Clinical trials: Body Weight Control
Obesity, Poor Glycemic Control
The Consumption of Beef on Appetite and Cognitive Function
The purpose of the main study is to determine whether the daily consumption of protein-rich meals containing high quality, lean beef products improves appetite control and cognitive function during a weight maintenance diet.
- Conditions
- Obesity, Poor Glycemic Control, Dietary Interventions
- Trial name
- NCT02614729
- Testing
- Standard Protein-Plant, Even Distribution (SP-PLANT-EVEN), Standard Protein-Beef, Even Distribution (SP-BEEF-EVEN), High Protein-Beef, Even Distribution (HP-BEEF-EVEN)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Morbid Obesity, Postoperative Pain
Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens
Adequate postoperative analgesia can facilitate recovery following gastric bypass surgery for morbid obesity. The efficacy and safety of intravenous patient - controlled analgesia has been studied, but up to date no data are…
- Conditions
- Morbid Obesity, Postoperative Pain, Postoperative Bowel Function, Postoperative Ambulation
- Trial name
- NCT01249872
- Testing
- GROUP A : 0 mg MORPHINE-0.1% LEVOBUPIVACAINE, GROUP B : 1 mg MORPHINE- 0.1% LEVOBUPIVACAINE, GROUP C : 2 mg MORPHINE-0.1% LEVOBUPIVACAINE
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- University of Patras
Obesity
To Investigate the Safety, Tolerability and Pharmacodynamics of GSK2890457 in Healthy Volunteers and Subjects With Type 2 Diabetes
This study is the first administration of GSK2890457 in humans. The study will be conducted in 3 parts: - Part A (conducted at a single investigative site) will determine the safety and tolerability of GSK2890457 alone in healthy…
- Trial name
- NCT01725126
- Testing
- GSK2890457, Metformin, Liraglutide
- Where
- 3 sites in United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity, Risk Factors
Motivational Interviewing to Promote Healthy Behaviours in Young Adults
The overall goals of this project are to evaluate the feasibility of web-based nurse-led motivational interviewing and educational interventions to promote healthy behaviours for obesity prevention and maintenance of healthy…
- Trial name
- Motivate (NCT05264740)
- Testing
- Motivational interviewing, Educational materials
- Where
- Canada
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obesity
A Study of Tirzepatide (LY3298176) in Participants With Obesity Disease
The main purpose of this study is to learn more about tirzepatide in participants with obesity disease. The study will also measure how Tirzepatide affects body weight with a low-calorie diet and increased physical activity.
- Trial name
- SURMOUNT-J (NCT04844918)
- Testing
- Tirzepatide
- Where
- 18 sites in Japan
- Volunteers
- 267 people
- Sponsor
- Eli Lilly and Company
Neuromuscular Blockade
Efficacy and Safety of Sugammadex Dosed According to Actual Body Weight (ABW) or Ideal Body Weight (IBW) in Reversal of Neuromuscular Blockade (NMB) in Morbidly Obese Participants (MK-8616-146)
The purpose of this trial is to evaluate the safety and efficacy of Sugammadex when administered according to actual body weight (ABW) as compared to ideal body weight (IBW) for the reversal of both moderate and deep…
- Trial name
- NCT03346070
- Testing
- Sugammadex 2 mg/kg ABW, Sugammadex 2 mg/kg IBW, Sugammadex 4 mg/kg ABW
- Where
- 24 sites in United States, Austria and 3 more
- Volunteers
- 207 people
- Sponsor
- Merck Sharp & Dohme LLC
PreDiabetes, Obesity
Comparison of Outreach Methods to Encourage Enrollment in Diabetes Prevention and Weight Management Programs
Individuals with prediabetes are at increased risk for developing diabetes. Higher hemoglobin A1c's (6.1-6.4%) are associated with a high risk of developing diabetes.
- Trial name
- NCT03200535
- Testing
- EHR gaps, Bulk outreach, Dietician call
- Where
- United States
- Volunteers
- 6,588 people
- Sponsor
- Kaiser Permanente
Obesity
Racial Differences in Vagal Control of Glucose Homeostasis
The investigators will test the hypothesis that acute central acetylcholinesterase inhibition will restore PNS activity and reduce oxidation in AAW compared to whites.
- Trial name
- RDVCGH (NCT02365285)
- Testing
- Galantamine, Intralipid, Heparin
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obesity
Study to Evaluate the Efficacy and Safety of Belviq XR® in Conjunction With Lifestyle Modification for Weight Loss in Obese Adolescents, Age 12 to 17 Years
This study will be conducted to demonstrate weight loss efficacy by change in body mass index (BMI) and safety in adolescents age 12 to 17 years (inclusive) during 52 weeks of treatment with Belviq XR 20 milligrams (mg)…
- Trial name
- NCT03338296
- Testing
- lorcaserin hydrochloride XR
- Where
- 16 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Obesity
Behavioral Weight Loss and Stigma Reduction
This is a randomized controlled trial to test the effects on long-term weight loss of a novel stigma-reduction intervention combined with standard BWL treatment, as compared to BWL alone.
- Trial name
- NCT03704064
- Testing
- Stigma-Reduction Intervention, Behavioral Weight Loss (BWL)
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Pennsylvania
Diabetes Mellitus
Adjunctive Metformin Therapy in Double Diabetes
The significance of this project is to investigate the effects of adjunctive metformin therapy in children and adolescents with double diabetes.
- Trial name
- AMTIDD (NCT01334125)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Massachusetts, Worcester
Obesity
Weight Management Intervention in College: A Pilot Study
This Proof-of-Concept study consists of a series of uncontrolled pilot studies to refine a behavioral weight loss trial using a "small change" approach for emerging adult college students with overweight/obesity.
- Trial name
- NCT05895461
- Testing
- BWLI-College, Control
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- The Miriam Hospital
Obesity, PreDiabetes
Reducing Cardiometabolic Risk and Promoting Functional Health in Older Adults With Obesity and Prediabetes
Obesity and pre-diabetes threatens the overall health and functional independence of older adults but lifestyle weight management for diabetes prevention, soon to be reimbursed by Medicare, can reduce this burden.
- Conditions
- Obesity, PreDiabetes, Aging
- Trial name
- Sustain-DPP (NCT03500640)
- Testing
- DPP Intensive: 30-minute calls, DPP Support: 15-minute calls
- Where
- United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Diabetes, Diabetes Mellitus, Type 2
Impact of Dietary Intervention on Weight Change in Subjects With Type 2 Diabetes
This trial is conducted in Europe, and North and South America. The aim of this trial is to investigate if a dietary intervention has an effect on weight when initiating insulin treatment in subjects with type 2 diabetes…
- Trial name
- DIET™ (NCT01232491)
- Testing
- Insulin detemir, Dietary regimen
- Where
- 112 sites in United States, Argentina and 9 more
- Volunteers
- 611 people
- Sponsor
- Novo Nordisk A/S
Overweight, Obesity
The Beneficial Effects of a Protein-rich Breakfast on Appetite Control & Cognition in Overweight and Obese Adolescents
The purpose of this study is to assess whether the daily addition of a protein-rich breakfast leads to beneficial changes in appetite control, food intake regulation,and cognitive function in overweight \& obese 'breakfast…
- Trial name
- NCT01192100
- Testing
- Breakfast Skipping, Normal Protein Breakfast Meals, Protein-rich Breakfast Meals
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obesity, Overweight
A Study of Tirzepatide in Overweight and Very Overweight Participants
The main purpose of this study is to measure the effect of tirzepatide on food intake in participants who are overweight or very overweight.
- Trial name
- NCT04311411
- Testing
- Tirzepatide, Liraglutide
- Where
- 3 sites in United States
- Volunteers
- 114 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes Mellitus
Study of Multiple Oral Doses of PF-07081532 in Adult Participants With Type 2 Diabetes Mellitus
This is a Phase 1, randomized, placebo-controlled, double-blind (investigator- and participant-blinded), sponsor-open study of PF-07081532.
- Trial name
- NCT05158244
- Testing
- PF-07081532
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Pfizer
Type 2 Diabetes Mellitus, Obesity
Resolution of Type 2 Diabetes Mellitus: Intensive vs. Conventional Glycaemic Control After Obesity Surgery
Obesity surgery is very effective in improving or even curing Type 2 Diabetes in patients with obesity. Many patients stop or reduce their medication after surgery and this can happen fairly quickly.
- Trial name
- GLUCOSURG1 (NCT01257087)
- Testing
- Insulin
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Imperial College London
Obesity, Morbid
GLP-1 Therapy for Weight Loss and Improved Glucose Tolerance in Obese Children
The prevalence of severely obese children is on the rise. Behavioral therapies for weight loss are successful in some, but others need more aggressive approaches such as drug therapy.
- Trial name
- NCT00886626
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Minnesota
Psychotic Disorders, Obesity
Web-Based Delivery of MOVE! to Veterans With Serious Mental Illness (SMI)
Obesity and physical inactivity have reached epidemic proportions, resulting in increased rates of a variety of chronic diseases, increased risk of death, and substantial health care costs.
- Conditions
- Psychotic Disorders, Obesity, Health Behaviors
- Trial name
- Web-MOVE! (NCT00983476)
- Testing
- in-person MOVE! SMI, web-based MOVE! SMI
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- VA Office of Research and Development