Clinical trials: Blood Stream Infection
Chronic Myeloproliferative Disorders, Infection
Antimicrobial Solution or Saline Solution in Maintaining Catheter Patency and Preventing Catheter-Related Blood Infections in Patients With Malignancies
RATIONALE: Antimicrobial solution comprising trimethoprim-sulfamethoxazole, edetate calcium disodium, and ethanol may help prevent blockages and infections from forming in patients with central venous access catheters or…
- Conditions
- Chronic Myeloproliferative Disorders, Infection, Leukemia, Lymphoma
- Trial name
- NCT01101412
- Testing
- Edetate Calcium Disodium, Ethanol, Trimethoprim-sulfamethoxazole
- Sponsor
- M.D. Anderson Cancer Center
Blood Stream Infection
Central and Peripheral Venous Catheters Associated Blood Stream Infection in ICU in Assiut University
Catheter related infections (CRIs) were found to be associated with several risk factors, including patient related risk factors such as age, gender, clinical status and catheter related risk factors such as the vascular access…
- Trial name
- NCT03379948
- Testing
- blood culture
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Central Line Associated Blood Stream Infections (CLABSI)
Machine Learning Prediction of Possible Central Line Associated Blood Stream Infections and Rate of Reduction
Prospective, multi-center, cluster-randomized trial of a hospital Infection Preventionist (IP)-led quality improvement study to provide clinical teams with just-in-time clinical education and reinforcement of existing best…
- Trial name
- CLABSI AI (NCT07108660)
- Testing
- Infection Preventionist Led Best Practices Reminders
- Where
- 19 sites in United States
- Volunteers
- 17,800 people
- Sponsor
- Swedish Medical Center
Central-line Associated Blood Stream Infections (CLABSI)
CLABSI Prevention With Tissue Adhesive
Our aim is to test the effect of tissue adhesive application at the Central-line exit-site on CLABSI rates in high-risk pediatric congenital heart disease patients.
- Trial name
- Cya-No-CLABSI (NCT05721677)
- Testing
- 2-octyl cyanoacrylate based topical skin adhesive
- Where
- Israel
- Volunteers
- 600 people
- Sponsor
- Rabin Medical Center
Blood Stream Infection, Gut Microbiota
Application of Nanopore Sequencing in Newly Diagnosed Acute Myeloid Leukemia Patients With Bloodstream Infection
Acute myeloid leukemia (AML) patients are prone to blood stream infection (BSI) due to bone marrow suppression, oral and gastrointestinal mucositis, endovascular tubes, and the application of a large number of broad-spectrum…
- Conditions
- Blood Stream Infection, Gut Microbiota, Acute Myeloid Leukemia
- Trial name
- NCT05016752
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Ventilator Associated Bacterial Pneumonia (VABP), Hospital Acquired Bacterial Pneumonia (HABP)
Safety, Pharmacokinetics and Efficacy of BV100 Plus Low Dose Polymyxin B Plus Ceftazidime/Avibactam, or Plus Cefiderocol in Patients With Pulmonary and Extrapulmonary Infections Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex
This Phase IIb study aims to evaluate the safety and efficacy of BV100 in combination with low dose polymyxin B plus ceftazidime/avibactam or cefiderocol in patients with suspected or confirmed CRABC infections.
- Conditions
- Ventilator Associated Bacterial Pneumonia (VABP), Hospital Acquired Bacterial Pneumonia (HABP), Blood Stream Infection, Meningitis, Bacterial
- Trial name
- RIV- CARE (NCT07431307)
- Testing
- BV100 with 50 mg polymyxin B plus ceftazidime/avibactam, BV100 with 50 mg polymyxin B plus cefiderocol, Best Available Therapy (BAT)
- Volunteers
- 120 people
- Sponsor
- BioVersys AG
Bacteremia, Sepsis
Epidemiology and Determinants of Outcomes of Hospital Acquired Blood Stream Infections in the Intensive Care
Eurobact II will investigate the mortality and morbidity of hospital-acquired blood stream infections in patients treated in intensive care units (ICU).
- Conditions
- Bacteremia, Sepsis, Hospital Acquired Condition, Resistance Bacterial
- Trial name
- EurobactII (NCT03937245)
- Where
- 2 sites in Australia, France
- Volunteers
- 3,058 people
- Sponsor
- Outcome Rea
Blood Stream Infections
Evaluation of MiSeq for Microbial Identification in Specimens
Background: Researchers are testing a new way to find out what causes infections in people in hospitals. Current techniques use chemical or biological tests on a person s samples.
- Trial name
- NCT02578875
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Catheter Related Blood Stream Infections
Clinical Trial With Catheter Locking TauroSept® (Taurolidine 2%) or Saline Solution 0,9%
The purpose of this study is to determine if TauroSept® taurolidine 2% is more efficient than saline solution 0.9% as a catheter lock solution in preventing catheter related blood stream infections in patients with home…
- Trial name
- NCT01826526
- Testing
- TauroSept®
- Where
- 7 sites in Denmark, Germany and 4 more
- Volunteers
- 105 people
- Sponsor
- Geert Wanten
Salmonella Septicemia, Salmonella Infections
IDIS Project Work Package 2: Establishing a Biobank at ITM and Collaborating Centres
The IDIS study aims to develop a new rapid diagnostic test for invasive salmonellosis using samples (blood, urine) collected from patients with fever and healthy controls at the Institute of Tropical Medicine (ITM) and…
- Conditions
- Salmonella Septicemia, Salmonella Infections, Fever, Blood Stream Infections
- Trial name
- IDIS (NCT02689193)
- Testing
- Blood sampling
- Where
- 3 sites in Belgium, Cambodia and 1 more
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
CLABSI - Central Line Associated Bloodstream Infection, Catheter-Related Blood Stream Infection
Study on the Reduction of Catheter-related Infections by Use of Self-disinfecting Venous and Arterial Access Caps
Observational study on the reduction of catheter-related Infections by use of self-disinfecting venous and arterial access caps (Curos caps ;3M, Saint Paul, MN, USA)
- Trial name
- STERILE (NCT04534348)
- Testing
- 70% isopropyl alcohol-impregnated catheter caps
- Where
- Germany
- Volunteers
- 598 people
- Sponsor
- University of Cologne
Catheter Related Infections, Short Bowel Syndrome
Trial of 70% Ethanol Versus Heparin to Reduce the Rate of Central Line Infections in Children With Short Bowel Syndrome
This study is designed to determine if the use of 70% ethanol lock solution in central lines decreases the rate of central line infections in children with short bowel syndrome.
- Trial name
- NCT01263574
- Testing
- 70% ethanol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Hepatitis B, Chronic
Entecavir Resistance-Associated Mutations in Chronic HBV Patients in Turkey (STREAM Study)
Chronic hepatitis B is a long-term viral infection that affects millions of people worldwide. Patients usually require lifelong antiviral treatment to control the virus and prevent liver damage.
- Trial name
- NCT07459426
- Testing
- Viral genetic material from blood samples using advanced sequencing technology
- Where
- 10 sites in Turkey (Türkiye)
- Volunteers
- 700 people
- Sponsor
- Yaşar Bayındır, MD
Bacteremia
Treatment Algorithm to Reduce the Use of Vancomycin in Adults With Blood Stream Infection
The purpose of this study is to accurately determine the length of appropriate drug treatment for staphylococcal blood stream infection.
- Trial name
- Bacteremia (NCT01191840)
- Testing
- Vancomycin
- Where
- 15 sites in United States, Spain
- Volunteers
- 509 people
- Sponsor
- Duke University
Stenotrophomonas Infection
Trimethoprim-Sulfamethoxazole vs Levofloxacin as Targeted Therapy for Stenotrophomonas Maltophilia Infections: a Retrospective Cohort Study
This study seeks to compare mortality outcomes of levofloxacin and trimethoprim-sulfamethoxazole treated patients who have Stenotrophomonas maltophilia blood stream or lower respiratory tract infections by retrospectively…
- Trial name
- NCT04639817
- Testing
- Levofloxacin, trimethoprim-sulfamethoxazole
- Where
- United States
- Volunteers
- 1,621 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Bacteremia
Bacteria Entering the Blood Stream From Tooth Extractions and Tooth Brushing
The major purposes of this prospective, randomized, clinical study are to: 1. Determine and compare the true incidence, nature, magnitude, and duration (INMD) of bacteremia (bacteria found in the bloodstream) resulting from a…
- Trial name
- NCT00454285
- Testing
- Effect of Amoxicillin on bacteremia following a single-tooth extraction
- Where
- United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Infection, Hospital, Antimicrobial
Hydrogen Peroxide and Ultraviolet Light for Disinfecting Surfaces in Intensive Care Units
Healthcare-associated infections (HAIs) remain a major problem in intensive care units (ICUs), driven by environmental contamination with multidrug-resistant organisms that persist despite routine manual cleaning.
- Conditions
- Infection, Hospital, Antimicrobial, Pneumonia Associated With Mechanical Ventilation, Urinary Tract Infection(UTI)
- Trial name
- Hylight (NCT07233837)
- Testing
- Aerosol of hydrogen peroxide, Irradiation of ultraviolet light
- Where
- 12 sites in Brazil
- Volunteers
- 5,000 people
- Sponsor
- Hospital Israelita Albert Einstein