Clinical trials: Blood Loss, Surgical
Hip Fracture
Tranexamic Acid in Hip Fracture Surgery
To determine if TXA utilization is effective at reducing transfusion rates in elderly patients undergoing surgery for treatment of a hip fractures.
- Trial name
- NCT02736383
- Volunteers
- 142 people
- Sponsor
- Corewell Health West
Cardiovascular Procedures, Thoracic Aortic Aneurysm
Post Market Surveillance Study Evaluating BioFoam Surgical Matrix in Cardiovascular Surgery
This is a prospective, multicenter, single-arm study designed to collect clinical data to support the safety and effectiveness of BioFoam used as a surgical adjunct to anastomotic hemostasis following cardiovascular surgery.
- Conditions
- Cardiovascular Procedures, Thoracic Aortic Aneurysm, Aortic Valve Replacement, Type A Aortic Dissection
- Trial name
- NCT02164201
- Where
- 2 sites in Germany, Italy
- Volunteers
- 75 people
- Sponsor
- CryoLife Europa
Blood Loss
The Use of FLOSEAL to Reduce Bleeding in Total Knee Replacement Surgery
The purpose of this study is to determine if the agent, Floseal, can decrease the amount of blood patients lose after total knee replacement (TKR) surgery.
- Trial name
- NCT00990288
- Testing
- Hemostatic Matrix
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Hospital for Special Surgery, New York
Hemorrhage
Indomethacin and Cardiac Bypass Surgery
Following signed informed consent, patients scheduled for elective cardiac surgery were randomly assigned to one of 3 groups to be given acetaminophen, Indomethacin or a combination of both immediately following induction and…
- Trial name
- NCT01073670
- Testing
- Indomethacin, Acetaminophen & Indomethacin, Acetaminophen
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Queen's University
Blood Loss, Surgical, Hemostasis
OSHES - Observational Study on Hemostasis in Surgery (TC-022-IT)
OSHES (= Observational Study on Hemostasis in Surgery) is a non interventional register settled in Italy with the purpose of collecting data on 800 patients intra-operatively treated with hemostatic supporting agents/techniques…
- Trial name
- NCT00279383
- Testing
- Fibrinogen (human) + thrombin (human) (TachoSil)
- Where
- Denmark
- Volunteers
- 800 people
- Sponsor
- Nycomed
Spinal Disorders, Degenerative Spine Disease
Dose-Dependent Effects of Intraoperative Tranexamic Acid on Surgical Bleeding and Transfusion Requirements in Multilevel Thoracolumbar Spinal Surgery
Multilevel spinal stabilization surgery is frequently associated with substantial blood loss and increased transfusion requirements.
- Conditions
- Spinal Disorders, Degenerative Spine Disease, Blood Loss, Surgical
- Trial name
- NCT07288697
- Testing
- low-dose TXA, high-dose TXA
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Edema, Ecchymosis
Effects of Hyperbaric Oxygen Therapy on Surgical Wound Healing
The aim of this study is to test the effect of Hyperbaric Oxygen Therapy) HBOT (100% oxygen; 2.0 ATA; 90 minute total exposure) and compare against a hyperbaric sham treatment (HBST) (patient's breathing room air; 2.0 ATA; 90…
- Trial name
- BLEPH (NCT01605110)
- Testing
- Hyperbaric oxygen treatment
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Restorix Research Institute, LLLP
Pelvic Organ Prolapse, Abnormal Uterine Bleeding
Evaluating Artisential Laparoscopic Instruments in Gynecologic Surgery
This study evaluates the efficacy and safety of Artisential laparoscopic instruments in minimally invasive gynecologic surgery.
- Conditions
- Pelvic Organ Prolapse, Abnormal Uterine Bleeding, Mesh Augmentation, Laparoscopic Surgery
- Trial name
- MIGS-ART (NCT06050161)
- Testing
- Articulating laparoscopic instrument, Conventional laparoscopic instrument, Robotic surgical instrument
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kern Medical Center
Intraoperative Bleeding
Epinephrine in Irrigation Fluid for Visualization During Ankle Surgery
The purpose of this study is to evaluate the effect of epinephrine in irrigation fluid for visual clarity in ankle arthroscopic surgery.
- Trial name
- NCT06264596
- Testing
- Epinephrine, Normal Saline irrigation fluid
- Where
- United States
- Sponsor
- The Guthrie Clinic
Knee Osteoarthritis
Comparison of Three Tourniquet Application Methods in Primary Total Knee Arthroplasty Surgery
Different strategies of tourniquet application during elective primary total knee arthroplasty are thought to be associated with different outcomes.
- Trial name
- NCT01355900
- Testing
- Total knee arthroplasty performed under tourniquet
- Where
- Lithuania
- Volunteers
- 120 people
- Sponsor
- Vilnius University
Blood Loss, Surgical, Fluid Retention
Comparison Between Hyperoncotic and Isooncotic Albumin to Support Blood Loss Replacement
Fluid intravascular replacement is usually performed with either balanced crystalloids or iso-oncotic colloids, (synthetic colloids, plasma and 5% albumin).
- Trial name
- VASCALB (NCT05391607)
- Testing
- Hyperoncotic Albumin 20%, Isooncotic Albumin 5%, Ringer's Lactate Crystalloid Solutions (control group)
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hemorrhage
Pre-emptive Hemodynamic Optimization of High Risk Patients Undergoing Elective Major Surgical Procedures
Several recent clinical trials have documented that early aggressive resuscitation approached guided by defined hemodynamic variables using thoughtful protocols may improve outcome.
- Trial name
- NCT00725972
- Testing
- Augment O2 Delivery by hemodynamic protocol, High Risk Surgery
- Where
- United States
- Sponsor
- University of Pittsburgh
Chronic Subdural Hematomas
Treatment of Chronic Subdural Hematoma by Corticosteroids
Chronic subdural hematomas are a frequent neurosurgical pathology in the elderly. Gold standard is surgical evacuation of these hematomas.
- Trial name
- SUCRE (NCT02650609)
- Testing
- Methylprednisolone
- Where
- 17 sites in France
- Volunteers
- 202 people
- Sponsor
- Rennes University Hospital
Gastric Bypass Surgery
Efficacy of Oversewing Versus Surgical Ligation Clips for Staple Line Reinforcement of the Gastric Pouch to Reduce Post Operative Bleeding in Laparoscopic One Anastomosis Gastric Bypass
1. To test if there is a significant differences between Oversewing versus surgical ligation clips for staple line reinforcement of the gastric pouch regarding the reduction of post operative bleeding and the need for blood…
- Trial name
- NCT07238309
- Testing
- Oversewing, Surgical Ligation Clips
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intracerebral Hemorrhage, Surgery
Comparison Between Stereotactic Aspiration and Intra-endoscopic Surgery to Treat Intracerebral Hemorrhage
Views for surgery method selection of intracerebral hemorrhage are still controversial. Since the application of neuroendoscopic technique in intraventricular hemorrhage was confirmed effective and safe, some investigators have…
- Trial name
- EndoSurofICH (NCT02515903)
- Testing
- Intra-endoscopic surgery
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Intracranial Hemorrhage
INVEST-REGISTRY: Minimally Invasive Endoscopic Surgical Treatment With Apollo/Artemis in Patients With Brain Hemorrhage
Objective: The primary objective of this multicenter prospective registry is to provide additional safety, technical outcomes and clinical outcomes data for minimally invasive endoscopic surgery (MIES) with Apollo or Artemis for…
- Trial name
- NCT02661672
- Testing
- Apollo Device, Artemis Device
- Where
- 7 sites in United States
- Volunteers
- 38 people
- Sponsor
- J. Mocco
Blood Loss, Postoperative Blood Loss
Evaluation of Intraarticular Tranexamic Acid to Reduction of Total Blood Loss Following Knee-Arthroplasty
A randomized, prospective, placebo-controlled study which aims to evaluate the effect of combined intraarticular and intravenous Tranexamic acid on total blood loss following unilateral knee replacement versus only intravenous…
- Conditions
- Blood Loss, Postoperative Blood Loss, Thromboembolic Complications
- Trial name
- NCT02427412
- Testing
- Tranexamic Acid, Saline water
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Hvidovre University Hospital
Bleeding, Tooth Extraction
Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery
Tranexamic acid (TXA) is an effective hemostatic agent used to reduce blood loss and the need for transfusion. It is a relatively safe drug with minimal significant side effects.
- Trial name
- NCT06806241
- Testing
- Tranexamic acid, saline irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Cardiovascular Surgery, Blood Loss, Surgical
Effectiveness of a Intraoperative Blood Recovery System in Cardiovascular Surgery in Brazil
Randomized trial to evaluate the effectiveness of a intra operative blood recovery system in reducing the need for allogeneic transfusion in cardiovascular surgeries using cardiopulmonary bypass
- Trial name
- NCT06601582
- Testing
- Use of a operative blood salvage system
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Cardiac Surgical Procedures, Blood Transfusion
Comparison of Three Tranexamic Acid Dose Regimens in Patients Undergoing Cardiac Valve Surgery
This study compares the effect of three different dose levels of tranexamic acid（TXA）in reducing blood loss and transfusion requirements in cardiac valve surgery.
- Conditions
- Cardiac Surgical Procedures, Blood Transfusion, Tranexamic Acid
- Trial name
- NCT04911413
- Testing
- Tranexamic acid
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital