Clinical trials: Blood Loss
Bleeding Hemorrhoids
A Prospective, Randomized, Three Arms, Open Label Study Comparing the Safety and Efficacy of Two Formulations of PP110 to the Active Comparator Preparation-H® Cream in the Treatment of Bleeding Hemorrhoids Grades 2-3
Eligible patients with bleeding hemorrhoids of grade 2-3 are randomized to test-1 product (PP110 Gel), test-2 product (PP-110 medicated wipes) or control (Preparation-H cream).
- Trial name
- NCT02010099
- Testing
- PP110 Gel, PP110 Medicated wipes, Preparation-H Cream
- Where
- 5 sites in Israel
- Volunteers
- 101 people
- Sponsor
- Peritech Pharma Ltd.
Trauma, Acute Hemorrhage
Evaluation of a Transfusion Therapy Using Whole Blood in the Management of Coagulopathy in Patients With Acute Traumatic Hemorrhage
The prognosis of traumatized hemorrhages is correlated with the nature of transfusion therapy: a 50% reduction in mortality for an early and massive supply of plasma, and 20% for an early and massive supply of platelets.
- Conditions
- Trauma, Acute Hemorrhage, Coagulopathy
- Trial name
- T-STORHM (NCT04431999)
- Testing
- Whole blood transfusion, Fractionated blood products transfusion
- Where
- 6 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Intracerebral Hemorrhage
Minocycline Accelerates Intracerebral Hemorrhage Absorption
Minocycline has been found to reduce cerebral edema secondary to cerebral hemorrhage, promote hematoma absorption, and shorten hematoma absorption time; clinical studies have been conducted to confirm the safety in the treatment…
- Trial name
- MACHA (NCT05630534)
- Testing
- Minocycline, starch
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Subdural Hematomas
PHIL™ Middle Meningeal Artery Embolization for First-Line Treatment of Chronic Subdural Hematoma IDE Trial
This is a prospective, randomized, controlled, open-label, blinded endpoint (PROBE) clinical investigation in which patients with non-emergent chronic subdural hematoma (cSDH) requiring treatment will be randomized (1:1) to…
- Trial name
- PHILFIRST (NCT07576998)
- Testing
- PHIL™ (Precipitating Hydrophobic Injectable Liquid), Surgical evacuation
- Volunteers
- 475 people
- Sponsor
- Microvention-Terumo, Inc.
Postpartum Hemorrhage
Carbetocin Versus Ergometrin in the Prevention of Postpartum Hemorrhage
In the present study will be compared Carbetocin with ergometrin in the prevention of postpartum haemorrhage (PPH) in parturients that are undergoing caesarean section and are not presenting risk factors for PPH.
- Trial name
- NCT04300452
- Testing
- Carbetocin, Ergometrine Maleate
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Intracerebral Hemorrhage, Sepsis
Machine Learning Predictive Models for Sepsis Risk in ICU Patients With Intracerebral Hemorrhage
Patients with intracerebral hemorrhage (ICH) in the intensive care unit (ICU) are at heightened risk of developing sepsis, significantly increasing mortality and healthcare burden.
- Trial name
- NCT06326385
- Testing
- no intervention
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Xiangya Hospital of Central South University
Postpartum Hemorrhage
Intrauterine Balloon (Bakri©) Versus Uterine Tamponade With Chitosan Gauze (Celox PPH©) in the Management of Postpartum Hemorrhage Refractory to Medical Treatmen
Postpartum hemorrhage (PPH) remains one of the leading causes of maternal morbidity and mortality worldwide, particularly in low- and middle-income countries.
- Trial name
- NCT06996808
- Testing
- Bakri Baloon, Celox gauze
- Volunteers
- 196 people
- Sponsor
- University of Roma La Sapienza
Polycystic Ovary Syndrome (PCOS), Myo-inositol
Myo-Inositol and D-Chiro-Inositol for Menstrual Irregularities and Hormone Changes in Women With Polycystic Ovarian Syndrome
The goal of this clinical trial is to determine whether a combination of myo-inositol (MI) and D-chiro-inositol (DCI) with folic acid is more effective than placebo (Folic acid alone) in improving menstrual irregularities and…
- Conditions
- Polycystic Ovary Syndrome (PCOS), Myo-inositol, D-chiro-inositol
- Trial name
- NCT07701525
- Testing
- Myo-Inositol and D-Chiro-Inositol Combination Therapy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Nishtar Medical University
The Efficacy of Percutaneous Catheter vs. Open Chest Tube, Traumatic Hemothorax
Multi-center:The Small (14F) Percutaneous Catheter vs. Large (28-40F) Open Chest Tube for Traumatic Hemothorax (P-CAT)
After sustaining severe trauma to the chest, patients will often bleed into the chest cavity (pleural space) which is called hemothorax or they may also experience air leakage within the chest cavity in combination with the…
- Trial name
- P-CAT (NCT03546764)
- Testing
- Percutaneous catheter
- Where
- 4 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Arizona
ST Elevation (STEMI) Myocardial Infarction
Correlation Between Triglyceride Glucose Index and Myocardial Injury Assessed by Cardiac Magnetic Resonance Imaging (CMR) in Patients With STEMI
This research aim is to investigate the correlation between triglyceride glucose index (TyG index) and myocardial infarct size, microcirculation obstruction (MVO) and intramyocardial hemorrhage (IMH) assessed by cardiac magnetic…
- Trial name
- NCT07261514
- Where
- China
- Volunteers
- 674 people
- Sponsor
- Chinese PLA General Hospital
Acute-On-Chronic Liver Failure
Incidence and Predictors of Bleeding Diathesis Development Due to DIC in Cirrhosis and ACLF Patients Undergoing CRRT
ACLF and cirrhotic patient have deranged coagulation parameters and this coagulation parameters altered when this group of patients undergoing dialysis because of renal failure. this group of patients is also high risk of sepsis.
- Trial name
- NCT04960163
- Testing
- No intervention
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage
The goal of this observational study is to understand if angiographic cerebral vasospasm (CV) can be predicted by levels of nitric oxide (NO) consumption in patients with aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- NCT07614906
- Where
- 2 sites in United States, Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Gastric Cancer, Bleeding
The Use of Proton Pump Inhibitor on the Prevention of Gastric Cancer Bleeding
The aim of this study is the effect of proton pump inhibitor (PPI) with respect to gastric cancer bleeding in inoperable patients.
- Trial name
- NCT02150447
- Testing
- Proton pump inhibitor
- Where
- 4 sites in South Korea
- Volunteers
- 394 people
- Sponsor
- National Cancer Center, Korea
Postmenopausal Bleeding
Role of MRI in Diagnosis of Postmenopausal Bleeding Causes
The aim of the study is to determine the diagnostic performance of MRI of endometrial pathology in postmenopausal women with postmenopausal bleeding
- Trial name
- NCT06004908
- Testing
- MRI
- Volunteers
- 36 people
- Sponsor
- Assiut University
Gastrointestinal Disease, Inflammatory Bowel Diseases
Using Virtual Reality for Patients With Gastrointestinal Disease
The primary aim of this study is to evaluate the effect and impact of a technology which creates a virtual reality (VR), personalized representation of a patient's endoscopic findings in comparison our standard practice (SP).
- Trial name
- NCT03719209
- Testing
- HealthVoyager, Standard Practice
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Boston Children's Hospital
Upper Gastrointestinal Bleeding
Safety & Efficacy of Omeprazole Sodium Bicarbonate for the Prevention of Upper GI Bleeding in the Critically Ill
Critically ill patients are at an increased risk of having upper gastrointestinal (GI) bleeding due to stress related mucosal damage.
- Trial name
- NCT00045799
- Testing
- Omeprazole sodium bicarbonate immediate release PWD/FS, Cimetidine IV
- Where
- 58 sites in United States
- Volunteers
- 354 people
- Sponsor
- Bausch Health Americas, Inc.
Alcohol-Related Disorders, Drinking and Driving
Interaction of Alcohol With Energy Drinks
The main objective of the project is to assess whether there is an interaction between the effects of ethanol and energy drinks on driving performance.
- Trial name
- AEDED (NCT02771587)
- Testing
- Alcohol and energy drink, Alcohol, Energy drink
- Where
- 2 sites in Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Stroke, Vascular Accident
PROpranolol for Cerebral Hemorrhage-ASsociated pnEumonia (PRO-CHASE)
Stroke-associated pneumonia (SAP) is a grave complication of stroke and one of the most important predictors for patients' poor outcomes.
- Conditions
- Stroke, Vascular Accident, Intracranial Hemorrhages, Intracerebral Hemorrhage
- Trial name
- PRO-CHASE (NCT05419193)
- Testing
- Propranolol Hydrochloride, control group
- Where
- 12 sites in China
- Volunteers
- 168 people
- Sponsor
- Beijing Tiantan Hospital
Macrohematuria
Air vs. Liquid: A Study on Cystoscopy Performance and Visibility Enhancement in Macrohematuria Cases
Macroscopic haematuria is a common urological emergency. Diagnostic cystoscopy is the gold standard for identifying the bleeding source; however, blood and clots within the bladder significantly impair endoscopic visibility when…
- Trial name
- AIROSCOPY (NCT07618221)
- Testing
- Air-based flexible cystoscopy, Saline-based flexible cystoscopy
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Kantonsspital Baden
Intracerebral Hemorrhage, Acute Stroke
Remote Ischemic Conditioning for the Treatment of Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) results from the rupture of small vessels damaged by chronic hypertension, amyloid angiopathy or other disease. Currently, ICH has been a devastating type of stroke that lacking effective therapy.
- Trial name
- RICH-2 (NCT04657133)
- Testing
- Remote ischemic conditioning, Standard medication therapy
- Where
- 13 sites in China
- Volunteers
- 452 people
- Sponsor
- Capital Medical University