Clinical trials: Body Weight Change
Obesity
Effect of Time-restricted Eating on Catecholamine-sensitivity of Adipose Tissue in Obese Adults
In a randomized controlled trial, the investigators intend to measure the health impact of time-restricted eating (TRE) in obese patients (body mass index (BMI) ≥ 30 kg/m2), who habitually eat for more than 14 hours every day.
- Trial name
- NCT04916730
- Testing
- Standard of Care, Time Restricted Eating
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of California, San Diego
Metastatic Pancreatic Cancer
Anamorelin Study for Advanced Pancreatic Cancer
Multicenter, double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of anamorelin HCl. Approximately 100 subjects with advanced PDAC and cachexia will be randomized 1:1 to anamorelin HCl 100 mg or…
- Trial name
- NCT04844970
- Testing
- Anamorelin Hydrochloride
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Lahey Clinic
Overweight and Obesity
Predictors of Lorcaserin-Induced Weight Loss
This two-phase study aims to explore ways to predict who will respond well to the weight loss drug lorcaserin and to understand the mechanisms that develop which limit drug efficacy.
- Trial name
- NCT03353220
- Testing
- Belviq
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Columbia University
Gut Health, Metabolism
A Single-Group Study to Examine the Efficacy of a Gut Health Supplement to Increase Metabolism, Improve Gut Health, and Support Weight Management
This study will evaluate the efficacy of Colon Broom Premium on gut health, metabolism, weight management, and energy levels. The study will be conducted as a virtual single-group trial in which all 120 participants will use the…
- Conditions
- Gut Health, Metabolism, Weight Loss, Energy
- Trial name
- NCT06023082
- Testing
- Colon Broom Premium supplement
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Gut Health, UAB
Hypogonadism, Hypogonadotropic, Obesity
Aromatase Inhibitors and Weight Loss in Severely Obese Men With Hypogonadism
The investigators have preliminary data suggesting that obese patients with hypogonadotropic hypogonadism (HHG) have minimal benefit from testosterone therapy likely because of its conversion to estradiol by the abundant…
- Trial name
- NCT03490513
- Testing
- anastrozole (1 mg/day)
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Baylor College of Medicine
Anorexia, Cachexia
Treatment of Cancer-anorexia Using Megestrol Acetate Concentrated Suspension in Lung or Pancreatic Cancer Patients
Purpose of the study is to compare the effects of megestrol acetate concentrated suspension and placebo on caloric intake for the treatment of cancer-associated anorexia in patients with lung or pancreatic cancer
- Conditions
- Anorexia, Cachexia, Weight Loss
- Trial name
- NCT00637728
- Testing
- Megestrol acetate concentrated suspension 110 mg/mL
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Par Pharmaceutical, Inc.
Obesity
Internet Assisted Obesity Treatment Enhanced With Financial Incentives
The investigators propose a randomized controlled trial to evaluate whether the addition of financial incentives to a high-quality, online behavioral weight loss intervention produces better weight losses than the online…
- Trial name
- iREACH3 (NCT02688621)
- Testing
- Internet Only, Internet + Incentives
- Where
- 2 sites in United States
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Obesity, Overweight
A Study of Tirzepatide (LY3298176) In Participants After A Lifestyle Weight Loss Program
This is a study of tirzepatide in participants with obesity. The purpose of this study is to learn more about how tirzepatide maintains body weight or adds to weight loss after an intensive lifestyle modification program.
- Trial name
- SURMOUNT-3 (NCT04657016)
- Testing
- Tirzepatide
- Where
- 65 sites in United States, Argentina and 2 more
- Volunteers
- 579 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes
Diabetes and Gastric By- Pass
The purpose of this study is to evaluate the mechanisms leading to rapid postoperative improvement in diabetes following Gastric By-Pass surgery for obesity.We will evaluate and compare the changes in glucose level, beta-cell…
- Trial name
- NCT01153516
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Texas Southwestern Medical Center
Weight Change, Body, Behavior, Health
Increased Monitoring of Physical Activity and Calories With Technology
Since severe obesity in youth has been steadily increasing. Specialized pediatric obesity clinics provide programs to aid in reducing obesity.
- Conditions
- Weight Change, Body, Behavior, Health, Obesity, Childhood, Parent-Child Relations
- Trial name
- IMPACT (NCT03961061)
- Testing
- Brenner mFIT (standard care), Brenner mFIT (standard care plus mobile health components)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Amputation Wound, Traumatic Amputation of Toe
Longitudinal Study of Weight Change Following Lower Limb Amputation
The purpose of this study is to assess weight change in a population of Veterans with amputations. Little is known about the how weight changes following an amputation.
- Conditions
- Amputation Wound, Traumatic Amputation of Toe, Dysvascular Amputation of Lower Limb
- Trial name
- NCT00932399
- Where
- United States
- Volunteers
- 4,549 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Diabetes, Weight Loss
Physical and Cognitive Function - Look AHEAD Ancillary Study
Obesity is associated with physical disability through both direct pathways (e.g., lower extremity pain, insufficient muscle strength) and indirect pathways (obesity-related comorbidities and inflammation).
- Conditions
- Diabetes, Weight Loss, Physical Function, Cognitive Function
- Trial name
- NCT01410097
- Testing
- Lifestyle intervention, Diabetes Support Education
- Where
- 4 sites in United States
- Volunteers
- 1,089 people
- Sponsor
- Wake Forest University
Weight, Blood Pressure
Interactive Web Program and Health Coaching for Prehypertensive Adults
This project will develop and evaluate an interactive blood pressure self-management program for adults with prehypertension. The program will target blood pressure self-monitoring and the five proven lifestyle modifications…
- Trial name
- Prehype (NCT02637063)
- Testing
- BlipHub mobile-web app, BlipHub mobile-web app + health coaching, Usual care
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Oregon Center for Applied Science, Inc.
Asthma
Pilot of Lifestyle and Asthma Intervention
This is to pilot test a weight loss intervention in obese patients with poorly controlled asthma. Obesity is a risk factor for the development of asthma (approximately 250,000 cases per year of asthma in the U.S.
- Trial name
- PLAN (NCT03291808)
- Testing
- Weight loss intervention
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Johns Hopkins University
Type 2 Diabetes Mellitus, Obesity
The Effect of Bariatric Surgery on Metabolism, the Metabolome and Microbiome in Patients With Type 2 Diabetes
What are the benefits of undergoing Roux-en-Y gastric bypass surgery in improving type 2 diabetes outside of weight loss alone?
- Trial name
- Microbiome (NCT02762708)
- Testing
- Roux-en-Y Gastric Bypass (RYGB), Caloric Restriction, Exendin-9,39
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Triglycerides, Weight Gain Trajectory
Effects of RDX-002 on Postprandial Triglycerides in Patients Discontinuing GLP-1 Agonists
The goal of this clinical trial is to learn if drug RDX-002 works to treat high levels of fat (known as triglycerides, or TGs) in the blood in adults. It will also learn about the safety of drug RDX-002.
- Conditions
- Triglycerides, Weight Gain Trajectory, Cholesterol, Elevated
- Trial name
- NCT06640972
- Testing
- RDX-002
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Response Pharmaceuticals
Diabetes, Obesity
Healthy Lifestyles for Mentally Ill People Who Have Experienced Weight Gain From Their Antipsychotic Medications - 2
This program aims to help Veterans who take antipsychotic medications lose weight. We use a program based on the American Diabetes Association's "Diabetes Prevention Program," and we have modified it to fit the lifestyles of…
- Conditions
- Diabetes, Obesity, Weight Gain
- Trial name
- MAMAO2 (NCT01052714)
- Testing
- Lifestyle Balance
- Where
- 3 sites in United States
- Volunteers
- 121 people
- Sponsor
- VA Office of Research and Development
Obesity
Effect of a Unique Web-based Behaviour Change Program on Weight Loss and Cardiovascular Risk Factors
Web- or internet-based programs have the potential to induce and, possibly, help to sustain, significant lifestyle modification.
- Trial name
- NCT01472276
- Testing
- Web-based program
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Schizophrenia, Schizoaffective Disorder
Demonstrate the Effects of Pramlintide on Weight Reduction in Schizophrenia
Primary Objective: To test the effect of pramlintide on body weight in clozapine- and olanzapine-induced weight gain in persons with schizophrenia who are currently taking either drug; measures of the metabolic syndrome will be…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Diabetes, Weight Gain
- Trial name
- NCT00690235
- Testing
- Pramlintide
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Texas Southwestern Medical Center
Obesity
A Study of the Laparoscopically-placed Adjustable Gastric Band for the Management of Obesity in Adolescent Patients
This is a prospective, non-randomized, single center study of a laparoscopically placed, adjustable gastric band medical device for the treatment of adolescent obesity.
- Trial name
- NCT01409928
- Testing
- LAP-BAND (Allergan, Inc.)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Texas Southwestern Medical Center