Clinical trials: Blood Pressures
Sedentary Behavior, Cardiometabolic Risk Factors
Breaking up Prolonged Sedentary Behavior to Improve Cardiometabolic Health
The purpose of this Phase 1 research study is to answer two questions: (1) How frequent should periods of prolonged sedentary time be interrupted? and (2) What is the appropriate duration or length of time of these breaks in…
- Conditions
- Sedentary Behavior, Cardiometabolic Risk Factors, Blood Pressure, Glucose
- Trial name
- NCT05353322
- Testing
- Sedentary Break (Walking) Condition, Sitting (Control) Condition, Controlled Diet
- Where
- United States
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Columbia University
Pregnancy, Pregnancy - Prenatal Testing
Effect of Isometric Handgrip Exercise on Blood Pressure in Pregnant Women
Hypertension during pregnancy is a major public health concern, increasing the risk of cardiovascular complications for both the mother and the fetus.
- Conditions
- Pregnancy, Pregnancy - Prenatal Testing, Hypertension (HTN)
- Trial name
- GRIP4HEALTH (NCT07607795)
- Testing
- Isometric Handgrip Exercise, Control Rest
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Poitiers
Primary Hypertension
Multi-Omics to Predict the Blood Pressure Response to Antihypertensives
The goal of this clinical trial is to develop biomarkers composed of multiple OMICs (MOMICs) for prediction of blood pressure response to antihypertensive drugs in the treatment of primary hypertension.
- Trial name
- HT-PREDICT (NCT05917275)
- Testing
- Amlodipine, Olmesartan, Hydrochlorothiazide
- Where
- Netherlands
- Volunteers
- 96 people
- Sponsor
- Radboud University Medical Center
Traumatic Brain Injury, Cerebral Hemorrhage
TCD Detection of Ophthalmic Artery Blood Flow Velocity Prediction Feasibility Study of Intracranial Pressure
Increased intracranial pressure is a cause of disease progression in patients with brain disease, a common cause of poor prognosis.
- Conditions
- Traumatic Brain Injury, Cerebral Hemorrhage, Increased Intracranial Pressure
- Trial name
- NCT02240394
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Aneurysmal Subarachnoid Hemorrhage, Aneurysmal Subarachnoid Hemorrhage (aSAH)
Early Blood Pressure Intervention After Coiling or Clipping for Subarachnoid Hemorrhage
The goal of this clinical trial is to learn if elevating postoperative blood pressure works to improve prognosis in aneurysmal subarachnoid hemorrhage (aSAH) patients.
- Trial name
- EPIC-SAH (NCT07149922)
- Testing
- Blood pressure was regulated within the normal target management range, Blood pressure was regulated within the elevated target management range
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Beijing Tiantan Hospital
Hypertension (HTN)
Finerenone and Empagliflozin Combination in Obesity With Hypertension: A 12-Week Prospective, Parallel-design, Double-blind, Randomized, Placebo-controlled Trial
The EFFORT Study (Empagliflozin and Finerenone Combination in Obesity with Hypertension) is a 12-week, randomized, double-blind, placebo-controlled trial that aims to test whether combining empagliflozin (10 mg/day) with…
- Trial name
- NCT07678151
- Testing
- Empagliflozin and Finerenone
- Where
- 2 sites in China
- Volunteers
- 260 people
- Sponsor
- Heart Health Research Center
Type 1 Diabetes Mellitus
Detection of Vascular Injury in Diabetes Through Eye and Nailfold Data (DIVIDEND) - A Pilot Study
This project aimed to explore novel methods of detecting small blood vessel disease in a paediatric population with type 1 diabetes mellitus.
- Trial name
- DIVIDEND (NCT01279928)
- Testing
- Video Nailfold Capillaroscopy, Ambulatory 24 hr Blood Pressure Monitoring, Fundoscopy of eyes
- Where
- Australia
- Volunteers
- 26 people
- Sponsor
- John Hunter Hospital
Vagus Nerve Stimulations
Acute Cardiovascular Effects of Transcutaneous Auricular Vagus Nerve Stimulation
Introduction Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, with arterial hypertension representing the most significant modifiable risk factor (Lim et al., 2012; Mills et al., 2020).
- Trial name
- NCT07501611
- Testing
- Active taVNS condition
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Anesthesia, Cerebral Blood Flow
Hypertension and Cerebrovascular Hemodynamics in General Anaesthesia
During anesthesia, blood pressure-raising medications are often required to achieve an adequate blood pressure level. However, there is limited knowledge about what constitutes an adequate blood pressure to ensure sufficient…
- Conditions
- Anesthesia, Cerebral Blood Flow, Regional Cerebral Oxygen Saturation, Blood Pressure
- Trial name
- NCT06855407
- Testing
- Blood pressure elevation
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Umeå University
Blood Pressure, Blood Pressure Measurement
NIBP Cuff Comparison Study
The purpose of the study is to compare NIBP cuff materials and their effect on the measurement results.
- Trial name
- NCT07024472
- Where
- 2 sites in Finland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Obesity, Bariatric Surgery
Impact of Weight Loss After a Bypass Surgery on Renal Hemodynamic Under Stress Conditions
The sympathetic nervous (SNS) and the renin angiotensin aldosterone system (RAS) have a direct impact on renal hemodynamic, hormonal secretion and vasoactive peptide.
- Conditions
- Obesity, Bariatric Surgery, Blood Pressure
- Trial name
- OBBYSS (NCT02218112)
- Testing
- bariatric surgery (gastric bypass)
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
End Stage Renal Disease
Conventional Hemodialysis vs. Short Daily Hemodialysis (6 Days / Week) and Mechanisms of Blood Pressure Control
More than 80% of patients with end stage renal disease have hypertension; 70% of whom are poorly controlled using conventional Hemodialysis therapy.
- Trial name
- NCT00759967
- Testing
- Microneurography, Bioimpedance testing
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Ottawa Hospital Research Institute
High Blood Pressure, Hypercholesterolemia
Cardiovascular Risk Factors And Intensive Dietary Counselling
The Intensive Dietary Counselling (IDC) intervention is a prevention and health promotion activity. It is being implemented by the Andalusian Health Service to reinforce basic intervention advice on healthy diet and exercise.
- Conditions
- High Blood Pressure, Hypercholesterolemia, Tobacco Smoking
- Trial name
- NCT02173600
- Testing
- Group-level Intensive dietary Counselling, Individual-level Intensive Dietary Counselling
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Andalusian Regional Ministry of Health
Hypertension
The Acute Effect of Beetroot Juice in Normal and Hypertensive Subjects
Inorganic nitrate can be converted to nitrite and thence nitric oxide in humans. Nitric oxide is normally produced by the inner lining of blood vessels and helps keep blood vessels open and therefore blood pressure lower.
- Trial name
- NCT01236872
- Testing
- Beetroot juice, Water
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Queen Mary University of London
Postmenopausal Flushing, Cardiovascular Risk Factor
Hot Flash as a Marker of Cardiovascular Risk in Recent Postmenopause: Effects of Non-hormonal Treatments
Hot flashes, vasomotor symptoms that affect many postmenopausal women, are associated with cardiovascular disease and endothelial dysfunction.
- Conditions
- Postmenopausal Flushing, Cardiovascular Risk Factor, Endothelial Dysfunction
- Trial name
- NCT03149419
- Testing
- Paroxetine
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Cardiovascular Diseases, Hypertension
Patient-Physician Partnership to Improve High Blood Pressure Adherence
To test the efficacy of a patient-centered, culturally tailored education and activation intervention designed to improve adherence to medication and life style recommendations among adults with uncontrolled hypertension.
- Trial name
- NCT00123045
- Testing
- health education
- Volunteers
- 279 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Caffeine
The Effects of e+Shots Energy Beverage on Mental Energy
The aim of the research project is to determine the changes in motivation to perform mental and physical tasks, feelings of vigor and fatigue, mental task vigilance and fine motor function after consumption of a commercially…
- Trial name
- NCT03850275
- Testing
- Intervention/treatment
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Clarkson University
Hypertension
Telmisartan Compared to Losartan + Hydrochlorothiazide in Patients With Mild-to-moderate Essential Hypertension
The general aim and clinical objective of this trial is to determine the effect of telmisartan 80 mg compared to losartan 50 mg + HCTZ (Hydrochlorothiazide) 12.5 mg on reduction of blood pressure (BP) in patients with mild to…
- Trial name
- NCT02183701
- Testing
- Telmisartan, Losartan + Hydrochlorothiazide
- Volunteers
- 715 people
- Sponsor
- Boehringer Ingelheim
Diet, Hypertension
The Ready-to-Eat Meals for Cardiovascular Health Study
The proposed project explores the acceptability and health benefits of ready-to-eat (RTE) meals based on the Dietary Approaches to Stop Hypertension (DASH) eating plan.
- Conditions
- Diet, Hypertension, Cardiovascular Diseases, Blood Pressure
- Trial name
- REACH (NCT05472454)
- Testing
- Ready-to-eat meals
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington State University
Hypertension (HTN), Vascular Diseases
The BASIC-S Feasibility Study for Vascular Risk Reduction
Vascular risk factors drive stroke, heart disease, and dementia, but translating lifestyle guidelines into routine clinical care remains challenging.
- Conditions
- Hypertension (HTN), Vascular Diseases, Stroke, Dementia
- Trial name
- BASIC-S (NCT07755631)
- Testing
- BASIC-S Intervention, Standard / Usual Care
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Andrew Appleton
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