Clinical trials: Body Weight Change
Bipolar Disorder, Weight Gain
Topiramate vs. Placebo in Preventing Weight Gain in Bipolar Disorder Treated With Olanzapine
The primary objective of this study is to examine the efficacy of topiramate in combination with olanzapine for the prevention of weight gain in youth with bipolar disorder.
- Trial name
- NCT00394095
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Cincinnati
Obesity; Familial, Pregnancy Related
Maternal Metabolic and Molecular Changes Induced by Preconception Weight Loss and Their Effects on Birth Outcomes
Our hypothesis is that aggressive preconception weight loss in obese women will improve the metabolic health of the mother and the intrauterine environment.
- Trial name
- NCT03244722
- Testing
- Very-low energy Diet (VLED), Standard of care (SOC)
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Ann Arbor Stage II Grade 1 Follicular Lymphoma, Ann Arbor Stage II Grade 2 Follicular Lymphoma
Obinutuzumab and Lenalidomide in Treating Patients With Previously Untreated Stage II-IV Grade 1-3a Follicular Lymphoma
This phase II trial studies how well obinutuzumab and lenalidomide work in treating patients with previously untreated stage II-IV grade 1-3a follicular lymphoma.
- Conditions
- Ann Arbor Stage II Grade 1 Follicular Lymphoma, Ann Arbor Stage II Grade 2 Follicular Lymphoma, Ann Arbor Stage III Grade 1 Follicular Lymphoma, Ann Arbor Stage III Grade 2 Follicular Lymphoma
- Trial name
- NCT02871219
- Testing
- Lenalidomide, Obinutuzumab
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- M.D. Anderson Cancer Center
Obesity
Safety & Tolerability of a Combination of Antidepressant and Peptic Ulcer Drug in Overweight Healthy Subjects
The hypothesis of this study is that up to 150 mg of sertraline and up to 3 mg of telenzepine will be safe, tolerable, and have the effect of suppressing appetite, when taken in combination daily by mouth by healthy, overweight…
- Trial name
- NCT01155531
- Testing
- Sertraline plus Telenzepine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Theracos
Weight Loss
Effect of T6 Dermatome Electrical Stimulation on Gastroduodenal Motility in Healthy Volunteers
The investigators are doing this research study to find out the effect of T6 Dermatomal Electrical Stimulation (delivered by a Transcutaneous Electrical Nerve Stimulation (TENS) unit) on stomach motor activity.
- Trial name
- NCT03316105
- Testing
- Elira Investigational TENS device
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hypercatabolic Status Related to Severe Burn
Study of Tolerability and Efficacy of BVS857 in Severe Burn Subjects
Study of tolerability and efficacy of BVS857 in severe burn subjects over 8 weeks and 15 weeks
- Trial name
- NCT02074995
- Testing
- BVS857
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Novartis Pharmaceuticals
Obesity
Evaluation of Pulse Fibre Supplementation on Obesity and the Metabolic Syndrome
The recent dramatic increase in obesity has been linked to a reduction of dietary fibre intake. We hypothesized that supplementing the diet of overweight and obesity adults with pulse fibre will improve their metabolic status…
- Trial name
- NCT01719900
- Testing
- Pulse fibre, Control
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Type 2 Diabetes, Overweight
Mechanisms of Weight Loss With SGLT2 Inhibition
The purpose of this study is to investigate the effect of canagliflozin, a medication approved by the FDA for the treatment of type 2 diabetes, on body weight and metabolism in people with type 2 diabetes who are overweight or…
- Conditions
- Type 2 Diabetes, Overweight, Obesity
- Trial name
- NCT02360774
- Testing
- Canagliflozin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Beth Israel Deaconess Medical Center
Pregnancy, Weight Gain
Maternal-Offspring Metabolics:Family Intervention Trial
The prevalence of maternal overweight and obesity has nearly doubled in the United States since 1976. In 2004-2005, 42% of pregnant women had body mass index (BMI) above 25 versus 23% in 1993.
- Trial name
- MOMFIT (NCT01631747)
- Testing
- Lifestyle Intervention Group, Usual Care Group
- Where
- 2 sites in United States
- Volunteers
- 281 people
- Sponsor
- Northwestern University
Lung Cancer, Malnutrition
Medical Nutrition Therapy or Standard Care in Treating Patients With Lung Cancer, Pancreatic Cancer, or Stage III or Stage IV Prostate Cancer
This is a two-part study. Part I is an observational study. Part II is a randomized clinical trial to see how well medical nutrition therapy works compared with standard care in treating patients with lung cancer, pancreatic…
- Conditions
- Lung Cancer, Malnutrition, Pancreatic Cancer, Prostate Cancer
- Trial name
- NCT00769652
- Testing
- Medical nutrition therapy, Standard Care
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rutgers, The State University of New Jersey
Overweight, Obesity
The Effects of Leucine on Body Weight
Protein-rich diets appear to show some benefits in promoting weight loss. It is thought that increased intake of leucine may account for some of this effect.
- Trial name
- NCT00683826
- Testing
- L-Leucine 8gr, Liquid meal, L-Leucine 4g
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Columbia University
Weight Loss
Impact of Volunteer Peer-Led Intervention for Weight Control in Primary Care
The specific objective of this research proposal is to determine the short-term efficacy of a primary care-based weight control intervention in which successful volunteer peers deliver a group-based program.
- Trial name
- KL2 (NCT01850550)
- Testing
- Weight loss Groups
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Overweight and Obesity
Neurocognitive Benefits of a Weight Management Program
This study will assess whether weight loss induced through diet and physical activity can change neural responses to high- and low-calorie food images.
- Trial name
- NCT04202133
- Testing
- WW (formerly Weight Watchers), Waitlist
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Frailty
Ghrelin in Healthy and Frail Older Women
The purpose of this research study is to see if giving women a hormone called "ghrelin" will increase levels of growth hormone in the blood and increase appetite.
- Trial name
- NCT00520884
- Testing
- Ghrelin Infusion - Healthy, Ghrelin Infusion - Frail
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Weight Loss, Diet Modification
The Healthy Moms Study: Comparison of a Post-Partum Weight Loss Intervention Delivered Via Facebook or In-Person Groups
The goal of the project is to conduct a feasibility pilot randomized trial comparing delivery of a post-partum weight loss intervention via Facebook versus via in-person group sessions.
- Conditions
- Weight Loss, Diet Modification, Physical Activity
- Trial name
- NCT03700736
- Testing
- Healthy Moms
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Connecticut
Advanced Malignant Solid Neoplasm, C-Reactive Protein Measurement
Anamorelin Hydrochloride, Physical Activity, and Nutritional Counseling in Decreasing Cancer-Related Fatigue in Patients With Incurable Metastatic or Recurrent Solid Tumors
This phase II trial studies how well anamorelin hydrochloride, physical activity, and nutritional counseling work in decreasing cancer-related fatigue in patients with incurable solid tumors that have spread to other parts of the…
- Conditions
- Advanced Malignant Solid Neoplasm, C-Reactive Protein Measurement, Cancer Fatigue, Metastatic Malignant Solid Neoplasm
- Trial name
- NCT03035409
- Testing
- Anamorelin Hydrochloride, Exercise Intervention, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- M.D. Anderson Cancer Center
Body Weight Changes
REseArCH INteGration in Women, Infants, and Children
WIC is a governmental program that provides healthy foods, nutrition education and referrals to other health and social services.
- Trial name
- NCT02657577
- Testing
- There is no intervention
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Bariatric Surgery Candidate, Bone Loss
Weight Loss With Risedronate for Bone Health
This is a pilot project to determine the feasibility of recruiting, enrolling, treating, and following 24 older sleeve gastrectomy patients into a randomized controlled trial (RCT) examining the efficacy of bisphosphonate use…
- Conditions
- Bariatric Surgery Candidate, Bone Loss, Weight Loss
- Trial name
- WERISE (NCT03411902)
- Testing
- Risedronate Sodium 150 MG
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Cancer, Heart Disease
Cancer Dietary Objectives Study
We hypothesize that adding beneficial high fiber foods to the diet will result in better overall dietary quality (measured by the Alternate Healthy Eating Index), which has been shown to be associated with cancer, than either…
- Trial name
- CanDo (NCT00561977)
- Testing
- High Fiber Diet, low saturated fat diet, Combination diet
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Weight Gain, Healthy Subjects
Dietary Essential Fatty Acid Regulation of Omega-3 HUFA Metabolism; Satiety and Body Composition
Background: Rates of obesity have increased dramatically in recent decades, and researchers are investigating how changes in diets and physical activity have contributed to this increase.
- Conditions
- Weight Gain, Healthy Subjects, Obesity, Women
- Trial name
- NCT01251887
- Testing
- Linoleic Acid, Docosahexaenoic Acid, Eicosapentaenoic Acid
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)