Clinical trials: Body Weight
Preeclampsia
The Effect of Two Aspirin Dosing Strategies for Obese Women at High Risk for Preeclampsia
Low dose aspirin (LDA) is used for preeclampsia (PE) prevention in high risk women, but the precise mechanism and optimal dose is not known.
- Trial name
- NCT03735433
- Testing
- 162mg aspirin dose
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Ohio State University
Obesity, Diabetes
Semaglutide 2.4 mg in Patients With Poor Weight-loss
A double-blinded, randomised, placebo-controlled trial of semaglutide 3.0 mg/ml in patients with poor weight-loss following bariatric surgery.
- Conditions
- Obesity, Diabetes, Metabolic Syndrome
- Trial name
- BARI-STEP (NCT05073835)
- Testing
- Semaglutide 3 mg
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University College, London
Obesity
A Research Study to See How Semaglutide Helps People With Excess Weight, Lose Weight (STEP UP)
This study will look at how much weight participants will lose from the start to the end of the study. The weight loss in participants taking the investigational high dose of semaglutide will be compared to the weight loss in…
- Trial name
- STEP UP (NCT05646706)
- Testing
- Semaglutide
- Where
- 107 sites in United States, Bulgaria and 10 more
- Volunteers
- 1,407 people
- Sponsor
- Novo Nordisk A/S
Overweight, Obesity
A Study to Evaluate the Effect on Body Weight of Leptin Administered in Conjunction With Pramlintide in Overweight and Obese Subjects
This study will evaluate the safety, tolerability, and effect on body weight of leptin, injected subcutaneously, in combination with pramlintide, injected subcutaneously.
- Trial name
- NCT00392925
- Testing
- pramlintide acetate 360 mcg, metreleptin, Pramlintide acetate 180 mcg
- Where
- 12 sites in United States
- Volunteers
- 177 people
- Sponsor
- AstraZeneca
Self-Perception, Body Weight
Effects of Active Video Games in Physically Inactive Children
Inactivity was reported to be high in children and considered to be the fourth common cause of death in all ages. The reason for children is usually the increasing indoor use of sedentary screen time.
- Trial name
- AVGAME (NCT03720938)
- Testing
- Active Video Games
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Obesity, Insulin Resistance
A Randomized, Double-blind Study of the Effects of Fenretinide Administered in Subjects With Obesity
Many metabolic complications of obesity are a consequence of abnormal responses of the liver, muscle, and fat to insulin actions. Fenretinide may improve the effects of insulin, preventing metabolic complications.
- Trial name
- NCT00546455
- Testing
- Fenretinide
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of California, San Diego
Sleep Apnea, Obstructive, Obesity
Propofol vs Propofol + Benzo/Opiates in High Risk Group
This will be a randomized controlled trial that compares the rates of sedation related complications in high risk patients (ASA greater or equal to 3, BMI greater or equal to 30, those at risk for OSA) undergoing advanced…
- Trial name
- NCT01315158
- Testing
- Propofol Alone, Propofol+Benzo/Opioids
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Washington University School of Medicine
Polycystic Ovarian Syndrome, Obesity
Oral Amino Acid Nutrition to Improve Glucose Excursions in PCOS
The Investigators will measure hepatic glucose and fat metabolism in obese girls with Polycystic Ovarian Syndrome (PCOS) and hepatic steatosis (HS) after taking 4 weeks of an essential amino acid (EAA) supplement or placebo and…
- Conditions
- Polycystic Ovarian Syndrome, Obesity, Hepatic Steatosis
- Trial name
- ORANGE (NCT03717935)
- Testing
- Essential Amino Acid (EAA) Supplement
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Colorado, Denver
Obesity
PK/PD of High Dose Pip/Tazo in Obese Patients
Worldwide rates of obesity have doubled in the last 30 years, and obesity has been associated as a risk factor for hospital-acquired infections and increased occurrence of death in critically-ill patients.
- Trial name
- NCT01923363
- Testing
- Piperacillin/Tazobactam Standard Dose to High Dose
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Loma Linda University
Obesity
Study Examining Parker-Flex Endotracheal Tube for Obese Patients
A recent article examined the use of Parker Flex-Tip tubes to standard ETTs for oral fiberoptic intubation and concluded that there was a significant benefit in terms of difficulty encountered when using the Parker Flex-Tip.
- Trial name
- NCT01894178
- Testing
- Parker Flex-Tip® tracheal tube, Portex® Tracheal Tube
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Childhood Obesity
The Louisiana (LA) Health Project
There is a worldwide pandemic of obesity with far-reaching consequences for the health of our nation. Obesity is the second leading cause of preventable death in the United States.
- Trial name
- NCT00289315
- Testing
- Primary (Environmental) Weight Gain Prevention, Secondary (Behavioral) Weight Gain Prevention, Control
- Where
- United States
- Volunteers
- 2,060 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity; Overweight
Effect of GLP-1 Analogue ROSE-010 on Appetite in Overweight and Obese Subjects
The primary objective of this study is to assess the efficacy of ROSE-010 on food intake in female subjects with overweight and obesity.
- Trial name
- NCT06621017
- Testing
- ROSE-010 99 mcg, ROSE-010 150 mcg
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rose Pharma Inc
Utilization, Health Care, Obesity
Healthcare Utilization in Obese Caregiver Living Donors
The goal of this study is to estimate risk of post-donation healthcare use attributable to informal caregiving among obese living donors.
- Trial name
- NCT04341896
- Testing
- Caregivers, Non-caregivers
- Where
- United States
- Volunteers
- 784 people
- Sponsor
- University of Alabama at Birmingham
Obesity
Enoxaparin Dosing in Obesity
The purpose of this study is to determine an effective enoxaparin dosing strategy in medically ill, morbidly obese patients. This study will include adult patients greater than 18 yrs of age being admitted to Grady Hospital in…
- Trial name
- NCT01798550
- Testing
- Enoxaparin
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Emory University
Obesity
A Study to Evaluate the Safety, Tolerability, and Weight Loss Efficacy of K-757 Alone and in Combination With K-833
This is a study to evaluate the safety and efficacy of K-757 alone and in combination with K-833 versus placebo in participants who are obese.
- Trial name
- NCT06019559
- Testing
- K-757 120 mg BID and K-833 100 mg BID
- Where
- 22 sites in United States
- Volunteers
- 155 people
- Sponsor
- TriGemX Bio, Inc.
Obesity
Reduced Carbohydrate Versus Fat in Obese Subjects
Popular weight loss strategies often involve reducing an individual's consumption of carbohydrates or fat. However, no controlled study has been carried out to evaluate the effects of reducing carbohydrate versus fat consumption…
- Trial name
- NCT00846040
- Testing
- Reduced fat diet, Reduced carbohydrate diet, Drug: f-18 fallypride
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Obese
Safety and Efficacy of Bimagrumab and Semaglutide in Adults Who Are Overweight or Obese
A phase 2 study to assess the efficacy of bimagrumab alone or in addition to semaglutide to assess efficacy and safety in overweight or obese men and women
- Conditions
- Obesity, Obese, Overweight or Obesity
- Trial name
- NCT05616013
- Testing
- Bimagrumab, Semaglutide
- Where
- 26 sites in United States, Australia and 1 more
- Volunteers
- 507 people
- Sponsor
- Eli Lilly and Company
PreDiabetes, Obesity
Tolerability, Acceptance, and Utility of Intermittent CGM Use in Youth With Prediabetes
We are evaluating whether intermittent use of continuous glucose monitors (CGMs) in addition to standard nutritional counseling and physical activity counseling is associated with improved metabolic health for youth with…
- Conditions
- PreDiabetes, Obesity, Insulin Resistance
- Trial name
- NCT05505565
- Testing
- Abbott Freestyle Libre 2, Standard physical activity and nutritional counseling for prediabetes management
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Alabama at Birmingham
Obesity, Morbid, Postoperative Pain
Study of the Effect of the Drug Gabapentin on Postoperative Pain and Incidence of Postoperative Nausea and Vomiting
The purpose of this research study is to evaluate the drug gabapentin (Neurontin®) for its ability to reduce postoperative pain, the need for morphine-like pain medication, and the severity and frequency of postoperative nausea…
- Conditions
- Obesity, Morbid, Postoperative Pain, Postoperative Nausea and Vomiting
- Trial name
- NCT00886236
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Medical University of South Carolina
Overweight, Obesity
A Study to Compare Two Different Forms of PF-07081532 in Adults Who Are Overweight or Obese
The purpose of this study is to compare the amount of PF-07081532 in blood after taking two different forms of PF-07081532. This study is seeking participants who are at least 18 years of age and are overweight and/or obese.
- Trial name
- NCT05677867
- Testing
- Formulation A (PF-07081532 20 mg plus 60 mg), Formulation B (PF-07081532 80 mg)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pfizer