Clinical trials: Blood Platelet Disease
Knee Osteoarthritis, Chronic Inflammatory Rheumatism
IDENTIFICATION OF BIOMARKERS ASSOCIATED WITH THE SEVERITY AND RADIO-CLINICAL PROGRESSION OF KNEE OSTEOARTHRITIS
Knee osteoarthritis (OA) is an heterogeneous disease, both symptomatically and structurally, with very different evolving profiles.
- Trial name
- BIOGO (NCT06600958)
- Testing
- SA brief descriptive name used to refer to the intervention(s) studied
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Immune Thrombocytopenia
Efficacy and Safety Assessment of a Treatment Combining Rituximab and Belimumab in Adults With Persistent Immune Thrombocytopenia
Previous studies have shown that increase level of BAFF could promote the settlement of long-lived plasma cells in the spleen of ITP patients treated with anti-CD20.
- Trial name
- RITUX PLUS (NCT03154385)
- Testing
- Rituximab (Mabthera ®) Belimumab (Benlysta ®)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Immune Thrombocytopenia
A Clinical Study to Evaluate the Efficacy and Safety of LIV-GAMMA SN Inj. in Primary Immune Thrombocytopenia (ITP)
The main purpose of this study is to assess the efficacy and safety of LIV-GAMMA SN Inj. in adult subjects with ITP. The primary objective of this study is to determine the responder rate.
- Trial name
- NCT03164915
- Testing
- LIV-GAMMA SN Inj.
- Where
- 6 sites in South Korea
- Volunteers
- 37 people
- Sponsor
- SK Plasma Co., Ltd.
Thrombocytopenia
Avatrombopag on the Treatment of Thrombocytopenia Induced by Chemotherapy of Malignant Tumors
To observe the clinical efficacy and safety of avatrombopag for chemotherapy-induced thrombocytopenia in patients with malignant tumors.
- Trial name
- NCT04609891
- Testing
- Avatrombopag
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Anhui Provincial Cancer Hospital
Purpura, Thrombocytopenic, Idiopathic
Phase II Study of Rituximab in Patients With Immune Thrombocytopenic Purpura
OBJECTIVES: I. Determine the response rate and response duration to rituximab in patients with immune thrombocytopenic purpura. II. Evaluate the toxicity associated with this treatment regimen in these patients. III.
- Trial name
- NCT00005652
- Testing
- rituximab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Periodontitis
Treatment of Periodontal Intrabony Defects Using Autologous Platelet Rich Fibrin vs Titanium Platelet Rich Fibrin
Background: To compare the effectiveness of open flap debridement (OFD) alone and OFD along with either Autologous Platelet Rich Fibrin (PRF) or Titanium Platelet Rich Fibrin (TPRF) in the treatment of intrabony defects (IBDs).
- Trial name
- NCT02512952
- Testing
- Open flap debridement (OFD), OFD with Platelet rich fibrin (PRF), OFD with Titanium Platelet rich fibrin (TPRF)
- Where
- 2 sites in India
- Volunteers
- 38 people
- Sponsor
- Government Dental College and Research Institute, Bangalore
Anemia, Hematopoietic/Lymphoid Cancer
Donor Stem Cell Boost in Treating Patients With Low Blood Cells After Donor Stem Cell Transplant
This clinical trial studies how well donor stem cell boost works in treating patients with low blood cells after donor stem cell transplant.
- Conditions
- Anemia, Hematopoietic/Lymphoid Cancer, Lymphopenia, Neutropenia
- Trial name
- NCT01660347
- Testing
- Allogeneic hematopoietic stem cell transplantation, Peripheral blood stem cell transplantation, Management of therapy complications
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Adhesive Capsulitis
Intra-articular Injection of Allogeneic Platelet Rich Plasma (PRP) for Adhesive Capsulitis
The purpose of this study is to compare the efficacy of intra-articular allogenic Platelet Rich Plasma injection and steroid injection in the treatment of adhesive capsulitis of the shoulder.
- Trial name
- NCT01458691
- Testing
- Steroid injection into the glenohumeral joint, Allogeneic PRP injection into the glenohumeral joint
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Sepsis, Thrombocytopenia
Platelet Transfusion in Sepsis Trial
Platelets are important mediators of an inflammatory response and a key component of the innate immune system to defend the human body against invading pathogens.
- Trial name
- NCT03968484
- Testing
- platelet transfusion
- Sponsor
- University Hospital Tuebingen
Atypical Hemolytic Uremic Syndrome
Eculizumab to Cemdisiran Switch in aHUS
Atypical Hemolytic Uremic Syndrome (aHUS) is a rare, lifethreatening, chronic disease of complement-mediated thrombotic microangiopathy (TMA) characterized by acute onset of renal impairment, thrombocytopenia, and…
- Trial name
- DANCE (NCT03999840)
- Testing
- cemdisiran
- Where
- Italy
- Sponsor
- Mario Negri Institute for Pharmacological Research
Platelets Dysfunction, Hematological Diseases
Daily Ginger Drinking and Platelet Function
This study aims to examine the effect of ginger beverage consumption on platelets activity in apparently healthy Saudi adult volunteers.
- Trial name
- NCT02882776
- Testing
- Ginger drink
- Where
- Saudi Arabia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Abdullah International Medical Research Center
Immune Thrombocytopenia
Effects of Helicobacter Pylori Eradication in Children With Chronic Immune Thrombocytopenic Purpura
Thrombocytopenia refers to a reduction in platelet count to (<150 × 109/L). Immune thrombocytopenic purpura is an acquired autoimmune disorder defined by isolated thrombocytopenia and the exclusion of other causes of…
- Trial name
- NCT03172676
- Testing
- Amoxicillin 50 mg/kg/day in 2 divided doses for 14 days., Clarithromycin 15 mg/kg/day in 2 divided doses for 14 days., Proton pump inhibitor 1 mg/kg/day in 2 divided doses 1 month
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Assiut University
Androgenetic Alopecia
Adipose Derived Stem Cells Versus Platelet Rich Plasma on Follicular Unit Extraction
Androgenetic alopecia is the most common type of alopecia in both men and women. About 80 % of Caucasian men and 40-50 % of Caucasian women are affected by androgenetic alopecia.
- Trial name
- NCT03388840
- Testing
- Adipose derived stem cells suspention, Platelet rich plasma
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Von Willebrand Diseases
The Lived Experience of People With Von Willebrand Disease
von Willebrand disease (vWD) is reported to be the most common bleeding disorder, with prevalence estimated at 1% of the general population.
- Trial name
- VWD360 (NCT06064643)
- Testing
- Online Survey, Qualitative Interview, Bleed Diary
- Where
- United Kingdom
- Volunteers
- 611 people
- Sponsor
- Haemnet
Obesity
Oro-gastro-intestinal Digestion of Emulsified Fat
Interaction of fat with the mouth, stomach and intestine will trigger physiological responses that will impact on the digestion, gut transit time and absorption of fat.
- Trial name
- NCT01478750
- Testing
- administration of fat (sunflower oil), emulsified, Insertion of nasoduodenal tube
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Coronary Heart Disease, Non ST-elevation Acute Coronary Syndromes
Residual Platelet Activity Despite Aspirin Utilization in Coronary Heart Disease
The purpose of this study is to compare the response to aspirin in the acute phase with the late phase of an acute coronary syndrome.
- Trial name
- NCT01820429
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- University of Sao Paulo General Hospital
Corticosteroid-resistant or Relapsed ITP
Combination of Danazole With Berberine in the Treatment of ITP
A prospective, multicenter, open-label, Phase II, single arm, trial performed in 6 departments of hematology in China
- Trial name
- NCT03909763
- Testing
- Berberine plus danazol
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Peking University People's Hospital
Extraction, Tooth, Tooth Fracture
Platelet-Rich Fibrin (PRF) vs Bone Graft With Membrane for Ridge Preservation After Tooth Extraction
This study uses a natural material called Platelet-Rich Fibrin (PRF) to help improve healing after tooth removal. PRF is made from your own blood.
- Conditions
- Extraction, Tooth, Tooth Fracture, Tooth Crown Fracture, Root; Fracture
- Trial name
- NCT07595198
- Testing
- Platelet-rich fibrin (PRF), Freeze-dried bone allograft, Collagen barrier membrane
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Aortic Stenosis
Study of Platelet Activation by Severe Aortic Stenosis and Its Correction by Transcatheter Aortic Valve Implantation
Study of platelet activation by severe aortic stenosis and its correction by Transcatheter Aortic Valve Implantation (TAVI)
- Trial name
- TAVI (NCT02504632)
- Testing
- test, control group
- Where
- France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Toulouse
Hemophilia A With Inhibitor, Hemophilia B With Inhibitor
Prospective, Non-interventional Study to Evaluate Immunogenicity of AryoSeven
This study evaluates the immunogenicity of the biosimilar rFVIIa (AryoSeven) in subjects receiving AryoSeven in real-life clinical practice.
- Conditions
- Hemophilia A With Inhibitor, Hemophilia B With Inhibitor, Factor VII Deficiency, Glanzmann's Thrombasthenia
- Trial name
- NCT03372993
- Where
- 2 sites in Iran
- Volunteers
- 200 people
- Sponsor
- AryoGen Pharmed Co.
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