Clinical trials: Blood Pressure Reduction
Cardiometabolic Syndrome, Physical Inactivity
Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention
Lower attainment of cardiovascular health (CVH), indicated by the American Heart Association's Life's Simple 7 (LS7; physical activity, diet, cholesterol, blood pressure, body mass index, smoking, glycemia) and Life's Essential 8…
- Conditions
- Cardiometabolic Syndrome, Physical Inactivity, Hypertension, Type 2 Diabetes
- Trial name
- NCT06055036
- Testing
- Black Impact Intervention
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- Ohio State University
Cardiovascular Diseases, Heart Diseases
Effects of Behavioral Stress Reduction Programs on Blood Pressure in African American Youth
This study will examine the effects of two behavioral stress reduction programs, mindfulness meditation (MM) and the lifeskills program (LP), and a health education control program (CTL) on blood pressure.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00241813
- Testing
- Mindfulness Meditation (MM) Program, Health Education Control Program (CTL), Lifeskills Program (LP)
- Where
- United States
- Volunteers
- 283 people
- Sponsor
- Medical University of South Carolina
Hypertension, Dyslipidemias
Reduction Efficacy of OLOMAX for Blood Pressure and Low-density Lipoprotein Cholesterol in Hypertensive Patients With Dyslipidemia
This study is a large-scale, prospective, multi-center, and non-interventional observation study to observe blood pressure and blood lipid changes and safety during administration of olomax tablets for 24 weeks in hypertensive…
- Trial name
- NCT05660135
- Testing
- Olmesartan Medoxomil/ Amlodipine Besylate/ Rosuvastatin Ca
- Where
- South Korea
- Volunteers
- 4,000 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Blood Pressure
Magnesium Supplementation and Blood Pressure Reduction
This double-blind, placebo-controlled randomized clinical trial will test whether a magnesium glycinate supplement (480 mg/day) taken for 12 weeks lowers blood pressure.
- Trial name
- NCT03688503
- Testing
- magnesium glycinate supplement
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Chronic Kidney Disease, Proteinuria
Oral Calcitriol for Reduction of Mild Proteinuria in Patients With CKD
The safety and efficacy of Caltriol on mild proteinuria (<1.0g/d) reduction in CKD patients.
- Trial name
- NCT01820832
- Testing
- Calcitriol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
Hypertension
Valsartan Intensified Primary Care Reduction of Blood Pressure Study
This study will assess the efficacy of an intensive blood pressure management strategy compared to usual care in a primary care (general practice) setting.
- Trial name
- VIPER-BP (NCT00902304)
- Testing
- Valsartan and hydrochlorothiazide (HCTZ) - monotherapy, Valsartan and amlodipine, Usual care
- Where
- 3 sites in United States, Australia
- Volunteers
- 2,337 people
- Sponsor
- Novartis Pharmaceuticals
Insomnia, Posttraumatic Stress Disorder
Blood Pressure, Heart Rate Variability & Sleep in Veterans With PTSD
Sleep disturbance and posttraumatic stress disorder (PTSD) are common conditions in returning Veterans, and both conditions are known to increase the risk of cardiovascular disease.
- Conditions
- Insomnia, Posttraumatic Stress Disorder, Hypertension, Cardiovascular Disease
- Trial name
- NCT01920451
- Testing
- Cognitive-Behavioral Therapy for Insomnia (CBTI)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Durham VA Medical Center
Hypertension
Antihypertensive Efficacy and Safety of Candesartan/HCT 32/12.5 and 32/25 mg in Comparison With Candesartan 32 mg
In this study it is intended to compare the blood pressure lowering effect of the combination of candesartan cilexetil (candesartan) 32 mg and hydrochlorothiazide (HCT) 25 mg and the combination of candesartan 32 mg and HCT 12.5…
- Trial name
- NCT00383929
- Testing
- Candesartan cilexetil, Hydrochlorothiazide
- Where
- 132 sites in Denmark, Estonia and 9 more
- Volunteers
- 1,979 people
- Sponsor
- AstraZeneca
Obesity, Overweight
Effect of Calcium/Vitamin D Supplementation on Body Weight and Fat Loss.
The aim of this study was to assess the effect of calcium/vitamin D supplementation (Caltrate 600 +D®) on body weight loss during a weight-reducing program
- Trial name
- NCT00353054
- Testing
- Caltrate® 600 + D, Weight loss intervention
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Laval University
Hypertension
Antihypertensive Efficacy and Safety of Candesartan/HCT 32/25 mg in Comparison With Individual Components and Placebo
The aim is to compare the blood pressure lowering effect of the combination of candesartan cilexetil (candesartan) 32 mg and hydrochlorothiazide (HCT) 25 mg to that of candesartan 32 mg alone, HCT 25 mg alone and placebo in…
- Trial name
- NCT00434967
- Testing
- Candesartan cilexetil, Hydrochlorothiazide, Candesartan/HCT 32/25 mg
- Where
- 27 sites in Belgium, Latvia and 4 more
- Volunteers
- 2,207 people
- Sponsor
- AstraZeneca
Hypertension
VALID: Study to Compare the Reduction of Predialysis Systolic Blood Pressure With Valsartan Compared to Irbesartan in Patients With Mild to Moderate Hypertension on Long-term Hemodialysis
The purpose of the study is to compare the efficacy, safety and tolerability of valsartan 80 mg (with a starting dose of 40 mg) to irbesartan 150 mg (with a starting dose of 75 mg) in patients on long-term haemodialysis with mild…
- Trial name
- NCT00171080
- Testing
- valsartan, irbesartan
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 86 people
- Sponsor
- Novartis
Obesity, Hypertension
A Study of the Effects of Eplerenone and Amlodipine on Blood Pressure and Basal Metabolic Rate in Obese Hypertensives
Obesity and hypertension are independent risks for congestive heart failure (CHF) and chronic kidney disease. In obesity induced hypertension, the most common cause of human essential hypertension, the potential importance of…
- Trial name
- NCT00825188
- Testing
- eplerenone, amlodipine, eplerenone, amlodipine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Mississippi Medical Center
Mild Hypertension, Air Pollution Exposure
Reducing Air Pollution to Lower Blood Pressure
Fine particulate matter <2.5 μm (PM2.5) air pollution is the fifth leading risk factor for global mortality. Mitigating the clinically significant blood pressure (BP) elevation from air pollution by reducing PM2.5 exposure will…
- Trial name
- AIR PRESSURE (NCT04908917)
- Testing
- Portable Air Cleaner with a HEPA Filter, Portable Air Cleaner without a HEPA Filter
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Hypertension (HTN), Food Insecurity
Navigating Hypertension and Food Insecurity
This multi-site randomized controlled trial uses a community-based approach to evaluate a Food as Medicine program for Native Hawaiian and Pacific Islander (NHPI) adults in Hawaii who have high blood pressure and difficulty…
- Trial name
- NCT07544836
- Testing
- Produce Prescription Only, Community Health Worker navigated Produce Prescription
- Where
- 3 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Hawaii
Cardiovascular Disease
High Cardiovascular Risk Management and Salt Reduction in Rural Villages in China
Cardiovascular disease is the leading cause of death in China. At the village level, strategies for the control of cardiovascular disease are mostly absent.
- Trial name
- NCT01259700
- Testing
- High-risk patient standardized management package, Community based salt reduction program
- Where
- 5 sites in China
- Volunteers
- 120 people
- Sponsor
- The George Institute for Global Health, China
Hypertension
Evaluating Mechanisms of Blood Pressure Reduction Using Meditation in Hypertensive African Americans
High blood pressure is a common health problem among people in the United States. This study will compare the effectiveness of a meditation program versus a health education program at decreasing stress and lowering blood…
- Trial name
- HMEC (NCT00681200)
- Testing
- Enhanced health education, Transcendental Meditation program
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Maharishi International University
Kidney Failure, Acute
Mean Arterial Pressure (MAP) and Renal Perfusion: Evaluation of Critically Ill Patients With Normal Creatinine or Reduced Renal Function
The purpose of this study is to evaluate the renal perfusion depending on the MAP.
- Trial name
- NCT00117416
- Testing
- controlling the MAP
- Where
- Belgium
- Sponsor
- University Hospital, Ghent
Hypertension, Prehypertension
Mindfulness-Based Blood Pressure Reduction: Stage 2a RCT
The primary aim is to evaluate impacts of a behavioral intervention called "Mindfulness-Based Blood Pressure Reduction" (MB-BP) vs.
- Trial name
- MB-BP (NCT03256890)
- Testing
- MB-BP Intervention, Enhanced Usual Care Control
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Brown University
Hypotension, Blood Pressure, Low
The Status of Autonomic Tone Before Tourniquet Deflation During Total Knee Replacement
This study evaluates the influences of the status of sympathovagal balance before tourniquet deflation on a decrease in arterial blood pressure following the deflation during total knee replacement arthroplasty
- Trial name
- NCT03408301
- Testing
- Tourniquet deflation
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Daegu Catholic University Medical Center
Blood Pressure, Hypertension
Effect of Dietary Salt Reduction on Blood Pressure in Kidney Transplant Recipients
Cardiovascular morbidity and mortality is increased in kidney transplant patients. High blood pressure (BP) contributes significantly to this risk and is also associated with shortened allograft survival.
- Conditions
- Blood Pressure, Hypertension, Kidney Transplant; Complications, Dietary Modification
- Trial name
- NCT03373500
- Testing
- Dietary salt reduction
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- Epsom and St Helier University Hospitals NHS Trust