Clinical trials: Blood
HIV Infections
Clinical Study of TUTI-16 in Asymptomatic HIV-1 Infected Subjects (THYMON-11001)
This protocol represents the third in human study of TUTI-16, and is being conducted to gather additional safety and human immunogenicity (anti-HIV-1 Tat titers) data of subcutaneously administered TUTI-16.
- Trial name
- NCT01335191
- Testing
- TUTI-16 (1.0 mg)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Thymon, LLC
Obesity, Hyperglycemia
The Effect of a Bifidobacterium and Polydextrose on Body Fat Mass
Obesity is a major problem worldwide, and it is related to abnormalities in glucose and lipid metabolism. The purpose of this study is to investigate the effect of a dietary supplement containing probiotic (Bifidobacterium…
- Conditions
- Obesity, Hyperglycemia, Insulin Resistance
- Trial name
- MetSProb (NCT01978691)
- Testing
- Bifidobacterium animalis ssp. lactis 420, Polydextrose
- Where
- 4 sites in Finland
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Danisco
HIV Infections
Enema Use and Acceptability in HIV Negative Men Who Have Sex With Men
This study is looking at 3 different types of enemas used before receptive anal intercourse in men who have sex with men (MSM). We are investigating whether the enemas cause any damage to the lining of the colon, how far up the…
- Trial name
- NCT00696618
- Testing
- Fleet Enema, tap water enema, Normosol-R enema
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Renal Impairment, Multiple Myeloma
PK of Melphalan During Treatment With Melflufen and Dexamethasone in Patients With RRMM and Impaired Renal Function
This was a multicenter study of the pharmacokinetics (PK) of melphalan during treatment with melflufen and dexamethasone in patients with relapsed refractory multiple myeloma (RRMM) and impaired renal function.
- Trial name
- BRIDGE (NCT03639610)
- Testing
- Melflufen, Dexamethasone
- Where
- 10 sites in Czechia, Greece and 1 more
- Volunteers
- 35 people
- Sponsor
- Oncopeptides AB
Human Immunodeficiency Virus
HIV Prevention in the Primary Care Setting
In the third decade of the HIV pandemic, what was once a uniformly and rapidly fatal disease has been transformed into a chronic illness by advances in the understanding of HIV pathogenesis and therapeutics.
- Trial name
- NCT00381524
- Testing
- Increase condom use
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- University of Alabama at Birmingham
Measuring Red Blood Cell Survival After Transfusion
Optimization of Biotinylation Protocol for Studies of Red Blood Cell Survival and Function After Transfusion
The goal of this clinical trial is to compare two methods of labeling red blood cells with biotin. The main question to answer is whether red blood cells labeled 48 hours before transfusion survive as long as red blood cells…
- Trial name
- NCT06788080
- Testing
- BioRBC
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vitalant Research Institute
Gastroenteropancreatic Neuroendocrine Tumor, Lung Neuroendocrine Neoplasm
Clinical Utility Assay as a Biomarker for Gastroenteropancreatic and Lung Neuroendocrine Tumors
The purpose of this study is to evaluate how well an investigational blood test performs. The study will look at the sensitivity and specificity of a blood-based multitranscriptome assay (NETest).
- Trial name
- NCT02948946
- Testing
- NETest
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Pit Viper Bite, Coagulopathy
Thrombelastography for Coagulopathy in Chinese Snakebites
This study aims to evaluate the coagulation disorders caused by pit viper bites in patients from Zhanjiang and surrounding areas.
- Conditions
- Pit Viper Bite, Coagulopathy, Thromboelastography (TEG), Venom-induced Consumptive Coagulopathy
- Trial name
- NCT06860503
- Where
- China
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hansung University
Healthy, Overweight
Carbohydrates and Related Biomarkers
This study is designed to investigate associations of low- and high-glycemic load diets with biomarkers of hyperglycemia, hyperinsulinemia and inflammation, potential biomarkers for cancer risk.
- Trial name
- CARB (NCT00622661)
- Testing
- Low Glycemic Load Diet, High Glycemic Load Diet
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Nicotine Dependence
Nicotine Related Brain Activity: The Influence of Smoking History and Blood Nicotine Levels
In this study, we sought to explore brain activity in nicotine-dependent men in response to acute intravenous nicotine using pharmacological magnetic resonance imaging (phMRI).
- Trial name
- NCT01588561
- Testing
- Intravenous Nicotine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
HIV Infections
A Study of DTC in Patients With AIDS and AIDS Related Complex
To determine if ditiocarb sodium (sodium diethyldithiocarbamate; DTC) restores immune and host defense function; if DTC ameliorates the AIDS related complex (ARC) symptoms in patients with AIDS and ARC; if DTC prevents…
- Trial name
- NCT00002069
- Testing
- Ditiocarb sodium
- Where
- 8 sites in United States
- Sponsor
- Merieux Institute
Spondylitis, Ankylosing
Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED)
This is an open-label, controlled sub-study to the parent protocol (P04041, NCT00779935) to examine the expression profile of genes in patients in the active stage of ankylosing spondylitis (AS) compared to the healthy population…
- Trial name
- NCT00778869
- Testing
- Remicade
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Atrial Fibrillation
Blood Pressure Assessment in Atrial Fibrillation
This is a cross-sectional study including patients with permanent atrial fibrillation. Assessment will include: clinic blood pressure measurements (mercury sphygmomanometer and automated oscillometric device) 24-hour ambulatory…
- Trial name
- NCT01088269
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Athens
HIV Infections
A Study of Thymopentin Effects on HIV-1 Infectivity of Blood Mononuclear Cells and Semen in HIV Infected Patients
Examine the ability of Timunox (thymopentin) to reduce the amount and/or frequency of virus isolation. Examine the ability of thymopentin to stimulate the immune system and alter the clinical findings in patients infected with…
- Trial name
- NCT00002050
- Testing
- Thymopentin
- Where
- United States
- Sponsor
- Immunobiology Research Institute
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health
Ambient air temperatures in Asian, Latin American, African, and Pacific climate hotspots have broken record highs in 2024, driven by man-made climate change. Solutions are needed to reduce heat exposure in communities.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06579950)
- Testing
- Cool roof
- Where
- 5 sites in Burkina Faso, Fiji and 3 more
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Enhance Immune Function
The Exploratory Study on the Nicotinamide Mononucleotide (Vital NAD ) to Promote the Rejuvenation of the Peripheral Blood Immune Cells of Adults.
The purpose of this study is to investigate the changes in adult peripheral blood immune cell subpopulations, subpopulations, and cell functional status before and after intervention with Nicotinamide Mononucleotide (Vital NAD )…
- Trial name
- NCT05984550
- Testing
- NMN
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Shanghai Cell Therapy Group Co.,Ltd
Healthy Subjects
Clinical Study to Investigate the Effect of Macitentan on the Concentrations of Rosuvastatin in the Blood of Healthy Male Subjects
The aim of this Phase 1 trial is to study a potential drug-drug interaction between macitentan and rosuvastatin, a model substrate of various transporter proteins (e.g. in the gut).
- Trial name
- NCT03359291
- Testing
- Rosuvastatin, Macitentan
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Actelion
Cerebral Astrocytoma, High Grade
Positron Emission Tomography-Computed Tomography (PET-CT) High-grade Glioma
The objectives of the trial are: To determine the localisation within the primary tumor of the therapy resistant cells, before and during radiotherapy to determine a possible accurate boost volume.
- Trial name
- NCT00643591
- Testing
- imaging (dynamic PET-CT scan)
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht Radiation Oncology
Small Vessel Cerebrovascular Disease, Stroke
Intensive Blood Pressure Control in Ischaemic Stroke Patients With Severe Cerebral Small Vessel Disease
Objectives: Cerebral small vessel disease (SVD) is a common disease in patients with ischemic stroke and the most common cause of vascular dementia. Blood pressure (BP)-lowering is generally considered neuroprotective.
- Trial name
- NCT05690997
- Testing
- Intensive treatment, Standard treatment
- Where
- Hong Kong
- Volunteers
- 104 people
- Sponsor
- The University of Hong Kong
Joint Bleed, Hemophilia A
Handheld Ultrasound (HHUS) for Home Use in Hemophilia
This is a study in 3 phases that will assess the feasibility and utility of handheld home ultrasound (HHUS) in a patient's home to assess whether a painful episode in the elbow, knee or ankle is a bleed or not.
- Trial name
- HHUS (NCT04131920)
- Testing
- handheld ultrasound: Philips Lumify integrated tele-ultrasound powered by Reacts collaborative platform
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington Institute for Coagulation
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