Clinical trials: Body Weight Control
Obesity
Weight Loss With Intensive Lifestyle Modifications Plus Bariatric Surgery Versus Liraglutide 3 mg
Background/Objectives: Only 1% of the clinically eligible subjects receive surgical treatment for their obesity, thus other options should be investigated.
- Trial name
- LETHE (NCT03534310)
- Testing
- LIRAGLUTIDE 3 Mg/0.5 mL (18 Mg/3 mL) SUB-Q PEN INJECTOR (ML), lifestyle modification, sleeve gastrectomy
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Catholic University of the Sacred Heart
Obesity
A Multicenter Study to Evaluate the Efficacy and Safety of of Four Doses of SR147778 in Obese Patients
The purpose of this study is to assess the effect of SR147778 on weight loss over a period of 24 weeks when prescribed with a hypocaloric diet in obese patients.
- Trial name
- NCT00239174
- Testing
- SR147778
- Where
- 5 sites in Argentina, Australia and 3 more
- Volunteers
- 394 people
- Sponsor
- Sanofi
Prediabetes, Overweight
FRESH Study (Fitness, Relaxation and Eating to Stay Healthy)
To examine whether a lifestyle program results in weight loss and thereby delays or prevents progression of pre-diabetes to diabetes, we propose a pilot randomized controlled trial of 6 weeks duration with 30 participants held at…
- Trial name
- FRESH (NCT01636258)
- Testing
- Stress Management, Diet, Exercise
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- The Cleveland Clinic
Cardiometabolic Risk, Weight Loss
Effects of Caloric Restriction and Exercise on Body Weight, Immune Function, and Intestinal Flora
The purpose of this study is to estimate the effects of caloric restriction and exercise on body weight, cardiovascular metabolic markers, immune function, and intestinal flora among college students, as well as the underlying…
- Conditions
- Cardiometabolic Risk, Weight Loss, Immune System, Intestinal Microbiome
- Trial name
- NCT04275440
- Testing
- Exercise, Caloric restriction
- Where
- China
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Morbid Obesity
Enhanced Recovery After Laparoscopic Sleeve Gastrectomy - a Randomised Controlled Trial
The investigators wish to standardise and optimise perioperative care for consecutive patients undergoing laparoscopic sleeve gastrectomy for weight loss.
- Trial name
- NCT01303809
- Testing
- Enhanced Recovery After Surgey for Sleeve Gastrectomy
- Where
- New Zealand
- Volunteers
- 106 people
- Sponsor
- University of Auckland, New Zealand
Obesity, Prevention & Control
KAN-DO: A Family-based Intervention to Prevent Childhood Obesity
The purpose of this study is to evaluate the efficacy of an intervention (KAN-DO: Kids \& Adults Now - Defeat Obesity) encouraging postpartum mothers and their preschool-aged children to work together to promote healthy eating…
- Conditions
- Obesity, Prevention & Control, Postpartum Period
- Trial name
- KAN-DO (NCT00563264)
- Testing
- KAN-DO
- Where
- 2 sites in United States
- Volunteers
- 832 people, healthy volunteers welcome
- Sponsor
- Duke University
Childhood Obesity
The Optimising Family Engagement in HENRY (OFTEN) Study
This study will test whether parent engagement (recruitment, attendance) in a Childhood obesity prevention programme (HENRY) can be improved in local authorities randomised to receive an Optimisation intervention (in addition to…
- Trial name
- OFTEN (NCT02675699)
- Testing
- Optimisation + HENRY, HENRY as standard
- Where
- United Kingdom
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Blood Pressure, End Stage Renal Disease
How to Get a Better Dry Weight in End-stage Renal Disease (ESRD) Population for Improving Blood Pressure Control
End-stage renal disease (ESRD) is a common clinical condition. In this population, the prevalence of systemic hypertension is high and its adequate control can determinate the outcome.
- Conditions
- Blood Pressure, End Stage Renal Disease, Hemodialysis
- Trial name
- NCT01104909
- Testing
- Clinical, electrical bioimpedance
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Universidade de Passo Fundo
Obesity
Multiple Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of THDBH120 in Chinese Patients With Obesity
The aim of this trial is to investigate the safety, tolerability, pharmacokinetics, and efficacy of THDBH120 injection in participants with obesity. This study includes three multiple-ascending dose cohorts.
- Trial name
- NCT06951945
- Testing
- THDBH120 injection
- Where
- 2 sites in China
- Volunteers
- 36 people
- Sponsor
- Tonghua Dongbao Pharmaceutical Co.,Ltd
Morbid Obesity
Semaglutide Before Primary Metabolic and Bariatric Surgery in Patients With BMI 60 kg/m² or Higher
Patients with BMI 60 kg/m² or higher are the hardest operations in bariatric surgery. Thick abdominal wall, massive hepatomegaly, reduced working space, fragile fatty tissue, higher conversion and complication rates.
- Trial name
- NCT07859137
- Testing
- Semaglutide weekly injection
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Overweight or Obesity, Healthy
A Study of LY4064912 in Healthy Participants and With Overweight or Obesity
The purpose of this study is to evaluate how well LY4064912 is tolerated and what side effects may occur in healthy participants and participants with overweight and obesity - global.
- Trial name
- YHAA (NCT07152002)
- Testing
- LY4064912
- Where
- 3 sites in United States, Singapore
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Overweight or Obese
Weight Management in Mothers and Adult Daughters
The purpose of this study is to develop, implement, and evaluate a behavioral weight management intervention with a communication training component for Mexican-American women. The study has three specific aims.
- Trial name
- NCT02787902
- Testing
- Communication, Standard
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Stroke, Cerebrovascular Accident
The Effectiveness of Body Weight Supported Treadmill Training in Stroke Patients
In this study, the investigators aimed to evaluate the effects of exercise on body weight-supported treadmill in stroke patients on gait parameters, activity, body functions and quality of life, and to determine whether it has an…
- Conditions
- Stroke, Cerebrovascular Accident, Gait Disorders, Neurologic, Walking, Difficulty
- Trial name
- NCT04597658
- Testing
- Bodyweight supported treadmill training (BWSTT), Conventional rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University
Obesity or Overweight
A Study Evaluating the Effect of Daily Oral RO7795081 in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity
This multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-range-finding, Phase II study aims to evaluate the efficacy, tolerability, and safety of RO7795081 for chronic weight management in adult…
- Trial name
- NCT07081958
- Testing
- RO7795081
- Where
- 36 sites in United States
- Volunteers
- 352 people
- Sponsor
- Hoffmann-La Roche
Abdominal Obesity
Rosuvastatin in Visceral Adiposity
The purpose of this study is to investigate whether 6 months treatment with the cholesterol-lowering drug rosuvastatin may reduce visceral fat tissue in obese middle aged men.
- Trial name
- RIVIERA (NCT01068626)
- Testing
- Rosuvastatin
- Where
- Sweden
- Volunteers
- 54 people
- Sponsor
- Göteborg University
Obesity, Overweight
A Study of Enicepatide (CT-388) in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity
This is a multi-center, randomized, double-blind, placebo-controlled, parallel group dose-finding study to evaluate the efficacy and safety of enicepatide at low, middle, and high doses in participants with obesity or who are…
- Trial name
- NCT06525935
- Testing
- Enicepatide
- Where
- 34 sites in United States
- Volunteers
- 469 people
- Sponsor
- Carmot Therapeutics, Inc.
Obesity, Weight Loss
Intra-gastric Fundal and Body Injection of Botulinum Toxin A for Weight Loss, a Randomized Controlled Trial
This is a randomized controlled trial to compare intra-gastric injection of Botulinum Toxin A (Botox; Allergan Inc. Irvine, Ca, USA) against non-surgical management for obesity (i.e. exercise/diet).
- Trial name
- NCT04274608
- Testing
- Botulinum toxin type A, Weight Management Program
- Where
- Singapore
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Diabetic Polyneuropathy, Weight Loss
Evaluating the Effect of Diabetes Control Through Intensive Lifestyle Modifications on Diabetic Peripheral Neuropathy
The purpose of this study is to find out the impact of improving diabetes control through weight reduction and lifestyle changes on a common diabetes complication called peripheral neuropathy.
- Trial name
- NCT01565317
- Testing
- Weight Achievement and Intensive Treatment (Why WAIT)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Joslin Diabetes Center
Hepatocellular Carcinoma (HCC), Cachexia
Nanocrystalline Megestrol Acetate Versus Placebo for Anorexia in Patients With Unresectable Hepatocellular Carcinoma Receiving TACE Combined With Targeted and Immunotherapy
Primary Objective: To evaluate the effect of nanocrystalline megestrol acetate versus placebo on body weight and appetite in patients with unresectable hepatocellular carcinoma receiving TACE combined with targeted and…
- Conditions
- Hepatocellular Carcinoma (HCC), Cachexia, Anorexia, Malnutrition
- Trial name
- NCT07565415
- Testing
- Nanocrystalline megestrol acetate
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Obesity, Weight Loss
A Study of a Values-Based Intervention to Promote Weight Loss
More than 160 million American adults are overweight or obese. Existing weight loss interventions from self-help to gold standard behavioral treatments, while often effective, do not sufficiently maintain motivation to adhere to…
- Trial name
- NCT03991676
- Testing
- Values-Based Behavioral Treatment
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Drexel University
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