Clinical trials: Blood Platelet Disease
Osteoarthritis, Knee, Chondral Defect
Evaluation of Treatment of Osteoarthritis of the Knee in the Form of Chondromalacia of the Articular Cartilage Treated in the Arthroscopic Technique With the Use of:Autogenous Transplantation of Fragmented Adipose Tissue,PRP GF,Mesenchymal Cells,Hyaluronic Acid-low Molecular Weight and Cross-linked
The main objective of the research project is to evaluate the results of the treatment of chondromalacia of the cartilage in the knee joint with the use of: autogenous transplantation of fragmented adipose tissue taken from the…
- Conditions
- Osteoarthritis, Knee, Chondral Defect, Chondromalacia, Left Knee, Chondromalacia, Right Knee
- Trial name
- NCT07110402
- Testing
- Autogenous transplant of fragmented adipose tissue taken from abdominal integuments, PRP GF (platelet-rich plasma with growth factors), Mesenchymal cells centrifuged from bone marrow cells taken from the iliac crest
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- eMKa MED Medical Center
Immune Thrombocytopenia
Cognitive Dysfunction in Chronic and Persistent Immune Thrombocytopenia
Individuals with immune thrombocytopenia (ITP) frequently report difficulties with attention and memory. The main question this study seeks to answer is: Do patients with ITP have evidence of cognitive impairment as detected by a…
- Trial name
- COGFIT (NCT06817395)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Acute Ischemic Stroke
Clopidogrel Preventive Effect Based on CYP2C19 Genotype in Ischemic Stroke
The hypothesis of this study is that "the poor metabolizer or intermediate metabolizer of the cytochrome P450 2C19 genotype in patients with acute ischemic stroke is associated with increased risk of composite cardiovascular…
- Trial name
- NCT04072705
- Testing
- General principles of care and judgement of researcher
- Where
- 37 sites in South Korea
- Volunteers
- 2,927 people
- Sponsor
- Gangnam Severance Hospital
Thin Endometrium
Hysteroscopic Injections of Autologous Endometrial Cells and Platelet-rich Plasma in Patients With Thin Endometrium
The investigation is devoted to the study of the effect of the introduction of autologous platelet-rich plasma (PRP) on the thickness of the endometrium.
- Trial name
- NCT05455151
- Testing
- Conservative therapy, PRP injection, Injection of PRP after conservative therapy
- Where
- Russia
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Unstable Angina, NSTEMI
Dual Antiplatelet Therapy Tailored on the Extent of Platelet Inhibition
The purpose of this study is to evaluate the efficacy (reduction of major ischemic events at 6 and 12 months of follow-up) of a tailored clopidogrel therapy in patients with UA/NSTEMI undergoing PCI with stent implantation and…
- Trial name
- DANTE (NCT00774475)
- Testing
- comparison of different dosage of clopidogrel, doubled therapy
- Where
- Italy
- Volunteers
- 442 people
- Sponsor
- University of Florence
Acute Coronary Syndrome
Continuous Clopidogrel Dose Adjustment in Acute Coronary Syndrome Patients With High On-treatment Platelet Reactivity
The purpose of this study is to determine whether continuous clopidogrel dose adjustment targeted after platelet function testing improves outcomes during 12 months of follow-up in acute coronary syndrome patients treated with…
- Trial name
- NCT02096419
- Testing
- Clopidogrel dose adjustment
- Where
- Croatia
- Volunteers
- 87 people
- Sponsor
- University of Zagreb
Peridontal Disease, Furcation Defects
PRF Versus Emdogain for Class II Furcation Defects of Mandibular Molars
This study evaluated the regenerative potential of platelet-rich fibrin (PRF) compared with enamel matrix derivative (Emdogain®) in the surgical treatment of Class II (F2) furcation defects of mandibular molars.
- Trial name
- NCT07841301
- Testing
- Platelet rich fibrin, Emdogain
- Where
- Bulgaria
- Volunteers
- 21 people
- Sponsor
- Medical University of Sofia
Plantar Fasciitis
Comparing Steroid Injections and Platelet Rich Plasma Injections in the Treatment of Plantar Fasciitis
In cases of Plantar Fasciitis not responding to conservative management, minimally invasive techniques may be used. These include platelet rich plasma injections and corticosteroid injections.
- Trial name
- NCT01957631
- Testing
- Corticosteroid injection (Bupivacaine and Depo Medrol), Platelet rich plasma injection
- Where
- Bahrain
- Volunteers
- healthy volunteers welcome
- Sponsor
- King Hamad University Hospital, Bahrain
Ovarian Cancer
The SENTRY Study: Testing Whether Changes in Platelet RNA Enhance the Early Diagnosis of Ovarian Cancer
The purpose of the SENTRY (Stability Enhanced Transcriptional Analytics) Study is to test whether combining a unique analytical approach with changes in platelet RNA expression accurately diagnoses ovarian cancer.
- Trial name
- SENTRY (NCT06665945)
- Testing
- Platelet RNA expression
- Where
- United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University of Utah
Sickle Cell Disease
Study to Evaluate the Effect of Ticagrelor Versus Placebo in Reducing Vaso-Occlusive Crises Rate in Pediatric Patients With Sickle Cell Disease.
The purpose of this study is to compare the effect of ticagrelor vs placebo for the reduction of Vaso-Occlusive crises in paediatric patients with Sickle Cell Disease
- Trial name
- HESTIA5 (NCT04293172)
- Testing
- Brilinta
- Sponsor
- AstraZeneca
Lateral Epicondylitis
Treatment of Lateral Epicondylitis: Platelet Rich Plasma Versus Steroid Versus Saline Solution
We wish to address the efficacy and safety of Platelet Rich Plasma (blood platelets), a new treatment for lateral epicondylitis (tennis elbow) and compare this new treatment to either injection with steroid or saline solution.
- Trial name
- NCT01109446
- Testing
- Platelet Rich Plasma, Isotonic Saline Solutions, Triamcinolonacetonid
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Purpura, Thrombocytopenic, Idiopathic
Multiple Rising Does Study (Subcutaneous Doses) of BI 655064 in Male and Female Patients With Chronic Primary Immune Thrombocytopenic Purpura (ITP).
BI 655064 will be administered subcutaneously once weekly in patients with immune thrombocytopenic purpura (ITP) for up to 12 weeks.
- Trial name
- NCT02009761
- Testing
- BI 655064
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Boehringer Ingelheim
Knee Osteoarthritis
Knee Osteoarthritis and Rehabilitation
Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage that causes hypertrophic changes in bone. OA is a non-inflammatory progressive musculoskeletal disease and is one of the most common degenerative…
- Trial name
- NCT06432842
- Testing
- Laser Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Karabuk University
Osteoarthritis
The Combined Use of PRP with Lipoaspirate And/or Bone Marrow Aspirate in Osteoarthritis
To demonstrate the efficacy of the combined use of platelet-rich plasma (PRP) with lipoaspirate and/or bone marrow aspirate in osteoarthritis of major joints, and to compare the outcomes achieved using three combinations: PRP…
- Trial name
- NCT03984461
- Testing
- Autologous cell therapy
- Where
- Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Dr. Grant M. Pagdin
Coronary Artery Disease, DES
A Randomized Comparison of CLOpidogrel Monotherapy Versus Extended Dual-antiplatelet Therapy Beyond 12 Months After Implantation of Drug-eluting StEnts in High-risk Lesions or Patients; A-CLOSE Trial
We hypothesized that clopidogrel mono-therapy will not be inferior to the extended DAPT in terms of the occurrence of both ischemic and bleeding events, for lesions or patients at high risk for either ischemic or bleeding…
- Trial name
- NCT03947229
- Testing
- Clopidogrel mono-therapy, Dual-antiplatelet therapy
- Where
- South Korea
- Volunteers
- 3,200 people
- Sponsor
- Yonsei University
Platelet Aggregation, Kidney Transplant Rejection
Platelet Aggregation in the Diagnosis of Acute Graft Rejection
The study titled "Platelet Aggregation in the Diagnosis of Acute Graft Rejection" is a pilot observational study evaluating whether alterations in platelet function can serve as non-invasive markers of acute rejection in kidney…
- Trial name
- NCT07275541
- Where
- Slovakia
- Volunteers
- 60 people
- Sponsor
- University Hospital, Martin
Infertility, Female, Perimenopausal Disorder
Autologous Platelet Rich Plasma (PRP) Intra Ovarian Infusion in Perimenopausal Women
Autologous PRP intra ovarian infusion may improve ovarian response and women's hormonal profile and may promote folliculogenesis in perimenopausal women.
- Conditions
- Infertility, Female, Perimenopausal Disorder, Menstrual Cycle Abnormal
- Trial name
- PRP (NCT03951194)
- Testing
- Autologous Platelet Rich Plasma (PRP) intra ovarian infusion
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genesis Athens Clinic
Oculocerebrorenal Syndrome
Study of the Pathophysiological Mechanisms Involved in Bleeding Events
Lowe syndrome is associated with mutations in the OCRL1 gene, which encodes OCRL1, a phosphatidylinositol-4, 5-bisphosphate (PtdIns(4, 5)P (2))5-phosphatase.
- Trial name
- LOWE (NCT01314560)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hemodialysis, Chronic Renal Failure
Prasugrel Versus High Dose Clopidogrel in Clopidogrel Resistant Patients Undergoing Chronic Hemodialysis
Clopidogrel administration is essential in patients undergoing percutaneous coronary intervention, in patients with previous stroke, in patients under chronic hemodialysis via fistulae and in patients with chronic atrial…
- Trial name
- NCT01155765
- Testing
- Prasugrel, Clopidogrel
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- University of Patras
Androgenetic Alopecia
Efficacy of Stromal Vascular Fraction Versus Platelet Rich Plasma in Treatment of Androgenitic Alopecia
The goal of this randomized controlled clinical trial is to test the efficacy \& safety of stromal vascular fraction in treatment of AGA \& compare it to PRP The main questions it aims to answer are: efficacy \& safety of SVF for…
- Trial name
- NCT06558565
- Testing
- stromal vascular fraction or platelet rich plasma
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Kasr El Aini Hospital
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