Clinical trials: Blood Loss, Surgical
Rhinoplasty, Depth of Anesthesia
Processed EEG Monitoring During Controlled Hypotension in Patients Undergoing Rhinoplasty
This prospective observational study evaluates intraoperative processed electroencephalography parameters in adult patients undergoing elective rhinoplasty under total intravenous anesthesia with controlled hypotension.
- Conditions
- Rhinoplasty, Depth of Anesthesia, Surgical Bleeding, Postoperative Recovery
- Trial name
- NCT07671781
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Gazi University
Postoperative Fistula, Complications of Surgical and Medical Care: General Terms
External Drainage Versus Internal Drainage of Pancreatic Duct With a Stent After Pancreaticoduodenectomy (EDIDPD)
Postoperative pancreatic fistula (POPF) and other surgical complications are common after pancreatoduodenectomy (PD) and POPF is a major complication.
- Trial name
- EDIDPD (NCT01634971)
- Testing
- Internal Drainage of Pancreatic Duct after pancreatomy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Blood Loss, Surgical
Tranexamic Acid Versus Placebo to Reduce Perioperative Bleeding After Major Hepatectomy
Blood loss was reported as a prognostic risk factor of morbidity and overall survival after hepatic resection. The aim of this study prospective randomized was compare the efficacy of the administration of tranexamic acid versus…
- Trial name
- NCT00657384
- Testing
- acid tranexamic, Nacl 0.9%
- Where
- 4 sites in France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Strasbourg, France
Hip Fracture
Tranexamic Acid in HIp Fracture Surgery (THIF Study)
The purpose of this study is to assess the efficacy of tranexamic acid in hip fracture surgery on the reduction of allogeneic red blood cell transfusion.
- Trial name
- THIF (NCT00327106)
- Testing
- Tranexamic acid (Exacyl)
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Spinal Metastases
Preoperative Embolization in Surgical Treatment of Spinal Metastases.
The main purpose of this study is to assess the efficacy of preoperative embolization in decreasing operative blood loss, decreasing the need for intraoperative transfusion and facilitate surgical resection in metastatic spine…
- Trial name
- NCT01365715
- Testing
- Arteriography and preoperative embolization, Arteriography
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Bleeding, Blood Loss, Surgical
PCC vs. FFP for Post Cardiopulmonary Bypass Coagulopathy and Bleeding
This will be the first prospective randomized controlled clinical trial directly comparing Prothrombin Complex Concentrate (PCC) Compared to Fresh Frozen Plasma (FFP) for post cardiopulmonary bypass microvascular bleeding and…
- Conditions
- Bleeding, Blood Loss, Surgical, Cardiovascular Surgical Procedures, Prothrombin Complex Concentrates
- Trial name
- NCT02557672
- Testing
- Prothrombin complex concentrate (Human), Fresh frozen plasma (FFP)
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cesarean Section
To Compare the Effects of Oxytocin and Carbetocin on Intraoperative Hemodynamic Changes in Cesarean Section Surgeries.
To compare the effects of oxytocin and carbetocin, used as uterotonics in elective caesarean section surgeries, in terms of intraoperative hemodynamic changes.
- Trial name
- NCT06956365
- Testing
- Group-C, Group-O
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Intraoperative Bleeding, Coblation Turbinoplasty
Phenylephrine Versus Tranexamic Acid to Control Bleeding in Patients Undergoing Inferior Turbinoplasty by Coblation
Coblation is a unique method of delivering radio frequency energy to the soft tissue for applications in otolaryngology. It induces reduction of the inferior turbinate by vaporizing and destroying the soft erectile tissue.
- Trial name
- NCT05841251
- Testing
- Topical Phenylephrine Solution, intravenous tranexamic acid
- Volunteers
- 80 people
- Sponsor
- Assiut University
Blood Loss, Surgical, Intrapartum Hemorrhage
Efficacy of Carbetocin Versus Oxytocin Plus Misoprostol in Decreasing Blood Loss During Cesarean Section
The aim of this clinical trial is to test if carbetocin is as effective as oxytocin plus misoprostol in decreasing intraoperative blood loss in women undergoing planned cesarean section.
- Trial name
- NCT05664659
- Testing
- Oxytocin + misoprostol, Carbetocin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams Maternity Hospital
Cardiovascular Surgery, Blood Loss, Surgical
Effectiveness of a Intraoperative Blood Recovery System in Cardiovascular Surgery in Brazil
Randomized trial to evaluate the effectiveness of a intra operative blood recovery system in reducing the need for allogeneic transfusion in cardiovascular surgeries using cardiopulmonary bypass
- Trial name
- NCT06601582
- Testing
- Use of a operative blood salvage system
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Pregnancy, Periodontal Disease
Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During Pregnancy
This randomized controlled clinical trial aims to evaluate the effectiveness of adjunctive coenzyme Q10 and probiotic supplementation (Limosilactobacillus reuteri Prodentis®) in improving periodontal health in pregnant women…
- Conditions
- Pregnancy, Periodontal Disease, Gingivitis, Dental Plaque
- Trial name
- PREG-Q10 (NCT07029360)
- Testing
- Limosilactobacillus reuteri Prodentis®, Coenzyme Q10 Toothpaste
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
C.Surgical Procedure; Cardiac, Blood Transfusion
Cost-Utility Analysis of Management of Peri Operative Haemorrhage Following Cardiac Surgery With Cardiopulmonary Bypass
Peri operative haemorrhage following cardio Pulmonary Bypass may occur in 5 to 10% of cardiac surgical interventions. Treatment of such complication often necessitates various combinations therapeutic intervention including…
- Conditions
- C.Surgical Procedure; Cardiac, Blood Transfusion, Blood Coagulation Disorders, Bypass, Cardiopulmonary
- Trial name
- IMOTEC (NCT02972684)
- Testing
- Thrombo-elastometry POC testing
- Where
- 15 sites in France
- Volunteers
- 1,098 people
- Sponsor
- Nantes University Hospital
Spine Surgery
Safety of Tranexamic Acid in Reducing Bleeding in Adults Undergoing Spinal Surgery
Spinal fusion surgery can be associated with significant blood loss requiring allogeneic blood transfusion. Tranexamic acid is a synthetic amino acid with antifibrinolytic action that has been shown to reduce perioperative blood…
- Trial name
- NCT00444470
- Testing
- Tranexamic acid
- Where
- 3 sites in Canada
- Volunteers
- 151 people
- Sponsor
- University Health Network, Toronto
Anesthesia, Carbon Dioxide
EtCO2 Level to Control Intraoperative Bleeding and Improve the Quality of Surgical Field Vision in Septorhinoplasty
It is unknown whether different end-tidal carbon dioxide pressure levels have a clinically significant effect on bleeding and surgical field quality in septorhinoplasty, especially during controlled hypotension.
- Conditions
- Anesthesia, Carbon Dioxide, Surgical Blood Loss
- Trial name
- EtCO2 (NCT05497375)
- Testing
- The amount of intraoperative bleeding, Quality of the intraoperative surgical field, Surgeon Satisfaction
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Bezmialem Vakif University
Osteoarthritis, Blood Loss, Surgical
Non-inferiority Trial of Oral Tranexamic Acid vs. Intravenous Tranexamic Acid in Joint Replacement Surgery
The purpose of this research is to determine if the oral form of a medication (tranexamic acid) to reduce bleeding can be used in place of an intravenous (IV) form, to learn the best way to give tranexamic acid: either a pill by…
- Conditions
- Osteoarthritis, Blood Loss, Surgical, Blood Loss, Postoperative
- Trial name
- NCT02438566
- Testing
- Tranexamic Acid (Oral), Tranexamic Acid (Intravenous)
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- The New England Baptist Hospital
Venous Thrombosis
Comparison of Arixtra vs. Lovenox to Prevent Blood Clots in Medically Ill Patients
A total of 50 patients >40 yrs of age with an expected hospital stay in the Medical Intensive Care or Regional Heart Unit at LVH Muhlenberg of 6 days or longer will be enrolled.
- Trial name
- BRiEF (NCT00521885)
- Testing
- Arixtra (Fondaparinox) 2.5 mg SC Daily, Lovenox 40mg SC Daily
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Lehigh Valley Hospital
Hemophilia
Safety and Efficacy of FVIIa to Prevent Excessive Bleeding in Hemophilia Patients With Inhibitors Undergoing Major Surgery
This is an interventional, prospective, international, multicenter, single-arm, Phase 3, and sequential efficacy and safety study in adolescents and adults with congenital hemophilia A or B with inhibitors to factor VIII (FVIII)…
- Trial name
- SCOPE HIM (NCT05695391)
- Testing
- Coagulation Factor VIIa (Recombinant)
- Where
- 15 sites in United States, Malaysia and 4 more
- Volunteers
- 2 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Tranexamic Acid, Burn
TXA Study in Major Burn Surgery
Major surgery can result in blood loss that can require a blood transfusion during and/or after surgery. Tranexamic acid (TXA) is a medication that was first introduced in the 1960's as a treatment for heavy menstrual bleeding.
- Conditions
- Tranexamic Acid, Burn, Major Surgery
- Trial name
- NCT02753816
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Corewell Health West
Intraoperative Bleeding
The Value of Tranxemic Acid to Reduce Intraoperative Blood Loss During Elective Cesarean Sections in High Risk Women
A full medical history will be obtained from all participants. Obstetric ultrasonography and laboratory tests will be performed.According to group assignment, either 1 g(10 mL) tranexamic acid stored in a dry container at 15…
- Trial name
- NCT03820206
- Testing
- Tranexamic Acid, Cesarean section
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Cairo University
Scoliosis
Recombinant Human Erythropoietin Compared to Autologous Pre-Donation Prior to Scoliosis Surgery in Children.
The purpose of this study is to establish whether rHuEpo is as effective as PAD in increasing red cell mass prior to surgery. Other benefits of the PAD program and preoperative administration of rHuEpo will also be compared.
- Trial name
- NCT00323752
- Testing
- rHuEpo
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia