Clinical trials: Blood Platelet Disease
Cardiopulmonary Bypass, Platelet Disorder
Preoperative Dual Antiplatelet Therapy: Platelet Function and Influence of Cardiopulmonary Bypass
Patients admitted for coronary artery bypass surgery taking antiplatelet medicine have an increased risk for bleeding. Present study aims to compare the platelet function in two patient groups using different types of heart-lung…
- Conditions
- Cardiopulmonary Bypass, Platelet Disorder, Bleeding Disorder, Platelet Dysfunction Due to Drugs
- Trial name
- NCT02979158
- Testing
- CPB Low Dose, CPB High Dose
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Umeå University
Traumatic Brain Injury
Cold-stored Platelet Early Intervention in TBI
The Cold Stored Platelet Early Intervention in Traumatic Brain Injury (CriSP-TBI) trial is a proposed 3 year, open label, single center, randomized trial designed to determine the feasibility, efficacy, and safety of urgent…
- Trial name
- CriSP-TBI (NCT04726410)
- Testing
- Cold Stored Platelets, Standard Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Jason Sperry
Stress Urinary Incontinence
Platelet-rich Plasma for Stress Urinary Incontinence
Stress urinary incontinence (SUI) is defined by the International Continence Society (ICS) as "the complaint of any involuntary loss of urine on effort or physical exertion or on sneezing or coughing.
- Trial name
- NCT04279210
- Testing
- Platelet-rich plasma
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Hematologic Diseases
Evaluation, Treatment, and Training for Patients With Blood Disorders
This study is designed to allow the evaluation, follow-up, and medical care of patients with blood disorders not currently participating in a research study being conducted by the Hematology Branch of the National Heart, Lung and…
- Trial name
- NCT00001397
- Where
- United States
- Volunteers
- 1,452 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Fasciitis, Plantar
RCT Comparing ESWT With PRP for Plantar Fasciitis in High Demand Cohort
A Randomized Controlled Pilot Trial Comparing Extracorporeal Shock Wave Therapy with Platelet Rich Plasma versus Extracorporeal Shock Wave Therapy in a High Demand Cohort with Resistant Plantar Fasciitis
- Trial name
- NCT02668510
- Testing
- platelet rich plasma, Normal saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Edna Rath
Systemic Lupus Erythematosus, Immune Thrombocytopenia
Sirolimus in Patients With Systemic Lupus Erythematosus-Associated Immune Thrombocytopenia
The goal of this clinical trial is to learn if sirolimus, added to standard background therapy (corticosteroids and hydroxychloroquine), works to treat systemic lupus erythematosus-associated immune thrombocytopenia (SLE-ITP) in…
- Trial name
- NCT07657793
- Testing
- Sirolimus
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Chinese SLE Treatment And Research Group
Myelofibrosis, Myelodysplastic Syndrome
Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms
The purpose of this study is to evaluate the safety, tolerability, and preliminary efficacy of INCB057643 as monotherapy or combination with ruxolitinib for participants with myelofibrosis (MF) and other myeloid neoplasms.
- Conditions
- Myelofibrosis, Myelodysplastic Syndrome, Myelodysplastic/Myeloproliferative Neoplasm Overlap Syndrome, Myeloproliferative Neoplasm
- Trial name
- LIMBER (NCT04279847)
- Testing
- INCB057643, Ruxolitinib
- Where
- 48 sites in United States, Canada and 6 more
- Volunteers
- 140 people
- Sponsor
- Incyte Corporation
Acute Coronary Syndrome, Coronary Artery Disease
Duration of Dual Anti-Platelet Therapy (DUAL-ACS)
Despite substantial evidence supporting the use of dual anti-platelet therapy in patients with acute coronary syndrome, there remains major uncertainty regarding the optimal duration of therapy.
- Trial name
- NCT03252249
- Testing
- 3 months dual anti-platelet therapy, 12 months dual anti-platelet therapy
- Where
- 49 sites in New Zealand, United Kingdom
- Volunteers
- 5,094 people
- Sponsor
- University of Edinburgh
Follicular Lymphoma, Marginal Zone Lymphoma
A Pilot Study of Oral Vorinostat Plus Oral Eltrombopag Support in Patients With Lymphoma (VEIL)
Vorinostat is a drug (Histone Deacetylase Inhibitor [HDACi]) administered orally that has been approved in United States for the patients with cutaneous Tcell lymphoma (CTCL) who have progressive, persistent or recurrent disease…
- Conditions
- Follicular Lymphoma, Marginal Zone Lymphoma, Mantle Cell Lymphoma
- Trial name
- VEIL (NCT01500538)
- Testing
- Eltrombopag and Vorinostat
- Where
- Australia
- Volunteers
- 1 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Diabetes
Effect of Platelet Concentrate in Treatment of Diabetic Ulcers
Autologous platelet concentrate will enhance the rate of healing of chronic diabetic wounds
- Trial name
- NCT00215735
- Testing
- debridement, dressing, and APC
- Where
- 9 sites in United States
- Sponsor
- Harvest Technologies
Vocal Cord Paralysis
Administration of Platelet-rich Fibrin to Autologous Fat Tissue in Injection Laryngoplasty for Vocal Cord Paralysis
The study tries to see the effect of using a combination of platelet-rich fibrin (PRF) and autologous fat as a filler for injection laryngoplasty procedures to treat unilateral adductor vocal cord paralysis.
- Trial name
- NCT04839276
- Testing
- Injection Laryngoplasty with Platelet-rich Fibrin and Autologous Fat, Injection Laryngoplasty with Autologous Fat
- Where
- Indonesia
- Volunteers
- 19 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Cardiovascular Disease, Acute Coronary Syndrome
Evaluating Additional Platelet Inhibition in Patients With High Platelet Reactivity Undergoing Percutaneous Coronary Intervention
Patients admitted to hospital with chest pain due to reduced blood flow to heart muscle (diagnosis Acute Coronary Syndrome) can be treated with medication and an angioplasty ± stent procedure, which restores blood flow to the…
- Trial name
- APACS-HPR (NCT01339026)
- Testing
- Prasugrel, Plavix
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Immune Thrombocytopenia, Autoimmune Hemolytic Anemia
Biological Bank for the Patients Followed in a Constitutive Reference Center for Autoimmune Cytopenia
The Internal Medicine Department of Haut-Lévêque Hospital (Pr E LAZARO, Pr JL PELLEGRIN, Pr JF VIALLARD) was accredited in 2017 by the Ministry of Health as a Constitutive Reference Center for Autoimmune Cytopenia.
- Conditions
- Immune Thrombocytopenia, Autoimmune Hemolytic Anemia, Autoimmune Neutropenia
- Trial name
- BIOCAI (NCT04005638)
- Testing
- blood sample, urine sample
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bordeaux
HIV Infections, Cytopenias
A Phase I, Open Label Trial to Evaluate the Safety, Tolerance and Biological Effects of SDZ ILE-964 (Recombinant Human Interleukin-3, RhIL-3) in HIV Infected Patients With Cytopenia
To determine the safety, tolerability and maximum tolerated dose of SDZ ILE 964 administered by daily subcutaneous injections in patients infected with human immunodeficiency virus (HIV) who have cytopenias (low blood cell…
- Trial name
- NCT00002258
- Testing
- Interleukin-3
- Where
- United States
- Sponsor
- Sandoz
Coronary Artery Disease
Clinical Significance of Platelet Reactivity on Clopidogrel During Off-pump Coronary Artery Bypass
Objective: To evaluate the early and late prognoses of patients according to platelet reactivity after clopidogrel administration and determine whether the measurement of platelet inhibition predicted 1-year clinical outcomes…
- Trial name
- NCT01959191
- Testing
- Dual antiplatelet therapy including aspirin and clopidogrel after off-pump coronary bypass surgery
- Where
- South Korea
- Volunteers
- 859 people
- Sponsor
- Yonsei University
Bone Marrow Diseases, Lymphoma
Thromboelastography, Platelet Function and Platelet Recovery in Haemato-oncologic Patients With Thrombocytopenia
This is a prospective observational clinical study to characterise abnormalities of thromboelastography (TEG) parameters in patients with chemotherapy-induced thrombocytopenia.
- Trial name
- NCT01928017
- Where
- Norway
- Volunteers
- 13 people
- Sponsor
- University of Bergen
Hematologic Malignancies, Hypoproliferative Thrombocytopenia
Efficacy of Mirasol-treated Apheresis Platelets in Patients With Hypoproliferative Thrombocytopenia
This is a prospective, multi-center, controlled, randomized, non-inferiority study to evaluate the clinical effectiveness of Conventional versus Mirasol-treated apheresis platelets in subjects with hypoproliferative…
- Trial name
- MIPLATE (NCT02964325)
- Testing
- Mirasol platelets (MIR PLTs), Reference platelets (REF PLTs)
- Where
- 10 sites in United States
- Volunteers
- 422 people
- Sponsor
- Terumo BCTbio
Immune Thrombocytopenia (ITP)
A Study of Pirtobrutinib in Participants With Immune Thrombocytopenia
The purpose of the phase 1 part of this study was to evaluate how well pirtobrutinib is tolerated and what side effects may occur.
- Trial name
- NCT06721013
- Testing
- Pirtobrutinib
- Where
- 43 sites in United States, China and 8 more
- Volunteers
- 68 people
- Sponsor
- Eli Lilly and Company
Hemorrhage, Surgical, Hip Replacement, Total
Comparison of the Effects of Gelatine Versus Balanced Crystalloid Solution for Volume Therapy
The purpose of the study is to determine whether volume therapy with a solution of gelatine has negative impact on coagulation, platelet function, renal function in comparison with crystaloid solution (Ringerfundin).
- Conditions
- Hemorrhage, Surgical, Hip Replacement, Total, Thrombocytopathy
- Trial name
- Gelaring (NCT02461329)
- Testing
- Gelofusine® B. Braun, Ringerfundin ® B. Braun
- Volunteers
- 50 people
- Sponsor
- Kratochvil Milan, MD
Cardiovascular Diseases
Effect of Ingesting a Tomato Pomace Extract on Platelet Aggregation
This study evaluates the acute and longer term effects of a tomato pomace extract on platelet aggregation in health subjects.
- Trial name
- Tomasa (NCT02986165)
- Testing
- Low dose pomace extract, High dose pomace extract
- Where
- Chile
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Centro de Estudios en Alimentos Procesados
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