Clinical trials: Blood Loss,
Cirrhosis, Liver, Gastroesophageal Varices
Development of 4D Flow MRI for Risk Stratification of Variceal Bleeding in Cirrhosis
The goal of this research is to validate novel non-invasive Magnetic resonance imaging (MRI) biomarkers to detect Gastroesophageal varices (GEV) in patients with cirrhosis, including fractional flow change in the portal vein and…
- Conditions
- Cirrhosis, Liver, Gastroesophageal Varices, Fontan Procedure
- Trial name
- NCT04867954
- Testing
- Ensure Plus®, Pre-clinical validation contrast enhanced MRI, Clinical validation MRI
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Pregnancy of Unknown Location (PUL)
Expediting Pregnancy of Unknown Location Risk Stratification Using the ROM-Plus Point of Care Test
The goal of this study is to learn if the ROM-Plus bedside test can effectively triage patients who present with pregnancy of unknown location (PUL) and vaginal bleeding as high or low risk for ectopic pregnancy.
- Trial name
- NCT07519954
- Testing
- ROM-Plus bedside test
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Delayed and Secondary Postpartum Hemorrhage
Immediate vs Delayed Postpartum Implanon-NXT
This prospective observational cohort study aims to compare immediate postpartum insertion (within 72 hours after delivery) versus delayed insertion (4-6 weeks postpartum) of the etonogestrel subdermal implant (Implanon-NXT®️)…
- Trial name
- NCT07626502
- Testing
- Etonogestrel subdermal implant (Implanon-NXT®)
- Volunteers
- 90 people
- Sponsor
- Assiut University
Postpartum Hemorrhage
Efficacy of Four Different Treatment Regimes on Postpartum Hemorrhage
Postpartum hemorrhage is the most important cause of maternal morbidity and mortality worldwide and accounts for approximately 25% of deaths worldwide.
- Trial name
- NCT05467462
- Testing
- I.V carbetocin administration, I.V Oxytocin administration, I.V carbetocin and tranexamic acid administration
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Postmenopausal Bleeding, Endometrial Cancer
Performance of Ultrasound in Women With Postmenopausal or Abnormal Uterine Bleeding Between White and Black Ethnic Groups- a Retrospective Cohort Study.
Primary Objective: To assess whether there is a higher incidence of uninformative ultrasound in black vs white women
- Trial name
- NCT06293066
- Testing
- Ultrasound
- Where
- United Kingdom
- Volunteers
- 330 people
- Sponsor
- King's College Hospital NHS Trust
Liver Cirrhoses, Variceal Hemorrhage
HVPG-Guided Therapy vs Carvedilol Plus Endotherapy for the Prevention of Esophageal Variceal Rebleeding in Cirrhotic Patients
Variceal bleeding is a major complication of cirrhosis, associated with a hospital mortality rate of 10%-20%. Surviving patients are at high risk for recurrent hemorrhage.
- Conditions
- Liver Cirrhoses, Variceal Hemorrhage, Esophageal Varices
- Trial name
- NCT04254822
- Testing
- Transjugular intrahepatic portosystemic shunt, Carvedilol, Endoscopic variceal ligation
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Air Force Military Medical University, China
Iron Deficiency Anemia, Abnormal Uterine Bleeding
Tolerability of Iron Therapy in Women With AUB
Telephone surveys of female patients using liposomally-bound iron and traditional iron sulphate preparations for the management of iron deficiency anemia to determine gastrointestinal tolerability.
- Trial name
- NCT04915196
- Testing
- Liposomally-bound Iron
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Pain Postoperative, Intraoperative Hemorrhage
Efficacy of Peritonsillar Dexmedetomidine Infiltration for Postadenotonsillectomy Pain
The purpose of the present study is the clinical assessment of the efficacy of preincisional peritonsillar infiltration of dexmedetomidine on postoperative pain relief in children undergoing adenotonsillectomy.
- Trial name
- NCT02013570
- Testing
- Dexmedetomidine
- Volunteers
- 71 people
- Sponsor
- TC Erciyes University
Venous Thromboembolic Disease, Pulmonary Embolism
CHIPs-VTE Study in Hospitalized Patients With Lung Cancer
Venous thromboembolism (VTE) is a common complication of malignancies, in particular to lung cancer. Patients with lung cancer in surgical and medical departments are at high risk of VTE development.
- Conditions
- Venous Thromboembolic Disease, Pulmonary Embolism, Deep Venous Thrombosis
- Trial name
- NCT04158973
- Testing
- Bleeding-risk based prophylaxis strategy during hospitalization and extended pharmacological treatment after discharge, Routine VTE prophylaxis in hospital
- Volunteers
- 3,200 people
- Sponsor
- China-Japan Friendship Hospital
Peptic Ulcer Hemorrhage
Role of Doppler Ultrasound in Severe Peptic Ulcer Hemorrhage
The aim of study is to evaluate whether Doppler ultrasound can accurately identify patients who are at risk of recurrent bleeding, who will require endoscopic therapy, and who will fail endoscopic therapy.
- Trial name
- NCT00164905
- Testing
- Doppler ultrasound probe
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Chinese University of Hong Kong
Atrial Fibrillation
MANAGE-AF Registry -MANAGEment of Atrial Fibrillation Outcomes Registry (MANAGE-AF)
The purpose of this research is to learn more about the normal care of patients with a new or pre-existing diagnosis of atrial fibrillation (AF).
- Trial name
- MANAGE-AF (NCT05978466)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- CorVita Science Foundation
Spontaneous Vitreous Hemorrhage, Retinal Break
Early VItrectomy in DENse Spontaneous Vitreous HEmorrhage
The aim of the protocol is to compare the ocular outcomes after spontaneous vitreous hemorrhage treated with an early vitrectomy versus ultrasound monitoring with late vitrectomy.
- Conditions
- Spontaneous Vitreous Hemorrhage, Retinal Break, Retinal Detachment
- Trial name
- EVIDENSE (NCT04676256)
- Testing
- Early vitrectomy
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Craniocerebral Injuries, Head Injuries
Defining the Operating Characteristics of NIRS in the Diagnosis of Pediatric Traumatic Intracranial Hemorrhage
In this study, investigators look at a different type of technology that might help to avoid having to perform CT scans in certain patients suspected of having a head injury.
- Conditions
- Craniocerebral Injuries, Head Injuries, Head Injury, Minor, Head Trauma
- Trial name
- NCT03905031
- Testing
- InfraScanner 2000
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Dayton Children's Hospital
Congenital Bleeding Disorder, Haemophilia A
Evaluation of Safety and Efficacy, Including Pharmacokinetics, of NNC 0129-0000-1003 When Administered for Treatment and Prophylaxis of Bleeding in Subjects With Haemophilia A
This trial is conducted globally. The aim of the trial is to evaluate the safety and efficacy, including pharmacokinetics (the exposure of the trial drug in the body) of NNC 0129-0000-1003 (N8-GP) in subjects with Haemophilia A.
- Trial name
- pathfinder™2 (NCT01480180)
- Testing
- turoctocog alfa pegol
- Where
- 93 sites in United States, Australia and 22 more
- Volunteers
- 186 people
- Sponsor
- Novo Nordisk A/S
Hereditary Hemorrhagic Telangiectasia (HHT)
A Trial of TER-1754 in Patients With Hereditary Hemorrhagic Telangiectasia
This is a Phase 1a/1b, multicenter study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and clinical activity of TER-1754 (a novel AKT1 inhibitor) in patients with HHT.
- Trial name
- NCT07255846
- Testing
- TER-1754
- Where
- United States
- Sponsor
- Terremoto Biosciences Inc.
Gastrointestinal Hemorrhage, Hematemesis; With Ulcer
Efficacy and Safety of Nexpowder™ for Non-variceal, Upper Gastrointestinal Bleeding
The purpose of this pilot clinical trial is to confirm the efficacy and safety of Nexpowder™ for hemostasis in pilot cohort of patients with NVUGIB in Singapore
- Conditions
- Gastrointestinal Hemorrhage, Hematemesis; With Ulcer, Endoscopy
- Trial name
- NCT06269588
- Testing
- Nexpowder
- Where
- Singapore
- Volunteers
- 24 people
- Sponsor
- Changi General Hospital
Bleeding Peptic Ulcer
Oral Omeprazole in Bleeding Peptic Ulcer
Find out if there is a significant difference between clinical outcome among the patients with bleeding peptic ulcer treated with oral omeprazole compared to those treated with intravenous omeprazole.
- Trial name
- NCT04170270
- Testing
- Omeprazole
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Subarachnoid Haemorrhage (SAH)
Evaluation of Transcutaneous Trigeminal Nerve Stimulation for Prevention of Cerebral Vasospasm After Subarachnoid Haemorrhage
Subarachnoid haemorrhage (SAH) secondary to ruptured aneurysm represents 5 to 15% of all cases of stroke. The mortality rate of SAH is 40% and the risk of serious neurological sequelae among survivors is 10 to 20%.The causes of…
- Trial name
- TRIVASOSTIM (NCT02482883)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Subarachnoid Hemorrhage, Aneurysmal
Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage
This is a single-site, single-arm, open-label pilot study assessing the safety, feasibility, and efficacy of non-invasive vagus nerve stimulation (nVNS), gammaCore, for the acute treatment of aneurysmal subarachnoid hemorrhage…
- Trial name
- STORM (NCT05103566)
- Testing
- gammaCore
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Intracranial Aneurysm, Subarachnoid Hemorrhage
CorPath® GRX Neuro Study
The primary objective of this study is to evaluate the effectiveness and safety of robotic-assisted endovascular embolization procedures compared to objective performance criteria for traditional, manual operation based on the…
- Conditions
- Intracranial Aneurysm, Subarachnoid Hemorrhage, Headache
- Trial name
- NCT04236856
- Testing
- Robotic Endovascular Procedure
- Where
- 10 sites in Australia, Austria and 4 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Siemens Healthineers Endovascular Robotics, Inc.
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