Clinical trials: Blood Platelets
Cardiac Surgical Procedures, Cardiopulmonary Bypass
Sequestration of Platelets Prior to Bypass Reduces Bleeding After Cardiac Surgery
Excessive bleeding is common after cardiac surgery. This may result in patients receiving a blood transfusion or suffering the life-threatening complication of cardiac tamponade.
- Conditions
- Cardiac Surgical Procedures, Cardiopulmonary Bypass, Blood Platelet Disorders, Blood Coagulation Disorders
- Trial name
- NCT00359398
- Testing
- Platelet rich plasma sequestration
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Immune Thrombocytopenia (ITP), Treatment
An Open, Exploratory Clinical Study of CM336 in the Treatment of Immune Thrombocytopenia
To evaluate the efficacy and safety of CM336 in the treatment of refractory adult primary immune thrombocytopenia
- Trial name
- NCT06799611
- Testing
- CM336 Injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Chronic Myeloproliferative Disorders, Leukemia
Combination Chemotherapy Followed By Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Severe Aplastic Anemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Umbilical cord blood transplantation may be able to replace cells destroyed by chemotherapy.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00054236
- Testing
- anti-thymocyte globulin, filgrastim, cyclophosphamide
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Case Comprehensive Cancer Center
Arterial Occlusive Diseases, Coronary Artery Disease
Safety of PZ-128 in Subjects Undergoing Non-Emergent Percutaneous Coronary Intervention
The object of the study is to determine whether different doses of PZ-128, when added to standard medical care in persons undergoing cardiac catheterization/percutaneous coronary intervention, will increase the risk of bleeding.
- Conditions
- Arterial Occlusive Diseases, Coronary Artery Disease, Coronary Disease, Arteriosclerosis
- Trial name
- TRIP-PCI (NCT02561000)
- Testing
- PZ-128
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Tufts Medical Center
Hematological Malignancies, Thrombocytopenia
PRevention Of BLeeding in hEmatological Malignancies With Antifibrinolytic (Epsilon Aminocaproic Acid)
STUDY BACKGROUND AND PURPOSE: Patients with hematological malignancies (blood-related cancers) often develop thrombocytopenia (low platelet count), which can be made worse by cancer treatment.
- Trial name
- PROBLEMA (NCT02074436)
- Testing
- EACA, Platelet transfusion
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Emory University
VWD - Von Willebrand's Disease
The Severe Von Willebrand Disease (sVWD) Patient Registry
A web-based registry will be created by the sponsor, VWD Connect Foundation (VCF), to collect data on patients with severe Von Willebrand Disease (sVWD).
- Trial name
- NCT05437536
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- VWD Connect Foundation
Polycythemia Vera, ET (Essential Thrombocythemia)
MPN PROGRESSion Registry: Observational Study Tracking Symptoms, Treatments, and Disease Progression in People With Myeloproliferative Neoplasms (MPNs)
The MPN PROGRESSion Registry is a multi-year, observational research study designed to improve understanding of myeloproliferative neoplasms (MPNs)-a group of rare, chronic blood cancers that include polycythemia vera (PV)…
- Conditions
- Polycythemia Vera, ET (Essential Thrombocythemia), Polycythemia Vera (PV), Essential Thrombocythemia (ET)
- Trial name
- NCT07362225
- Where
- 2 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- MPN Research Foundation
Idiopathic Thrombocytopenic Purpura
Multicentre, Randomised Phase III Study of the Efficacy and Safety of Hetrombopag Olamine in Idiopathic Thrombocytopenic Purpura (ITP) Patient
A multicentre, randomised, double-blind,4-stages phase III study enrolled 414 patients with chronic, previously treated ITP. Dosage could be adjusted (2.5~.75 mg/day) to maintain platelet counts 50~250×109/L
- Trial name
- NCT03222843
- Testing
- Hetrombopag Olamine
- Where
- 3 sites in China
- Volunteers
- 424 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Poor Ovarian Response, Ovarian Reactivation
Proteomic and Biological Characterisation of Plasma for the Study of Changes Following Ovarian Reactivation Treatment
The samples used in PRGF treatments owe their effectiveness to the handling, concentration, and preservation of their components, which explains why samples obtained with different platelet-rich plasma preparation systems may…
- Trial name
- NCT07376460
- Testing
- Platelet Rich Plasma + BMDSCs mobilization
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI Alicante
Immune Thrombocytopenia
Low-dose Baricitinib Plus High-dose Dexamethasone for Patients With Newly Diagnosed Immune Thrombocytopenia
A randomized, open-label, multicenter, phase 2 trial to compare the efficacy and safety of baricitinib plus high-dose dexamethasone compared to high-dose dexamethasone monotherapy for the first-line treatment of adults with…
- Trial name
- NCT05932524
- Testing
- Baricitinib 2 MG, Dexamethasone
- Where
- 10 sites in China
- Volunteers
- 132 people
- Sponsor
- Peking University People's Hospital
Pulp Necrosis, Immature Permanent Teeth
PRF and CGF Scaffolds With EDTA in Regeneration
This study evaluated the regenerative outcomes of immature permanent teeth with necrotic pulps treated using three scaffold types-blood clot, platelet-rich fibrin (PRF), and concentrated growth factor (CGF)-combined with either…
- Conditions
- Pulp Necrosis, Immature Permanent Teeth, Open Apex, Periapical Periodontitis
- Trial name
- RET-EDTA-CGF (NCT07265804)
- Testing
- Blood Clot + 5% EDTA, Blood Clot + 17% EDTA, PRF + 5% EDTA
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Schizophrenia
ECT Schizophrenia Serotonin Study
We suggest to investigate serotonin uptake in schizophrenia patients receiving ECT
- Trial name
- NCT00278668
- Volunteers
- 15 people
- Sponsor
- Sha'ar Menashe Mental Health Center
Immune Thrombocytopenic Purpura
Efficacy of Immunomudulatory Therapy With All-trans Retinoid Acid for Adults With Chronic Immune Thrombocytopenia
The purpose of this study is to determine whether All-trans retinoic acid (ATRA) are effective in the treatment of refractory idiopathic thrombocytopenic purpura (RITP).
- Trial name
- ITP (NCT01668615)
- Testing
- all-trans-retinoid acid
- Where
- China
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Suzhou Medical College
aHUS, Atypical Hemolytic Uremic Syndrome
Post-Marketing Clinical Study of Ravulizumab in Participants With Clinical aHUS
The primary objective of this study is to assess the platelet count response to ravulizumab in participants clinically diagnosed as atypical hemolytic uremic syndrome (aHUS).
- Trial name
- NCT07308574
- Testing
- Ravulizumab
- Where
- 12 sites in Japan
- Volunteers
- 20 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Autoimmune Thrombocytopenia, Warm Autoimmune Haemolytic Anaemia
IASO-782 in Autoimmune Hematological Diseases
This study is a randomized, double-blinded, and placebo-controlled phase Ia clinical study in subjects with autoimmune hematological diseases.
- Trial name
- NCT06534021
- Testing
- IASO-782 injection
- Where
- 2 sites in China
- Volunteers
- 16 people
- Sponsor
- Shanghai IASO Biotechnology Co., Ltd
ITP - Immune Thrombocytopenia
Avatrombopag Combined With All-trans Retinoic Acid in the Treatment of Primary Immune Thrombocytopenia
This study is an open label, randomized controlled, multicenter clinical trial aimed at comparing the efficacy and safety of the combination of atorvastatin and all trans retinoic acid with atorvastatin alone in the treatment of…
- Trial name
- NCT07278908
- Testing
- Avatrombopag+All trans retinoic acid, Avatrombopag
- Volunteers
- 248 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Purpura, Thrombotic Thrombocytopenic, TTP
A Pilot Study of N-acetylcysteine in Thrombotic Thrombocytopenia Purpura
In this study, the investigators want to determine if N-acetylcysteine(NAC), given intravenously, will decrease complications in patients with Thrombotic Thrombocytopenia Purpura (TTP) who are receiving treatment with therapeutic…
- Trial name
- NACinTTP (NCT01808521)
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Bloodworks
Immune Thrombocytopenic Purpura
A Trial of Eltrombopag or Intravenous Immune Globulin Before Surgery for Immune Thrombocytopenia Patients
This is a study to investigate if eltrombopag can be used instead of Intravenous Immune Globulin (IVIG) in patients with ITP, to adequately raise their platelet count when they undergo minor or major surgery.
- Trial name
- NCT01621204
- Testing
- Eltrombopag, IVIG infusion
- Where
- 10 sites in Canada, Netherlands
- Volunteers
- 74 people
- Sponsor
- McMaster University
Von Willebrand Disease
Collection of Blood in Normal Subjects and Subjects With Von Willebrand Disease (VWD)
Von Willebrand disease is an inherited bleeding disorder that impacts the blood's ability to clot properly. Von Willebrand disease is cause by the lack or not working substance in the blood known as Von Willebrand factor.
- Trial name
- NCT00630448
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Thrombotic Microangiopathies
Study of Patients With Thrombotic Microangiopathy Associated With Mitomycin C, Treated or Not With Eculizumab
Thrombotic microangiopathies (TMA) are defined as a triad combining mechanical hemolytic anemia, peripheral thrombocytopenia and ischemic organ damage.
- Trial name
- m-TMA (NCT06098378)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France