Clinical trials: Blood Platelet Disease
CMML, Thrombocytopenia
A Study of Eltrombopag in Patients With CMML and Thrombocytopenia
Treatment of patients with chronic myelomonocytic leukemia (CMML) and thrombocytopenia.
- Trial name
- NCT02323178
- Testing
- eltrombopag
- Where
- 26 sites in France
- Volunteers
- 30 people
- Sponsor
- Groupe Francophone des Myelodysplasies
Platelet Function, Thrombocytopenia
Platelet Function During ECMO (Extra Corporeal Membrane Oxygenation)
Platelet transfusions are routinely administered during neonatal ECMO, with an average of 1.3 platelet transfusions per day being administered while a patient is undergoing ECMO treatment.
- Trial name
- NCT00748878
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Utah
Diabetes Mellitus
for Adipose Tissue DIabetes VAriants (fATDIVA)
The adipose (fat) cells under the skin are where individuals store excess fat. The more excess fat they have, the more "strain" they put on these cells which then get bigger and don't work as well as they should.
- Trial name
- fATDIVA (NCT02505321)
- Testing
- Oral Triglyceride Tolerance Test (OTTT), Abdominal fat biopsy (optional)
- Where
- United Kingdom
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Eosinophilic Myeloid Neoplasm, Hypereosinophilic Syndrome
Tyrosine Kinase Inhibition to Treat Myeloid Hypereosinophilic Syndrome
The purpose of this study is to evaluate the safety and efficacy of the tyrosine kinase inhibitor, imatinib mesylate (Gleevec ) in reducing peripheral blood eosinophilia in patients with the myeloid form of hypereosinophilic…
- Trial name
- NCT00044304
- Testing
- Imatinib, Ruxolitinib
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Knee Osteoarthritis
Bone Marrow Aspirate Compared to Platelet Rich Plasma for Treating Knee Osteoarthritis
This study is intended to compare whether bone marrow aspirate concentrate or platelet rich plasma injections is more effective in treating knee osteoarthritis.
- Trial name
- EmCyte (NCT03289416)
- Testing
- Pure PRP II, PureBMC
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Andrews Research & Education Foundation
Coronary Artery Disease
The Effects of Tirofiban in Diabetic Patients Undergoing Elective Percutaneous Coronary Intervention
The purpose of this study is to examine the effects of tirofiban on platelet function the Ultegra RPFA in diabetic patients undergoing elective coronary angioplasty and stenting already treated with high loading dose (600mg)…
- Trial name
- NCT00407771
- Testing
- Tirofiban
- Where
- Jordan
- Volunteers
- 44 people
- Sponsor
- Jordan Hospital
Idiopathic Thrombocytopenic Purpura
Study of the Safety and Immunogenicity of Long-term GNR-069 Therapy in ITP Patients
It is a phase III extension study to assess safety and immunogenicity of long-term therapy with GNR-069 in patients with idiopathic thrombocytopenic purpura
- Trial name
- NCT05492409
- Testing
- GNR-069
- Where
- 13 sites in Russia
- Volunteers
- 160 people
- Sponsor
- AO GENERIUM
Stroke, Acute, Stroke, Ischemic
Glenzocimab for REperfusion in the Setting of Endovascular Therapy for Brain infarctioN: GREEN Study
Emergent reperfusion is the main goal for acute ischemic stroke therapy (AIS). Endovascular therapy (EVT) is recommended within 6 hrs of stroke onset, and up to 24 hrs following perfusion imaging criteria.
- Trial name
- GREEN (NCT05559398)
- Testing
- Glenzocimab
- Where
- 12 sites in France
- Volunteers
- 108 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bone Loss
Release Kinetics of rhBMP-2 Using E-PRF as an Autologous Carrier: An In Vitro Analysis
This study is seeking to evaluate the binding of a commercially-available, recombinant human osteoinductive growth factor, rhBMP-2, to a human blood derived product scaffold, enhanced Platelet-rich fibrin (E-PRF), and the release…
- Trial name
- NCT04670965
- Testing
- E-PRF/rhBMP-2 (similar ratios), E-PRF/ACS/rhBMP-2, rhBMP-2/E-PRF
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Coronary Artery Disease
Short and Optimal Duration of Dual Antiplatelet Therapy Study
The purpose of this study is to evaluate safety of reduction of thienopyridine treatment period to 3 months after implantation of Cobalt-Chromium everolimus-eluting Stents.
- Trial name
- STOPDAPT (NCT01659034)
- Testing
- Thienopyridine for 3 months
- Where
- Japan
- Volunteers
- 1,525 people
- Sponsor
- Takeshi Morimoto
Bone Density Increased
Radiographic Assessment of Bone Dimension Around Immediate Implants With FDBA and I-PRF vs FDBA Alone
The present study is a human, prospective, parallel, randomised controlled clinical trial conducted for radiographic assessment of bone dimension around immediate implants with FDBA and I-PRF vs FDBA Alone The trial is in…
- Trial name
- NCT06522321
- Testing
- i-PRF and FDBA
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Acute Myeloid Leukemia, Myeloproliferative Neoplasms
Study of Molecular and Genetic Abnormalities in Patients With Myeloid Neoplasms
The objective of this study is to describe the prevalence and prognostic impact of the most common genetic abnormalities in patients with Myeloid Neoplasms, including Acute Myeloid Leukemia (AML), Myeloproliferative Neoplasms…
- Conditions
- Acute Myeloid Leukemia, Myeloproliferative Neoplasms, Myelodysplastic Syndromes, Myeloproliferative/Myelodysplastic Neoplasm
- Trial name
- NCT02084563
- Testing
- Induction Chemotherapy, Consolidation Chemotherapy, Autologous Stem Cell Transplantation
- Where
- Brazil
- Volunteers
- 455 people
- Sponsor
- Hospital Israelita Albert Einstein
Bladder Exstrophy-Epispadias Complex
Use of Platelet-Rich Fibrin in Bladder Exstrophy Repair
Bladder exstrophy-epispadias complex (BEEC) is a rare condition in which the bladder and surrounding structures do not form normally.
- Trial name
- PRF-BEEC (NCT07294612)
- Testing
- Autologous Platelet-Rich Fibrin, Standard Surgical Closure
- Where
- Uzbekistan
- Volunteers
- 20 people
- Sponsor
- National Children's Medical Center, Uzbekistan
Dry Eye Disease, Dry Eye
Phase III Study of Topical Fibrinogen-Depleted Human Platelet Lysate Compared to Placebo for Moderate to Severe Dry Eye
Prospective, multicenter, randomized, vehicle-controlled, double-masked, study of CAM-101 topical ophthalmic solution compared to vehicle control followed by crossover to long-term follow-up open-label treatment with CAM-101 for…
- Conditions
- Dry Eye Disease, Dry Eye, Dry Eyes Chronic, Dry Eye Syndromes
- Trial name
- CAMOMILE-2 (NCT06903611)
- Testing
- CAM-101, Vehicle Control
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Cambium Bio Limited
Myocardial Infarction
Ticagrelor Pharmacokinetics in NSTEMI
Patients with myocardial infarction, which does not include all layers of the heart's muscle wall are common and they often receive pharmacological treatment with the platelet inhibiting drug ticagrelor.
- Trial name
- NCT02292277
- Testing
- Ticagrelor
- Where
- Sweden
- Volunteers
- 63 people
- Sponsor
- Karolinska University Hospital
Immune Thrombocytopenia
Long-term Study of Romiplostim in Thrombocytopenic Pediatric Patients With Immune Thrombocytopenia (ITP)
This is a phase 3b single arm, open label, multicenter study describing the percentage of time pediatric participants with ITP have a platelet response while receiving romiplostim, defined as a platelet count ≥ 50 x 10^9/L in the…
- Trial name
- NCT02279173
- Testing
- Romiplostim
- Where
- 78 sites in United States, Australia and 15 more
- Volunteers
- 203 people
- Sponsor
- Amgen
Acute Coronary Syndrome (ACS)
OPTImal Management of Antithrombotic Agents: OPTIMA-5
This is a prospective, randomized, open-label clinical trial which will enroll 80 acute coronary syndrome (ACS) patients after Percutaneous Transluminal Coronary Intervention (PCI) in China.
- Trial name
- NCT04116931
- Testing
- Switch ticagrelor to clopidogrel
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Herniated Disc
Comparison of Interlaminar CT Guided Epidural Platelet Rich Plasma Versus Steroid Injection in Patients With Lumbar Radicular Pain
The treatment of persistent lumbar radicular pain (LRP) using CT-guided epidural steroid injection (ESI) is widely used and associated with rare but serious complications.
- Trial name
- NCT07036445
- Testing
- Epidural Steroid Injection, Epidural platelet-rich plasma injection
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Clinique du Sport, Bordeaux Mérignac
Chirurgical Intervention, Thrombocytopaenia
Preoperative Use of Romiplostim in Thrombocytopenic Patients Undergoing Cardiac Surgery.
Romiplostim has demonstrated its efficacy and good tolerance in multiple indications. If the efficacy of Romiplostim is confirmed in this population, thrombocytopenic patients will be able to undergo cardiac surgery, which is…
- Trial name
- CT-PLATE (NCT07278661)
- Testing
- Nplate, NaCl %0.9
- Where
- 8 sites in France
- Volunteers
- 142 people
- Sponsor
- Nantes University Hospital
Stress Urinary Incontinence
Platelet-rich Fibrin Versus HIFU in Management of Stress Urinary Incontinence
Aim of the study is to compare effect of High Intensity Focused Ultrasound (HIFU) and platelet-rich fibrin in management of stress urinary incontinence. It is a randomized prospective study.
- Trial name
- NCT04144829
- Testing
- HIFU, Fibrin
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Intima Clinic
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