Clinical trials: Body Weight Control
Overweight and Obesity
Adapting an Evidenced-based Weight Management Intervention and Testing Strategies to Increase Implementation in Community Mental Health Programs
This is a pilot randomized clinical trial testing an implementation intervention to support delivery of a behavioral weight loss program at community mental health programs.
- Trial name
- ACHIEVE-D (NCT03454997)
- Testing
- training including in-person and online, organizational strategy meetings, performance coaching
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Neonatal Hypoglycemia, Infant, Small for Gestational Age
Effect of Tahneek on Hypoglycemia in Newborn Infants
Tahneek is an Arabic word which means putting something sweet such as dates, in the infant's mouth after the birth. Neonatal hypoglycemia is common in the first few days after birth.
- Conditions
- Neonatal Hypoglycemia, Infant, Small for Gestational Age, Macrosomia, Fetal, Intrauterine Growth Restriction
- Trial name
- THIN (NCT03726697)
- Testing
- Tahneek
- Where
- Saudi Arabia
- Volunteers
- 324 people
- Sponsor
- King Abdullah International Medical Research Center
Obesity, Obesity, Childhood
A Novel Obesity Prevention Program for High-Risk Infants in Primary Care
The goal of this clinical trial is to test a responsive parenting obesity prevention program with infants and caregivers of color (e.g., non-White; Hispanic/Latinx) and/or who are economically marginalized (i.e., publicly…
- Conditions
- Obesity, Obesity, Childhood, Weight Gain, Weight Gain Trajectory
- Trial name
- THRIVE (NCT06028113)
- Testing
- THRIVE 2.0
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Obesity
Tailored Worksite Weight Control Programs
Given the prevalence of overweight and obesity, worksite-based health promotion programs have been recommended due to their potential reach and social support impact.
- Trial name
- NCT01880060
- Testing
- INCENT weight loss program, Livin My Weigh
- Volunteers
- 1,790 people
- Sponsor
- Virginia Polytechnic Institute and State University
Obesity, Morbid, Diabetes Mellitus, Type 2
Impact of an Increased Restrictive Factor of One Anastomosis Gastric Bypass on Metabolic Outcomes Type 2 Diabetes.
The purpose of the study is to evaluate the effect of an increased restrictive factor of one gastric anastomosis (OAGB) using a "FundoRing" fundoplication on metabolic outcomes in type 2 diabetes mellitus.
- Trial name
- NCT06176443
- Testing
- One anastomosis gastric bypass with combined fundoplication, One anastomosis gastric bypass without combined fundoplication
- Where
- Kazakhstan
- Volunteers
- 300 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Pediatric Obesity
Pilot RCT of E4W App in Adolescents
Recommendations for weight management in adolescents with obesity include setting small goals to improve eating behaviours. This frequently includes manually recording food intake over a few days.
- Trial name
- NCT05548868
- Testing
- E4W mobile app, Standard Care
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- The Hospital for Sick Children
Severe Obesity, Morbid Obesity
Sleep and Immune Response in Severe Obese Patients Undergoing Bariatric Surgery.
Obesity is a major public health problem in developed and developing countries, causing a range of respiratory and metabolic changes. There is a strong correlation between obesity and cardiorespiratory sleep disorders.
- Trial name
- NCT02409160
- Testing
- Standard Roux-en-Y gastric bypass
- Where
- 3 sites in Brazil
- Volunteers
- 17 people
- Sponsor
- Centro Universitário de Anapolis
Obesity
The Role of Values, Acceptance, and Mindfulness Strategies in Long Term Weight Management
Obesity is a prevalent, destructive, and costly chronic disease. In 2008, 37% of Canadian adults were measured as overweight, and 25% as obese.
- Trial name
- NCT02749552
- Testing
- Acceptance and Commitment Therapy
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Fetal Growth Abnormalities, Fetal Weight
Impact of AI Feedback on Ultrasound Biometry Accuracy Across the Expertise Levels
Objective: To evaluate the impact of real-time AI feedback on fetal biometry accuracy and investigate the Expertise Reversal Effect-whether AI benefits diminish as user experience increases.
- Trial name
- NCT07476638
- Testing
- AI interventional group
- Where
- 3 sites in Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Severe Obesity
Mazdutide as Adjuvant Therapy Following Sleeve Gastrectomy in Severe Obesity
The SMART study is a 96-week, multicenter, randomized, double-blind, placebo-controlled superiority clinical trial. A total of 256 severe obesity patients are randomized 1:1 to either receive the bariatric surgery plus GCG/GLP-1…
- Trial name
- SMART (NCT07135141)
- Testing
- Sleeve gastrectomy plus early mazdutide initiation
- Where
- 14 sites in China
- Volunteers
- 256 people
- Sponsor
- Beijing Friendship Hospital
Diabetes Mellitus, Schizophrenia
Diabetes Prevention Program in Schizophrenia [DPPS]
Diabetes is 2-5 times more common in schizophrenia and it is a preventable; but the current diabetes prevention guidelines are not suitable for implementation in the severely mentally ill population.
- Trial name
- NCT00182494
- Testing
- Modified diabetes prevention protocol & Metformin
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Hamilton Health Sciences Corporation
Pregnancy Complications, Preterm Birth
Group Antenatal/Postnatal Care in Rwanda
The focus of this work is to improve antenatal care (ANC) and postnatal care (PNC) at the health center level in five districts in Rwanda (Bugesera, Burera, Nyamasheke, Nyarugenge, and Rubavu).
- Conditions
- Pregnancy Complications, Preterm Birth, Preterm Labor, Stillbirth
- Trial name
- PTBi Rwanda (NCT03154177)
- Testing
- Group ANC/PNC, Ultrasound+Pregnancy Testing
- Where
- 2 sites in Rwanda
- Volunteers
- 26,381 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Binge Eating Disorder, Binge Eating
Effectiveness of a 10-week Multicomponent Intervention Combined With Parent Education on Binge Eating Behavior in Children and Adolescents
The main purpose is to investigate the effectiveness of a 10-week multicomponent camp intervention to reduce BE behavior in children and adolescents and explore in a randomized controlled setting if a parent-based…
- Conditions
- Binge Eating Disorder, Binge Eating, Loss of Control Eating, Overweight , Obesity
- Trial name
- STOB (NCT07301541)
- Testing
- A 10-week multicomponent camp intervention for children, A BED intervention for parents
- Where
- 2 sites in Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Morbid Obesity
Lifestyle vs.Surgery for Morbid Obesity Treatment
The purpose of the current study is to determine whether an intensive lifestyle intervention was as effective as surgery to treat morbid obesity nine years post-intervention.
- Trial name
- NCT02122029
- Testing
- Lifestyle counselling, Bariatric Surgery
- Where
- Greece
- Volunteers
- 29 people
- Sponsor
- Harokopio University
Obesity in Pregnancy, Labor Complication
Antibiotic Prophylaxis to Prevent Obesity-Related Induction Complications in Nulliparae at Term 2.0
Obesity increases the risk of pregnancy complications, including puerperal infections and cesarean delivery, and risk rises with increasing body mass index (BMI).
- Trial name
- NCT06488781
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 787 people
- Sponsor
- University of Oklahoma
Lifestyle, Healthy, Weight Management
Implementing Strategies for Eating Behaviour Modification Based on Portion Control
This is a pre-post intervention study designed to evaluate the feasibility of a self-applied weight management intervention based on portion control.
- Conditions
- Lifestyle, Healthy, Weight Management, Behavior Change
- Trial name
- PORTIONS-4 (NCT06519539)
- Testing
- PORTIONS-4 behaviour change strategies
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Obesity, Adolescent
Preoperative Use of Liraglutide Additionally to Common Dietological Measures as Opposed to Dietological Measures Alone
The aim of the study is to investigate the effects of preoperative Saxenda (liraglutide). There are two groups, one group receives Saxena in addition to dietary measures when first seeking the operation, one group only diet.
- Trial name
- NCT06865365
- Testing
- Liraglutide daily (0.6-3.0mg, highest tolerable dose) additional to dietological measures and lifestyle optimization suggestions, Dietologic measures and lifestyle optimization for weight loss
- Volunteers
- 72 people
- Sponsor
- Medical University of Vienna
Anorexia Nervosa, Constipation
The Role of Lactobacillus Reuteri in Children and Adolescents With Anorexia Nervosa
The aim of this study is to investigate whether Lactobacillus reuteri could have a beneficial role in treatment of children and adolescents with Anorexia nervosa who develop motility disorder due to the malnutrition regarding the…
- Trial name
- NCT02004288
- Testing
- Lactobacillus reuteri Protectis DSM17938
- Where
- Croatia
- Volunteers
- 31 people
- Sponsor
- BioGaia AB
Infections, Obesity and Obesity-related Medical Conditions
Evaluation of the Achievement of a Pharmacodynamic Target of Piperacillin-Tazobactam for the Population With Obesity
This study aims to evaluate the feasibility of an open randomized controlled study which would assess the proportion patients with obesity who will have a favorable pharmacodynamic parameter (i.e.
- Trial name
- NCT06690905
- Testing
- Piperacillin-tazobactam administered in a prolonged infusion, Piperacillin-tazobactam administered in a standard infusion
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- CR-CSSS Champlain-Charles-Le Moyne
Obesity, Childhood, Diet Modification
A Trial to Improve the Healthiness of Packed Lunches in Primary School Aged Children
Public Health England's (PHE) Behavioural Insights Team are leading and fully funding a randomised controlled research trial in collaboration with Derby City Council's Public Health Team and the Health and Social Care Research…
- Trial name
- NCT03104777
- Testing
- Behaviourally Informed Intervention Materials
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Public Health England
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