Clinical trials: Blood Vessel (Vascular) Dysfunction
Cerebral Small Vessel Diseases, Cognitive Impairment
Intermittent Theta Burst Stimulation on Cognitive Impairment of Cerebral Small Vessel Disease
The cerebral small vessel diseases (CVSD) can cause severe and lasting damage to cognition function while the current available treatment of vascular cognitive impairment (VCI) is limited.
- Trial name
- NCT06579664
- Testing
- iTBS
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Beijing Tiantan Hospital
Erectile Dysfunction
Fundus Oculi and Erectile Dysfunction
The purpose of this study is to evaluate the correlation between fundus oculi's vascularization in patients with erectile dysfunction and not, and, in the same patients, before and after using drugs for ED.
- Trial name
- NCT02845765
- Testing
- Dynamic Vessel Analyzer (DVA), Phosphodiesterase type 5 Inhibitor (PDE5I)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ospedale San Raffaele
Multiple Myeloma, Plasma Cell Neoplasm
Human Immune Globulin in Treating Patients With Primary Amyloidosis That is Causing Heart Dysfunction
RATIONALE: Antibodies, such as human immune globulin, can block the growth of abnormal cells in different ways. Some block the ability of abnormal cells to grow and spread.
- Trial name
- NCT00547365
- Testing
- Human immune globulin intravenous (IGIV)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Tennessee
Cerebral Small Vessel Diseases
Visit-to-Visit Variability in Blood Pressure as a Predictor of Poor Cognitive Function
Hypertension in midlife is an independent risk factor of late life cognitive dysfunction or dementia. Chronic hypertension cause vascular damage and cerebral ischemia, which ultimately gives rise to the cognitive dysfunction or…
- Trial name
- BPV-COG (NCT01688505)
- Where
- 5 sites in South Korea
- Volunteers
- 140 people
- Sponsor
- Hallym University Medical Center
Postoperative Cognitive Dysfunction, Postoperative Delirium
Neuroimaging Combining Biomarkers for Identifying Long-term Cognitive Dysfunction and Delirium
Postoperative Cognitive Dysfunction(POCD) is commonly seen in cardiac surgery, which may lead to poor pognosis. Cerebral small vessel disease(CVSD) is refer as the main resource of delirium among elderly people.
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Cerebral Small Vessel Diseases, Covert Postoperative Stroke
- Trial name
- NeuroIDEA (NCT05594966)
- Testing
- multimodal MRI
- Where
- China
- Volunteers
- 211 people
- Sponsor
- RenJi Hospital
Hypertension, Inflammation
The Role of the Immune and Inflammatory Systems in Hypertension
To define the cytokine and cellular immune signature of primary hypertension. Cross sectional clinical/laboratory study.
- Conditions
- Hypertension, Inflammation, Vascular Diseases
- Trial name
- NCT04015635
- Testing
- None involved
- Where
- United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Coronary Artery Disease
Effect of BNP (Brain Natriuretic Peptides) on Endothelial Dysfunction Induced by Coronary Angioplasty
Patients receiving BNP or nitroglycerin (IV) during the angioplasty procedure. 24 h after the procedure, vascular reactivity will be re-examined using the brachial artery flow-mediated dilatation study.
- Trial name
- NCT00262574
- Testing
- Nesiritide,
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Chronic Kidney Diseases, Dementia
BRINK (BRain In Kidney Disease) Memory Study 2.0
In this study, the investigators will be looking at results of tests of memory and thinking and daily activities in a group of people without known chronic kidney disease (CKD) , and a group of CKD patients, and follow the…
- Conditions
- Chronic Kidney Diseases, Dementia, Dementia, Vascular, Stroke
- Trial name
- BRINK (NCT04975464)
- Where
- 2 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Anne Murray
Autosomal Dominant Polycystic Kidney, Hypertension
Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease
People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may…
- Conditions
- Autosomal Dominant Polycystic Kidney, Hypertension, Endothelial Dysfunction
- Trial name
- BEET-PKD (NCT05401409)
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- 2 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Western Sydney Local Health District
Multiple Myeloma
Study of PD-1Ab21-BCMA CAR-T Therapy for Consolidation of Multiple Myelomawith Renal Dysfunction
The purpose of this study is to determine the efficacy and safety of targeted BCMA CART cells secreting PD1 and interleukin 21 fusion protein immunotherapy for first-line consolidation therapy of multiple myeloma with renal…
- Trial name
- NCT07489534
- Testing
- PD-1Ab21-BCMA CAR-T cell immunotherapy
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Daihong Liu
High Blood Pressure
The Effect of Nebivolol on Endothelial Dysfunction in African Americans With Hypertension
High blood pressure (hypertension) is called the "silent killer" because many people do not know they have it, and do not know when it is well controlled.
- Trial name
- NCT01049009
- Testing
- Nebivolol, Metoprolol XL
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Emory University
Stroke, Cognitive Decline
Association Between Blood Pressure and Risk of PSCI
This retrospective cohort study was designed to explore the relationship between blood pressure and cognitive impairment after stroke
- Conditions
- Stroke, Cognitive Decline, Blood Pressure
- Trial name
- NCT06730711
- Where
- China
- Volunteers
- 600 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
HIV Infections, Dyslipidemia
Effect of Atazanavir on Endothelial Function in HIV-Infected Patients
It is known that certain antiviral therapies, the socalled protease inhibitors, used in the treatment of HIV infection has an untowarded effect on the blood vessels, promoting early occurence of atherosclerosis.
- Trial name
- ENDOPACT (NCT00447070)
- Testing
- ATAZANAVIR
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Foundation for Cardiovascular Research, Zurich
Blood Pressure, Endothelial Dysfunction
Novel Time-efficient Inspiratory Muscle Strength Training for Lowering Systolic Blood Pressure
Above-normal systolic blood pressure (SBP), defined as SBP >/= 120 mmHg, is the major modifiable risk factor for cardiovascular disease, stroke, cognitive decline/dementia, and other chronic health problems.
- Conditions
- Blood Pressure, Endothelial Dysfunction, Hypertension
- Trial name
- NCT04848675
- Testing
- Inspiratory muscle strength training, Brisk walking
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Vascular Cognitive Impairment, White Matter Lesions
Mechanism of Gamma Oscillation Synchronization in the Prefrontal-hippocampal Circuit for Memory Dysfunction in Patients With White Matter Lesions of Cerebral Small Vessel Disease
The mechanism underlying memory impairment caused by white matter lesions of cerebral small vessel disease is still unclear. The disrupted synchronization of gamma oscillations in the prefrontal-hippocampal circuit is a potential…
- Conditions
- Vascular Cognitive Impairment, White Matter Lesions, Gamma Oscillation
- Trial name
- NCT07042633
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Henoch Schönlein Purpura
Study of the Role of Regulator T Cells in the Pathophysiology of Childhood Henoch Schönlein Purpura
The primary objective of this study is to search for evidence of quantitative or functional defects in plasma regulatory T cells (Tregs) in pediatric patients with Henoch Schönlein Purpura (HSP) as compared to a control…
- Trial name
- FOX-TREG (NCT02317133)
- Testing
- Blood samples, Stool samples
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Ischemic Stroke
Effects of Intravascular Laser Irradiation of Blood for Mitochondral Dysfunction in Cerebral Ischemic Stroke
Background : This research is designed through randomization, control, and double-blind trial to explore the clinical effectiveness of intravenous laser irradiation of blood for ischemic stroke patient; The research will further…
- Trial name
- NCT06932627
- Testing
- ILIB
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- Tri-Service General Hospital (TSGH)
MPO-ANCA Vasculitis, Microscopic Polyangiitis
CellCept in p-ANCA Vasculitis
Microscopic polyangiitis (MP) is a primary systemic vasculitis predominantly affecting small blood vessels. Following the widespread introduction of ANCA testing, the primary systemic vasculitis (SV), Wegener?s granulomatosis…
- Trial name
- NCT00405860
- Testing
- CellCept (mycophenolate mofetil)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Cardiovascular Diseases, Endotoxemia
Cardiometabolic Benefits of Potatoes Mediated Along the Gut-Vessel Axis in Adults With Metabolic Syndrome
This study is focused on assessing potential health benefits of daily consumption of potatoes, specifically its resistant starch content (i.e.
- Conditions
- Cardiovascular Diseases, Endotoxemia, Endothelial Dysfunction, Postprandial Hyperglycemia
- Trial name
- NCT03624569
- Testing
- Bagel, Potato
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Ohio State University
Stroke, Ischemic, Small Vessel Cerebrovascular Disease
Antiplatelet Therapy and Endothelial-stabilizing Agents in Cerebral Small Vessel Diseases
Cerebral small vessel disease (cSVD) is a common accompaniment of aging. Recent small subcortical (or lacunar) infarcts (i.e. symptomatic cSVD) and white matter hyperintensities are typical cSVD lesions on neuroimaging.
- Conditions
- Stroke, Ischemic, Small Vessel Cerebrovascular Disease, White Matter Hyperintensity
- Trial name
- Athena-cSVD (NCT06715007)
- Testing
- Clopidogrel, Aspirin, Cilostazol + Isosorbide Mononitrate
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University