Clinical trials: Body Weight
Diabetes, Obesity
Prospective Metabolic Surgery in T2DM Chinese Subjects
The primary goal of this study is to assess impact of metabolic surgery on glycemic control in diabetic patients.
- Trial name
- NCT02217943
- Testing
- Roux-en-Y gastric bypass, Sleeve gastrectomy
- Where
- 6 sites in China
- Volunteers
- 101 people
- Sponsor
- Ethicon Endo-Surgery
Obesity
Exercise Dose Response for Improving Insulin Sensitivity
Many of the beneficial metabolic effects of endurance exercise training are not due to adaptations to weeks, months, or even years of training, but rather much is due to the response to the most recent exercise session(s).
- Trial name
- NCT01452035
- Testing
- Exercise
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Overweight, Obesity
Effect of Intake of Dehydrated Nopal Powder From Highly Mature Cladodes on the Lipid Profile
Background: Opuntia ficus-indica is a plant from the cactus family (Cactaceae) that is widespread and of great economic importance in Mexico.
- Conditions
- Overweight, Obesity, Dyslipidemia
- Trial name
- NCT07018908
- Testing
- supplementation with 5 g dehydrated nopal powder from highly mature cladodes, supplementation with 15 g dehydrated nopal powder from highly mature cladodes, Control Group (only diet)
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- Universidad Autónoma de Querétaro
Sedentary Lifestyle
Innovative Physical Activity Interventions for Overweight Latinos
This research aims to investigate the effectiveness of an automated Simple Message Service (SMS, also known as text messaging) advisor system relative to a proven human advisor program to promote regular, sustained physical…
- Trial name
- SMS-Stanford (NCT02385591)
- Testing
- Telephone Support, SMS Support
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Stanford University
Safety/Effacy
Effects of a Nutritional Supplement Combination on Body Weight Management
Title: A Phase IV, Open-label, Single-Center Study on the Effects of a Nutritional Supplement Combination on Body Weight Management over a 90-day period
- Trial name
- NCT01725958
- Testing
- Nutritional supplement and protein shakes
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pharmanex
Weight Change
Weight Change Among Users of Three Progestin-Only Methods of Contraception Over a 12-Month Time Period
The purpose of this study is to learn whether women who use progestin-only methods of birth control such as the contraceptive implant (Implanon), the levonorgestral-releasing IUS (Mirena), or depot medroxyprogesterone…
- Trial name
- BMI (NCT01592058)
- Where
- United States
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obesity; Chronic Kidney Disease; Albuminuria
Study on the Efficacy and Safety of Initial Combination of Finerenone and Semaglutide in Non-Diabetic Adult Patients With Obesity Complicated by Chronic Kidney Disease With Albuminuria
This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate whether starting finerenone together with semaglutide provides an additional reduction in urinary albumin-to-creatinine ratio…
- Trial name
- NCT07849348
- Testing
- Finerenone, Semaglutide
- Volunteers
- 266 people
- Sponsor
- Peking University People's Hospital
Obesity
A Study to Assess Safety, Tolerability, and Pharmacokinetics of MEDI0382 in Non-diabetic Obese Participants
This is a Phase 1, randomized, blinded, placebo-controlled study in up to approximately 51 non-diabetic obese participants with a body mass index (BMI) ≥ 35 kg/m^2.
- Trial name
- NCT03625778
- Testing
- MEDI0382
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- MedImmune LLC
Polycystic Ovary Syndrome, Overweight and Obesity
Lifestyle Intervention in Pregnant Women With PCOS
Polycystic ovarian syndrome (PCOS) is the most common reproductive disorder in women of childbearing age and is also associated with metabolic abnormalities including obesity, type 2 diabetes, dyslipidemia, etc.
- Conditions
- Polycystic Ovary Syndrome, Overweight and Obesity, Gestational Diabetes
- Trial name
- NCT04216485
- Testing
- Intensive Lifestyle Intervention, Standard Care
- Where
- China
- Volunteers
- 296 people
- Sponsor
- Capital Medical University
Obesity
Exercise as a Buffer Against Stress-induced Overeating
The purpose of this study is to examine the psychological benefits of chronic exercise as well as the effects of exercise training on eating behaviors and stress-induced overeating in overweight and obese women.
- Trial name
- NCT02936076
- Testing
- Exercise intervention, Delayed exercise intervention
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Obesity, Inflammation
Inflammasome Activation and Cortisol Metabolism in Obese Women With Recurrent Miscarriage
The prevalence of obesity among women of reproductive age is increasing. Obesity represents a chronic low-grade inflammatory state and NLRP3 inflammasome plays a pivotal role in obesity-induced inflammation.
- Trial name
- NCT04275674
- Where
- Taiwan
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Obesity
Body Composition Outcomes in MS Patients
Objectives The objective of this project is to generate pilot data substantiating our hypothesis that advanced body composition measurement tools will provide more accurate and clinically relevant data on the outcomes of…
- Trial name
- BCOMS (NCT07530718)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Pennington Biomedical Research Center
Body Weight, Insulin Resistance
The Effects of Calorie Restriction With or Without Metformin on Weight and Insulin Resistance
This is a study to: Determine the difference between strong hypo-energetic "standard diet advice" and modest hypo-energetic "personal diet advice"; and Determine the influence of insulin-insensitivity on obesity and weight…
- Trial name
- NCT00134290
- Testing
- metformin, "standard diet advice", "personal diet advice"
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- University Hospital, Ghent
Overweight and Obesity
A Trial Comparing Two Approaches to Weight Loss
This study compared the recently developed Transforming Your Life (TYL) weight loss program to the Diabetes Prevention Program (DPP), considered the "Gold Standard" in behavioral weight loss treatment.
- Trial name
- NCT02671110
- Testing
- Transforming Your Life, Diabetes Prevention Program
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Robert Carels
Healthy Diet, Microbiota
The Link Between Diets and Health Indicators
The cohort study investigates the effect of different dietary intake among omnivorous, vegan, vegetarian and low-carb diets on health parameters and on long-term overall health.
- Trial name
- DIETE (NCT04347213)
- Testing
- Regular lifestyle in different circumstances
- Where
- Slovenia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Obesity, Overweight
Use of a Mobile Application by Parents to Prevent Obesity in Their Children Apply for Your Health
Background. Lifestyles that promote a positive energy balance increase the prevalence of obesity. Due to the magnitude of this problem, community-level strategies are required on how to provide families with useful information to…
- Trial name
- NCT07376252
- Testing
- Applícate por tu salud
- Where
- Mexico
- Volunteers
- 743 people, healthy volunteers welcome
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Obesity, Chronic Kidney Diseases
Comparison of the Efficacy and Safety of SGLT2i and GLP-1 Receptor Agonists in Obese Patients With Kidney Disease
The goal of this clinical trial is to exploring the changes in 24-hour urinary protein and renal function in obese patients with kidney disease after the application of sodium glucose cotransporter 2 inhibitors (SGLT2i) and…
- Trial name
- NCT06344247
- Testing
- RAS inhibitors：Losartan®️/Valsartan®️, dapagliflozin：Forxiga®️, simagliptin：Forxiga®️
- Where
- China
- Volunteers
- 48 people
- Sponsor
- RenJi Hospital
PREG1, Obesity
Pilot Study: Identification of a Multi-omic Predictive Signature for Preterm Birth in Obese African American Women
1. Determine if the stool or vaginal microbiome and urinary metabolite profiles in a pregnant obese population of African American women differ from their pregnant non-obese counterparts 2.
- Trial name
- NCT03181555
- Testing
- Exploratory
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Baylor University
Cardiovascular Disease, Preeclampsia
Heart Health 4 Moms Trial to Reduce CVD Risk After Preeclampsia
This study will compare two arms in a randomized clinical trial of cardiovascular risk prevention in women with a history of preeclampsia.
- Conditions
- Cardiovascular Disease, Preeclampsia, Hypertension, Post-partum Weight Retention
- Trial name
- HH4M (NCT02147626)
- Testing
- Web-based educational and motivational modules, Information and Screening Group
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
End Stage Renal Failure on Dialysis
Low Molecular Weight Heparin for Hemodialysis Anticoagulation
Low-molecular weight heparins (LMWHs) as well as Unfractionated heparin (UFH) is used as anticoagulation during hemodialysis (HD) therapy.
- Trial name
- NCT01356615
- Testing
- low molecular weight heparin (enoxaparin sodium), standard unfractionated heparin
- Volunteers
- 27 people
- Sponsor
- Tehran University of Medical Sciences