Clinical trials: Body
Obesity, Metabolic Syndrome
Is Fructose Linked to Adiposity in Babies?
The obesity epidemic has reached down into the infant and toddler age group. Dietary indiscretion during pregnancy, particularly in our current food environment, is a major risk factor for both gestational diabetes and neonatal…
- Trial name
- FLAB (NCT01262781)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Esophageal Squamous Cell Carcinoma
A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)
This is a Phase 1/2, multicenter, randomized, open-label umbrella platform study to evaluate the safety and efficacy of investigational agents with or without pembrolizumab and/or chemotherapy, for the treatment of participants…
- Trial name
- NCT05319730
- Testing
- Paclitaxel, Irinotecan, Pembrolizumab
- Where
- 58 sites in United States, Brazil and 12 more
- Volunteers
- 230 people
- Sponsor
- Merck Sharp & Dohme LLC
Obesity
Fasted Evening Exercise: Performance and Compensatory Eating
This study will compare the appetite, energy intake, and exercise performance responses to a bout of exercise completed in the evening after an extended period of fasting with a similar bout of exercise completed in the evening…
- Trial name
- NCT04742530
- Testing
- Fasted Evening Exercise, Fed Evening Exercise, Fed Morning Exercise
- Where
- 2 sites in United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Obesity
Snacking, Satiety &Weight: A Randomized, Controlled Trial
Proposed is a parallel-design randomized controlled trial to compare the effects of consuming two types of snacks on a daily basis for a 12-week period on health outcomes, diet quality, and self-reported satiety in a group of…
- Trial name
- Snack (NCT02050165)
- Testing
- KIND Bars, Typical American Snack
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Griffin Hospital
Type 2 Diabetes, Control Condition
Exercise and Protein Efficiency in T2D
In this randomized controlled trial, 30 older adults (aged> 65 years; 15 with T2D, 15 controls) will participate in a 12-week progressive exercise training program.
- Trial name
- ADA (NCT07477067)
- Testing
- 12 week progressive exercise training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Obesity
The Effect of Vitamin D Repletion on Insulin Resistance
The reason for doing this study is to learn whether raising a person's vitamin D level from below normal to normal levels will improve his or her body's ability to use sugar.
- Trial name
- NCT00606957
- Testing
- Vitamin D3 (cholecalciferol)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Obesity
SPARK a Healthy and Fit Lifestyle
The purpose of this study is to determine the best format for delivering a brief behavioral weight loss intervention to young adults 18-25 years of age.
- Trial name
- SPARK (NCT01578512)
- Testing
- Face-to-Face, Web-based, Single session
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The Miriam Hospital
Hyperthermia, Thermoregulation
Enhancing Heat Resiliency in Older Adults During Indoor Overheating Via Heat Acclimation by Warm Water Immersion
As overheating in buildings is expected to increase as global warming continues, proactive measures to increase heat resiliency in heat-vulnerable older people are needed, especially for those without access to home cooling or…
- Conditions
- Hyperthermia, Thermoregulation, Aging, Heat Acclimation and Thermotolerance
- Trial name
- NCT06670365
- Testing
- Heat acclimation by warm-water immersion
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Pancreatic Ductal Adenocarcinoma (mPDAC), Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)
A Study Comparing Whole-Body Heat Treatment Plus Systemic Therapy to Systemic Therapy Alone, for Advanced Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis and limited treatment options following failure of first-line therapy.
- Trial name
- MATTERS-2 (NCT07711067)
- Testing
- Whole-body hyperthermia, Standard-of-Care Systemic therapy
- Where
- 4 sites in Belgium, Spain
- Volunteers
- 95 people
- Sponsor
- ElmediX
Adenocarcinoma of the Prostate
Stereotactic Boost and Long-Term Androgen Deprivation for Adenocarcinoma of the Prostate
We hypothesize that Stereotactic Body Radiotherapy Boost (SBRT) as a boost to the prostate following whole pelvic intensity modulated radiotherapy (IMRT) can be delivered effectively and safely in a population of men with…
- Trial name
- CCRO025 (NCT02064036)
- Testing
- Stereotactic Radiosurgical Boost, Casodex, Leuprolide
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, Davis
Obesity, Overweight
Family Based Treatment for Weight Loss With Breakfast Prescription
The purpose of this study is to evaluate whether a behavioral weight loss group in conjunction with a prescribed breakfast can help children between 8 and 12 years of age change their behaviors to help them lose weight and become…
- Conditions
- Obesity, Overweight, Overeating, Weight
- Trial name
- FAB (NCT02467036)
- Testing
- Family Based Behavioral Treatment
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Non-small Cell Lung Cancer Stage I
Oncolytic Adenovirus-Mediated Gene Therapy for Lung Cancer
The primary objective of this phase 1 trial is to determine the dose-dependent toxicity and maximum tolerated dose (MTD) of oncolytic adenovirus-mediated cytotoxic gene therapy in combination with SBRT in medically inoperable…
- Trial name
- NSCLC (NCT03029871)
- Testing
- Ad5-yCD/mutTKSR39rep-ADP Adenovirus
- Where
- United States
- Sponsor
- Benjamin Movsas, M.D.
Orthostatic Hypotension, Ischemia
Evaluation of the ORTHO-LBNP System
The pilot study aims to evaluate a prototype system that enables military pilots to train under conditions of orthostatic hypotension and ischemic hypoxia.
- Conditions
- Orthostatic Hypotension, Ischemia, Hypoxia
- Trial name
- ORTHO-LBNP (NCT03354234)
- Testing
- Head up tilt (HUT), Lower body negative pressure (LBNP), Head down tilt (HDT)
- Where
- Poland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Military Institute of Aviation Medicine
Inflammatory Bowel Diseases, Depressive Episode
Risk of Mental Health Conditions in Children and Young Adults With Inflammatory Bowel Disease and Influence on Health
This study is a large population-based analysis in the United Kingdom (UK) using routine primary care data to investigate the impacts on quality-of-life outcomes and use of healthcare services in people aged 5 - 25 years…
- Conditions
- Inflammatory Bowel Diseases, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorder
- Trial name
- NCT05206734
- Testing
- No specific intervention
- Where
- United Kingdom
- Volunteers
- 19,469 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Obesity
The Effect of Semaglutide on the Intestinal Flora in Obesity
For obese individuals, semaglutide treatment was adopted. By using multi-omics techniques such as fecal metagenomic sequencing and based on in vitro strain screening platforms, the effects and specific mechanisms of semaglutide…
- Trial name
- NCT07323134
- Testing
- Semaglutide Injection
- Volunteers
- 40 people
- Sponsor
- Beijing Chao Yang Hospital
Body Dysmorphic Disorder
Milk Thistle in Body Dysmorphic Disorder
The proposed study will consist of a 9 week double-blind cross-over study trial of milk thistle in 15 people (ages 18-65). The study will be divided into an initial 4 week phase, a one week wash out phase, and a second 4 week…
- Trial name
- NCT02843451
- Testing
- Milk Thistle
- Where
- United States
- Sponsor
- University of Chicago
Pre-Diabetes, Weight, Body
Prevention of Progression of Prediabetes, Obesity and CV Risk
The investigators are studying how to help people with prediabetes (Pre-DM) and obesity. The goal is to use new and affordable treatments to bring blood sugar levels back to normal and help participants to lose weight.
- Conditions
- Pre-Diabetes, Weight, Body, Cardiovascular Diseases
- Trial name
- Pre-DM (NCT06446531)
- Testing
- Rybelsus Tablet, Jardiance 25Mg Tablet, Metformin
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Obesity
Efficacy and Safety of HDM1005 Compared to Tirzepatide in Obese Adults Without Diabetes
This is a 56-week randomized, open-label, controlled study evaluating the efficacy and safety of the HDM1005 compared to tirzepatide in adults with obesity but without diabetes.
- Trial name
- NCT07521631
- Testing
- HDM1005 dose level 1, HDM1005 dose level 2, HDM1005 dose level 3
- Where
- China
- Volunteers
- 372 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Obesity, Life Style
EYTO (European Youth Tackling Obesity): A Randomized Controlled Trial in Catalonia (Spain)
Our hypothesis is that healthy lifestyles improvement by an intervention designed according 8 social marketing Benchmark criteria, can reduce overweight or obesity implemented by adolescents on their colleges.
- Trial name
- EYTO-SPAIN (NCT02157402)
- Testing
- Social marketing activities and pop-up events to promote healthy lifestyles
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Obesity, Bariatric Surgery
Evaluation of Characteristics of Patients With Nonsurgical Complications After Bariatric Surgery and Quality of Life
Retrospective study: Analysis of characteristics of patients that were hospitalised with nonsurgical complications after bariatric surgery.
- Trial name
- NCT05957237
- Volunteers
- 796 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven