic nerve of the intact limb in patients with limb loss pain on the contralateral side.
- Trial name
- NCT06045936
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Nerve Block, Regional Anaesthesia
A Comparative Study of Combined Adductor Canal and Interspace Between Popliteal Artery and Knee Capsule Versus Combined Adductor Canal and Genicular Nerve in Total Knee Arthroplasty
The aim of this study is to investigate the effectiveness of combined adductor canal block (ACB) with interspace between popliteal artery and the knee capsule (IPACK) versus combined ACB with genicular nerve block (GNB) for…
- Trial name
- NCT06864663
- Testing
- nerve block with bupivacaine 0.25%
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Menstrual Cycle, Subcostal Transversus Abdominis Plane Block
Effect of Hormonal Cahanges During Menstrual Cycle on Subcostal Transversus Abdominis Plane Block
Fascial plane blocks are traditionally considered regional anesthesia techniques, where a mixture of local anesthetic (LA) is injected into a plane between two fascial layers, with the aim of spreading along this anatomical plane…
- Trial name
- NCT06566365
- Testing
- Subcostal Transversus Abdominis Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Adiyaman University Research Hospital
Pericapsuler Nerve Group Block, Postoperative Pain
The Effect of Pericapsular Nerve Group Block With Different Local Anesthetic Volumes
Early postoperative pain following shoulder surgery is a significant clinical problem for both patients and orthopedic surgeons. Effective pain control is crucial for improving postoperative comfort and optimizing rehabilitation.
- Trial name
- NCT07666737
- Testing
- pericapsular nerve group (PENG) block
- Volunteers
- 60 people
- Sponsor
- Selcuk University
Thoracic Surgery, Videoassisted Thoracoscopic Surgery,One-lung Ventilation
The Impact of Video-assisted Thoracic Surgery and Regional Anaesthesia on Postoperative Opioid Consumption and Pain Scores
This present study aims is to compare the effects of ultrasound-guided paravertebral block, intertransverse process block, and erector spinae plane block on postoperative opioid consumption, and pain scores in patients undergoing…
- Conditions
- Thoracic Surgery, Videoassisted Thoracoscopic Surgery,One-lung Ventilation, Regional Anaesthesia, Postoperative Analgesia
- Trial name
- NCT07578545
- Testing
- Paravertebral block group, İntertransverse process block group, Erector spinae plane block group
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Antalya Training and Research Hospital
Myocardial Ischemia, Diabetes Complication
Evaluation of Perioperative Myocardial Injury in Patients Undergoing Below-Knee Lower Extremity Surgery
The aim of this observational study was to detect myocardial damage by monitoring high-sensitive troponin I levels in patients undergoing below-knee extremity surgery with peripheral nerve block.
- Trial name
- NCT07241572
- Testing
- high sensitive Troponin I
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Aortic Stenosis Disease
Aortic Stenosis - Prognosis, Risk and Outcomes
The investigators will prospectively enroll 300 patients undergoing TAVI at Sahlgrenska University Hospital, which is the second largest TAVI hospital in Sweden.
- Trial name
- MASTER (NCT06863883)
- Where
- 2 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Vastra Gotaland Region
Obstructive Sleep Apnea of Child
Endoscopic Classification and DISE-Guided Surgery in Pediatric Obstructive Sleep-Disordered Breathing.
Pediatric obstructive sleep apnea (OSA) can lead to severe health issues if untreated. While polysomnography is the gold standard for diagnosis, current surgical treatment in Denmark relies on caregiver reports and clinical…
- Trial name
- DISE (NCT06093802)
- Testing
- Drug-induced Sleep Endoscopy findings (identified obstruction sites)
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Regional Hospital West Jutland
Adverse Effect, Feasibility Study
Feasibility and Safety of Sciatic Nerve Paraneural Sheath Block Using a Mid-Femoral Lateral Approach
This study is designed as a randomized controlled trial aiming to evaluate the feasibility and safety of ultrasound-guided mid-femoral lateral approach sciatic nerve paraneural sheath block, in order to provide a new sciatic…
- Conditions
- Adverse Effect, Feasibility Study, Safety and Effectiveness
- Trial name
- iSNB-LF (NCT07366853)
- Testing
- Ultrasound-guided lateral mid-femoral sciatic nerve block, Ultrasound-guided popliteal sciatic nerve block
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Aortic Stenosis
Deep Learning Enhanced Detection of Aortic Stenosis - The DETECT-AS-Diagnostic Study
The DETECT-AS Diagnostic Study will assess the performance of artificial intelligence (AI) risk predictions to detect aortic stenosis using results from portable electrocardiogram (ECG) and cardiac ultrasound devices.
- Trial name
- NCT06749145
- Testing
- Portable 1-lead electrocardiogram, Point-of-care ultrasound, AI-ECG risk algorithm
- Where
- 3 sites in United States
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Yale University
Acute Ischemic Stroke, Medium Vessel Occlusion
Intra-arterial Recombinant Human Tenecteplase Tissue-type Plasminogen Activator (rhTNK-tPA) Thrombolysis for Acute Medium Vessel Occlusion
Medium vessel occlusion (MeVO) accounts for 20-45% of acute ischemic stroke (AIS). Although patients with MeVO often present with relatively low NIHSS scores, up to one-third remain functionally dependent at follow-up despite…
- Trial name
- MeVO-TNK Ⅱ (NCT07302854)
- Testing
- Intra-arterial Thrombolysis, Standard medical treatment
- Where
- China
- Volunteers
- 382 people
- Sponsor
- Xiang Luo
Erector Spinae Plane Block, Neutrophil to Lymphocyte Ratio
The Relationship Between NLR and PONV and ESPB
This study aims to investigate whether preoperative NLR (Neutrophil-to-Lymphocyte Ratio) serves as a biomarker for PONV (Postoperative Nausea and Vomiting).
- Trial name
- NCT06127966
- Testing
- Erector Spinae Plane Block, 0.9% physiological saline (20ml) injection under ultrasound-guided Erector Spinae Plane Block (ESPB).
- Volunteers
- 220 people
- Sponsor
- Qianfoshan Hospital
Ischemic Mitral Regurgitation
Serotonin Receptor Blockers in Ischemic Mitral Regurgitation
This study is intended to investigate the effect of cyproheptadine (a 5HT2B receptor blocker) on mitral regurgitation severity.
- Trial name
- CYPRO-MR (NCT05469165)
- Testing
- Cyproheptadine 4 Mg Oral Tablet
- Where
- Canada
- Volunteers
- 214 people
- Sponsor
- Laval University
Breast Cancer Surgery, Breast Cancer Surgery Pain
Impact of High Thoracic Paravertebral Block on Diaphragmatic Function: a Prospective Study
The high thoracic paravertebral block is a regional anesthesia technique commonly used for oncologic breast surgery. Local anesthetic is injected into the paravertebral space to provide anesthesia and pain relief.
- Conditions
- Breast Cancer Surgery, Breast Cancer Surgery Pain, Hemidiaphragmatic Paralysis
- Trial name
- NCT07907692
- Testing
- High thoracic paravertebral block
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Pain and Diaphragmatic Dysfunction After Shoulder Arthroscopy
Effect of Optimal Biological Volume Bupivacaine Liposome Interscalene Brachial Plexus Block on Postoperative Analgesia After Shoulder Arthroscopy
This study aims to evaluate whether 15ml/75mg low-dose bupivacaine liposome is non-inferior to 15ml/133mg standard-dose bupivacaine liposome for postoperative analgesia in interscalene brachial plexus block during arthroscopic…
- Trial name
- NCT07792044
- Testing
- OBV bupivacaine liposome group, Standard dose bupivacaine liposome group
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Diaphragm Issues
Comparison of the Interscalene Block Alone Versus Combined With Superior Truncus Block During Shoulder Surgery in Diaphragmatic Function
Primarily, This study aims to compare between interscalene block alone versus combined with superior truncus block in producing diaphragmatic paralysis and Secondarily aims to evaluate 1. Effect on the pulmonary function. 2.
- Trial name
- NCT07338630
- Testing
- Regional anesthesia in shoulder surgery
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Sleep Quality, Postoperative Recovery
Sleep During Recovery: Effect of Preoperative Regional Block on Postoperative Sleep Quality in Mastectomy Patients
This prospective observational study investigates the impact of preoperative regional anesthesia on postoperative sleep quality in patients undergoing mastectomy.
- Conditions
- Sleep Quality, Postoperative Recovery, Anesthesia Techniques
- Trial name
- NCT07051434
- Testing
- Regional Analgesic Block
- Volunteers
- 66 people
- Sponsor
- Istinye University
Biliary Obstruction
Safety and Efficacy of Mechanical Versus Electrocautery Dilator for EUS-guided Biliary Drainage (MED-BD)
The purpose of this study is to investigate the likelihood of post-dilation bleeding using mechanical or electrocautery dilation. We hypothesized that the risk of bleeding is lower in the mechanical group.
- Trial name
- MED-BD (NCT06620328)
- Testing
- endoscopic ultrasonography-guided biliary drainage
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- National Taiwan University Hospital
Cardiac Valve Disease, Coronary Heart Disease
Superficial Parasternal Block Combined With Rectus Sheath Block for Open Cardiac Surgery
The investigators will examine whether the combination of a superficial parasternal block and rectus sheath block with multimodal analgesia can enhance postoperative pain control and reduce opioid administration when compared to…
- Trial name
- NCT07890857
- Testing
- Parasternal and rectus sheath block, ropivacaine 0.25 %
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Hôpital du Valais
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