Clinical trials: Body Weight Control
Hypertension, Gut Dysbiosis
The Effects of a Commercially Available Synbiotic on the Gut Microbiome and Cardiometabolic Health
The purpose of this study is to see the effect of 30 days of synbiotic vs. probiotic supplementation (usingJuice+ nutrition products) on body weight, metabolism, cardiovascular health, and gut health.
- Conditions
- Hypertension, Gut Dysbiosis, Overweight , Obesity
- Trial name
- NCT07515443
- Testing
- Synbiotic
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Southern Utah University
Obesity and Overweight, Dietary Intervention
Efficacy of Different Dietary Pattern in Long-term Weight Management
This study is a nationwide multi-center, long-term randomized controlled clinical trial, aiming to evaluate the effects of individualized dietary pattern management programs compared to traditional energy-restricted diets in…
- Trial name
- EDI-Weight (NCT07773558)
- Testing
- Individualized dietary intervention, Traditional energy-restricted balanced diet
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Guang Ning
Obesity, Bariatric Surgery Candidate
Tele-BARICARE to Manage COVID-19-Related Distress
Background: Over 60% of Canadians are overweight or obese and more than half have a history of a mental illness. The COVID-19 pandemic has made it difficult for people living with obesity to manage their weight even after…
- Conditions
- Obesity, Bariatric Surgery Candidate, Mental Health Disorder, Eating Disorders
- Trial name
- TELE-BARICARE (NCT05258578)
- Testing
- Tele-CBT, Self-Help Resources
- Where
- 4 sites in Canada
- Volunteers
- 140 people
- Sponsor
- University Health Network, Toronto
Binge Eating Disorder, Obesity
Treatment for Obesity and Binge Eating Disorder
This study is a test of cognitive behavioral therapy(CBT) and behavioral weight loss (BWL) treatments for obese patients with binge eating disorder (BED).
- Trial name
- NCT00537758
- Testing
- Cognitive Behavior Therapy, CBT and BWL, Behavioral Weight Loss Treatment
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Yale University
Obesity, Overweight
Semaglutide for Post-Smoking Cessation Weight Management
This trial will examine the effect of semaglutide 2.4mg on changes in body weight, body composition, and peripheral and central mechanisms that control appetite, satiety, and food intake in the context of smoking cessation.
- Conditions
- Obesity, Overweight, Cigarette Smoking
- Trial name
- NCT06173778
- Testing
- semaglutide 2.4mg, Nicotine Replacement Therapy (NRT, nicotine patch), Brief Smoking Cessation Counseling
- Where
- 2 sites in United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Eating Behavior, Healthy Diet
PROFRUVE Program to Promote Fruit and Vegetables Intake Among Children.
Because fruit and vegetables (FV) intake of children of Vitoria city is low, a controlled intervention program was proposed at school level.
- Conditions
- Eating Behavior, Healthy Diet, Fruit and Vegetable Intake, Childhood Obesity
- Trial name
- PROFRUVE (NCT03400891)
- Testing
- Program based on the theory of planned behaviour
- Volunteers
- 230 people
- Sponsor
- University of the Basque Country (UPV/EHU)
Obesity
Mechanism of Decreased Iron Absorption in Obesity: Controlling Adiposity-related Inflammation
The main iron regulatory protein in the human metabolism is hepcidin. In normal weight, healthy subjects, hepcidin is regulated through the iron status of the body: low iron status results in low hepcidin concentrations, which…
- Trial name
- NCT02745925
- Testing
- Ibuprofen
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Swiss Federal Institute of Technology
Binge-Eating Disorder
EMDR vs. CBT in the Treatment of Inpatients With Obesity and Binge Eating Disorder: the EMDRDCA Study.
Overweight and obesity are linked with Binge Eating Disorder (BED). Traditionally, Cognitive Behavioral Therapy (CBT) is the therapeutic approach indicated both for inpatient and outpatient treatment of BED.
- Trial name
- EMDRDCA (NCT06474689)
- Testing
- EMDR, CBT
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Istituto Auxologico Italiano
Obesity, Overweight or Obesity
A Phase 2b Study to Evaluate the Efficacy and Safety of Once-Monthly MET097 in Adults With Obesity or Overweight
This study is designed to test the weight loss effects, safety, and tolerability of multiple monthly doses of MET097 after 12 weekly doses, compared to placebo.
- Trial name
- VESPER-3 (NCT06973720)
- Testing
- MET097
- Where
- 5 sites in United States
- Volunteers
- 268 people
- Sponsor
- Pfizer
Obesity
A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity
The main purpose of this study is to determine if combining tirzepatide with mibavademab will result in more weight loss in adult participants than tirzepatide alone.
- Trial name
- NCT06373146
- Testing
- Tirzepatide, Mibavademab
- Where
- 17 sites in United States
- Volunteers
- 392 people
- Sponsor
- Eli Lilly and Company
Overweight and Obesity, Hypertension
Get-a-Grip Lifestyle Management Programme
The primary aim of this study was to examine weight reduction in primary care in obese or overweight subjects with a comorbidity that would benefit from weight loss during 1-year comprehensive lifestyle management programme…
- Conditions
- Overweight and Obesity, Hypertension, Dyslipidemias, Diabetes
- Trial name
- NCT04003259
- Testing
- Lifestyle management programme
- Where
- Finland
- Volunteers
- 134 people
- Sponsor
- Tampere University
Weight Management
Satiating Effects of Isolated Soy Proteins
Proteins are known to be more satiating than the other macronutrients; however, the type and amount of protein needed to induce a significant effect on satiety (fullness between meals) is sometimes difficult to determine.
- Trial name
- NCT01731197
- Testing
- Dry-Blended Beverage
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- DuPont Nutrition and Health
Obesity, Childhood
Pharmacotherapy for Pediatric Obesity: A Phentermine Clinical Trial
This is a multi-site, randomized, placebo-controlled clinical trial to examine the weight loss efficacy and cardiovascular safety of phentermine 15 mg daily plus lifestyle therapy versus placebo plus lifestyle therapy among 200…
- Trial name
- NCT04678323
- Testing
- Lifestyle Management
- Sponsor
- University of Minnesota
Gastroesophageal Reflux Disease, Acid Reflux
Efficacy of Gaviscon-Advance® in Suppressing Post-supper Acid-pocket and Night-time Acid-reflux in Obese Participants
A randomized, open-label study with antacid-control will be performed over 48 hours period by continuous pH impedance and bravo capsule monitoring.
- Conditions
- Gastroesophageal Reflux Disease, Acid Reflux, Obesity
- Trial name
- NCT03516188
- Testing
- Alginate-antacid group, Non antacid alginate group
- Where
- Malaysia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Obesity
A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight
This study will look at how well semaglutide helps children and teenagers losing weight. This will be tested by comparing the effect on body weight in children and teenagers taking semaglutide in comparison to placebo, a "dummy"…
- Trial name
- STEP Young (NCT05726227)
- Testing
- Semaglutide
- Where
- 56 sites in United States, Austria and 8 more
- Volunteers
- 212 people
- Sponsor
- Novo Nordisk A/S
Obesity
Herb-partitioned Moxibustion Plus Lifestyle Modification Treatment for Simple Obesity
This study is designed as a three-dummy randomised controlled trial to evaluate the efficacy and safety of herb-partitioned moxibustion plus lifestyle modification treatment in patients with simple obesity.
- Trial name
- NCT04606680
- Testing
- Heat application at acupoints, Medicated plaster at acupoints, Herb-partitioned moxibustion at acupoints
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Hubei Hospital of Traditional Chinese Medicine
Osteoarthritis, Knee, Obesity
Weight Loss Intervention Before Total Knee Replacement
The purpose of this study is to compare the efficacy in a group of patients who must follow the current procedure for treatment of artificial knee, compared with a group of patients who must undergo an 8-week weight loss program…
- Trial name
- NCT01469403
- Testing
- 8 weeks weight loss program, Cambridge.
- Where
- Denmark
- Volunteers
- 76 people
- Sponsor
- University of Aarhus
Obesity
Improving Weight Management at the VA
Compared to the general public, a higher percentage of Veterans are obese or overweight with a weight-related medical condition.
- Trial name
- NCT02626819
- Testing
- MOVE! Toward Your Goals, Enhanced Usual Care
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- VA Office of Research and Development
Overweight, Obesity
The Weight-Wise Weight Loss Translation Study
The overall goal of the translational research is to evaluate the processes and outcomes of implementing, in a range of public health agencies, an intense, evidence-based behavioral weight loss intervention with demonstrated…
- Conditions
- Overweight, Obesity, Cardiovascular Disease
- Trial name
- Weight-Wise (NCT01141348)
- Testing
- Special Intervention, Delayed Intervention
- Where
- 6 sites in United States
- Volunteers
- 189 people
- Sponsor
- University of North Carolina, Chapel Hill
General Health and Wellness, Energy and Vitality
M4C Nutraceutical Intervention Human Health Effects Pilot
This 3 month pilot study will be an unblinded, convenience sampling, nutraceutical intervention trial. Twenty fasted subjects will undergo a baseline health assessment via a questionnaire, baseline clinical chemistries, blood…
- Conditions
- General Health and Wellness, Energy and Vitality, Cognitive Function and Mental Health, Weight Management
- Trial name
- M4C Pilot (NCT06476236)
- Testing
- M4C
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Concordia University Wisconsin
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