Clinical trials: Blood Platelet Disease
Stable Coronary Artery Disease
A Study of the Antiplatelet Effects Comparing Ticagrelor (Ticag. - AZD6140) With Clopidogrel (Clop.) Responder and Non-responders
The purpose of this study is to see how Ticagrelor, a new oral reversible anti-platelet medication, affects platelets. Anti-platelet agents are medications that block the formation of blood clots by preventing the clumping of…
- Trial name
- RESPOND (NCT00642811)
- Testing
- Ticagrelor, Clopidogrel, Aspirin
- Where
- 10 sites in United States, Canada and 2 more
- Volunteers
- 98 people
- Sponsor
- AstraZeneca
Coronary Heart Disease
Intracoronary Stenting and Antithrombotic Regimen: ADjusting Antiplatelet Treatment in PatienTs Based on Platelet Function Testing
Clopidogrel low response is associated with a significantly higher risk for ischemic complications after percutaneous coronary intervention.
- Trial name
- ISAR ADAPT PF (NCT01456364)
- Testing
- Ticagrelor, Prasugrel
- Where
- 3 sites in Germany, Hungary
- Volunteers
- 70 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Infection, Implant Infection
A New Predictor Marker for Cochlear Implants Infection
Introduction: Surgical site infections associated with the cochlear implant can have serious consequences. Although advances in surgical techniques reduce these complications, it may be necessary to remove a device that works as…
- Conditions
- Infection, Implant Infection, Cochlear Hearing Loss
- Trial name
- NCT04120181
- Testing
- There is no intervention.
- Volunteers
- 13 people
- Sponsor
- Selcuk University
Myocardial Infarction
The Effects of Lovaza® in Acute Myocardial Infarction
This study will explore the safety and effectiveness of adding Lovaza® to the therapeutic program utilized internationally for the treatment of individuals with acute coronary syndromes.
- Trial name
- OmegaMI (NCT01155336)
- Testing
- Lovaza®
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Rochester
Coronary Artery Disease
Drug-Eluting Stenting Followed by Cilostazol tREAtment Reduces SErious Adverse Cardiac Events (DECREASE-PCI)
The DECREASE-PCI trial is a prospective, randomized, placebo controlled, double-blind, phase 4 study to evaluate efficacy and safety of triple anti-platelet therapy compared with dual antiplatelet therapy in patients treated with…
- Trial name
- NCT01346865
- Testing
- Cilostazol
- Where
- 12 sites in South Korea
- Volunteers
- 402 people
- Sponsor
- Seung-Jung Park
Thrombocytopenia
Platelet Augmentation Using C. Papaya Leaf Extract in Live Donor Liver Transplantation
This project is a pilot randomized controlled trial aimed at investigating the potential of Carica Papaya Leaf Extract, available in a marketed pill formulation, in increasing platelet counts in live donor liver transplant…
- Trial name
- NCT05360134
- Testing
- Carica Papaya Leaf Extract
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Non-Alcoholic Fatty Liver Disease
Lysosomal Acid Lipase Activity in Nonalcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease affecting a quarter of the world population. Pathological accumulation of fat, into the hepatocytes, is the first hit and is due to altered hepatic and…
- Trial name
- NAFLD LAL (NCT05419765)
- Testing
- Peripheral blood withdrawn
- Where
- Italy
- Volunteers
- 316 people
- Sponsor
- University of Roma La Sapienza
Extracorporeal Circulation; Complications, Coagulation Disorder
Impact of Cardiac Surgery With a Minimal Invasive Extracorporeal Circuit οn Coagulation: Data From Point of Care Devices
This study includes patients undergoing elective cardiac surgery on MiECC. Coagulation status is assessed with ROTEM (TEM International GmbH, Munich, Germany) and Platelet function with impedance aggregometry using the…
- Conditions
- Extracorporeal Circulation; Complications, Coagulation Disorder, Extracorporeal Circulation of Blood; Thrombocytopenia
- Trial name
- NCT04159064
- Testing
- Thromboelastometry, Impedance Aggregometry
- Where
- Greece
- Volunteers
- 57 people
- Sponsor
- AHEPA University Hospital
Liver Cirrhosis
Effects of Platelet Mimicking Nanoparticles in Patients With Cirrhosis
Haemostasis of cirrhotic patients is disturbed at different levels: primary haemostasis, coagulation and fibrinolysis, leading to a new haemostatic balance.
- Trial name
- HEMCITAP (NCT06050993)
- Testing
- Additional blood sampling at the same time and in addition of samplings already done for the patient's standard of care.
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thrombocythemia, Hemorrhagic
A Study of Anagrelide and Hydroxyurea in High-Risk Essential Thrombocythemia Patients
Essential thrombocythaemia is a disorder of bone marrow, which causes too many platelets to be produced. Platelets are small cells carried around in the blood, which help form blood clots.
- Trial name
- NCT00202644
- Testing
- Anagrelide, Hydroxyurea
- Where
- 15 sites in Bulgaria, France and 4 more
- Volunteers
- 150 people
- Sponsor
- Shire
Thrombocytopenia
Mirasol-Treated Platelets - (Pathogen Reduction Extended Storage Study)
The PRESS trial is a single-center, two-part, randomized cross-over pilot study in Copenhagen that will evaluate 1) the safety and performance of Mirasol-treated and untreated platelet products stored for 2-4 days and for 7-days…
- Trial name
- PRESS (NCT01368211)
- Testing
- 2-4-day-old Mirasol-treated Platelets Transfusion, 2-4-day-old Untreated Platelets Transfusion
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Terumo BCTbio
Pulp Necrosis, Immature Permanent Teeth
PRF and CGF Scaffolds With EDTA in Regeneration
This study evaluated the regenerative outcomes of immature permanent teeth with necrotic pulps treated using three scaffold types-blood clot, platelet-rich fibrin (PRF), and concentrated growth factor (CGF)-combined with either…
- Conditions
- Pulp Necrosis, Immature Permanent Teeth, Open Apex, Periapical Periodontitis
- Trial name
- RET-EDTA-CGF (NCT07265804)
- Testing
- Blood Clot + 5% EDTA, Blood Clot + 17% EDTA, PRF + 5% EDTA
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Thrombotic Thrombocytopenic Purpura
Study of Cyclosporine or Corticosteroids as an Adjunct to Plasma Exchange in Thrombotic Thrombocytopenic Purpura (TTP)
This research involves the use of immune base therapy as an adjunct to plasma exchange, the present standard of care for thrombotic thrombocytopenic purpura (TTP). Funding source -FDA OOPD
- Trial name
- NCT00713193
- Testing
- Cyclosporine, Prednisone
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Ohio State University
Malocclusion, Angle Class II, Division 1
Efficacy of Injectable Platelet Rich Fibrin (i-PRF) in Enhancing Bone Quality
Twenty patients need therapeutic extraction of the maxillary first premolars with subsequent retraction of the maxillary canines, will be divided randomly into two groups, and will randomly assigned to one side of the maxillary…
- Trial name
- NCT03399760
- Testing
- i-PRF, canine retraction
- Where
- Syria
- Volunteers
- 20 people
- Sponsor
- Damascus University
Thrombotic Thrombocytopenic Purpura
Observational Study of the Use of octaplasLG®.
This observational study enrolls patients who have received at least one infusion of octaplasLG®. OctaplasLG® will be administered standard of care and observation occurs during the treatment and 24 hours after the end of…
- Trial name
- NCT03369314
- Testing
- octaplasLG®
- Where
- 14 sites in France
- Volunteers
- 263 people
- Sponsor
- Octapharma
Coronary Artery Disease
The Bochum Optimizing Clopidogrel-Aspirin Therapy and MORTality Study (BOCLA-Mort)
Comparing standard treatment versus optimized antiplatelet therapy and outcomes measures.
- Trial name
- BOCLA-Mort (NCT01796691)
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Ruhr University of Bochum
Hiatal Hernia Large, Reflux, Gastroesophageal
Platelet Rich Plasma in Hiatal Hernia Repair
Rationale: Gastroesophageal reflux disease (GERD) is a common disease caused by a dysfunctional lower esophageal sphincter and an abnormal esophageal hiatus or hiatal hernia.
- Trial name
- PPR-HHR (NCT05023174)
- Testing
- Hiatal Hernia Repair with Platelet Rich Plasma, Hiatal Hernia Repair without Platelet Rich Plasma
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Southern California
Fabry Disease
Lipidomics and Functional Analyses of Platelets in Fabry Disease
This study aims to evaluate whether platelets are biochemically and functionally altered in Fabry disease (FD) and therefore possibly implicated in FD manifestations such as cerebrovascular events.
- Trial name
- NCT02649660
- Where
- 2 sites in Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Spital Linth
Corticosteroid-resistant or Relapsed ITP
A Study of Switching Avatrombopag and Rh-TPO in ITP
Thrombopoietin receptor agonists (TPO-RAs) represent a highly effective and well-tolerated second-line ITP treatment that provides excellent responses.If there is cross-resistance between 2 drugs for the treatment of adult ITP is…
- Trial name
- NCT04913597
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Diminished Ovarian Reserve, Premature Ovarian Insufficiency
Autologous Platelet-rich Plasma (PRP) Infusion to Improve Outcomes in Women With Ovarian Insufficiency: a Pilot Study
The investigators propose a pilot study to determine if autologous platelet-rich plasma (PRP) improves ovarian reserves and In-vitro fertilisation (IVF) outcomes in women with diminished ovarian reserve / premature ovarian…
- Conditions
- Diminished Ovarian Reserve, Premature Ovarian Insufficiency, Fertility Issues, IVF
- Trial name
- NCT05385848
- Testing
- Autologous Platelet-rich Plasma (PRP) Injection
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- KK Women's and Children's Hospital
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