Clinical trials: Blood
Hepatitis B, Viral Hepatitis
Tenofovir Alafenamide Versus Entecavir for the Treatment of Chronic Hepatitis B
To compare the efficacy and renal safety of tenofovir alafenamide (TAF) versus entecavir (ETV) in the chronic hepatitis B patients.
- Trial name
- NCT03933384
- Testing
- Tenofovir alafenamide, Entecavir
- Where
- Taiwan
- Volunteers
- 140 people
- Sponsor
- Taichung Veterans General Hospital
Endoscopic Sinus Surgery
PRD-guided Analgesia During FESS for Intraoperative Blood Loss
The aim of this randomized trial is to assess the utility of Pupillary Dilatation Reflex (PRD) for monitoring pain perception intraoperatively and its influence on intraoperative blood loss, quality of surgical field using…
- Trial name
- FESSPRD (NCT03417206)
- Testing
- Remifentanil, pupillary dilatation reflex
- Volunteers
- 120 people
- Sponsor
- Medical University of Silesia
Obesity
Evaluation of the Effect of Body Weight and Composition on Iron Absorption and Blood Volume
A total of 75 subjects will be recruited for this study (25 normal weight, 25 overweight, 25 obese). In each subject blood volume will be determined using the minimally invasive carbon monoxide-rebreathing method (substudy 1) and…
- Trial name
- NCT01884506
- Testing
- labeled iron solution, labeled iron solution and ascorbic acid
- Where
- Switzerland
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Primary Immunodeficiencies, APECED
Participation in a Research Registry for Immune Disorders
Background: People with primary immune deficiency diseases (PIDD) have weak immune systems. This makes it hard for their bodies to fight infection.
- Conditions
- Primary Immunodeficiencies, APECED, CGD, Wiskott-Aldrich Syndrome
- Trial name
- NCT01953016
- Where
- United States
- Volunteers
- 716 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
HIV Infections
"The Once A Day Protease Inhibitor Regimens"
Atazanavir (ATV) and fosamprenavir (fAPV) are new protease inhibitors that can be administered once-a-day and boosted with ritonavir (r).
- Trial name
- NCT00242216
- Testing
- ritonavir-boosted atazanavir, ritonavir-boosted fosamprenavir
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- The University of Texas Health Science Center, Houston
Iron Overload Due to Repeated Red Blood Cell Transfusions
Safety and Acceptability of Deferiprone Delayed Release Tablets in Patients With Systemic Iron Overload
Safety, tolerability, and acceptability of twice-daily dosing with deferiprone delayed-release (DR) tablets in patients with systemic iron overload.
- Trial name
- TWICE (NCT03802916)
- Testing
- Deferiprone DR tablets 1000 mg (Low dosage), Deferiprone DR tablets 1000 mg (High dosage)
- Where
- 5 sites in United States, Canada and 2 more
- Volunteers
- 30 people
- Sponsor
- ApoPharma
HIV/AIDS, HIV Infections
Enhancing Sexual Safety: Couples' Communication and HIV Testing Among YMSM
The purpose of this study is to compare different ways to deliver the couples HIV Testing and Counseling (CHTC) intervention that is suited for adolescents and young adults.
- Trial name
- WeTestATN156 (NCT04289116)
- Testing
- We Test, IHTC
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Florida State University
Hepatitis B
Comparing Immunogenicity and Safety of Different Formulations of HBV-MPL Vaccine With Engerix™-B in Adults Aged 19-40 y
This study will evaluate the immunogenicity and safety of different formulations of the HBV-MPL vaccine administered according to a 2-dose schedule and compare it to that of Engerix™-B administered according to a 3-dose schedule…
- Trial name
- NCT00698906
- Testing
- HBV-MPL vaccine, Engerix™-B
- Where
- Austria
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Abnormal; Birth
Changes of Gas Values in Cord Blood Versus Time and Temperature
The pH levels of a neonatal at his birth are an important factor in establishing the connection between events that occurred during the actual time of birth, to the risk of a significant morbidity development in the future.
- Trial name
- NCT02785367
- Testing
- Cord blood samples
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Hypoxia, Normobaric Hypoxia
Effect of Acute Hypoxia on RIght VEntRicular Function in Healthy Adults.
More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland.
- Conditions
- Hypoxia, Normobaric Hypoxia, Altitude Hypoxia, Right Heart Function
- Trial name
- RIVER-H (NCT07431567)
- Testing
- Normobaric Hypoxia
- Where
- 2 sites in Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mona Lichtblau
Fracture of Hip, Ileus
Peripheral Perfusion Index, Haemoglobin and Blood Transfusion in Acute Surgical Patients
The peripheral perfusion index (PPI) is a non-invasive, feasible measure of peripheral perfusion and, assumed, the overall circulation, which all patients are monitored by.
- Conditions
- Fracture of Hip, Ileus, Perforated Viscus, Anastomotic Leak
- Trial name
- NCT03795467
- Where
- Denmark
- Volunteers
- 1,500 people
- Sponsor
- Hvidovre University Hospital
Multiple Myeloma
Study of FasT CAR-T GC012F Injection NDMM Patients
This is a single-arm, single-center, open-label clinical study to evaluate the safety and efficacy of CAR-T in patients with NDMM.
- Trial name
- NCT05840107
- Testing
- GC012F injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai Changzheng Hospital
Weaning of Mechanical Ventilation
Arterial Blood Gases in Weaning of Mechanical VEntilation
Weaning of mechanical ventilation is an important phase of ICU (Intensive Care Unit) patient hospitalization. Patients have to pass a spontaneous breathing trial, can have a phase of pause with mechanical ventilation before…
- Trial name
- WAVE (NCT05801692)
- Testing
- Weaning of mechanical ventilation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Diffuse Large B-cell Lymphoma
Phase III Study of RAD001 Adjuvant Therapy in Poor Risk Patients With Diffuse Large B-Cell Lymphoma (DLBCL) of RAD001 Versus Matching Placebo After Patients Have Achieved Complete Response With First-line Rituximab-chemotherapy
Phase III study of RAD001 adjuvant therapy in poor risk patients with Diffuse Large B-Cell Lymphoma (DLBCL) of RAD001 versus matching placebo after patients had achieved complete response with first-line rituximab-chemotherapy
- Trial name
- PILLAR2 (NCT00790036)
- Testing
- Everolimus
- Where
- 202 sites in United States, Argentina and 32 more
- Volunteers
- 742 people
- Sponsor
- Novartis Pharmaceuticals
Cardiopulmonary Bypass
The Effect of Washing Red Blood Cells on Post Heart Surgery Blood Loss
When a child undergoes heart surgery, a heart lung machine is used to keep blood flowing while the child's own heart is stopped. After surgery, a significant amount of the child's own blood is left in this machine.
- Trial name
- NCT00624611
- Testing
- Residual pump blood management post aortic cannula removal
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- University of British Columbia
Acute Coronary Syndrome
99th Percentile Upper Reference Limit (URL) for the Meritas Troponin I Test
Prospective multicenter sample collection and testing study.
- Trial name
- NCT02638311
- Where
- 3 sites in United States
- Volunteers
- 769 people, healthy volunteers welcome
- Sponsor
- Trinity Biotech
Purpura, Thrombocytopaenic, Idiopathic
Study Of SB-497115 in Healthy Subjects and Subjects With Mild, Moderate or Severe Renal Impairment
The main purpose of this study is to compare how one 50 mg tablet of SB-497115 is broken down in the body by healthy subjects versus subjects with mild, moderate or severe kidney problems.
- Trial name
- NCT00442871
- Testing
- eltrombopag
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hypertension
The Effects of Potassium on Physiological and Cardiovascular Variables in Healthy Persons
In humans living of fruit and vegetables, hypertension is rarely seen. We wish to study if the development of hypertension has a connection to our intake of potassium.
- Trial name
- NCT00801034
- Testing
- Calcium, Potassium
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Erling Bjerregaard Pedersen
Thrombocytopenia, Primary Thrombocytopenia,Unspecified
Protocol for the Infusion of Buffy Coat-derived Cryopreserved Platelets in Patients With Severe Thrombocytopenia
The increasing need for blood components and the increasingly careful donor selection procedures, make the availability of blood components very reduced, in particular for platelets that are currently administered preferably…
- Conditions
- Thrombocytopenia, Primary Thrombocytopenia,Unspecified, Thrombocytopenia Chemotherapy Induced
- Trial name
- MICE (NCT02032134)
- Testing
- Transfusion of Pooled Platelets Cryopreserved In DMSO
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- Napolitano Mariasanta
Hepatitis C, Chronic
SYREN Study: A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Plus Copegus (Ribavirin) in Non-Responder Patients With Chronic Hepatitis C (CHC) Genotype 1.
This study will evaluate the efficacy and safety of 4 regimens of PEGASYS plus Copegus, in patients with chronic hepatitis C (CHC) genotype 1 who have failed to respond to previous treatment with standard doses of PEGASYS plus…
- Trial name
- NCT00412334
- Testing
- Copegus, peginterferon alfa-2a [Pegasys]
- Where
- 22 sites in France
- Volunteers
- 104 people
- Sponsor
- Hoffmann-La Roche
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